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The Root Causes of HPV

The Root Causes of HPV

Adrienne Hill-Strathy
We know that the Human Papillomavirus (HPV) causes 98% of all cancers of the cervix. HPV is also linked to anal, vulva, and other cancers of the genital tract. With that said, not everyone who contracts HPV will develop complications. Most cases of HPV will spontaneously regress on their own within 2-3 years. In the small few where HPV doesn’t revert and becomes chronic, it can lead to progressive cellular changes over time which can sometimes lead to cancer. So, what makes one person more susceptible to persistent HPV infections than another? Let’s explore a few root factors that could be at play. Addressing these root causes can help support the body to clear HPV and prevent cervical and other HPV-related cancers. Nutrient Deficiencies Nutrients form the backbone and catalysts for many reactions and processes in the body. Today, many individuals are deficient in important nutrients, and these deficiencies make it difficult for the body ecosystem to function optimally. Studies have found several nutrients to be correlated with HPV infections. Persistent HPV infections are more common in individuals with low levels of folate (B9), vitamin A, vitamin C, vitamin E, and selenium. With these deficiencies, there is also an increased risk of progression to cervical cancer. HPV rates decline in individuals with higher levels of these nutrients. The underlying action of these nutrients is to help support healthy immune function through inhibiting cancer cell growth and their powerful antioxidant activities. Nutrient deficiencies can be corrected by consuming a diet rich in diverse whole foods, especially fruits and vegetables. We like to aim for 8 to 10 servings per day with at least one serving coming from green leafy vegetables.  Nutrient levels can also be corrected through supplementation. Papillex™ was formulated with this research in mind. Our nutritional supplement offers the daily recommended serving of micronutrients known to support HPV.  The Vaginal Microbiome Within our body’s ecosystem exists separate micro-ecosystems including the vaginal microbiome. The vagina is home to trillions of microorganisms – bacteria, fungi, and viruses. These organisms play a role in the health and function of the vagina. When certain species overgrow or get depleted, health complications can occur. The vaginal microbiome is largely populated by the Lactobacillus species. Studies find that HPV is more common in individuals with lower levels of Lactobacillus. In individuals with cervical dysplasia levels of unhealthy microbes like Prevotella, Sneathia, and Clostridiales are increased. Research also seems to indicate that HPV infection can disrupt the vaginal microflora, allowing the virus to persist.  Screening for vaginal infections like bacterial vaginosis, candida, and trichomonas vaginalis can help detect if there is an underlying imbalance and inform how to treat it. If you notice any changes in vaginal symptoms such as irritation, redness, pain, or changes to discharge, contact your doctor. Taking care of your vaginal health is just like taking care of your overall health - eat a nutrient-rich diet, reduce sugar intake and processed food, and fill up on those pre-biotics and probiotics. Maintain proper hygiene practices by avoiding douches and soaps, using organic, scent-free personal care products, and cotton underwear. Safe sex practices are also important to your overall wellbeing - wearing condoms can reduce exposure to other bacteria and sexually transmitted infections as well as maintain vaginal pH. Inflammation Inflammation is a natural immune response to repair tissue damage and defend the body against invaders. However, unchecked and chronic inflammation is at the root of many chronic diseases. It is helpful to think of the body as one interconnected ecosystem when considering the impact of inflammation on cervical health. When inflammation is out of balance, it can contribute to the body’s vulnerability to tissue damage. Research has found inflammation and oxidative stress to play a role in HPV persistence. The HPV virus is better able to infiltrate into the cells when the tissue is inflamed. Chronic inflammation also helps cells proliferate over time, allowing for those cervical cell changes to occur. In addition, the HPV itself is also inflammatory and its cellular process further induces inflammation at the local site. Reducing inflammation is another whole-body approach. Dietary factors play a role in supplying the body with antioxidants, known to balance inflammatory oxidative processes. Antioxidants are best obtained from eating a diverse diet of whole foods. We also recommend reducing exposure to inflammatory triggers like cigarette smoke, alcohol, and processed foods (trans fats and refined carbohydrates) as well as managing blood sugar through consuming adequate protein, fats, and complex carbohydrates to keep inflammation down. In addition to dietary changes, getting 7-8 hours of good quality sleep per night is crucial for the immune system. Genetics Certain genetic factors have also been explored for their role in HPV. Studies suggest there is a familial predisposition to cervical cancer. More specifically, research indicates that individuals whose mother or sister had HPV have an increased chance of developing cervical dysplasia and cervical cancer. This increased risk could be due to several factors. Certain genes were found to be associated with HPV risk as well as HLA alleles. A person’s genotype may also influence risk behaviors that influence HPV. Our genes may also impact our DNA repair and detoxification pathways. Associations between the MTHFR gene and cervical cancer may also exist. MTHFR plays a role in converting dietary folate into folic acid to be used in detoxification and cellular repair pathways. An MTHFR mutation increases the risk of several diseases including heart disease, colon cancer, and breast cancer. Some evidence suggests there is a link between genetic variants of MTHFR and cervical cancer, but more research is needed. Increasing dietary folate through intake of leafy green vegetables, beans, and supplementation, can help support this pathway. Hormones Hormones also play an important role as the chemical messengers that act throughout the body. Hormones were first thought to play a role in HPV infections following findings that HPV infections were more common in individuals on oral contraceptive pills and after having multiple pregnancies. The sex hormone, estrogen, is thought to explain why rates of cervical dysplasia increase in these groups. Reducing exposure to xenoestrogens, estrogens found outside the body can help reduce this risk. Consider non-hormonal methods of birth control as a way to reduce risk. Again, diet and lifestyle factors play a role in supporting healthy hormone production and function. A diet rich in cruciferous vegetables (broccoli, cabbage, and kale) can help support estrogen detoxification and clearance. Intake of phytoestrogens like flaxseed and soy can help support a healthy hormone balance. Why lifestyle is key The good thing is most of these factors are modifiable through lifestyle practices. The daily choices you make can influence your likelihood of developing cervical cancer or other HPV complications. As we have said, supporting the body against invaders like HPV is a whole systems approach. Focusing on a nutrient-rich diet, reducing stress and exposure to harmful chemicals, and targeted supplementation can help address many of the underlying root causes that lead one to develop complications of HPV.
Jan 03, 2022
5 min read
How Does Birth Control Impact HPV?

