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Apple Cider Vinegar For Cervical Dysplasia
Adrienne Hill-Strathy
Is Apple Cider Vinegar Actually Good for You?
In the web of natural health remedies, it is hard to find an ailment that apple cider vinegar can’t help treat.
Apple cider vinegar is claimed by many as a miracle remedy for everything from soothing digestion to clearing acne.
Despite the popularity, and longstanding legend of the vinegars' use, we wanted to investigate if the science has been able to back up the main claims. Including whether it can be beneficial in the treatment of cervical dysplasia.
What Is Apple Cider Vinegar?
Apple cider vinegar is a fermented apple juice.
It is made by combing a mixture of chopped raw apples, sugar, and water in a sterilized glass jar for several weeks. As the mixture ferments the sugar gets converted into alcohol and acetic acid.
The vinegar can be added to salads and sauces for an added flavor punch. Wellness shops and juice bars have also turned apple cider vinegar into immune shots, but you need to be a bit braver to go for them!
Perceived Health Benefits
The health benefits of the vinegar are thought to come from acetic acid, which has been shown to possess antifungal and antiviral properties.
The acid has been studied in vitro for its role in inducing tumor necrosis factor (TNF), a pro-inflammatory immune molecule that facilitates cell survival, proliferation, and death.
Acetic acid has been linked to increased cognitive functioning. The acetic acid and bacteria found in traditional foods like apple cider vinegar have a unique and highly pure membrane lipid component called sphingolipids that are also components of brain tissue. Ingestion of sphingolipid-derivatives find improvements in cognitive function.
Acetic acid in ACV is though to increase cognitive function
Apple cider vinegar also contains probiotics that form during fermentation. When consumed, these bacteria supply the body with beneficial microbes important for gut function and our overall health.
The strongest evidence around the health impacts of apple cider vinegar comes from its impact on cardiovascular health and diabetes. The vinegar may protect against heart disease due to its chlorogenic acid content. It may also have a positive effect on blood lipid levels, making it an attractive addition for managing hyperlipidemia and regulating blood sugar.
However, the research supporting apple cider vinegar in other areas like improving constipation, weight loss, acid reflux, teeth whitening, and acne remains anecdotal. More research is needed to verify whether actual health benefits exist.
Apple Cider Vinegar and HPV
Likewise, there are no studies to date investigating the role of apple cider vinegar on cervical dysplasia.
Anecdotal evidence has claimed apple cider vinegar can be used topically as a treatment for warts. The remedy is thought to be due to the acid, which burns the wart and causes it to peel off from the skin.
But again, no studies have specifically looked at whether application of the vinegar improves clearance rate of warts and elimination of HPV.
Should You Consume Apple Cider Vinegar?
Apple cider vinegar can be a tasty addition to salad dressings, sauces, and meals. It adds a pungent flavor and delicious taste.
Health wise, incorporating the vinegar into your regime can add some extra nutrients, probiotics, and beneficial compounds from the acids to potentially boost brain power and keep your blood glucose in check.
But the vinegar is not a saving grace to your health problems. Incorporating more nutrient dense and whole foods in your diet, getting enough exercise, reducing stress, getting quality sleep, etc. is likely to have a greater impact on your health than an extra tablespoon of vinegar.
I also wouldn’t overdo it on the vinegar. Apple cider vinegar is very acidic and difficult to consume in large quantities. The acid can damage the enamel on your teeth and upset the stomach.
Topical application of the vinegar can also be rough on the skin. When applied to the face and neck, vinegar should always be diluted to avoid irritation.
Aug 01, 2020
3 min read
Medicinal Mushrooms: Preparation is the Key to Success
Dr Elizabeth Goldspink
Medicinal mushrooms have had a long and celebrated tradition throughout Asia, in fact, there are many different types of medicinal mushrooms, with over 200 species commonly used in Chinese medicine.
Examples of medicinal mushrooms include Reishi, Chaga, Cordyceps, Maitake, Coriolus, and the mushroom compound AHCC, to name a few popular ones.
Medicinal mushrooms have been well-researched for their immune-enhancing and anti-cancer properties. Most recently, research has emerged showing that medicinal mushrooms can help eradicate HPV, dramatically impacting the clearance rate of the virus.
Research from France showed that HPV-positive patients (HPV 16 and 18) who were treated with two variety of medicinal mushrooms Turkey Tail and Reishi, tested negative for HPV after two months of treatment.
In another study from the University of Texas Medical School, ten HPV positive women were treated with AHCC, a mushroom extract, for six months. At the end of the study, eight out of the ten patients were confirmed to be HPV free.
Antiviral Activities of Mushrooms
Ganoderma Lucidum – Reishi mushroom
Reishi has been used for many years in traditional cultures as a cancer treatment and to promote health and longevity.
Reishi prevents infection by bacteria and viruses by enhancing the body’s immune surveillance system, identifying and eliminating abnormal molecular patterns. Studies have found that Reishi inhibits cancer cell growth through activating proteins that induce apoptosis, cell death.
Clinical studies have also shown that the use of Reishi can dramatically impact the clearance of HPV.
Reishi Mushrooms
Lentinula Edodes – Shiitake Mushroom
Lentinula edodes, or shiitake mushroom, is the third most cultivated mushroom worldwide. It is used commonly in cuisine and has been found to have a number of therapeutic properties.
The mushroom contains high levels of beta-glucans known to inhibit viral replication and inhibit tumor cell growth.
Shiitake is also the medicinal mushroom used to produce AHCC (active hexose correlated compound), an extract obtained from shiitake mushrooms.
