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Adrienne Hill-Strathy
Cervical cancer remains the second most common cancer among women worldwide. Certain high-risk strains of the Human Papilloma Virus (HPV) are responsible for causing cervical cancer.
Around 70-90% of individuals with HPV will clear the virus 12 to 24 months after infection. However, in few individuals, the viral infection can persist and cause cellular changes to the cervix that may lead to cervical cancer.
What allows some people to quickly clear the viral infection and others to develop cancer?
Several identified factors may impact an individual’s ability to clear an infection. These include frequent re-infections, immune health, hormone levels, or infections by more than one HPV type.
Genetic factors also play a role. In this article, we explore the relationship between HPV and genetics.
How Do Genes Influence Cancer?
Genes play a role in directing healthy cellular development by controlling cell growth and cell death.
Genes that control how our cells grow, work, and stay alive are called oncogenes. Other genes, called tumor suppressor genes, keep cell growth under control and initiate cell death at the right time. Cancer occurs when DNA mutations alter the genes that turn on oncogenes or turn off tumor suppressor genes, allowing abnormal cellular growth.
Research has found that high-risk HPV contains special proteins called E6 and E7. These proteins turn off tumor suppressor genes. When these genes are deactivated, cells in the cervix can progress and lead to further gene changes and potentially cancer.
Is Cervical Cancer Heritable?
Research suggests that a familial predisposition to cervical cancer may be present.
If your mother or sister had cervical cancer, your chances of developing cervical dysplasia or cancer are increased. Moreover, the risk increases with the increased degree of genetic relatedness.
A Swedish study found that genetic heritability accounted for 27% of the underlying factors for cervical cancer development. The study also tested the role of the environment but found shared environmental factors accounted for only 0-2% of disease progression. The results showed a greater impact than other cancers like colorectal cancer, lung cancer, and melanoma.
The reason for these genetic correlations is not completely understood. It could be explained by a few factors:
Our genetics may impact our DNA repair pathways associated with CIN3 cervical dysplasia and HPV persistence. Genes have also been associated with supporting viral infection and cell entry.
Genotypes may influence an individual’s likelihood of exposure to HPV. For example, genetics may influence an individual’s sexual or risk behaviors, thereby influencing the risk level of contracting HPV.
Genetics may also influence an individual’s cervical cancer risk through HLA alleles. Seven alleles have been associated with cervical cancer, while another four showed a negative association.
Specific genotypes like BRACA have also been investigated on cervical cancer. It was found that the BRACA1 genotype was associated with a decreased risk of cervical cancer. The same variant is also associated with an increased risk of inherited breast cancer.
Genetics and The Immune System
Cervical cancer may also be driven by genetic factors that influence the immune system, decreasing some women’s ability to fight off infections like HPV.
The immune system is the key factor allowing HPV infections to progress from cervical dysplasia to invasive cancer. The progress from infection to cancer takes several years to decades to develop. The innate and adaptive immune responses are responsible for the regression, persistence, and progression of HPV infections.
For example, women with HPV infections that evolve into high-grade lesions have a reduced immune cellular response. Genetics may also influence the number of immune cells an individual has to defend against infection.
MTHFR Genetic Mutation
Some people have a genetic mutation that prevents them from properly converting dietary folate into its active form (5-MTHF) by a process called “methylation”. This mutation may explain why some women with healthy diets and lifestyles struggle to clear the infection.
The MTHFR mutation increases the risk of several diseases including heart disease, colon cancer, and breast cancer. Studies evaluating the association between genetic variants of MTHFR and cervical cancer show some association between the MTHFR C677T polymorphism and CIN 3. However, further studies are needed to determine the actual cause.
An Emerging Field
The research behind genetic predispositions to cervical cancer and cervical dysplasia is very much still evolving. As more research emerges, we may have more clarity as to what leads some to develop more severe reactions to HPV infection than others.
May 17, 2021
3 min read
Normal Pap Smear: Could I Still Have HPV?
Adrienne Hill-Strathy
The regular Pap test can be a dread for many women. The situation is uncomfortable, and the fear of an abnormal result can be anxiety-provoking.
What’s more, the results of a Pap smear can often be confusing.