How Does Birth Control Impact HPV?

Adrienne Hill-Strathy
One question we commonly get asked is how birth control may impact HPV. Birth control is commonly used by women of reproductive age to prevent pregnancy. Today, many also use birth control to support hormonal symptoms like PMS, acne, dysmenorrhea, and heavy menstrual bleeding. Many factors are often considered when choosing a birth control that is right for you. In this article, we will explore three popular birth control methods and things to consider with regard to HPV. Let’s Start With The Oral Contraceptive Pill (OCP) The OCP is a hormone modulating birth control. The OCP contains estrogen and progesterone, two hormones involved in the reproductive cycle. Individuals who menstruate often go on the OCP to prevent pregnancy as well as control hormonal symptoms like premenstrual syndrome (PMS), acne, painful periods, and heavy menstruation. The OCP is speculated to increase HPV persistence and progression. The pill may do this by altering certain genes as well as increasing the cervical maturation process which allows cell proliferation of HPV. By taking a synthetic hormone you may change the susceptibility of the cervical cells to high-risk infections. Moreover, because the OCP contains growth-stimulating hormones estrogen and progesterone, there is some risk that they can increase the risk of cervical cancer. Studies have found that long-term use (10 years or longer) of oral contraceptives has a four-fold increased risk of developing cervical cancer. A study of over 46,000 individuals found that those who are used OCP had a significantly higher rate of cervical cancer and abnormal cervical cell growth than non-users. The research does also suggests that the risk decreases after stopping the pill. HPV rates decline with time since quitting. The OCP may also lead to nutrient deficiencies associated with HPV.  The pill can deplete riboflavin, vitamin B6, folic acid, vitamin C, and zinc. We know these nutrients are important players in supporting the immune system and some have even been specifically linked to HPV. Moreover, the birth control pill is also known to alter the gut microbiome. The pill may increase leaky gut, dysbiosis, and candida overgrowth. A healthy gut is another foundation for our immune and overall health. Impairing this system can have a widespread impact on the rest of the body. Considering these impacts, it is important to support nutrient levels and gut health if taking the OCP. We recommend optimizing dietary intake of diverse fruits and vegetables, fibers, and probiotic foods as well as considering supplementation. Condoms Condoms are a favorable form of birth control when it comes to protecting against Sexually Transmitted Infections (STIs) and pregnancy. Condoms form a barrier between mucosal contacts and are found to be 98 percent effective at protecting against STIs like chlamydia and gonorrhea. However, because skin-to-skin contact can still occur with condom use, they are less effective at preventing the spread of herpes, genital warts, and HPV. That’s right. Unfortunately, HPV can still be transmitted through condom use. Nevertheless, condom use is still warranted and recommended. Some studies have found that the risk for genital warts and the grade of cervical intraepithelial neoplasia (CIN) was reduced in condom users. Condoms also protect against other STIs and infections that can contribute to co-infections and impair the vaginal microbiome. IUD The intrauterine device comes in both a hormonal and non-hormonal form. Both are inserted into the uterus for long-term, effective pregnancy prevention. The hormonal IUD delivers a small amount of progestin to the local uterine tissue. Some individuals notice side effects like changes in mood, bloating, cramping, or reduced menstruation. The IUD can also get displaced and in rare cases perforate the uterus. The hormonal release of the IUD is lower than the OCP. The IUD releases one hormone, progestin, at a dose of fewer than 20 micrograms each day. Whereas the OCP releases 1 milligram of progestin and 0.02 to 0.06 milligrams of estrogen each day. The non-hormonal option is a copper IUD that prevents pregnancy by releasing copper in the uterus that is toxic to sperm. The copper IUD will not suppress ovulation and the most common side effect is heavier menstrual bleeding. While the copper IUD has no hormonal impact, the heavier menstrual bleeding can contribute to iron deficiencies and anemia. What’s The IUD Connection with HPV? Some studies have shown that sexually active individuals with the IUD group had higher clearance rates of HPV. While others, when adjusted for other variables, found no association between IUD use and HPV infection or persistence. Research comparing the difference between the copper IUD and hormonal has found mixed results. One study found the hormonal IUD to have a lower risk of high-risk HPV than the copper IUD. Another study found the copper IUD to have a lower risk of cervical neoplasm. Overall, it is unclear how these devices are influencing cervical dysplasia and HPV infections or the mechanism of action. It is also important to note that the IUD and OCP do also not protect against other STI’s like chlamydia and gonorrhea, while condoms do. So how can you decrease your risk of HPV? You are probably thinking, what then can I use to protect myself against HPV and STI’s? Currently, condoms and engaging with fewer sexual partners are the best ways to reduce your risk of exposure to HPV. However, we understand that other factors are involved. We always recommend talking to your health practitioner to help decide what is best for you. Because most sexually active individuals carry some form of HPV and it can be transmitted through skin contact, no form of birth control can completely protect you. More importantly, you can support your whole-body system so that if you are infected, you are better equipped to defend against pathogens and viruses.
Dec 13, 2021
4 min read
Inflammation and HPV