AHCC has been studied for its therapeutic role in defending the host against a wide range of viral infection in humans.
Promising research evaluating the use of AHCC® on HPV showed a profoundly positive effect. 8/10 participants taking a daily dose of 3g of AHCC® for 6 months, tested negative for HPV infection at the end of the study.
According to a new research paper published in Italy, AHCC® has shown a protective response to a wide range of viral infections, and this could support its use in the prevention of human pathogenic coronavirus, including COVID-19.
This paper notes that AHCC® has been extensively investigated as an immunostimulant both in animals and/or in humans affected by a whole host of viral infections by promoting a regulated and protective immune response.
These include:
West Nile Virus
Influenza
Avian Influenza (Bird Flu)
Hepatitis C
Papillomavirus
Herpes
Hepatitis B
Human Immunodeficiency Virus (HIV)
Shiitake Mushrooms
Coriolus Versicolor – Turkey Tail
Coriolus versicolor, better known as turkey tail, has been used for centuries for its ability to enhance the immune system.
Turkey tail contains immune-boosting polysaccharopeptides, Krestin (PSK) and Polysaccharid peptide (PSP) that have been found to increase white blood cells, stimulate dendritic cells, allowing the body to produce molecules that fight infections and naturally strengthen the immune system.
Turkey tail has also been studied for its effective clearance of oral HPV 16 and 18, and early stages of cervical cancer caused by HPV.
Orange Turkey Tail Mushrooms
How to Consume Medicinal Mushrooms
What part of the mushroom should I look for?
The therapeutic strength of mushrooms can be owed to its several active ingredients: polysaccharides, triterpenes, polyphenols, and phytosterols.
In order for our bodies to absorb and benefit from these superfoods, the active ingredients must be extracted. If they are not properly extracted, they are deemed not absorbable, with little to no benefits.
The active ingredients found in mushrooms are locked away in a covering called chitin, the same material that forms the shells of insects, lobsters, and crab. This compound is indigestible by humans, making it almost impossible to access the active ingredients in non-extracted mushrooms.
How can you get these active ingredients?
To be most effective, medicinal mushrooms must be standardized to the polysaccharides, the component that activates the immune system. The higher the percentage of polysaccharides, the better.
The most common extraction technique is hot water extraction. Hot water is able to melt the chitin and release the water-soluble active compounds. It can be quite expensive to extract biologically active compounds, which is why quite a few supplement companies contain limited or no bioactive compounds at all.
Papillex uses a dual extraction method of medicinal mushrooms so that our customers have the immune-enhancing active component of the mushroom delivered to where they need it.
What Else Can You Do Naturally?
Most HPV infections are easily cleared by a strong, healthy immune system. You will most likely clear the infection with a robust immune system having not experienced any symptoms.
Your immune system can be supported in a number of natural ways:
Eat plenty of fruits and vegetables
Reduce alcohol consumption
Drink green tea
Exercise to sweat
Take an antiviral supplement
Papillex includes mushroom extract in its formula, along with a whole host of other key nutrients designed to help your body respond to HPV.
In addition, we are delighted to announce our new AHCC® Supplement to help you better respond to HPV naturally. With growing evidence supporting its ability to reduce rates of HPV, we thought it about time to bring a product to market that our customers could trust!
Discover Papillex's AHCC Supplement today!
Jul 15, 2020
4 min read
Adrienne Hill-Strathy
Many are picking up on the power of plants to maintain optimal health beyond just eating a plant-rich diet.
Plant compounds in the form of herbal supplements and essential oils are becoming increasingly popular forms of therapeutic care.
Traditionally plant oils have been used in cosmetics and perfume for many years. Our understanding of how these compounds can be used to help treat and influence the body is now extending their scope.
Here, we discuss how essential oils work, their biological activities, and some potential uses for treating HPV.
How Do Essential Oils Work?
Essential oils or “essences” are derived from the raw material of plants. Extraction occurs through the process of steam distillation or mechanical cold press. Active chemicals are extracted from plants and combined with a carrier oil to create a product for use.
The essential oils' chemical structures include a unique aromatic compound that gives each oil its characteristic essence or scent.
Terpenes are respobsible for many natural aromas across the plant kingdom, such as pinene found in pine trees and limonene found in citrus fruits
Essential oils belong to two general chemical families, terpenes and esters.
The terpene family includes monoterpenes and sesquiterpenes that help inhibit the accumulation of toxins. They also help remove toxins from the liver and kidneys. The ester family includes compounds like aldehydes, ketones, alcohols, and phenols that have various anti-fungal and anti-bacterial properties. Most oils will have a combination of these volatile compounds.
Some biological activities of essential oils include:
Antibacterial
Essential oils have mostly been studied for their role as antimicrobials.
Oils with a high phenol content like thymol, carvacrol, and eugenol have been found to have important antibacterial activities.
Phenol compounds do this by destroying the cytoplasmic membranes of bacteria cells, making them more permeable and disrupting the overall bacteria cell structure.
Aloe Vera is a famous antibacterial - it's oils can be harnassed as essential oils
Antioxidant Activity
The antioxidant potential of essential oils depends on its composition.
Phenolics and metabolites with conjugated double bonds show antioxidant properties. The essential oils of cinnamon, nutmeg, clove, basil, parsley, oregano, and thyme have the most important antioxidant properties.
This is due to their phenolic structure, which neutralizes free radicals.