Here, we have provided a breakdown to help you better understand your Pap results and how we can use testing to better prevent complications like cervical cancer.
What Is a Pap and HPV Test?
The HPV and Pap Smear Tests are the primary ways for women to test for HPV and signs of abnormal cells.
A Pap test involves taking a sample of cells from your cervix to assess for any abnormalities. It is usually combined with a pelvic exam and sometimes an HPV test, which screens for the presence of HPV viruses in your cell tissues.
What Do Your Pap Results Mean?
The test results from a Pap smear can go one of three ways: NORMAL, UNCLEAR, ABNORMAL.
Normal: a normal Pap test suggests no abnormal cellular changes on the surface of the cervix. Pap testing will be recommended every three years.
Unclear: an unclear test indicates some mild abnormality and usually warrants a repeat Pap test. Mild abnormality could be due to a vaginal or sexually transmitted infection, changes in hormones, such as those seen in pregnancy or menopause, with certain medications, or poor test collection.
Abnormal: an abnormal pap test means that cervical cell changes were found. This does not mean that you are positive for cervical cancer but further investigation is needed.
Can You Have a Normal Pap Smear But Be Positive for HPV?
Because the Pap test and HPV test for two different things, abnormal cellular changes and the presence of HPV in your cells, it is possible for your Pap test to come back normal, but you screen positive for HPV.
This results likely means you have HPV, but the virus remains in a state of low activity and has not caused significant abnormal changes to your cervix.
HPV is typically cleared by activation of the adaptive immune system, which releases immune molecules called T-cells into the circulation to suppress viral replication. Over time, a healthy immune system should prevent HPV from further proliferating into your cervical epithelial cells and render the virus in a latent state.
A normal Pap test could therefore indicate that your immune system is actively suppressing cell proliferation, but the virus is still active.
Errors In Pap Testing
A normal Pap test could also mean the swab may not have caught the areas of abnormality on your cervix. While Pap testing is a great tool, it isn’t always perfect.
Studies find that abnormal findings increase when conventional Pap smears are replaced by liquid-based cytology (LBC). However, because most HPV infections resolve over time and cytology exams lead to costly follow-up investigations with repeat Pap smear and biopsies, HPV reflex testing is being used to identify high-risk strains.
HPV Reflex Testing
Pap and HPV testing are usually done in combination to evaluate whether the strain of HPV that is infecting a host, has a high risk of developing into cancer.
HPV reflex testing can help identify the particular HPV strain that is causing the infection.
We know that high-risk HPV types 16, 18, 31, 33, 35, 45, 52, and 58 account for about 88% of all cervical cancers worldwide. Detection of these strains within an individual can help prioritize preventative measures and screening to monitoring changes and cell development.
By performing more specific screening we can ensure that individuals at high-risk are getting proper follow ups and avoiding undue stress to minor cases that are unlikely to progress into cervical cancer.
It should be noted that HPV reflex screening is not typically included in screening guidelines but is offered as a commercial test to better screen for a patient’s risk.
What Can You Do?
If you have received a result of a normal Pap test but remain positive for HPV, it is still important for you to take steps to support your immune system and keep watch on the situation.
We recommend:
Eating a diet rich in plants and high in micronutrients.
Supplementing with herbal formulas, like Papillex, and medicinal mushrooms to support your immune system.
Developing techniques to reduce daily stressors and manage overwhelm.
Limiting the consumption of alcohol and avoiding smoking.
Getting daily exercise and movement into your day.
May 03, 2021
3 min read
Research update: AHCC® found to clear HPV in a human clinical study conducted by Dr Judith A. Smith
Adrienne Hill-Strathy
Many of you have expressed interest in the results of Dr. Judith A. Smith’s HPV study on the use of AHCC® in people with HPV. Her previous studies showed positive findings, suggesting that AHCC® may help eradicate HPV in individuals with persistent high-risk infections. We are excited to learn that a further clinical trial confirms positive findings and will soon be published.
HPV and Cervical Cancer
Cervical cancer represents around 10 percent of all cancers worldwide. The human papillomavirus (HPV) is the virus found to cause 99 percent of cervical cancers and is also associated with cancers of the throat, anus, vagina, vulva, and penis.