Inflammation and HPV

Adrienne Hill-Strathy
Inflammation is the body’s natural response to injury and infection. Without the natural inflammatory response, we would not fair very well! When inflammation occurs, immune molecules are recruited to the site of injury or invasion to release other immune cells (cytokines, hormones, and white blood cells). These immune cells help repair and restore the body to optimal, healthy function. However, inflammation can also cause harm. If the inflammatory response is stimulated too much and for too long, chronic inflammation occurs. During prolonged inflammation, the balance between oxidants and antioxidants is thrown off causing oxidative stress. Oxidative stress promotes the release of more inflammatory molecules. These reactive oxygen molecules damage proteins, cells, and DNA, which increases the risk of diseases and cancers. This inflammatory response is thought to contribute to the progression of HPV infections to cervical cancers. Inflammation and cervical health We know that the immune system is a key factor in regressing HPV infections. Studies have found inflammatory molecules assist the virus to integrate and proliferate into an individual’s tissues. This means that the more inflammation present, the easier it is for viruses to infect our tissues. Inflammation leaves our cells more vulnerable to further damage. HPV itself also drives inflammation. The viral particles produced by the HPV (E6, and E7) are also inflammatory and drive more inflammation which further decreases the level of antioxidants, our main weapons against oxidative damage. Together these processes allow HPV to persist. What increases inflammation? Chronic inflammation is caused by multiple factors. Some factors we have little control over like infections and injury. Other factors are lifestyle-based like diet, nutrient levels, environmental toxins, stress, and lack of sleep. Fortunately, we do have some control over these factors. How to tame the flame Eliminate inflammatory triggers Reducing exposure to known inflammatory triggers like smoking and alcohol is number one in lowering our overall load. Processed foods, refined sugar, and hydrogenated oils can also be pro-inflammatory. We also know smoking increases the risk of HPV and cervical cancer. Fuel up on antioxidants Antioxidants are some of our best sources of inflammation-fighting molecules. Obtaining antioxidants is best done through the diet. With 80 percent of the immune system located in the gut, so what we put into our bodies in the form of food directly interacts with the immune system. Plant-based whole foods offer our greatest source of antioxidants. Aim for 8-10 servings of colorful fruits and vegetables each day. Rotate your veggies often to optimize the unique nutrients and antioxidants in different plant foods. Supplementation can also play a role in supplying antioxidants. By consuming a greater ratio of antioxidants, we can reduce chronic inflammation. Studies find intake of antioxidants like vitamin A, vitamin E, and vitamin C can neutralize free radicals and are associated with a preventative effect on cervical cancer. The star players Some antioxidants have potent disease-fighting properties than others. Our favorites include Glutathione Glutathione is best known for its powerful antioxidant activities. The compound is composed of three naturally occurring amino acids, cysteine, glutamic acid, and glycine. Glutathione can help repair cellular damage caused by oxidative stress and supports the liver in detoxifying hormones and toxins. Studies have found glutathione levels to be low in individuals with cervical cell changes. We can support the body’s natural production of glutathione through supplementing NAC, a natural form of cysteine. Vitamin C, methyl folate, selenium, and curcumin also support glutathione production. Green tea extract Green tea contains powerful polyphenols, called EGCG, that have been found to play a role in regressing HPV infections. The antioxidants in EGCG inhibit the cell changes that occur in cervical cancer. Several studies have found supplementing green tea extract has anti-viral and anti-infective effect that stimulates the immune system. The compound can also be used topically to clear genital warts. To obtain the therapeutic amount of green tea extract, drinking a cup of green tea isn’t enough. Supplementing offers a much stronger dose. We recommend taking 300-600 mg a day. Indole-3-Carbinol (I3C) and diindolylmethane (DIM) I3C and DIM are superfood antioxidants found in the broccoli family. 3C and DIM are produced in the stomach after consuming cruciferous vegetables. The compounds have been found to help naturally support and repair DNA damage and reduce the risk of cancer. One study evaluated oral DIM treatment in individuals with CIN 2 or 3 cervical lesions scheduled for LEEP procedure. Those in the treatment group took 2 mg/kg/day of DIM for 12 weeks. The placebo took a rice bran pill for 12 weeks. At the 6 months follow-up of the study, 84% of the treatment group had improved findings on colposcopy and 85% didn’t require a LEEP. However, no statistical significance was found between the treatment and placebo. While it is unclear if DIM treatment alone can clear HPV, its powerful antioxidant capabilities in combination with other nutrients and support can contribute to our overall HPV defense.  Medicinal mushrooms Medicinal mushrooms are another natural compound that has been used for centuries to support the immune system and inflammatory processes. Mushrooms contain active compounds called polysaccharides. These compounds can inhibit chronically elevated inflammatory molecules like IL-6, prostaglandins, and leukotrienes. Glucans are a type of polysaccharide that stimulates the production of immune molecules like natural killer cells and cytokines. These cells help the immune system clear away unwanted invaders. Reishi mushroom is commonly used for immune support. It has been found to have anti-inflammatory properties in melanoma and breast cancers. Active Hexose Correlated Compound or AHCC is another mushroom extract that contains a high level of alpha and beta-glucans that modulate the immune system. AHCC has been found to support immune support in cancers and viral infections.
Nov 29, 2021
4 min read
Sulfated Polysaccharides and HPV