Anti-inflammatory Activity
Anti-inflammatory properties are correlated with alpha-terpineol. This compound acts by inhibiting the release of histamine or reducing the production of inflammation mediators. Geranium essential oil is one example of an essential oil that has been found to have anti-inflammatory properties.
Oil from the geranium plant has anti-inflammatory properties
Cancer and Chemoprotective Activity
Attention is also being given to the potential activity of essential oils against cancer. Garlic essential oil for instance contains sulfur compounds that have a preventive effect against cancer. This occurs through detoxification processes of phase 1 and phase 2 in the liver.
Cytotoxicity
Essential oils that contain the presence of phenols, alcohols, and monoterpene aldehydes that have also been found to elicit cytotoxic properties against microorganisms of bacteria, viruses, fungi, protozoa, parasites, and mites.
How To Use Essential Oils?
The oils are commonly inhaled through the nose as aromatherapy. Essential oils are also applied topically to the skin using a carrier oil such as jojoba or coconut for a therapeutic effect.
Inhalation of essential oils has been found to stimulate the limbic system, the area of the brain that controls emotions, behaviors, and long-term memory. The limbic system also exerts control over physical sensations in the body like breathing, heart rate, and blood pressure.
Safety and Side Effects of Essential Oils
Just because essential oils are derived from plants and other natural compounds, does not mean they are not powerful. Oils can be up to 75 times more powerful than dried herbs. Their bioactive components can pose dangers to health if overconsumed.
Oils should be combined with a carrier oil like coconut or jojoba for topical use. Keep watch for any side effects of rash, headaches, or allergic reactions. The oils should also never be eaten.
Coconut Oil is an excellent choice of carrier oil
Essential Oils for HPV
Tea Tree Oil
Tea tree oil is a natural antibacterial, antifungal, and antiviral. The oils broad-spectrum properties can be used to treat several ailments, including HPV warts.
A drop of pure tea tree oil applied with a carrier oil to affected areas daily is an effective topical treatment to clear warts.
Thuja Oil
Thuja is an Ayurvedic remedy derived from the Thuja tree. The bioactive component of thuja is called thujone, a medicinal herb reported to have anti-viral properties.
Thuja appears to play a role in the immune system by activating several immune cells.
Check out our blog on Herbs for HPV where both Tjua Oil and Tea Tree Oil make an appearance!
Neem
Neem oil is another oil rich in antioxidants. The oil is widely used in traditional medicines to treat and prevent disease. Animal studies have found neem oil to play a pivotal role in cancer management.
The active compounds in Neem, azadirachta indica, have also been evaluated for their ability to heal wounds. Azadirachta promotes wound healing by increasing the inflammatory response.
The leaf extracts of Neem have also been shown to have anti-viral activity by controlling viral loads.
Calendula Essential Oil
Calendula oil is comprised of several bioactive chemical compounds. The oil contains triterpene alcohols, saponins, flavonoids, carotenoids, and polysaccharides that have been traditionally used to treat skin conditions like tumors, lesions, and ulcers.
Calendula officinalis has been extensively studied and its essential oil has been used for centuries to help calm the nervous system and heal wounds. Pharmacological studies have also found the herb to exhibit antibacterial, antiviral, anti-inflammatory, anti-tumor and antioxidant properties.
Calendula Oil is found to have a whole host of beneficial properties
Oregano Essential Oil
Oregano essential oil is commonly recognized for its antimicrobial, antiviral, and antifungal activity. Recent research is also finding the compound to have potent antioxidant, anti-inflammatory and cancer suppressor agents.
Studies have found oregano essential oil to elicit antiproliferative, and anti-tumor effects and may have positive benefits for cancer research.
What's The Verdict on Essential Oils for HPV?
The world of essential oils and their use is being increasingly understood and accepted.
The oils appear to provide benefits both topically and internally enhancing the system’s ability to fight off infections and even cancer development.
Despite the many health claims, we still have limited research on the ability of the essential oils to treat health conditions. The oils are best used alongside other treatments to assist in reducing stress, promoting relaxation, relieving pain, enhancing energy, and promoting overall health.
As more research emerges, we will have a better understanding of how these compounds can be used across a range of health conditions, including HPV.
If you're looking for more than just essential oils to help tackle HPV, why not check out our iconic Papillex supplement?
And if you're feeling really proactive, we've just released our amazing AHCC® supplement too! This mushroom extract has undergone clinical trials finding that it can help in reducing HPV rates! Why not take a look and make that positive change?
Jul 01, 2020
5 min read
Why Are Rates of HPV and Cervical Cancer Higher In Black Women?
Adrienne Hill-Strathy
Disparities between race and disease continue to exist in many areas of the health field, including with HPV and cervical cancer.
Black women are found to be significantly more at risk for contracting HPV and having more persistent infections that can lead to cervical cancer, compared to white women.
It is estimated that:
Black women are 1.5 times more likely to test positive for high-risk HPV infections and 1.7 times more likely to have an abnormal Pap test.
56% of black women were still infected 2 years after infection compared to just 24% of white women.
Black women are 40% more likely to get cervical cancer and are two times more likely to die from the disease compared to white women.
These numbers are staggering and can be linked back to the underlying factors that allow HPV infections to persist and develop into serious complications.
Diet
A key factor in warding off persistent HPV infections and cervical dysplasia is a varied and healthy diet. Missing key nutrients like folate, vitamin C, vitamin E, and selenium, have all been associated with higher rates of persistent HPV infections.
The demographics and socioeconomic classes that struggle to make a healthy diet their reality based on both financial pressures and access to health information, end up suffering the most.