High-risk strains of HPV infect the epithelial layer of cells of the cervix. When HPV infections persist overtime (classified by positive HPV testing over two or more years), there is an increased risk of developing cervical cancer. As we understand more about the cause and progression of cervical cancer and HPV, we are also learning more ways to prevent and protect against it.
Research has evaluated the use of a natural medicinal compound, AHCC® on HPV infections.
What is AHCC® and how can it help eradicate HPV? What Do Your Pap Results Mean?
AHCC® stands for Active Hexose Correlated Compound. It is a nutritional supplement derived from shiitake mushroom that acts as an immune modulator. The compound is safe and effective at increasing the number and activity of immune molecules including natural killer cells, dendritic cells, and cytokines, which help the body identify and fight off infections.
The standardized extract of AHCC® was developed in Japan in 1992 by the company Amino Up Chemical Co. Ltd. Several studies have reported a variety of therapeutic effects from AHCC®, including antioxidant, anticancer activity, and improved immune responses. The positive findings of AHCC® in enhancing the immune response have led to the question of whether the compound could benefit people with HPV.
The human research on AHCC® and HPV has been led by Dr. Judith A. Smith, Pharm D. a Professor and Director of Women’s Health Integrative Medicine Research Program in the Department of Obstetrics, Gynecology and Reproductive Sciences at McGovern Medical School. Here is what we currently know about Dr. Smith’s recent research endeavors:
From Bench to Bedside
In 2019, Dr. Smith published an article in the Frontiers in Oncology entitled: From Bench to Bedside: Evaluation of AHCC supplementation to Modulate the Host Immunity to Clear High-Risk Human Papillomavirus Infections.
The study found clearance of high-risk HPV in vitro, in mouse models, and in two human pilot studies of 10 patients. The human trials found dosing of 1-3 grams of AHCC® daily for 3-8 months led to a 44-66.7% clearance rate of HPV infections. Dosing of 3 grams led to slightly higher clearance rates than 1 gram. This research study spurred further interest in the topic and led to a recently completed phase II trial.
The New Research
The most recent research study was a human double-blind, placebo-controlled trial. This means that the participants and the researchers were not aware whether the participants had supplemented with AHCC® or with placebo.
The study included 50 participants, evaluated for either active treatment with a 3-gram dose of AHCC® for 6 months or a placebo. Participants were followed for 12 to 30 months. Individuals that continued to be HPV positive at the end of the 12 months, were considered treatment failures. Those that were negative after 6 months were followed for another 6 months to confirm if they remained HPV negative.
This study also evaluated immune markers like CD8+ T cells or natural killer (NK) cells to monitor the physiological response to AHCC® supplementation.
While the results of the study have yet to be published, Dr. Smith has confirmed reports that the results are aligned with the positive findings found in the first two pilot studies. The results of this follow-up study will be published this year.
As soon as the new paper is made available, we will be the first to share it with you.
What’s next?
We are excited about the growing knowledge base around HPV, cervical dysplasia, and cervical cancer prevention and the use of natural medicine to play a role in responding to HPV naturally.
Dr. Smith plans to extend the research to evaluate the potential of AHCC® supplementation in combination with chemotherapy for the treatment of HPV related cancers.
Mar 02, 2021
3 min read
Adrienne Hill-Strathy
Viruses aren’t living organisms but strands of DNA or RNA that make a home in other living organisms. By doing so, the viruses can survive.
The life-cycle of a virus includes gaining entry into a living organism, replicating, and making itself a home.
Understanding the life-cycle and how the immune system interacts with HPV can better understand why some strains develop into complications like cancer.
What Makes The HPV Life-Cycle Unique?
HPV includes a family of more than 150 types that have slight variations. HPV has adapted over time to target different tissue regions and cause different diseases.
Most HPV infections occur around the mouth or genitals. Some infections cause visible growths like warts and others are asymptomatic.
In addition to the type of HPV strain, symptoms also depend on the individuals' immune system. The immune system influences how quickly the virus is identified and eliminated from the body. Most HPV infections will complete their life-cycle without causing disease or symptoms at all.
Infection Stage
Infection occurs when the HPV gains entry into skin tissue, called epithelial cells. Epithelial cells line the surface of the body and can be classified into three shapes: squamous, columnar, and cuboidal.
