Being Well Blog

Being informed means being empowered. Welcome to the latest information and actionable insights.

Latest Insights

HPV Keeps Coming Back!

HPV Keeps Coming Back!

Adrienne Hill-Strathy
Contracting a strain of HPV is very common. You may have had it as a child in the form of a pesky plantar wart on the bottom of your foot or a small nodule that developed on your finger. In early adulthood, HPV is commonly contracted through sexual contact, with 80% of women contracting a strain within her lifetime. The common occurrence of HPV and its often-invisible symptoms may make you wonder, what happens after you’ve been infected, and can a virus reactivate? Here we breakdown a little more about HPV, HPV testing, how the virus enters latency, and whether infection can come back. We also provide some tips to help you maintain optimal immune health. What is HPV? The human papillomavirus includes a diverse group of over 150 viruses that infiltrate the body through our skin tissue and use the machinery of our cells to replicate their viral code. Depending on the strain and the immune system, an HPV infection may present a range of symptoms from visible papilloma, or warts, on the skin surface or genitals to no symptoms at all. Few high-risk strains may develop into complications like cervical cancer years after infection. HPV is typically considered a lifelong infection, once you have contracted a viral strain the DNA lives within your cells. However, the HPV virus can get deactivated and stop producing its viral load, referred to as viral latency. For more information on HPV, check out our article on What Is HPV? for an in-depth guide to HPV. HPV Testing HPV testing is done to evaluate the active presence and strain of HPV in a host. The screening tools for cervical cancer typically classify infection on the following levels: First HPV-positive results: this is a common result and most new infections will likely revert to a negative within 6 to 12 months but require follow-up. HPV-positive, cytology negative- patients with positive HPV status but negative cytology are at an increased risk of developing cervical cancer. A patient with the result will be recommended to be followed and repeat HPV and cytology in 12 months. Recurrent HPV-positive- often a positive HPV screen will be followed by an HPV negative. This suggests the immune system has made the HPV infection latent. The HPV infection can still recur upon reactivation due to a weakened immune system. Persistent HPV positive- a persistent HPV infection, that has been positive for over 12 months, is likely to develop into a CIN 2 infection within five to seven years. The infection should be closely monitored for potential progression. Persistent HPV-positive, low-risk cytology and negative colposcopy- In the situation, patients may still be at risk of disease progression, and active surveillance is still needed. Viral Latency The majority (80-90%) of HPV infections will enter a state of latency. Latency refers to a virus remaining in a resting state without producing its viral code so symptoms or complications don’t develop. In a healthy immune system, active infections will initiate an immune response through CD4+ T cells. Once these cells are activated more immune molecules accumulate at the site of infiltration and overtake the viral gene expression. A compromised or weak immune system seems to be the hallmark of HPV infections, where the failure to develop effective cell-mediated immunity to clear or control the infection results in persistent infection and increases the probability that the cells progress to cancer. Recurrence of Latent Infections Because the HPV particles continue to exist within the bottom layer of the epithelial cells, the virus can get reactivated following a change in immune status. Maintaining viral latency requires one to maintain a healthy immune system. When this fails or is compromised the virus can begin replicating again and may lead to symptoms or progress to complications like cervical cancer. Can I Get Re-infected? If you have contracted a strain of HPV in the past, you are not immune from catching further infections. The 150 different strains of HPV all have slightly different DNA and mechanisms of infiltrating an individual. It is estimated that 75-85% of females and males carry a strain of HPV. Therefore, engaging in sexual activity can expose an individual to further HPV infections and complications. Even women in long-term monogamous relationships can get re-infected. Research is looking to evaluate whether exposure to HPV viruses, particularly HPV 16 and 18, which cause the most cases of cervical cancer, can lead to natural protection against additional HPV strains. Thus far, there has been a lack of sufficient data on naturally acquired immunity and whether the previous infection can reduce rates of recurrence. Maintaining a healthy immune system Regardless of the strain of HPV, you have contracted, the key to silencing the virus and keeping it in its latency state depends on the health of the immune system. The immune system is multi-faceted, which means supporting it is complex as well. First, reducing risk factors like smoking, prolonged oral contraceptive use, assessing coinfections, and immune-related diseases is key to ensuring adequate immune functioning. Second, implementing a healthy diet, rich in diverse plant-based foods and good-quality proteins, reducing stress, getting good quality sleep, and engaging in regular exercise is also important to support our body and immune health. Lastly, supplementation can help replenish nutritional deficiencies that are essential for proper immune function. Papillex includes a range of nutrients known to be low in patients with persistent HPV infections and a number of herbs that help optimize our immune system.
Dec 01, 2020
4 min read
Three Antiviral Plants to Fight Infection Naturally