Black Americans are disproportionally more likely to live in low-income neighborhoods and to have reduced access to healthy food. According to The FoodTrust, access to healthy food and full-service grocery stores is challenging for many Americans, particularly in low-income neighborhoods and in communities of color. Furthermore, the study finds that having better access to healthy food corresponds with healthier eating and a lower risk for obesity and other illnesses.
Access to health information and the recent rise of the ‘wellness industry’ is also disproportionality white-washed, making it more difficult for women of color to model and implement healthy behaviors. More effort is needed to make both healthy food and information more accessible to these groups.
Stress
We all experience a variety of stressors in our lives. However, black women are much more likely to suffer from stress than white women. This is largely due to socioeconomic determinants, as well as experiences of racism and discrimination that combined, contribute to greater mental health issues.
We know that stress can play a negative role in impacting our immune system and increasing our risk of developing a number of diseases, including cervical dysplasia.
Risk Behaviors
A number of lifestyle behaviors that are associated with greater rates of HPV infection and persistence, such as cigarette smoking and number of sexual partners, have been found to be more common amongst low-income black women, than other low-income racial and ethnic groups.
A study evaluating HPV positivity across races found that black women had the highest HPV positivity and reported more HPV risk behaviors than white or Hispanic groups.
Access to Health Care
Another reason black women may be more likely to die from cervical cancer is due to cervical abnormalities being caught at a later stage of diagnosis. Many low-income women of color still do not have access to basic quality screenings, either because the services are not readily offered or are too expensive with their insurance.
One study found that black women had 50 percent lower odds of receiving surgery and 50 percent higher odds of receiving radiation compared with white women.
Considering cervical dysplasia that is caught early is highly treatable with the right lifestyle approaches and interventions, there is significant room for improvement needed in providing health care services to this population.
Are black women being left out of medical research?
Research also suggests that black women are less likely to benefit from the HPV vaccine, leading to higher rates of high-risk infections.
The HPV vaccines currently cover two high-risk strains, HPV 16 and HPV 18, which are responsible for about 70% of cervical cancers. Research looking at the specific strains of HPV found in white women and African-Americans has found women were infected with different subtypes.
The most frequent HPV subtype found in white women with early cervical dysplasia were strains 16, 18, 56, 39, 66. Whereas the most frequent subtypes in black were strains 33, 35, 58, 66, and 68. Because current vaccines do not cover the three HPV strains blacks are getting the most, 35, 66, and 68, they are having higher rates of infection.
The researchers concluded, “Since African-American women don’t seem to be getting the same subtypes of HPV with the same frequency, the vaccines aren’t helping all women equally.”
What You Can Do to Help
The disparity in HPV amongst women of color is multi-faceted and requires systemic changes to allow for greater access to screening, services, products and the education needed to address reproductive health and general wellbeing of this population.
The good news is a lot of these factors are within our collective capacity to change. We all have the ability to educate ourselves and advocate for the changes that are needed, now:
Educate yourself: Being an advocate for change requires us to be well-informed on the topic and where we can be of service to help. Read books, watch movies, and engage in conversation on these topics with a diverse number of people to get a better understanding of the issues and what can be done to help.
Engage in dialogue: Part of the issue with HPV and cervical cancer rates being higher in black women is due to a lack of information on the topic. Do what you can within your social circles and on social media to inform others about the importance of Pap tests and to direct those who have been recently diagnosed to resource and information providers, like Papillex, that provide accurate and actionable information on HPV.
Amplify black voices: follow, share, and engage more with the black community to expand your perspective on the health struggles that are experienced by black women and to help make wellness an accessible part of their lives.
Vote: action is needed at the government level to allow greater access to health care, proper screening, healthy food, and support services. Stay informed on local elections and encourage political action on issues that black people are disproportionately experiencing.
2020 is bringing to light an opportunity for us to all rise together. For this opportunity to lead to the reforms that are needed, we need to do our part as individuals, businesses and communities to level the playing field when it comes to health and well-being.
Jun 18, 2020
5 min read
Food to Build Your Immune System
Christine Chung
We all know that what you put into your body has an immense effect on your health.
Current nutritional education places a significant focus on processed foods and how these relate to chronic illness and obesity.
But did you know that what you eat can also affect your outcome with HPV?
Keep reading for more information about how you can fuel your body in the right way to fight HPV.
Building your Immune System with Food
Although an HPV diagnosis may feel terrible, there are many treatment options available for HPV complications ranging from intensive surgeries to at-home treatments.
Though there are many treatments available, addressing HPV can be as simple as changing your diet, which creates the foundation for our immune system.
Rather than patiently waiting for your doctor to make the call for treatment, you can take responsibility for your health through education, nutrition, and lifestyle changes. With these adjustments, you can set your body on the path to recovery.
Dietary changes can give your immune system a boost to help reduce HPV symptoms. These changes alone can give your body a fighting chance of clearing up the infection naturally! The diet that works for each of us is unique - one size does not fit all. With that said, there are some sensible guidelines we all can follow to improve overall nutrition.
Three Golden Nutrition Rules
Three simple must-do’s are:
1. Decrease sugar consumption
Cutting refined sugar may be the best thing you can do for your health.
Sugar in the form of sweet, confectionery treats are practically designed to be addictive. Your body will continue to crave sickly sweet goods until you consciously cut down.
Choosing natural forms of sugar are less toxic and more supportive for your body. Natural sugars include sugars obtained from fruits (fructose) as well as milk products (lactose). Other sugars are called “added sugars”, they include white sugar, brown sugar, honey, and other chemically-manufactured sweeteners.