When it comes to testing for HPV and cell abnormality, squamous cells are the ones that typically develop abnormalities.
Squamous cells are found in body tissue which forms the very surface of the skin. During a Pap smear, a swab is taken from this layer to examine for abnormalities.
The cells meet the rest of the body through a layer called the basement membrane. This basement layer is where the HPV virus attaches and enters the cell. Once the virus has accessed the cell it can then use the cell to replicate.
Squamous Cells Diagram
Replication:
Depending on the strain of HPV and the body the virus makes a home in, the life-cycle will have different outcomes.
The virus may remain relatively silent. In this case, the virus doesn’t move beyond the basement membrane to cause disease.
The virus may also begin to replicate, releasing its viral particles deeper into the host. When the virus replicates deeper into the skin tissue it is called a productive infection.
Productive Infections
Infections can be classified into grades CIN 1 (deregulated) to 3 (high-grade neoplasia). Persistent high-grade infections at CIN2 or CIN3 can further lead the virus to integrate into the individuals' genes. This puts the individual at greater risk of developing cancer.
Some areas within the cervix lining are more susceptible to infection. HPV that gain access to the transformational zone in the cervix have been linked to higher rates of cancer progression.
Two viral proteins, E6 and E7, have also been found on high-risk strains of HPV. These proteins are thought to be responsible for stimulating cell cycle entry into the upper epithelial layers and linked to cancerous changes.
Latency
In most cases, HPV will not reach a cancerous state. The majority (80-90%) of HPV infections will clear on their own. Even high-risk strains will likely be cleared by a local immune response.
The virus gets inactivated through interaction with our immune system.
In a healthy immune system, active infections will stimulate immune cells called CD4+ T cells. The presence of CD4+ T cells activates more immune molecules to overtake the virus.
A compromised or weak immune system appears to increase HPV infections.
In viral latency, viral particles continue to exist within the basement membrane in an inactive state. However, the virus can get reactivated following a change in immune status.
What Makes Certain HPV Subtypes More Carcinogenic?
In order for cancer to develop, the virus has to go undetected by the immune system over a prolonged period.
Certain subtypes of HPV, like HPV-16 and 18 are more powerful carcinogens. What makes the virus carcinogenic is its ability to invade the cell layer for longer periods of time allowing changes in the gene expression of the underlying tissue.
It is thought that the presence of E6 and E7 proteins on high-risk strains allows for cervical abnormalities to occur.
How Can You Assist Your Immune System?
It is clear from the research that a healthy immune system is key to preventing HPV infections from reaching a cancerous state.
Diet and lifestyle create the foundation for a healthy immune system. Some important factors in supporting your overall health include:
Optimizing nutrition and supplementation: Consuming fruit and vegetable-rich diet, limiting sugar and refined carbohydrate intake has a positive effect on the immune system.
Managing psychological stress: Prolonged stress can imbalance the ability of the body to fight incoming infections. Engaging in daily stress management practices like meditation, exercise, and socializing can have a positive effect in improving the body's overall resiliency.
Getting good quality sleep: Getting adequate rest, or seven to eight hours of quality sleep per night allows the immune system time to revitalize. Adequate sleep balances hormones and initiates cellular repair. Setting a regular bedtime, limiting caffeine intake in the afternoon, and eating a nutrient-dense diet are all ways to improve your sleep quality.
Engaging in regular exercise and movement: From improved circulation to naturally increasing the immune cells, staying active has a range of benefits in helping support health and prevent disease. We recommend taking daily walks and engaging in bi-weekly strength training and aerobic activity.
Mar 01, 2021
4 min read
Adrienne Hill-Strathy
HPV is very widespread amongst the population. It is estimated that 80 percent of women will contract a strain of HPV in their lifetime. Most of these infections are silent, causing no visible symptoms or side effects within a host.
In about 90 percent of patients, a healthy immune system will typically develop an immune response to regress the virus within a period of 1 to 2 years, with most in fact regressing over the course of a few months.
However, a small number of people who contract an HPV infection may have symptoms or complications that range from low-risk visible papilloma’s on the skin to persistent chronic infections that may develop into precancerous or cancerous lesions.
Here, we outline a few of the most common symptoms of HPV, including potential side effects of HPV vaccination.