Sulfated Polysaccharides and HPV

Adrienne Hill-Strathy
Within the world of plants and fungi lie a vast array of medicinal compounds. Sulfated polysaccharides are powerful therapeutic compounds being explored for their anti-viral activity. These polysaccharides are shown to have potent anti-viral effects against viruses like the human papillomavirus (HPV) and the herpes virus (HSV). Sulfated polysaccharides include compounds like heparin, cellulose sulfate, and dextran sulfate. Structurally, these compounds look very similar to heparan sulfate, an HPV cell-attachment factor. These compounds are found to inhibit papillomavirus and herpes infections due to their ability to block the viruses from attaching to healthy cells. These polysaccharides also contain potent anti-inflammatory and antioxidant properties that help support cellular health and prevent tumor progression. Where can you find these potent polysaccharides? Sulfated polysaccharides can be found in some species of medicinal mushroom as well as marine plants like red and brown algae. Red Algae – Irish Moss (Chondrus crispus) Irish moss is a type of seaweed or algae that is found on the Atlantic coast in Britain, Europe, and North America. The moss is rich in the sulfated polysaccharide carrageenan. You might know carrageenan from the back of your almond milk or yogurt. It is commonly used as a stabilizer and emulsifier in food products. The carrageenan found in common packaged foods is chemically processed and may even have negative health effects. However, consuming the moss in its pure form offers a range of beneficial vitamins and nutrients. Keep reading for a recipe. In addition to its rich carrageenan content, Irish moss is also rich in other minerals like iodine, important for thyroid health. It also contains omega-3 fatty acids, which can reduce the risk of heart disease and high blood pressure. The moss also contains a carotenoid called fucoxanthin, which benefits blood sugar regulation and acts as an antioxidant, which we know is important for fighting HPV. Irish moss has been consumed for centuries and was used as a nutrient supply during times of famine. Carrageenan acts as a potent HPV inhibitor by blocking HPV from binding to its attachment sites. Considering condom use is minimally effective in preventing HPV infection, carrageenan is being explored as a topical microbicide to be used preventatively against HSV, HIV, and HPV. The inhibitory effect appears to be strongest for HPV compared to HSV and HIV. Topical applications were found to be safe and well-tolerated, reporting no increased risk of reproductive tract infections or irritations. So far, carrageenan-containing sexual lubricants have been found to be effective at blocking HPV16. Brown Algae – Fucoidan Brown seaweeds contain a sulfated polysaccharide, called fucoidan. Fucoidan is a sulfated alpha L-fucan that has been found to support the immune system, reduce inflammation, and have an impact on blood pressure and infection. Animal studies have shown fucoidan to have a protective effect against liver injury by suppressing inflammatory mediators and increase the production of liver-protective enzymes. The anti-viral activity of fucoidan comes from its natural killer cell stimulation which promotes immune modulation and antitumor effects. Brown algae also contain fucoxanthin, an antioxidant that gives algae its brown color, as well as other microminerals like iodine for thyroid health. Fucoidan in brown seaweeds has been reported to possess anti-viral activities against viruses like HIV and HSV. The compound acts by inhibiting virus and entry and replication. More human studies are still needed to support its effects, but the compound could be used preventatively to reduce viral infections. Lentinus Edodes- Shiitake mushroom Shiitake mushrooms are one of the most well-known mushroom species. Medicinally, the shiitake mushroom is shown to be effective in the treatment of prostate cancer, can help lower high cholesterol, stimulates the activity of immune cells, and has antiviral and antibacterial properties. The potent medicinal properties come from their high polysaccharide content of Beta-D-glucans. These glucans have been found to enhance the number of immune cells and have antiviral activity against the poliovirus and herpesvirus. The beta-D-glucans found in shiitake aid in slowing tumor growth and kill viruses and other microbes.  Agaricus Blazei- Almond Mushroom Another medicinal mushroom rich in polysaccharides is Agaricus Blazei, also called Agaricus subrufescens. Agaricus is a Brazilian basidiomycete often consumed as food or in tea to help with emotional stress, high cholesterol, diabetes, and gastric disorders. Agaricus contains active compounds that have repeatedly been shown to activate the immune system and prevent the herpes virus from attaching to and infecting healthy cells. The compound also has anti-inflammatory and antioxidant properties, helping maintain the overall health of the cells. Reaping the many therapeutic benefits of mushrooms isn’t as easy as eating sauteed mushrooms. Medicinal compounds must be extracted through water or alcohol-based decoctions. These powerful extracts are then taken in tinctures or powdered form. What are the risks to consuming sulfated polysaccharides? While generally quite safe for use, mushrooms like shiitake may cause an elevation in white blood cells, upset the stomach, and skin inflammation. Agaricus extracts can cause hypoglycemia, nausea, diarrhea, and upset stomach. Few have also reported liver damage and allergic reactions. Because seaweeds contain iodine, there is a risk of consuming too much iodine and disrupting thyroid function. Sea vegetables like algae may also be exposed to environmental contaminants like arsenic and mercury. Make sure to purchase these supplements from a reputable source. Algae should not be taken with anticoagulant drugs like warfarin and heparin. Given the immune stimulatory effects of sulfated polysaccharides, supplements should be taken with caution in individuals with autoimmune or immune system conditions. We always recommend seeking advice from a health care provider before starting any supplement or treatment. Image from: https://divascancook.com/how-to-make-sea-moss-gel-recipe/ How to reap the benefits of Irish Moss Irish moss can be bought in raw form or cultured into a gel. The moss can then be used topically or ingested. If taken orally, add 1 heaping tablespoon into a smoothie with frozen mangoes and dates. 2 oz of raw Irish moss 1700 ml of spring water To make: Wash moss thoroughly in filtered water. Soak 2 ounces of dried Irish Moss on the counter in 1700 ml filtered water for one day. Simmer on low until a gel is formed. Irish moss has minimal taste, so it is perfect to blend into smoothies, juices, and soups or strews. Store in the refrigerator for up to 2-3 weeks or kept frozen.
Nov 15, 2021
5 min read
How the Vaginal Microbiome may be Contributing to your HPV