Natural sugars are better for your health because they include additional nutrients like antioxidants, seen in naturally sweet acerola cherry, raspberries, and goji berries. Citrus fruits, another natural sugar, are also great for high levels of vitamin C to fight HPV, which helps to support your immune system.
Sugars in fruits also contain fibers, allowing for a slower release of glucose into the bloodstream and a smaller spike in insulin. Overproduction of insulin and cellular resistance are now found to be contributing factors to many chronic diseases.
While sugars from fructose are much better for our health, we also have to be mindful not to overdo indulge. These sugars still influence our blood sugar and can contribute to insulin resistance and gut dysbiosis. We opt to aim for 2-3 servings of fruits per day, preferably from low glycemic fruits like berries and apples.
Goji Berries are full of antioxidants
2. Cut out any simple, refined carbohydrates from your diet
Simple refined carbs include white sugar, white bread, white flour, and white pasta.
Instead, opt for complex carbohydrates like vegetables, legumes, and whole grains. These types of carbohydrates contain longer chains of sugar molecules that slowly release sugar into the bloodstream, leading to a smaller insulin spike as well as a higher concentration of other macro and micronutrients.
Simple switches like white rice to brown rice or quinoa, white bread to multigrain and white flour to sweet potato can make all the difference, and help keep you full and satisfied!
Switch from white to brown carbs where you can
3. Increase your daily intake of vegetables
Try to aim for two handfuls of veggies with every meal, or about 7 to 10 servings per day.
There are easy ways to do this, like a smoothie full of blended veggies, balanced out by some sweet fruit for taste!
Choose your favorite vegetables and eat those in large quantities! Green leafy vegetables, such as kale and spinach, are great sources of carotenoids, vitamin C, vitamin K, fiber, calcium, and folate to protect against HPV.
Cruciferous vegetables, such as broccoli, Brussel sprouts, cabbage, and kale have several very important compounds, specifically diindolylmethane, or DIM and indole-3-carbinol that play a key role in killing HPV infected cells and cancer cells.
Vegetables are essential in any healthy diet.
Specific foods that build your immune system include:
Richly-pigmented vegetables such as bell peppers, tomatoes, carrots, mangoes, sweet potatoes
Cruciferous vegetables such as cabbage, broccoli, brussel sprouts, and cauliflower
Dark, leafy green vegetables, spinach, and kale
Citrus fruits, such as lemon and kiwi
Green tea
Avocado
Nuts and seeds, specifically sunflower seeds, brazil nuts, walnuts, and almonds
Herbs such as Astragalus, Reishi mushroom, Echinacea
How to Build Your Immune System to Fight HPV
A few foods have also been specifically studied for their ability to fight HPV infections:
Foods rich in carotenoids, like papaya, squash, grapefruit, oranges, and apricots, are associated with decreased risk of persistent HPV infections.
Vitamin C levels are often low in cervical cancer patients, emphasizing the importance of Vitamin C consumption through food for health.
In recent years, curcumin found in turmeric has been highlighted for its ability to induce self-destruction of harmful cells and suppress regulatory molecules involved in upregulating cancers and other diseases.
Incorporating HPV superfoods into your diet can be an easy (and tasty!) way to support your immune system.
Medicinal Mushrooms
Another way to support the immune system is through consuming medicinal mushrooms. Mushrooms contain chemical compounds called glucans that have been found to have an immunomodulatory effect. Beta and alpha glucans help increase the production of natural killer cells, cytokines, and other immune molecules that help detect and fight off pathogenic invaders.
Mushrooms can be incorporated into the diet through supplementation or their whole food form. However, the therapeutic compounds require specific extraction methods to be effective, which is why supplementation is often recommended.
Mushroom powders of Reishi or shiitake can be added to your morning coffee or smoothie. Mushrooms can also be taken in capsule form as a daily supplement. A daily serving of Papillex™ includes a therapeutic dose of Reishi mushroom. Our AHCC™ capsule is another potent immunomodulator that can be taken daily to support and balance your immune health.
Finding a balance
Consuming an overall healthy diet, including the foods mentioned above, is the best way to help support your immune system and fight off viral infections such as HPV.
Building up your immune system takes time and consistency. It is more important to adopt healthy lifestyle changes that you will implement throughout your lifetime as opposed to doing a short-term cleanse.
Remember to be gentle on yourself, it is not about eating the perfect diet, but incorporating as many nutritious foods as possible and enjoying what you eat.
How Can I Support My Improved Diet Naturally?
Most HPV infections are easily cleared by a strong, healthy immune system. Besides diet, your immune system can be supported in several other natural ways:
Quit smoking: Smoking is positively associated with persistent HPV infections and an increased risk of cervical cancers. Quitting smoking is key to preventing future complications.
Prioritize sleep: sleep is when our immune system steps into action. We need 7-8 hours a day to run optimally. Practice good sleep hygiene; maintain a regular bedtime, avoid caffeine in the evening, turn off your phone and electronics, and find a relaxing way to wind down.
Reduce alcohol consumption: Alcohol can cause a burden on the body, spiking inflammation and impairing detoxification. If you choose to drink, aim for one drink three times a week or less to keep inflammation at bay.
Exercise: prioritize daily activity in a form you enjoy. Even one hour of brisk walking has a positive impact on the immune system.
Get outdoors: Fresh air and nature have a positive impact on our physical and mental health. We recommend aiming for 20 to 30 minutes outdoors each day.
Maintaining a positive mindset: Our immune system isn’t only influenced by the things we put it in but also our mental state. Find ways to set a positive mindset each day through journaling, setting daily intentions or mantras, or creating a list of things you are grateful for.