HPV Symptoms
Typically, if HPV symptoms do develop, they will either cause visible warts on the surface of the skin or cause chronic infections that persist within the cell tissue and are only detected through clinical examination, like a pap smear.
Warts
The large variety of HPV strains gives rise to several different types of warts on the body surface, face, and genital areas. These warts can be classified into:
Common warts: the common wart is most frequently caused by HPV-2. These warts usually present with an irregular shaped rough nodule that shows up in multiples.
Plane warts: mostly caused by HPV-3, 10, or 28. They cause small and less rough, flesh-colored, or lightly pigmented lesions. Usually on the hands or face. Plane warts have an unusual characteristic in that they can spontaneously regress and cause swelling and a rash at the surface of the skin.
Plantar warts: usually found in 10-14-year-olds. They are contracted through barefoot activity and are found on the bottom of the feet. Plantar warts are typically caused by HPV 1 and 2.
Genital warts: are most frequently caused by HPV 6 and 11. They are renowned for their resilience and ability to continually come back, as well as being both painful and irritating.
Cancerous or Precancerous Changes in the Cells of the Cervix
Only a few of the over 180 different strains of HPV are associated with increased cancer risk.
HPV that causes cervical, anal, or oral cancer is typically caused by a few high-risk strains of HPV that infiltrate the epithelial cells and have developed special mechanisms to evade the immune system.
There are typically no symptoms that HPV is developing into cancer until several years of cell proliferation and development. HPV that has progressed to a stage of cervical cancer may present as symptoms of abnormal vaginal bleeding.
The fact that it takes many years for HPV to develop into cancer is both a positive and a negative for us because it gives us time to detect the virus at an early stage in development before it has progressed into cancer and take action.
It is negative because having no symptoms can prevent some people from being proactive about their health, allowing the situation to progress to a more serious state. Typically, Pap screening should be done every three years from the age of 21 to 65 to screen for these abnormalities.
The HPV Vaccine and Potential Side Effects
Today, we have a vaccine offered as a preventative measure against high and low risk HPV strains, primarily to protect women against cervical cancer.
The Centers for Disease Control and Prevention recommends the HPV vaccine for routine vaccination at age 11 or 12 years. The vaccine may be started as early as age nine.
Females aged 13 to 26 and males aged 13 to 21 are recommended to receive the vaccine. The vaccine is only recommended past the age of 26 for gay, bisexual, transgender, and those who have chronically weakened immune systems.
Gardasil is the most commonly used vaccination, protecting against the two strains of HPV that cause genital warts, and the two strains that are the most high-risk HPV strains, commonly known to cause cancer, such as cervical cancer.
Two doses of the vaccine should be given, the second being 6 to 12 months after the first. If less than 6 months apart, the recipient is of a weakened immune system or is past the age of 15, three doses are required to ensure the vaccination is effective.
It is important to keep in mind that the vaccination does not protect you against all HPV strains, just the most high-risk, so routine screening is still recommended.
Side Effects of Vaccination
Side effects of the HPV vaccine may include:
Injection site irritations such as pain, redness, or swelling
Fever
Systemic reactions such as nausea, muscle pain, malaise, and dizziness
Fainting
The vaccination is quite safe; different types of the vaccine having been studied in almost 75,000 individuals.
These side effects are not commonly experienced, and for most people, it is definitely worth the risk to receive the vaccine than forgo it because of potential mild and temporary side effects.
Feb 01, 2021
4 min read
Green Tea Extract and Cervical Cancer/Warts
Christine Chung
The Greatness of Green Tea
Green Tea Extract is one of the many great ingredients in Papillex™.
Green Tea, also known by its Latin name Camellia sinensis, is high in compounds called polyphenols. Polyphenols are naturally occurring chemicals abundant in plants that have beneficial properties to human health.
The polyphenols found in green tea are specifically beneficial in boosting the immune system in people with HPV. Two polyphenols, in particular, epigallocatechin gallate (EGCG) and polyphenol E are effective in the treatment of cervical lesions and warts caused by HPV.
These master players, EGCG and polyphenol E, are antioxidants that help protect cells from oxidative stress and fight inflammation. EGCG is also associated with relaxation and keeping you alert. It is now recognized for the prevention of several conditions including autoimmune disease, heart disease, neurodegenerative disorders, and Alzheimer’s.