How the Vaginal Microbiome may be Contributing to your HPV

Adrienne Hill-Strathy
Our bodies are inhabited by millions of tiny living microbes. You may already be familiar with the living organisms in the gut. Our genitals each have an ecosystem of microbes as well. The bacterial composition of our vaginal microbiome plays a role in our overall health, including simmering infections like HPV. Vaginal microbial diversity and richness is a key player in the immune system. Healthy microbes help prevent many urogenital diseases, yeast infections, and other Sexually Transmitted Infections. Breaking down the microbes The key player in the vaginal microbiome is a bacteria called Lactobacillus. This lactic-acid-producing organism is thought to be the main defense against incoming invaders in the vagina. Lactobacillus helps maintain a low vaginal pH and protects the vaginal mucosal lining. The abundance of Lactobacillus species is lower in individuals infected with HPV. Moreover, individuals with cervical dysplasia show higher proportions of unhealthy microorganisms like Prevotella, Sneathia, and Clostridiales. The chicken or the egg? It seems HPV infections may impact normal microflora. Likewise, an unhealthy flora can also allow for HPV to persist. As the virus initiates healthy cervical cell immune defenses, it can disrupt the vaginal microbiome and promote HPV persistence and progression. As we continue to learn more about the microbial connection to STIs, it is important to consider how the vaginal microbiome may be contributing to your HPV infection and what you can do to fix it. Types of vaginal infections: There are three main types of vaginal infections.  Bacterial vaginosis (BV) is the most common type of vaginal infection in adult women. Around 30 percent of women between the ages of 20 and 50 have BV. BV is characterized by an overgrowth of certain bacteria and an elevated vaginal pH. It often presents with symptoms of a fishy odor, greyish discharge, itching, and irritation. Studies have found a positive correlation between BV infections and HPV. The connection is thought to be due to reductions in Lactobacillus (the beneficial microbes) and an increase in sialidases (the pathogenic ones). The loss of beneficial bacteria reduces the protective microorganisms and changes in the vaginal microflora, which may promote the survival and development of HPV. The increase in the presence of sialidases can cause microdamage to the epithelial cells and increase the susceptibility to cervical HPV infections. Trichomonas vaginalis (TV) is another common STI. It can also cause a foul odor, genital redness or burning, and pain with urination and intercourse. A positive association was also found between TV infections and positive HPV infections. Vulvovaginal candidiasis, also known as a yeast infection, is another common vaginal infection. Candida results from an overgrowth of fungal species in the vaginal canal. Research has found that candida infections were not associated with an increased risk of HPV infections. This is likely because candida does not impair the lactobacillus-predominated vaginal microbiota. How do I know if I have a vaginal infection? Vaginal infections often present with signs and symptoms. You may notice: Vaginal irritation Changes in color, odor (often fishy), and/or consistency of discharge Redness Pain or tenderness Itching Burning or pain on urination If you notice changes in vaginal symptoms, contact your doctor. A vaginal exam and swab can be done to determine the cause. Tips to take care of your vaginal health Lifestyle choices can play an important role in supporting the vaginal microbiome. Optimal vaginal health depends on the health of the whole body. Treatment is focused on supporting both the local environment, as well as the wider body system. organic basil herbs on display at the farmer's market. Diet: Because the body is one interconnected system, what you eat can influence the vaginal microbiome. A diet low in sugar and refined carbohydrates can support a healthy microflora. Sugars are found in cakes, cookies, pastries, and alcohol should be limited to special occasions. Sugars from fruits and other natural sources like honey and maple syrup should be enjoyed but not overdone. By reducing sugar intake, blood sugar is better managed allowing for healthy hormone regulation. Consuming a diet rich in a diversity of fruits and vegetables can also help support a healthy microbiome and supply micronutrients to enhance overall health. Probiotics: oral and vaginal probiotics can help support the vaginal microflora. It is important to opt for a high-quality probiotic. Probiotics that contain Lactobacillus reuteri, Lactobacillus rhamnosus, and Lactobacillus crispatus are known to support vaginal microflora. For vaginal suppositories, probiotics are often recommended for 10 days through insertion into the vaginal canal each night before bed.   Hygiene: The vagina is self-cleaning. Maintaining proper vaginal hygiene by simply washing with warm water and avoiding douches and soaps is also helpful. Because the tissue in the vagina is some of the most absorptive tissue in the body, toxins, and chemicals in tampons can be easily absorbed and disrupt the microbiome and cause inflammation. We recommend opting for organic, scent-free products to reduce disruption. Sexual activity: Sexual intercourse and semen can also change the vaginal microflora and alter the vaginal pH. New partners can initiate the vaginal immune defenses and cause inflammation. Wearing condoms has been found to reduce occurrences of BV and other Sexually Transmitted Infections.