Papillex is a clinically researched supplement designed to increase key nutrient levels often found to be low in those suffering with HPV. That makes it the perfect supplement to help in your ability to respond to HPV naturally.
Jun 15, 2020
6 min read
What to Expect in a Colposcopy Exam
Adrienne Hill-Strathy
If you are reading this, you may have recently been referred by your doctor to get a colposcopy.
Colposcopies are rarely talked about so can evoke some distress and confusion for patients upon referral.
Here we hope to provide some details about the procedure, what to expect, and why it’s a great step to help you get on top of your reproductive health.
What Is a Colposcopy Exam?
A colposcopy, pronounced kol-POS-kuh-pee, is typically referred to patients following an abnormal Pap smear.
Abnormal Paps suggest some cell changes have occurred on the cervix, vagina, or vulva. The device, called a colposcope offers a way to get a closer look at what is going on internally.
How Does the Procedure Work?
Colposcopies are typically performed by gynecologists.
During the exam, you will be asked to remove your clothes from the waist down. Your feet are placed into two stirrups and a speculum is used to view the vagina and cervix.
A solution of acetic acid is applied to the area using cotton swabs to make it easier to observe any cellular changes. The acid can burn slightly upon application and may cause slight discomfort.
The physician will then move the colposcope into view, depicting an image of the cervix on a digital screen. Many physicians will offer you the option to take a look at the screen, but you can also choose to look away if you wish.
Here, the physician can visualize the cervix and observe any changes in color, discharge, irritation, etc. Depending on the observation, the physician may decide to take a swab or biopsy of the cervix for further examination of cell changes.
There are two types of biopsies, one taken from the outside of the cervix and another from the inside opening. The biopsy may cause mild discomfort but is generally quick and painless.
What Happens Next?
Because abnormal cell changes depicted on the cervix will usually be cleared by a healthy immune system within two years, most patients will be asked to monitor the situation by getting a follow up Pap test done every six months.
If a biopsy was taken, a follow up appointment will be made to discuss the results, next steps, and if further intervention is warranted.
What can you do?
Although the procedure and fear of an abnormal Pap test can be anxiety provoking, be proud that you are taking proactive care of your reproductive health. Understanding your risks makes you more prepared to prevent more severe outcomes later in life.
Instead of watching and waiting between follow up Pap tests, why not take actionable steps to naturally support your immune system in clearing off the virus?
Adopting a healthly lifestyle, diet, implementing stress management techniques and supplementing with products like Papillex, that replenish the nutrients that have been found to be low in people with persistent HPV infections, can effectively help your immune system respond naturally to HPV and leave you in a better state of overall wellness.
Jun 01, 2020
2 min read
Epithelial Cell Abnormality: All You Need To Know
Christine Chung
You go for your normally scheduled pap test, but this time things are different. You get your test results, and you see ABNORMAL.
You, along with 8% of Canada’s female population, are wondering the same thing. What does this mean?
In this blog post, we break down what you need to know about the Pap smear, the possible results, and what it means to have epithelial cell abnormality.
First, let’s break down what an epithelial cell is.
What is an Epithelial Cell?
Epithelial cells are found on the surface layers of the body such as the skin, respiratory tract, urinary tract, and organs. The cells create a barrier between the inside and outside of the body, protecting it from invaders like viruses, bacteria, and other pathogens.
Epithelial tissue is one of the four major tissue groups and can be found lining many parts of the digestive system, the epidermis, the oral cavity, many of the body’s glands, and the cervix.
There are three types of epithelial cells: squamous, cuboidal, and columnar. Squamous cells are what we commonly examine when it comes to Pap testing and cell abnormality. Squamous cells are found in the esophagus, mouth, and vagina, protecting the body against wear and abrasion.
Different layers of Epithelial Cells
What Is An Epithelial Cell Abnormality?
An Epithelial Cell Abnormality is when an epithelial cell has undergone abnormal cellular changes, which could indicate cancerous or pre-cancerous cells. When abnormal cells are found on the cervix, this is also known as cervical dysplasia.
Epithelial cell abnormality and cervical dysplasia are detected through a Pap test.
Normal vs Abnormal Cervix Cells Taken from a Pap Smear
What is the Pap Test?
The Pap test or Pap smear was invented in the 1920s by a gynecologist named George Papanicolaou. While researching, Papanicolaou discovered certain cellular smears taken from the vagina and cervix and viewed under the microscope differed in epithelial cellular normality. His discovery revealed early detection of cancerous cells in women presenting without any current symptoms.
The Pap test has now become part of routine physical examination for individuals with female reproductive parts to detect and monitor the presence of precancerous or cancerous cells on the cervix that may progress into cervical cancer.
The test results from a Pap smear can go one of three ways: NORMAL, UNCLEAR, ABNORMAL.
Normal: Indicates no cellular changes or precancerous activity was found.
Unclear: Often warrants a repeat Pap test. This indicates that your cells could be mildly abnormal, due to a vaginal or sexually transmitted infection, changes in hormones, or poor test collection.
Abnormal: An abnormal Pap test means that some level of cervical cell changes were found. It does not mean that you have cervical cancer but further testing is recommended.