What does the research say?
A handful of studies have begun investigating the use of green tea extract on HPV clearance, preventing cervical cancer, and eliminating genital warts caused by HPV. Green tea has been shown to influence a variety of mechanisms that are favorable towards preventing and treating HPV-related lesions.
Most notably, green tea extract has been found to play a role in regulating immune molecules called T cells. T cells are important immune system modulators. EGCG from green tea extract has been found to increase the production of T regulatory cells, helping regulate and balance the immune response.
How do these compounds impact HPV?
A review investigating the potential mechanism of action of green tea extract on HPV cells found that EGCG and polyphenol E specifically stopped the spread of HPV-related cancer cells by halting cervical epithelial and cancer cell growth. The study also found the compounds had a greater effect on squamous cells and less in adenocarcinoma cells. EGCG was also found to have a stronger growth inhibition than polyphenol E.
One study conducted in South Korea of 51 patients evaluated the use of green tea extracts, polyphenol E and EGCG, in a form of ointment or capsule in patients with mild to severe cervical dysplasia. The local ointment was applied to half the participants twice a week. The patients that received the oral treatment took 200 mg capsules every day for 8-12 weeks.
The findings showed an overall reduction of 69% of cervical dysplasia lesions in patients who received green tea extracts, compared to only 10% improvement in the group with no green tea treatment. The participants in the ointment application had a slightly better response.
How is green tea extract used to clear HPV warts?
Warts are another pesky symptom of HPV. Green tea extract has been studied as a treatment option for both plantar warts and genital warts caused by HPV.
A study in the British Journal of Dermatology has found the topical treatment of green tea to be both effective and safe. The study used an ointment containing 10% green tea catechins and evaluated over 1000 adults with external genital and perianal warts. The participants that used the ointment containing green tea extract were found to be 2-folds more effective than the participants without green tea in their ointment. The green tea cleared existing warts and prevented recurrence 12 weeks after treatment.
All of this promising research shows that green tea extract can serve as a worthwhile natural therapy for men and women with HPV associated cervical lesions (CIN) or warts.
Is it safe for me to take?
Green tea has an excellent safety profile in moderate doses, both orally and topically, and is associated with many health benefits ranging from heart health to anti-cancer properties.
The efficacy and safety of this topical green tea extract were confirmed by one of the few clinical trials available, including 397 adults with HPV genital warts. People who applied the treatment 3 times a day had complete clearance of warts in 16 weeks.
So, do I just drink a lot of tea?
Now you may be wondering, how many cups of green tea do I need to be drinking to benefit from these positive effects?
Unfortunately, to get enough of the green tea catechins to have an actual effect on prevention and healing, you would need to drink a ridiculous amount of green tea every day. Something in the 20 to 30 cup-per-day range! Nevertheless, the data does suggest that regular and high consumption of green tea may contribute to the prevention of cervical cancer.
To obtain the optimal dose, we recommend consuming green tea extract as a supplement. Luckily, there are many high-quality products, including Papillex™, that can provide you with a therapeutic dose to help your body naturally rid of HPV.
What about topical application?
The FDA approved a topical cream called Veregen®, a standardized extract of green tea leaves, containing 85% catechins, most abundant being EGCG. The compound is also being evaluated for its use in skin cancers like basal cell carcinoma. The topical cream can be applied in a thin layer twice daily to affected areas.
How Can Papillex Help?
Attaining the therapeutic daily dosage of green tea can be a challenge without supplementation. Papillex has made it easy for you, combining high-quality therapeutic level extracts of EGCG from green tea containing in combination with several ingredients that work together to boost the immune system to respond to HPV naturally.
Papillex is a simple and effective way to support your body and immune health.
Jan 15, 2021
4 min read
Could your rash be a symptom of HPV?
Adrienne Hill-Strathy
You’ve recently noticed a rash developing on your skin, making you wonder, is this HPV?
HPV infections reside within the skin tissue and are transmitted through skin to skin contact. There are over 150 different viral strains of HPV that have evolved to infiltrate different areas within the skin and mucous membranes and are associated with different symptoms and progress to different diseases.