Nov 01, 2021
4 min read
Seven Steps to Healthier Habits

Seven Steps to Healthier Habits

Adrienne Hill-Strathy
When it comes to taking care of our health, daily habits are key. It is the consistent things we do every day that add up to enhance our overall wellness and prevent disease. Habits are powerful because they become automatic behaviors that we do with minimal thought or effort. Over time, these small efforts accumulate and have a significant impact. For instance, most of us brush our teeth twice a day without much complaint or question, but this little action has a huge impact. Brushing helps to prevent cavities and supports our oral health and digestive system. Habits can also be harmful. Smoking, drinking, overeating, negative self-talk, or too much time on technology can have negative impacts on our health over time. When forming new habits, we want to do our best to engage in the things we know will benefit our wellbeing and reduce harmful behaviors. When it comes to supporting the immune system to defend against HPV, habits play an important role. Even if you already live a healthy lifestyle, we can all benefit from adopting an extra healthy habit or two. So, how do you create healthier habits and make them stick? First, start by identifying what health goals you want to achieve Before making any lifestyle change it is important to understand your why. Health will mean different things for each of us so understanding why you want to change will help guide the habits you target. For example, you may want to support your body against HPV. With that goal in mind, you may want to quit smoking, incorporate an extra serving of green leafy vegetables into your diet, or go to bed earlier to get 7-8 hours of sleep. Your goal may be to feel more at peace. Habit for that may look like saying no to more engagements or setting aside time to meditate each morning. Spend some time identifying what you want and then brainstorm how you think you can get there.  Start small Often when we are trying to make lifestyle changes, we can get overwhelmed by making too many big changes too quickly. When we feel overwhelmed, we are less likely to follow through with our intended actions. Remember to slow down and start with something small and achievable. Try setting a time and place to complete your new habit. For example, “I am going to go for a walk every day after dinner”, is more realistic than “I am going to walk 5 km a day”. This helps keep your habits flexible and takes the pressure off. It also helps creates a ritual around the new habit which brings us to our next tip. Creating rituals Daily rituals are a great way to start implementing a new behavior into your routine. A helpful way to do this is to pair it with something you already do. Let’s use brushing your teeth again because most of us do that daily. You may be trying to take new supplements to support your immune system. After brushing your teeth in the morning, you could take your supplements. Place your supplement container near your toothbrush so you are easily reminded. Soon, you will naturally pair teeth brushing with taking your supplements and a new habit is formed. You could also try creating a ritual before bedtime, when putting your clothes on in the morning, or drinking your morning cup of coffee or tea. Take note of things you do every day and then see how you can pair the new behavior with what you already do. Checking in through reflection Things don’t always go as planned. Setting aside time each week to reflect on how you are doing and adjust accordingly can help you stay on track. For example, schedule a Sunday evening check-in to write down how you did this week on your goals. Consider what went well and what you could do differently. Then plan accordingly for the next week. Maybe your goal was too ambitious - that is okay! Ask yourself, what could make it a little easier this week? Try rating how likely you would be to follow through on a scale of 0-10 (10 being very likely, 0 being not at all). If you score below a 7, that’s a sign to bring it back a level and make it easier. Setting reminders We all have busy lives and get caught up in things. Setting alarms, reminders, or scheduling in your habits helps you stay consistent. Maybe you want to set a reminder on your phone to take your supplements or drink water throughout the day. Use your calendar to schedule times to exercise, rest, or meal prep. That way even if you have a busy schedule, you can account for those healthy habits into your routine. Accountability Having someone to help hold you accountable for your health goals can support your success! Whether that’s a friend, family member, support group, partner, or practitioner, it’s helpful to have someone you can check in with. It can be especially helpful to find someone that will adopt healthy habits with you to encourage you when you’re not feeling up to it. Be kind to yourself Lastly, and most importantly, remember to show yourself compassion. Changing behaviors can be challenging. We are not going to be perfect all the time. Aim for doing the best you can. Put in the effort and be gentle with yourself on the rest - tomorrow is always a new day. One small setback doesn’t mean you can’t get up and try again! You can do this!
Oct 18, 2021
4 min read
How Do Your Hormones Influence HPV?