Three Antiviral Plants to Fight Infection Naturally

Christine Chung
Plants have been credited with having antiviral and immune-stimulating properties dating back centuries. Herbal medicine was used regularly in Ancient Egypt and China as natural remedies for all sorts of ailments. Today, studies show that many plants not only have antiviral properties but can also increase the body’s endurance and resistance to a range of biological, chemical, and physical stressors. Unlike prescription medicines, whose list of potential side effects can be long – antiviral herbal plants and adaptogens often have little to no side effects. Antiviral Adaptogens Adaptogens represent one category of herbs that help the body adapt to a variety of stressors. Adaptogens help strengthen the body's resilience to stress on a cellular level. What makes adaptogens unique is that they: Cause no harm or additional stress on the body. Help the body adapt to many and varied environmental and psychological stresses. Do not have a specific action on the body. They support all major systems like the nervous system, hormonal system, and immune system. Adaptogens benefit the immune system by stimulating a specific white blood cell called a macrophage. Macrophages are the first line of defense in eating up or destroying pathogens in the blood and clearing invaders from our system. Supplementing adaptogens have been found to inhibit viral replication by interfering with the early events of viral adsorption and entry into target cells. Natural Antivirals For HPV Are you looking for a natural treatment for HPV? Below, we have highlighted three antiviral herbs that are key ingredients in our clinically-researched, nutrient-rich supplement designed to optimize your body’s ability to respond to HPV naturally. Camelia Sinensis - Green Tea Extract Green tea (Camelia sinensis) has long been known to be a powerful antiviral that benefits the immune system. Green tea is often used topically for genital warts, and can also be used topically in treatments of cervical dysplasia. Orally, green tea intake has been associated with a decreased risk of cancer due to its powerful antioxidants. It contains polyphenols, catechins, and flavonoids, which are protective anti-cancer compounds. Green tea extract provides antiviral activities through active compounds called epigallocatechingallate (EGCG), which have been found to play a critical role in cancer chemoprevention, diabetes, neurodegenerative diseases, stroke, and other biochemical disorders. In viral infections, EGCG has been found to inhibit the early stage of infections, through attachment, entry and membrane fusion by interfering with viral membrane proteins. Astragalus Astragalus root could be your best friend when you’re looking to stop a virus from multiplying. This powerful immune modulator has been used for centuries to promote resilience in the body. Recent studies have shown this herb’s impact on halting the growth of abnormal cells. Astragalus does this by stimulating the immune system through enhancing the activity of our natural killer cells and killer t-cells. These immune molecules attack and neutralize invading pathogens in the body. Astragalus also plays a role in the adaptive immune response. It stimulates the production of white blood cells, antibodies, and production of interferons, which respond to viral invaders. Ganoderma Lucidum - Reishi Mushrooms Ganoderma lucidum, more commonly known as Reishi mushroom, has been celebrated for its antiviral properties for more than 2000 years. Reishi mushroom is a powerful anti-inflammatory and is tied to longevity, improved immune function, and mental clarity. Perhaps that’s why they’ve adopted the nickname “King of mushrooms.” Clinical studies have shown that the use of these medicinal mushrooms has dramatically impacted the clearance rate of HPV, both genital and oral. Reishi is considered an adaptogenic herb. It contains proteins effective against viruses like herpes simplex and HPV by inhibiting viral replication and adsorption into target cells. Papillex Supplement Want to learn more about Papillex™? Check out the What is Papillex page to get the full list of our high potency ingredients. Sources: Lyu, Ling, et al. “Effects of Astragalus injection on cervical immortalized epithelial cell growth and its cell cycle regulation mechanism.” Journal of Hainan Medical University 22.4 (2016): 17-20. Donatini, Bruno. “Control of Oral Human Papillomavirus (HPV) by Medicinal Mushrooms, Trametes versicolor and Ganoderma lucidum: A Preliminary Clinical Trial.” International journal of medicinal mushrooms 16.5 (2014). Hernandez-Marquez, Eva, et al. “Inhibitory activity of Lingzhi or Reishi medicinal mushroom, Ganoderma lucidum (Higher Basidiomycetes) on transformed cells by Human Papillomavirus.” International journal of medicinal mushrooms 16.2 (2014).
Nov 15, 2020
3 min read
HPV And Fertility: What's The Impact?

HPV And Fertility: What's The Impact?