Pap Smear Tests Are Essential For Detecting HPV
Breaking down the Abnormal Pap Test Results
The Pap test is a screening test that reports different grades of abnormality. The following table displays the severity of these results from lowest to highest:
Degree of Severity
Pap Test Result
0
Normal
1
ASC-US
2
LSIL
3
ASC-H
4
HSIL
5
AIS
6
Squamous Carcinoma
Abnormal Result Breakdown
Here is a breakdown of abnormal Pap test results:
Atypical Squamous Cells of Undetermined Significance (ASC-US) The most common of all abnormal Pap test findings. ASC-US means the squamous cells of the cervix look abnormal. This is likely due to an HPV infection. Usually, the cells return to normal on their own, but your doctor will likely recommend monitoring to be safe.
Atypical Glandular Cells (AGC) This type of result is unique from the others listed here as they relate to glandular cells instead of squamous cells. Cervical mucus and mucus in the uterus are produced by these glandular cells. An AGC result indicates that there are abnormalities in the cervix’s glandular cells and raises concerns about pre-cancerous or cancerous cells. Further testing and monitoring will be recommended.
Low-grade Squamous Intraepithelial Lesions (LSIL) This indicates mild cervical dysplasia, abnormal tissue potentially signifying early stages of cancerous processes. These changes are likely due to an HPV infection. Often these changes return to normal over time but require monitoring. This could also be known as cervical intraepithelial neoplasia, or CIN 1.
Atypical Squamous Cells (ASC-H) Atypical squamous cells are another form of cell abnormality that has a high possibility of being HSIL. Further testing must be completed to know for sure.
High-grade Squamous Intraepithelial Lesions (HSIL) This result indicates moderate to severe dysplasia. An HPV infection is present and spreading, causing more serious changes. This is still not cancer, but it has a higher risk of progression into cancer if untreated. With adequate support and treatment, it may go back to normal findings. A CIN 2 or 3 classification would fit here.
Adenocarcinoma In Situ (AIS) This finding indicates an advanced lesion was found with a high risk to develop into cancer without proper treatment. This is a stage where it is critical to prevent cervical cancer progression. A CIN 3 classification would fit here.
Squamous Carcinoma: A positive screening for squamous carcinoma indicates cancer. Squamous cell cervical cancer makes up 80% of all cervical cancers. At this stage, precancerous cells have progressed to cancer and require further treatment of surgery, radiation, chemotherapy, or other immunotherapies. A diagnosis of squamous is quite rare. Women who receive regular Pap tests will catch cervical cell changes before cancer develops and are very unlikely to ever unknowingly reach this stage.
Discuss with your healthcare professional how to proceed following abnormal cell results.
What does Cervical Intraepithelial Lesion (CIN) mean?
The Pap test cannot tell the exact severity of cervical cellular changes. A cervical biopsy taken through colposcopy is needed to find out whether precancer or cancer is actually present. Cervical biopsy results are reported as Cervical Intraepithelial Lesion (CIN) on a grade of 1, 2, or 3.
CIN 1: indicates mild, low-grade changes in the cells. CIN 1 often will go away on its own without treatment.
CIN 2: is used for moderate cellular changes. This is a higher-risk for progression into a pre-cancerous stage.
CIN 3: indicates more severe (high-grade) changes, with a higher likelihood to progress to cancer and may be classified as precancer.
A healthy ldiet and ifestyle helps your immune system
Frequently Asked Questions:
What is an HPV test?In individuals with abnormal Pap test or females above the age of 30, the Pap test may be combined with an HPV test. The HPV test screens for the presence of the HPV virus, which causes cervical cancer. HPV is very common and can be present without any signs of cervical abnormality. It is often tested to determine which strain of HPV you have contracted. Because some strains have a higher chance of progressing to cancer, knowing the specific strain and viral presence can help your doctor monitor your risk.
How often do I need to get a Pap test?Pap smears have now been recommended for sexually active females between the ages 25-69 to be performed once every 3 years. If you have had an abnormal Pap your doctor will repeat your Pap every 6- 12 months until they are clear.
What should I do following an abnormal Pap?Following an abnormal result, your primary healthcare provider will refer you for colposcopy. A colposcopy allows for closer examination of the cervix using a microscope. A cervical biopsy may also be taken for more accurate detection of cell types. Read more on what you can expect in a colposcopy appointment.
How are abnormal cervical cells treated?Depending on the severity of cervical abnormality your doctor will recommend monitoring or treatment. Treatment usually includes an excisional and ablative treatment where cervical tissue is removed or destroyed. Loop electrosurgical excision procedure (LEEP) and Conization are the two most common excisional treatments. LEEP uses a thin wire loop that carries an electric current to remove abnormal cells. Conization removes a cone-shaped piece of the cervix that contains abnormal cells. Cryotherapy and laser are the two most common ablative treatments.
How can I naturally support my body to clear HPV?A healthy diet and lifestyle are key to supporting your immune system eradicate the virus. Making lifestyle changes such as eating more fruits and vegetables, exercising daily, sleeping at least 7-8 hours a night, cutting out smoking, and excessive alcohol consumption. By making sustainable changes to support your overall health you will also help your immune system clear HPV.
We developed the Papillex supplement for this very reason, to boost your immune system and best prepare your body to regress those abnormal cells back to normal cervical cells. Papillex contains high-quality, fine-tuned ingredients hand-picked specifically to fight HPV infections.
May 15, 2020
6 min read
Antiviral Supplements and Vitamins for HPV Treatment
Adrienne Hill-Strathy
The body requires a certain level of macro and micro-nutrients in order to carry out proper functions. These nutrients are typically obtained through eating a diverse diet of plants, seeds, legumes, and animal products.