How Do Your Hormones Influence HPV?

Adrienne Hill-Strathy
Hormones play an important role in the body’s chemical messaging system. Hormones help direct and regulate many bodily processes. Like most systems, hormones operate within a delicate balance that can lead to undesirable symptoms and disease when disturbed. We have talked a lot about the importance of lifestyle and dietary factors as well as genetics and nutrient levels in the progression of HPV. But how do hormones fit into all of this? Here is what we know. Hormones and HPV The role of hormones in the development of HPV first started to be explored following findings that HPV infections were more common in individuals on oral contraceptive pills (OCPs) and women with multiple pregnancies. There is a two to four-fold increase in HPV persistence in individuals on the OCP than non-OCP users. The risk increases the longer the individual is on birth control and declines once they go off it. The mechanism that might explain this is the increase in synthetic estrogen delivered through the OCP, leading to an increase in estrogen in the blood. In individuals with seven or more pregnancies, cervical cancer risk increases 3.8-fold as well. Like the OCP, pregnant women are exposed to elevated estrogen levels, which may explain the correlation. To further understand the estrogen-HPV link, mouse studies have been conducted. In one study mice were injected with estrogen for 6 months or 9 months. All mice in the study developed cervical tumors. However, the mice that were given estrogen for longer (9 months, instead of 6 months) showed a significant increase in the number of tumors and their size. Moreover, the mice treated for less time saw a reduction in tumors compared to those treated for 9 months. This suggests that the longer the exposure to estrogen, the higher incidence of cervical tumor number and size. The study also helped shed light on the part of cancer development impacted by estrogen. Because tumor growth was seen in all mice, estrogen appeared to initiate tumor development. Additionally, the increased growth in the 9-month group also supports estrogen’s role in cancer progression. It is important to note that this study was done in mice models and therefore may not be replicable in humans. Nevertheless, these findings may warrant more caution used with OCPs in HPV-infected individuals and increased screening in women with more pregnancies. A Bit About The Hormone Estrogen Estrogen is a sex hormone. Both males and females carry this hormone, but it plays a larger role in the development of the female reproductive tract. Estrogen is typically released cyclically during the menstrual cycle to stimulate the growth of the egg follicle and the endometrium lining to prepare the uterus for a possible pregnancy. Estrogen also contributes to many other bodily processes like cognitive health and the cardiovascular system. Estrogen levels fluctuate among different individuals and can vary over the month and lifetime. The fluctuations can alter growth processes in the body, influence mood, and create symptoms like hot flashes during menopause. While estrogen generally supports bodily processes, the hormone is carcinogenic in certain doses and can contribute to the formation and growth of tumors. Excess or lost estrogen can also lead to disruptions in the menstrual cycle and increase symptoms of premenstrual syndrome. Other Estrogen Exposures In addition to OCPs and pregnancy, estrogen levels may be increased through other external sources or xenoestrogens. Many foods, environmental contaminants, and personal care products have been found to contain hormone modulating chemicals that mimic estrogen in the body. Accumulated exposure to these compounds may disrupt normal hormone levels and contribute to estrogen-related cancers. Research has found an increased risk of gender-related cancers and xenoestrogen exposure. However, we currently do not have a good understanding of the cumulative impact of these hormone disruptive chemicals on cervical cancer. How to support healthy estrogen levels Avoid the OCP: Given the strong association between OCP and HPV, alternative birth control options may be preferred to reduce the risk of HPV. Buy organic foods: pesticides, chemicals, hormones, and antibiotics added to some foods can alter natural hormone levels in humans. Focus on antibiotic-free and organic produce and meats as much as possible to limit exposure to harmful estrogens. Eat your fruits and vegetables: eating a diversity of plant foods supplies the body with the micronutrients and antioxidants to support healthy detoxification. The liver and gastrointestinal system are primarily responsible for metabolizing and eliminating estrogen to keep them in a healthy balance. Green leafy vegetables and cruciferous vegetables (Brussel sprouts, kale, cauliflower, cabbage) are especially helpful in supporting liver metabolism. Aim for 7-10 servings of plants a day. Consume flaxseeds: flax is a phytoestrogen, a form of estrogen we get from foods. Phytoestrogens have been found to support healthy hormone levels. Aim for 1-2 tbsp of ground flaxseed per day.
Oct 04, 2021
4 min read
Papillex™and AHCC®, Which One Should You Take?