Adrienne Hill-Strathy
HPV is now considered the most common sexually transmitted infection among North Americans. The Center of Disease Control estimates that nearly everyone who is sexually active will have contracted a strain of HPV at some point in their lives. With HPV being highly prevalent in the young female population and infertility now affecting one-fifth of couples trying to conceive worldwide, many wonder whether contracting HPV will negatively impact fertility. Here, we outline the link and potential risks between HPV and fertility as well as some tips on what you can do about it. The HPV Fertility Link Most HPV infections do not pose fertility risks, but in some cases, they can. A healthy immune system will typically clear an HPV infection within a few years. Leaving the cervix and reproductive system in health to conceive and carry a baby. However, in the small percentage of HPV infections that do progress to cellular changes, lesions on the cervix, and inflammation have been associated with premature labor and low birth weight. Recent research on HPV infections and fertility is finding a correlation between HPV infections and reduced fertility through a higher number of premature ruptures of the membrane and spontaneous abortions. However, before you go sound your alarm bells, remember these studies are correlation-based, not causation. Many other factors can be contributing to this decline in fertility that was not identified in the study. More research is needed to make any conclusions that HPV does indeed reduce fertility. Does Treatment of Cervical Dysplasia Affect Fertility? Although most HPV infections will go away on their own, some require treatment that may affect the ability to conceive or reach full term in pregnancy. Cryotherapy, cone biopsy and LEEP procedures remove cells on the cervix and change your cervical mucus production. Procedures may also cause stenosis, or narrow the cervix, making it more difficult for sperm to reach the egg and get fertilized. The cervix may also weaken during treatment, leading to cervical insufficiency when your cervix widens and thins before coming to full term. Most women do not ever reach the stage of cervical cancer or require treatment. Cell progression is caught easily in pap tests, and preventative measures can be taken. The recommendation for disease control and prevention is to get one pap test every three years to keep an eye on your cervical cells, and more frequently if you have ever had an abnormal pap test. Can You Give HPV to Your Baby? There is a very low risk of transmission of a pregnant woman’s HPV infection to a child. One study followed 153 pregnant women through their pregnancies, some of which had previous HPV infections, and some with newly diagnosed HPV diagnoses through their pregnancies. Most pregnancies continue to full-term with no complications and babies are born with no signs of being carried by someone with an HPV infection. HPV Infection in Men There is growing interest in the impact of HPV in men and on male fertility in particular. Studies have found HPV infections are associated with reduced sperm quality, altering both motility and concentration of sperm. It was also found that HPV infection decreased cell count of normal-shaped cells and increased levels of ani-sperm antibodies. Nevertheless, research on the impact of HPV on male fertility is still developing and more research is needed to make any conclusions. What Can You Do About It? Fertility is impacted by a number of factors including hormones, stress, diet, age, lifestyle, etc. We know that taking proactive steps to protect and support your overall health and immune system will not only help fight off an HPV infection but foster a healthy home for a new life. Making lifestyle changes like eating better, exercising, sleeping well, keeping your stress levels low, cutting out smoking, alcohol consumption, and other toxic components of your life, will not only help you clear an HPV infection but also benefit fertility. Can I Take Papillex while Pregnant? Papillex is a great supplement for you prior to pregnancy. It will help keep your immune system robust, fighting the HPV infection. Papillex also contains supportive compounds like folic acid that helps with neural development and protects against birth defects. As well as vitamin C and E for a healthy immune system. However, Papillex is not recommended during pregnancy due to the mixed carotenoids in the ingredient formula. While beta-carotene, great against HPV, has not been associated with any complications in pregnancy, high doses of vitamin A have been. It is always important to consult your healthcare practitioner when taking any new supplements, especially if you are pregnant. For more information, head to our HPV and Pregnancy article.
Nov 01, 2020
3 min read
Superfoods and Juice Recipes to Fight Cervical Cancer

Superfoods and Juice Recipes to Fight Cervical Cancer

Christine Chung