Most HPV Infections are Asymptomatic
Most HPV infections are silent. A person will contract an infection without having any visible symptoms.
In about 90 percent of patients, a healthy immune system will typically develop an immune response to regress the virus within a period of 1 to 2 years.
A small number of people suffer from persistent HPV infections and have an increased risk of developing cancer. However, these infections take many years to develop and through early detection and pap screening, complications rarely develop into malignancies.
HPV Symptoms
Typically, if symptoms do develop, they will either cause visible papilloma’s or warts on the surface of the skin or cause chronic infections that persist within the cell tissue and are only detected through clinical examination like a pap smear.
HPV symptoms may include:
Genital warts
Skin warts
Cancerous or precancerous changes in the cells of the cervix, detected during a pap test.
Genital Warts
Some low-risk strains of HPV can cause visible symptoms on the skin like common warts, genital warts, and plane warts.
Genital warts are also known as condylomata acuminate. They are usually caused by HPV types 6 and 11.
The warts appear as a soft, fleshy, cauliflower-like growths that grow in genital areas including the anus and penis. They can be painful, itchy, annoying, and, worst of all, highly persistent. Genital warts may also cause swelling in the genital area and lead to itching and discomfort.
In women, warts often grow on the vulva, the walls of the vagina, or in between the external genitals and the anus. In men, they usually occur on the tip or shaft of the penis.
Other Warts Caused By HPV
Other warts caused by the HPV infection include plane warts, which tend to show up as small nodules on the hands or face. Plane warts can cause a mild rash on the hands of face during viral regression, but it is uncommon.
Common warts typically show up as irregular shaped rough nodules that occur in multiples. These warts are also most commonly found on the fingers or hands, often featuring small black dots of clotted blood vessels.
How Do I Get Rid of Warts?
Each individual’s immune system responds differently to HPV, so each of us will have a different reaction to the virus as well.
HPV strains that cause warts are classified as low-risk strains because they rarely develop into serious complications like cancer. Most warts will be cleared naturally by a healthy immune system.
Implementing a healthy diet and lifestyle as well as incorporating natural treatments like green-tea extract, found in Papillex, has also been found to improve wart clearance.
Rashes
Although HPV affects the skin tissue, rashes are not typically a symptom of an HPV infection. As mentioned, some plane warts may present with a rash during viral regression but otherwise it is not a common symptom of an HPV infection.
A rash likely indicates another skin infection, irritation, or sexually transmitted disease and requires further examination by your doctor.
Jan 01, 2021
3 min read
Christine Chung
Remember when your mom told you to eat your apples and oranges to fight colds and flu? She was onto something!
Vitamin C does it all - boosting energy, improving skin quality and mood, supporting iron absorption, and functions as an antioxidant and immune support.
Vitamin C, also known as ascorbic acid, is a water-soluble vitamin that plays an important role in human health. Vitamin C is an essential vitamin for humans, as we are unable to make it on our own. This makes it very important to get enough of this crucial vitamin through our diets or supplementation.
Vitamin C is most known for its role in fighting colds and flu. However, this vitamin is also essential for maintaining the structure and function of our skin tissues. It is involved in the creation of collagen for your skin and fuel for your cells and neurotransmitters. It is also a strong antioxidant, meaning it neutralizes toxic substances in your body.
This powerful vitamin is also an important player in supporting HPV infections.
Benefits of Vitamin C
The mechanism behind many of these benefits comes from Vitamin C’s role in managing oxidative stress. Oxidation occurs when the body breaks down proteins and cells, creating free radicals. These free radicals contribute to cellular damage. Vitamin C (an antioxidant) combats oxidative stress by neutralizing free radicals.
These antioxidant effects help protect connective tissue and form collagen layers in our skin tissues. Vitamin C also supports the immune system by neutralizing pathogens and inflammation which helps immune cells perform their job effectively.
New research sheds light on the connection between Vitamin C status and cancer risk. The study found that Vitamin C from fruits and vegetables was associated with a lower risk of cancer by decreasing the formation of carcinogens in your body.
Vitamin C levels are a good way to measure a healthy lifestyle and can be associated with heart health and decreased risk of strokes.