Papillex™and AHCC®, Which One Should You Take?

Adrienne Hill-Strathy
Supplementation can be confusing. If you have been diagnosed with HPV, you might be wondering, is there a supplement you can take? How much and when should you take it? And how do you know if it is working? The good news, you can supplement to support your immune system to defend against HPV. Recommended supplements and dosages will depend on the supplement and the person’s specific needs. Papillex has formulated two nutritional supplements based on the current evidence-based research on HPV. Our products are formulated with nutrients known to be associated with HPV infections and have been evaluated to support the immune response against viral infections like HPV. In this blog, we spill the beans on our supplements to help you decide which would be best for you. What to know about Papillex™ Papillex™ is a nutritional supplement and immune support that was designed to correct nutrient deficiencies commonly found in individuals with HPV. The supplement contains beta carotene, vitamin E, vitamin C, folate, selenium, and indole-3-carbinol. These nutrients have been consistently found to be low in individuals with persistent HPV infections. Moreover, increased levels have been associated with improvements in HPV through powerful antioxidant capabilities and inhibiting cancer cell growth. Papillex™ also contains immune-modulating compounds like astragalus, reishi, and green tea extract. The research on these compounds shows powerful anti-viral properties that stimulate the immune system to eradicate infections. Together, the supplement offers well-rounded nutrient and immune support. The micronutrients found in Papillex™ can help support general health in most individuals. The supplement might be right for you if your diet is low in fruits in vegetables, you have difficulty absorbing foods into your diet, or you have high levels of stress. Papillex™ is not recommended in pregnancy due to its Vitamin A concentration, which can be toxic in fetal development. Dosage: If you are HPV positive and/or have cervical dysplasia take two capsules twice daily. Once in the morning and once in the afternoon 2-3 hours away from food. As dysplasia improves and HPV is eradicated, you can decrease the dosage to 2 capsules once a day for maintenance and general immune support. What to know about AHCC® AHCC® is new to the Papillex toolbox. The product was launched in 2020 following research studies supporting its use in eradicating high-risk HPV infections. The supplement contains a mushroom extract derived from the shiitake mushroom. The extract is one of a kind and only manufactured by one company out of Japan, Amino Up Chemical Co.   AHCC® acts on the immune system by stimulating molecules like cytokines, NK cells, and dendritic cells. These molecules help support a healthy immune response against viral invaders. We are only starting to research and understand the variety of uses of AHCC®. The compound has been researched for its use in eradicating viral infections, including HPV. In a randomized control trial participants taking AHCC® for 3-6 months had a 66.7% clearance rate of high-risk HPV infection. In contrast, in the general population, the expected clearance rate of HR-HPV is around 0-10%.   AHCC® is well tolerated in most individuals and supports general health. Because AHCC is a strong immune stimulant, it may be too stimulating for individuals with autoimmune conditions. The supplement may be right for you if you are prone to colds and flu and frequent infection. Dosage: If you have an active HPV infection and signs of cervical dysplasia, take 2 capsules twice daily, away from food. Continue this for 3-6 months. Reduced the dosage to 2 capsules daily for another 3-6 months. AHCC® has not been studied for use for over one year. Before purchasing AHCC make sure the product has a registered TM or R sign next to its name. Products sold without this label as not sourced from the real AHCC source and do not include the compounds evaluated in clinical research trials. The power couple You can also supplement AHCC® and Papillex™ together for extra support. The duo provides both micronutrient and added immune support against HPV. How do I know if it’s working? It isn’t always easy to know if your supplements are effective. Herbal and nutritional supplements act slow and gently. It can take time and consistent use to have an impact. Making it difficult to know if they have made any difference. We recommend keeping track of basic indicators like energy levels, the number of days sick, level of dysplasia found on Pap testing, and HPV positivity to see how your supplementation is working for you!
Sep 20, 2021
3 min read

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