Human beings are naturally programmed to eat foods that are healing and beneficial for our bodies. However, we all know that it isn’t always easy to follow this inner wisdom. When we really tap in and listen, healthy eating can become second nature – it’s truly conscious eating. Knowing the value of the foods you eat, as well as where they’ve come from and how to best infuse your body with the nutrients it needs, helps you help your body and allows you to thrive.  Excellent HPV Protection Properties So, which foods should we be packing our kitchens with to protect against HPV & cervical cancer? In general, stocking up on green leafy vegetables like spinach and romaine lettuce (packed with lutein and carotenoids), broccoli and cabbage (which have indole-3-carbinol) plus foods rich in antioxidants, vitamins C, E, and A (oranges, grapefruit, raspberries, carrots, and kale) offer protection from cancer by preventing the growth of free radicals in your body. Free radicals One way a healthy diet can positively impact health is by stabilizing free radicals in the body. Free radicals are molecules that contain an unpaired electron in their atomic structure. This electron is highly reactive in the body, damaging cell membranes, DNA, proteins, carbohydrates, and lipids. The body naturally produces free radicals during normal metabolic processes. However, we can also obtain free radicals from external sources like exposure to cigarette smoke, air pollutants, and chemicals. Cancers often stem from free radical diseases, as defects and oncogene activation get initiated by free radical reactions. Antioxidants, on the other hand, are molecules that can donate an electron to a rampaging free radical and neutralize it, reducing its capacity to cause damage. Consuming a plant and animal-rich diet, supplies the body with these antioxidants. Vitamin C, for example, is one antioxidant found in both animals and plants. It cannot be made by the body so we need to obtain it from our diet. The compounds from vitamin C reduce oxidative reactions in the body, helping maintain balance and reduce disease. Top 3 Superfoods The super foods we’ve included on this list are known for their exceptional HPV & cervical cancer fighting nutrients. Green Tea Green tea has also been shown to suppress urokinase, a type of enzyme that is thought to play a key role in the spread of cancer cells. Epigallocatechin gallate, or EGCG, and polyphenols E showed the inhibition of cervical dysplasia and cancer cell growth in cell studies. These studies actually show EGCG stopping the cancer cells right in their path and inducing cell death. Green tea extracts in ointment topically AND capsule forms were also shown to treat cervical lesions!  Papaya Papaya is one of the best sources of vitamin C, and carotenoids. Papaya’s nutrient combo has been associated with lower HPV infection rates and lower risk of cervical lesions. Low levels of carotenoids, found in many fruits and vegetables, was associated with increased risk of persistent HPV infections. Vitamin C levels were also seen to be significantly lower in cervical cancer patients with high positive rates of HPV 16 and 18, the cancer-causing strains of HPV.  Turmeric In recent years western medicine has started to pay attention to this extraordinary root. The compound found in turmeric that induce self-destruction of harmful cells is called Curcumin. Curcumin contains a class of compounds called curcuminoids that act by suppress regulatory molecules and signaling pathways involved in upregulating cancers and other diseases. Curcumin has been shown in research to not only eliminate HPV infections, but also help treat cervical cancer. It has been previously seen to have protective effects against cancer in HPV and non-HPV related cancers. Recipes Incorporating HPV fighting superfoods into your diet can be easy and delicious, which is why we’ve included three of our favourite easy recipes that will allow you to incorporate more of these ingredients into your day to day menu. If you don’t have all of the ingredients, creativity is key when it comes to keeping things fresh in the kitchen – so sub in what you do have and challenge yourself to add at least one of these foods into your life daily. So, here's a few of our favourites :) Papaya Coconut Green Smoothie This smoothie requires only a few ingredients. The papaya provides a boost of those HPV fighting carotenoids and vitamin C, while the kale is rich in antioxidants called quercetin and kaempferol. Add in some coconut milk and flakes for some extra creaminess and help keep you full. Frozen papaya Coconut milk Coconut flakes Fresh Kale Image via Loving it Vegan Matcha Green Tea Smoothie Drink this smoothie in the morning for a perfect hint of caffeine or it works as an afternoon pick. The subtle green tea flavor gives you cancer-fighting benefits of EGCG and a dose of vitamin C and carotenoids from the mango. Spinach provides an extra hit of folic acid another important vitamin in protecting against HPV infections. Mango (fresh or frozen) Frozen Bananas Handfuls Baby Spinach Matcha Green Tea Powder Coconut Milk Carrot & Turmeric Tonic Juicing can also be a great and delicious option to get in your daily nutrients. This juice provides a delicious mixture of carotenoids from carrots and cancer-fighting curcuminoids from turmeric. Lemons are full of vitamin C, folate and antioxidants. The ginger adds a flavourful bite and naturally reduces inflammation in the body and stimulates the immune system. Golden Delicious Apple Turmeric Ginger Lemon Carrots Cucumber
Oct 15, 2020
4 min read
HPV 16 18 45