Let’s not forget the good old-fashioned common cold. Many people take Vitamin C at high doses to prevent colds, or shorten the duration and decrease the intensity of colds. Vitamin C has an anti-histaminic effect at high doses, which is likely to help with colds as well as allergies.
Vitamin C Deficiency
Vitamin C deficiency is famous for causing scurvy back in the days where men would be on ships for long periods, or during times of war and famine. Surprisingly enough, scurvy has been seen more recently in some university student populations.
The most common cause of Vitamin C deficiency is due to poor diet, alcoholism, anorexia, or smoking. Because Vitamin C is widely obtained from fruits and vegetables, it takes several months of poor nutrient intake for severe deficiency to develop.
Vitamin C deficiency can present with symptoms such as fatigue, malaise, and inflammation of gums.
Because vitamin C is an important component of collagen production, deficiency can result in skin conditions like keratosis pilaris, where rough, bumpy skin appears on the back of the upper arms and thighs. Skin may also appear dry, damaged, and bruise easily.
Vitamin C deficiency may also lead to slow-healing wounds, joint pain and it may contribute to iron-deficient anemia by reducing the absorption of iron from plant-based foods and negatively affecting iron.
How much Vitamin C do I need?
Vitamin C can be easily obtained through eating a fruit and vegetable-rich diet.
The recommended daily intake of Vitamin C is about 75 to 90mg. One kiwi contains about 75mg of vitamin C, an orange 83mg, and Brussel sprouts 70mg of vitamin C. Taking an additional 500mg in supplement form can provide an added positive effect.
The Vitamin is considered quite safe, the tolerable upper intake of vitamin C is around 2000mg a day for adults.
Food Sources
Food sources of Vitamin C includes:
Citrus fruits, including lemons, oranges, grapefruit, kiwi)
Bell peppers (specifically red and green)
Broccoli
Strawberries
Brussels sprouts
Tomatoes
Cantaloupe
* It’s important to remember that Vitamin C content may be decreased with heat and prolonged storage.
Remember that significant amounts of vitamin C in food are lost during high-temperature cooking, and during prolonged warming (i.e. keeping meals warm at 75°C for 4 hours). To get the most vitamin C intake from food, cook foods at lower temperatures and for shorter durations if possible, or opt for raw versions of foods when applicable.
Vitamin C’s Role In HPV
Vitamin C’s antioxidant and immune support properties explain Vitamin C’s important role in HPV clearance.
Vitamin C may be useful in preventing and treating a wide range of conditions. Many studies are showing that this Vitamin may even help treat and prevent cervical dysplasia due to HPV infection.
Persistent HPV and Vitamin C
A study in the Journal of Infectious Diseases found that the risk of type-specific persistent HPV infection was lower among women reporting the highest intake of Vitamin C in the study, compared to those reporting the lowest intake.
CIN and Vitamin C
Another study in the International Journal of Gynecological Cancer looked at whether dietary supplements, such as Vitamin C and multivitamins, were associated with cervical intraepithelial neoplasia (CIN), and found that dietary supplements may reduce the risk of CINs in women with high-risk HPV infections.
Natural sources of vitamin C include citrus fruit, cantaloupe, broccoli, Brussels sprouts, cauliflower, and potatoes as well as through supplements like Papillex. Relief of HPV symptoms is another amazing reason to increase your daily intake of fruits and vegetables, and to try taking Papillex!
Vitamin C for Genital Warts
The immune-boosting properties of Vitamin C, along with its propensity for wound healing and creating healthy skin tissue also makes it an important ingredient in treating HPV complications like genital warts.
Studies have found oral intake of 1000mg of Vitamin C per day shortens the time of genital wart remission and marginally decreased the rate of recurrence compared to controls.
Obtaining Your Daily Dose
Obtaining a healthy level of Vitamin C can be as simple as adopting a healthy lifestyle and eating a diet rich in a variety of fruits and vegetables.
For example, having a kiwi with your breakfast, a serving of broccoli at lunch, and fresh tomato sauce at dinner can naturally replenish your body’s stores of Vitamin C. Remember, consistency is key. Eating fruits and vegetables throughout the day regularly is the best way to support our natural stores.
Supplementing with Papillex also offers a serving of 100 percent the daily value of Vitamin C.
Dec 15, 2020
5 min read
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