Unfortunately today, most diets do not fulfill our baseline nutrient requirements. When we lack nutrients, it becomes more difficult to perform proper cellular functions and impairs immunity. This is mostly due to our food system. Today food is heavily industrialized, highly processed, and low in fruits and vegetables.
Studies show that ongoing micro-nutrient deficiencies can lead to infections, like HPV and influenza.
In addition to eating a greater variety of plant foods, taking a nutritional supplement can help raise baseline nutrient status and improve immune function.
We have listed a few of our favorite immune-supportive vitamins and minerals. These compounds may help eradicate HPV and other viral infections.
Vitamin A - Carotenoids
Vitamin A is a group of nutritional compounds that include retinol, retinal, retinoic acid, and carotenoids. This vitamin is typically found in colorful foods like carrots, dark leafy greens, and bell peppers. Carotenoids play multiple functions, particularly in the growth and development of the immune system and vision.
Low levels of dietary carotenoids are associated with an increased risk of persistent HPV infections.
Funnily enough, carrots are a great source of Carotenoids!
Increasing concentrations of carotenes and tocopherols through eating dark green and deep yellow vegetables was associated with a 50% decrease in risk of cervical abnormalities in HPV-infected individuals.
Supplementing with mixed carotenoids (a combination of beta-carotene, alpha-carotene, zeaxanthin, lycopene, etc.) has been found to be superior to supplementing with beta-carotene alone. Combined consumption improves the absorption, efficacy, and safety of vitamin consumption.
Lycopene is another antioxidant found in fruits and vegetables like tomato, watermelon, and pink grapefruit. The compound also has anti-viral properties. Higher blood levels of lycopene are associated with a decreased risk of HPV-associated CIN 1, 3, and cervical cancer.
Selenium
Selenium is an essential trace mineral, meaning we need to obtain small amounts of it from our diet. Selenium plays a role in many bodily functions. The mineral also influences our immune system.
Selenium deficiencies can lead to impaired cognition, immune function, fertility, and cancer.
Low levels of selenium are associated with cervical dysplasia. Furthermore, deficiencies in this mineral have been found to allow strains of viruses to mutate into more infectious strains.
Supplementing with selenium is one way to improve levels in the blood. Dietary supplements containing up to 200 ug/d of selenium have the potential to support immune function.
Vitamin E
Vitamin E is found in many foods like cooked spinach, almonds, and sunflower seeds.
Almonds are a good source of protein and Vitamin E!
The vitamin contains a group of eight fat-soluble compounds, four tocopherols, and four tocotrienols. Because vitamin E is fat-soluble, it can build up in fat tissue. Vitamin E can prevent oxidative damage through free-radical scavenging.
Vitamin E is a powerful antioxidant. The compound can help stop cancer cell growth and support the immune system.
Low levels of vitamin E have been found to increase the risk of cervical cancer and cervical abnormalities caused by HPV types 16 and 18. Whereas nutrient sufficiency of vitamin E has been found to reduce the oxidative stress-induced in influenza and by virus-infected organisms.
Vitamin B9 – Folate/Folic Acid
Folate is a water-soluble B vitamin. The body uses folate to help make DNA and RNA and metabolize molecules called amino acids.
The body cannot make folate on its own so we must obtain it from our diet.
This B vitamin is naturally found in many foods like dark leafy greens, vegetables like spinach, brussels sprouts, nut and legumes.
You remember being told to eat your sprouts... now you know why :)
However, deficiency is common.
Deficiency can predispose individuals to an increased risk of HPV, as well as an increased risk of cervical and oral cancer.
Folate deficiencies lead to immune dysfunction by impairing the folate pathway and immune cells, known to fight off invaders.
Vitamin B12 – Cobalamin
Is a water-soluble vitamin involved in every cell in the human body. B12 is also a cofactor in DNA synthesis, and fatty acid and amino acid metabolism.
We obtain B12 from animal products like meat, milk, eggs, and fish. Because vitamin B12 is so widely used in the body, deficiency can cause serious, irreversible damage to the brain, nervous system, and immune function.
Vitamin B12 is involved in the metabolism of every cell in the human body
Poor levels of B12 impact the immune response by inhibiting the activity of immune cells. Low vitamin B12 also interferes with metabolic processes like methylation and amino acid cycles. All of which are important for contributing to a healthy immune system.
Because we obtain B12 from animal products, vegans and vegetarians are particularly at risk for deficiencies. B12 levels can be assessed through a basic blood test.
Vitamin C
Vitamin C is a powerful antioxidant involved in several important enzymes for immune system function. The vitamin is found naturally in foods like kiwis, dark leafy greens, and broccoli.
Kiwis are a delicious way to incorporate Vitamin C into your diet
Vitamin C has various roles in the immune system, protecting the skin barrier function and against environmental oxidative stress.
Individuals with higher vitamin C levels tend to have a reduced HPV viral load and decreased likelihood of developing oral and cervical cancers.
Studies have found dietary intake of vitamin C to prevent both respiratory and systemic infections. Supplementation with vitamin C has also been found to decrease cold and flu symptoms by 85% compared to control groups.
Eat Your Veggies and Supplement Smart
With our food becoming more nutrient-depleted and more processed, it is on us to make more of an effort to ensure we reach our daily dose. Including a greater variety of plant-based foods in your diet is one way to help naturally boost our nutrient levels.
Supplementing with a clinically-researched supplement like Papillex is also an option to increase nutrient levels. Papillex supports nutrients that are persistently low in people with HPV, and optimizes the body’s immune system to respond to viruses. However, before starting any nutritional supplement, we recommend you consult with a health care professional first.
May 01, 2020
5 min read
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