HPV 16 18 45

Adrienne Hill-Strathy
High-Risk HPV, 16 18 45: What You Need to Know The family of human papillomaviruses contains a variety of over 150 different strains of HPV. These strains have evolved over time to have different ways to infiltrate and evade the immune system of individuals, causing different disease progressions. Nearly all sexually active individuals will come into contact with a strain of HPV. It is estimated that 80% of women will contract an HPV infection at some point in their lifetime. While most cases of HPV infections are asymptomatic, some can manifest in lesions from genital warts to cervical cancer. A few HPV strains, in particular, HPV 16, 18, and 45 have been classified as the most high-risk HPV types, accountable for approximately 70% of cervical cancers around the world. The prevalence of high-risk HPV infections is estimated at around 22.7%. The most common of these high-risk infections to cause changes to the cervix were HPV types 16, 18, and 45. High-Risk HPV High-risk strains often do not cause symptoms so many are unaware that they have contracted a strain of HPV. The high-risk strains develop slowly over time, causing minor changes to the cells of the cervix, anus, or oral cavity. High-risk strains that persist for a number of years can eventually alter the genome of an individual and increase the risk that cancer will evolve. 12 HPVs (16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, and 59) are defined by the World Health Organization (WHO) as being high-risk cancer-causing types. Together these HPV’s cause half a million cases of cervical cancer per year worldwide. These strains can also cause cancers at other sites, including the penis, vagina, and vulva and in the oral cavity. What Makes High-risk Strains More Cancerous? The reason high-risk strains are more likely to cause cancer is due to where the virus has evolved to infiltrate the body and specific proteins within the viral machinery. Particular areas within the cervix lining are more susceptible to fostering cell replication than others. HPV that gains access to the transformational zone in the cervix have been linked to higher rates of cancer progression. This site has a lower density of immune cells called Langerhans cells, that provide our first line of defense in fighting off pathogens. High-risk HPV strains are the leading cause of cervical cancer Two viral proteins, E6 and E7, have also been found to be more active on high-risk strains of HPV. These proteins are thought to be responsible for allowing the virus to enter the upper layers of the epithelial tract. The proteins have also been found to downregulate toll-like receptors of the innate immune system, leading to greater threats to the individual's DNA. These E6 and E7 proteins appear to be inactive or weakly active in low risk HPV types. High-Risk HPV Strains and Cancer Rates Despite high-risk strains increasing one’s risk of cancer, contracting a strain does not mean you are going to get cancer. The majority (90%) of individuals will clear the infection within three years and have no complications. Of the 10% of cases that become chronic only 1% will result in cervical cancer. Women with a high-risk HPV strain have a 210-fold higher risk of developing a CIN 3 complication in 6 years as compared with negative women. This means that instead of every 9 in 10,000 women contracting cervical cancer, 210 in 10,000 with a high-risk strain will develop into cancer. HPV Testing and mRNA E6 E7 HPV testing can detect which strain of HPV you have contracted and indicate whether you have been infected with a high-risk strain. To provide a better understanding of the strains risk of developing into cancer, mRNA E6 and E7 testing can also be done. Testing can be done to detect the presence of these proteins within an individual. E6 and E7 are usually expressed at low levels during a transient HPV infection. When the virus has integrated into the individual gnes, the oncogene transcripts are over-expressed, leading to the development of cervical cancer. HPV E6 and E7 mRNA expression level are highly correlated with the severity of cervical lesions and can be tested and used as a biomarker for HPV infections that are more likely to progress to cancer. Having more reliable and better testing for HPV has played a significant role in reducing mortality from cervical cancer in the past several years. Staying on top of your pap testing and monitoring your situation with your doctor is key to fighting off high-risk strains. What Can You Do If You Have Contracted HPV? In addition to regular testing, fighting off high-risk strains of HPV requires a healthy immune system. We believe implementing a healthy lifestyle is built around four foundational lifestyle therapies: 1. Nutrition and Supplementation The gut is home to around 80% of the immune system. Consuming a fruit and vegetable-rich diet, limiting sugar and refined carbohydrate intake has been found to have a positive effect on the overall function of the immune system. Papillex is a supplement which is designed specifically to help your body respond to HPV and is packed full of ingredients which have been researched with HPV in mind. Building a strong immune system with good nutrition is an important factor in your body's ability to fight off viral infections 2. Psychological Stress Prolonged stress has been found to create an imbalance in the ability of the body to fight incoming infection, by over activating areas of the immune system that exacerbate chronic illness. Engaging in daily stress management practices like meditation, exercise, and socializing can have a positive effect in improving the bodies overall resiliency. 3. Sleep Getting adequate rest, seven to eight hours of quality sleep per night, allows the immune system time to revitalize, balance hormones and it initiates cellular repair. Setting a regular bedtime, limiting caffeine intake in the afternoon, and eating a nutrient-dense diet are all ways we can improve our sleep quality. 4. Exercise and Movement From improved circulation to naturally increasing the bodies white blood cell and antibody count, staying active has a range of benefits in helping support the immune system and defense against disease. We recommend talking daily walks and engaging in bi-weekly strength training and aerobic activity.
Oct 01, 2020
5 min read
A Cure For HPV? Or Too Good To Be True?

A Cure For HPV? Or Too Good To Be True?

Christine Chung
Recently there has been buzz online surrounding a cure for HPV.  Is there a cure? Will it reverse the damage that’s already occurred? Do I have to go to Mexico? Learn about HPV and whether or not there is a cure here. What is Human Papillomavirus? Human Papillomavirus is one of the most common viruses that affect humans and the most common sexually transmitted infection in the United States. It affects countless men and women every year. That’s right -  HPV affects men, too. The Center for Disease Control and Prevention estimates that almost every sexually active adult will get HPV at some point in their lifetime. It can be spread by skin-to-skin contact, most commonly through sexual activity. How does it become Cervical Cancer? HPV causes 91% of cervical cancer. However, not all HPV infections can or will cause cancer. Only a few out of the 100+ known strains of HPV have the potential to become carcinogenic. Most infections will present with no symptoms at all and be cleared naturally over time with a robust immune system!  However, when your immune system is weakened, or when your body is invaded by a strong strain of HPV, cell proliferation can occur. This is the growth of abnormal cervical cells, which can lead to cervical intraepithelial neoplasia (CIN), and eventually, cancer. Is there a cure? The short answer is no. There is no magic treatment that will completely eradicate HPV or reverse all damage. But, outcomes for HPV and cervical cancer are very good with routine screening and well-informed treatments. How can we naturally respond to HPV? There are many ways to naturally respond to symptoms and complications of HPV including genital warts and cervical dysplasia. The two most popular treatment options are Cryotherapy and LEEP. Cryotherapy Cryotherapy uses liquid nitrogen, a very cold substance, to freeze off abnormal cells from your cervix. Cryotherapy is also a commonly used procedure for wart removal. This treatment kills off the cancerous cells allowing for new growth of healthy cells in its place.  How it works: Similar to a Pap test, you will be laying down and your doctor will insert a speculum into your vagina. Instead of the brush used for Pap testing, your doctor will use a cryoprobe, holding it at certain places on your cervix to freeze the cells. The whole process should only take 5 minutes or so. You may feel some cold sensation or mild cramping.  The result: Cryotherapy is quite effective for eliminating abnormal cells with a low recurrence rate.  Loop Electrosurgical Excision Procedure (LEEP) LEEP is another cervical cancer prevention treatment, where abnormal cervical cells are removed from your cervix using a small electrical wire loop.  How it works: Similar to a Pap, you will be lying down while your doctor inserts a speculum into your vagina. Numbing cream will be applied, and your doctor will use the wire loop to remove the cells. The electricity of the loop cauterizes the blood vessels in the area to prevent bleeding. The whole process should take about 10 minutes.  The result: Highly effective. LEEP will usually remove all the abnormal cells. One study even showed LEEP was more effective than cryotherapy.  Other treatments Conization, or a cone biopsy, removes a cone-shaped section of the abnormal tissue for lab examination of CIN. Surgical removal, including electrocautery, laser surgery, and excision. Photodynamic therapy, combined with Aminolevulinic acid, has been a novel treatment generating a lot of hype in the media as the “cure to HPV”. Photodynamic therapy uses wavelengths to damage the surface layer cells affected by HPV. The treatment poses a lower risk to women looking to get pregnant in the future. However, the treatment is still in its infancy. Further quality research is needed to determine its long-term effectiveness. You may read conflicting information about these treatments online. You and your doctor will know what’s best for you; every treatment should be specific to each case. Vaccination An HPV vaccine exists that protects against two strains of HPV, HPV 16 and 18, that cause genital warts and two strains that most commonly cause cervical cancer. For the vaccine to be effective, it must be given before the virus has been contracted. Typically, it is recommended for females aged 13 to 26 and males aged 13 to 21. While the vaccine protects against a few of the high-risk and common strains, it is important to keep in mind that the vaccination does not protect against all HPV strains. Several other high-risk strains exist and are being detected in patients that have been vaccinated, so routine screenings are still recommended. HPV Vaccines typically take place between the ages of 13 and 26 Are new vaccines on the way? A new immune-based vaccine was recently developed that may be effective in treating women with existing HPV and precancerous changes on the cervix. The therapeutic vaccine injects a specific protein that triggers the immune system to attack high-risk HPV which is known to cause cervical cancer. A randomized controlled trial that followed women for over two years post-vaccination found that those who received the vaccine were more than twice as likely to see their CIN eliminated compared to those who received placebo. The vaccine shows promising evidence that it may not only eliminate the lesions but also the HPV infection. However, research is still in its infancy and more long-term trials are needed to determine the safety and effectiveness of treatment. Consult your doctor to work out the best plan of action for you to stay healthy Natural Methods to Fight HPV Most HPV infections can be easily cleared by a strong, healthy immune system. Immunity can be heavily supported and improved through our daily lifestyle choices, including: Eat plenty of fruits and vegetables – fruits and vegetables contain many essential vitamins and nutrients to keep your body functioning at its best! These food groups are specifically high in antioxidants, which may help neutralize bad molecules floating around in your body. The food we eat also plays a crucial role in supporting our gut health, where nearly 70% of our immune system is housed. Quit smoking – smoking significantly increases your risk for HPV-related cancers, and even second-hand smoke exposure increases your risk. While cutting down your cigarette count will still have an effect, nothing is quite as good as quitting entirely. Reduce alcohol consumption – high consumption of alcohol is related to several negative outcomes, including a reduction of immune function. Drink green tea – green tea has been shown in many studies to have immune benefits and anti-cancer effects, some specific to HPV. Exercise to sweat – movement is important to improve your circulation for immune benefits and general well-being, while sweating will help release toxins from within your body. Get adequate sleep – getting 7 to 8 hours of high-quality sleep is important to regulate your bodily functions, including your circadian rhythm. All of these factors have a distinct effect on your ability to fight infections. Keep a positive mindset – positivity has several health benefits, including stress reduction which will keep your immune system strong. Supplement your diet appropriately – for some people, it can be difficult to get the nutrition they need to keep their immune system working at 100%. Papillex is a supplement specifically designed to help both women and men respond to HPV naturally and give their immune systems the support it needs. Could Medicinal Mushrooms be the Cure? Promising new research on the benefits of a shiitake mushroom compound called Active Hexose Correlated Compound (AHCC) could help eradicate persistent HPV infections. Two small human clinical research trials have been conducted by Dr. Judith A. Smith, Pharm D., an associate professor in the Department of Gynecologic Oncology and Reproductive Medicine at the University of Texas.  The studies have found daily intake of 1-3 grams of AHCC eradicated the virus in 44-66.7% of patients with high-risk HPV status after 3-7 months. Medicinal mushrooms have been used for centuries in traditional medicine to support the immune system and fight viral infections and cancers. You can learn more about AHCC for HPV here.  While the trials have been successful so far, more research is needed to determine if it is effective. Patients should talk with their doctors before starting any supplementation.  The Ultimate Cure-All? It seems we are always looking for the ultimate cure-all - that one thing that will do the trick and solve our problems. Unfortunately, a magic pill rarely exists, and instead, a more nuanced and multi-faceted approach is needed. This nuanced approach applies when we talk about curing HPV. 
Sep 15, 2020
6 min read
How Many Types of HPV Are There?

How Many Types of HPV Are There?

Adrienne Hill-Strathy
There are over 150 different HPV strains that have been identified in humans. Different strains have evolved over time through evolution into five sub-groups, each with unique ways to infiltrate and cause disease in an individual. Some strains cause minor papilloma’s on the surface of the skin, while others have no symptoms but have the ability to slowly develop into cancers. The most widely studied HPV sub-group is classified as Alpha types. Alpha types are more researched because they are typically associated with cervical cancer. The alpha types can be divided into high-risk and low-risk strains. Broadly speaking, we can classify HPV strains into low and high-risk Low-Risk Strains Low-risk strains often cause common warts on the surface of the skin. These strains of HPV are considered low-risk because they rarely develop into cancer. HPV strains 6 and 11 are the most common low-risk HPV strains, causing 90% of genital warts. Genital warts are soft, fleshy, cauliflower-like growths that can grow in genital areas including the anus and penis. These warts can be painful, itchy, annoying, and, worst of all, highly persistent. Warts generally show up a few weeks or months after sexual contact with an infected partner. Like most HPV infections, genital warts will usually be cleared by a strong, healthy immune system. Taking supplements like green tea extract, found in papillex, can also help improve wart clearance. High-Risk Strains High-risk strains of HPV have a higher likelihood of developing into cancers. High-risk strains often do not cause symptoms so many are unaware that they have contracted a strain of HPV. The high-risk strains develop slowly overtime, causing minor changes to the cells of the cervix, anus, or oral cavity. High-risk strains that persist for a number of years increase the risk that cancer will evolve. 12 HPVs (16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, and 59) are defined by the World Health Organization (WHO) as being high-risk cancer causing types. Together these HPV’s cause half a million cases of cervical cancer per year worldwide. HPV-16 and 18 are the most common strains associated with cervical cancer, causing about 70% of cervical cancers. These strains can also cause cancers at other sites, including the penis, vagina, and vulva and in the oral cavity. The reason high-risk strains are more likely to cause cancer is thought to be due to where the virus has evolved to infiltrate the body and specific proteins within the viral machinery. Particular areas within the cervix lining are more susceptible to fostering cell replication than others. HPV that gain access to the transformational zone in the cervix have been linked to higher rates of cancer progression. Viral proteins identified as E6 and E7, have been found to be responsible for stimulating cell cycle entry into the upper epithelial layers and linked to cancerous changes. Despite high-risk strains increasing one’s risk of cancer, contracting a strain does not mean you are going to get cancer. The majority of individuals will clear the infection within a few years and have no complications. Transmission and Infection Rates The variety of HPV strains and the transmissibility of the virus means most individuals will pick up one strain of HPV in their lifetime. HPV is one of the most easily transmitted sexually transmitted diseases. The virus can be contracted just through skin contact with an infected individual. Because the virus lives within the skin cells, even protected sexual contact can lead to transmission from areas that aren’t covered by a barrier. Getting Regular Pap Tests Getting regular pap tests is important to monitor any potential infections and complications. Cell progression is caught easily in pap tests, and awareness is key to taking preventative measures to clear the virus. The recommendation for disease control and prevention is to get one pap test every three years to keep an eye on your cervical cells, and more frequently if you have ever had an abnormal pap test. It is essential to go for regular pap smear tests if you are a young woman, even if you display no symptoms How Can I Protect Myself Against HPV? The most important thing you can do to protect yourself from HPV complications is maintaining your overall health. A healthy immune system is the hallmark of HPV infections, where the failure to develop effective cell-mediated immunity to clear or control the infection results in persistent infection and increases the probability that the cells progress to cancer. We can support and build our immune system by making healthy choices every day. Some important factors in supporting your overall health include: Optimizing Nutrition and Supplementation Consuming a fruit and vegetable-rich diet, limiting sugar and refined carbohydrate intake has been found to have a positive effect on the overall function of the immune system. Managing Psychological Stress Prolonged stress has been found to create an imbalance in the ability of the body to fight incoming infection, by over activating areas of the immune system that exacerbate chronic illness. Engaging in daily stress management practices like meditation, exercise, and socializing can have a positive effect in improving the bodies overall resiliency. Getting Good Quality Sleep Getting adequate rest, seven to eight hours of quality sleep per night, allows the immune system time to revitalize, balance hormones and it initiates cellular repair. Setting a regular bedtime, limiting caffeine intake in the afternoon, and eating a nutrient-dense diet are all ways we can improve our sleep quality. Engaging in Regular Exercise and Movement From improved circulation to naturally increasing the bodies white blood cell and antibody count, staying active has a range of benefits in helping support the immune system and defense against disease. We recommend talking daily walks and engaging in bi-weekly strength training and aerobic activity.
Sep 01, 2020
4 min read
Herbs for HPV

Herbs for HPV

Dr Elizabeth Goldspink
With the rising rates of HPV, people are seeking out more natural options to manage their symptoms and prevent recurrences. That's why we've put together our top 10 list of herbs for HPV! Lifestyle changes can really help support your immune system against viral infections of any kind, not just HPV! Read below to know more about HPV, if you should be worried, and how to manage it using natural methods! Herbal Remedies Human papillomavirus is highly contagious and is responsible for warty growths in human beings with some strains having also been linked to cancers of cervix and penis. If you are looking for natural treatments, herbs are one way to help treat HPV. These herbs are not only effective against HPV but almost all types of viruses can benefit from herbal remedies as most of them carry strong antiviral properties. There are many antiviral herbal remedies for HPV that can also boost the immune system; we’ve included some of the best studied ones below:  Thuja Oil and Tea Tree Oil  Tea tree and thuja oils are natural antibacterial, antifungals and antivirals. The oils broad-spectrum properties can be used to treat a number of skin ailments, including HPV warts. A drop of pure tea tree oil applied to affected areas daily has been found to be an effective topical treatment to clear warts. Tea Tree Oil Goldenseal  Goldenseal is one of the best anti-microbials, commonly known as a natural antibiotic. The herb is one of the top selling botanical medicine in North America, often taken to prevent cold and flus. An alkaloid component of goldenseal, called berberine has been found to inhibit certain tumor promoters and inhibit angiogenesis. More research is needed on the direct impact of berberine on HPV infections but its actions in stimulating the immune system are thought to improve viral clearance. Goldenseal Astragalus This herb appears to increase antibodies and interferon levels in the body. It enhances the immune-system activity by stimulating the activity of helper-T cells and is therefore helpful in the treatment of immune deficiency-related problems. It works so well that it’s not recommended long term as it can overstimulate your immune system. It’s available in the form of daily supplements for whole body benefits and can also be applied topically. Astragalus has also been specifically studied for its inhibitory effect on cervical epithelial cell growth (cervical cancer cell growth). Astragalus Reishi Mushroom Extract Medicinal mushroom enhances the activity of T-helper cells or CD4 cells, both of which are immensely important for immune function. It also stimulates the production of interferons, IL-1 and IL-2, involved in quickly initiating the immune system to react. This helps fight serious conditions by not only supporting but also regulating the immune system. Clinical studies have also shown that the use of Reishi can dramatically impact the clearance of HPV. Reishi Mushroom Green Tea Extract This herb contains polyphenols, catechins, and flavanoids. These are potent anti-cancer compounds. Results of a controlled study confirmed that a botanical supplement containing green tea extract is an effective and well-tolerated treatment for external genital and anal warts. In viral infections, the active compound called epigallocatechinagallate (EGCG), has been found to inhibit the early stage of infections, through attachment, entry and membrane fusion by interfering with viral membrane proteins. Read our latest post about green tea extract and cervical cancer to find out more! Green Tea Echinacea A popular botanical used to fight colds and flu has anti-inflammatory and immunostimulatory properties. Numerous studies have also shown the extract to possess significant antiviral activity, with virucidal effect against influenza, herpes, and coronaviruses. The herb works by inhibiting initial contact with the virus at the beginning of infection and preventing further transmission to infected cells. Echinacea has been found to reduce the relapse risk and induce a protective immune response to viral clearance in patients with HPV lesions over a period of 12 months. Echinacea can be taken as a supplement, tonic, and can also be used for topical application. Echinacea Curcumin This is the active ingredient in Indian spice turmeric. It contains a class of compounds called curcuminoids that act by suppressing regulatory molecules and signaling pathways involved in upregulating cancers and other diseases. The compound has been found to suppress cell growth and tumor formation and induce phase II metabolizing enzymes and antiangiogenic effects. Curcumin has an effect on enhancing the clearance of high risk HPV 16, and downregulating the HPV oncogene expression against cancers. Cucumin derived from Turmeric Garlic Garlic has long been supported for its role in preventing disease and supporting health. The herb is said to have pharmacologic effects based on its ability to be hypoglycemic, hypolipemic, anticoagulant, antimicrobial, and an immune system modulator. Garlics immune boosting and anti-viral properties provide benefits to HPV clearance, through enhancing natural killer cells that destroy viral pathogens and other immune molecules that target infected cells. The herb can be taken orally through food, applied topically to warts, and also ingested in high doses for immune functioning. Garlic Birch  Willow bark, or birch bark can be used as an astringent in wound and wart healing. The extract contains salicin, as acid that helps dissolve warts. Birch can be applied topically to break down the hard coverings of the warts.  Birtch Bark Ginkgo Biloba  This herb is a potent antioxidant and also helps improve circulation, particularly the circulation of blood to your brain. It has been used for years in traditional medicine. Ginkgo contains ginkgolic acids with alkylphenol constituents that have been shown to have antitumor effects through disrupting cellular function and viral entry into a variety of viruses. There is limited research on ginkgo on HPV but the underlying mechanisms found in exisiting research suggest it would be useful in clearing HPV infections as well. Ginkgo Biloba Olive Leaf  Olive leaf contains a high quantity and variety polyphenols that are anti-inflammatory and protect against DNA damage. The leaf has been shown to be useful against many viral illnesses, the olive leaf induces cell death of cervical cancer cells, a common outcome of high risk HPV strains. Olive Leaf Herbs for HPV: Special Mentions Bayberry, Horehound, Red clover, Fenugreek and Hawthorn can also be useful herbal remedies for HPV as these enhance the immune system’s response to viruses. These herbal remedies for HPV are available as supplements (to act internally), tonics, and can also be applied topically. Herbal remedies for HPV have little to no side effects. Conclusion So there you have it! Our top 10 herbs for HPV! If you are interested in finding out our recommendations for herbal antiviral remedies in general, please take a look at our antiviral herbs article! For a supplement that packs essential ingredients to help you better respond to HPV, why not check out Papillex and make a positive change today!
Aug 15, 2020
5 min read

Example subheading

Subscribe & Save

  • Savings of up to 20% off
  • Plus Enjoy Free Shipping to US / CA
  • Switch or Pause anytime
  • Peace of Mind