Being Well Blog

Being informed means being empowered. Welcome to the latest information and actionable insights.

Latest Insights

Pap Screening Guidelines for Cervical Cancer

Pap Screening Guidelines for Cervical Cancer

Adrienne Hill-Strathy
The Pap smear is a dreaded appointment for many but, thanks to this handy screening tool, cervical cancer rates and complications from HPV have seen a decline. Increased screening has led to earlier detection of cervical cell changes and with it, led to earlier treatment. Today, Pap smears are incorporated into regular screening for individuals with a cervix. However, when and how often you get tested can differ depending on your country, age, and past HPV status. Read on to learn more about screening in your location. First, what is a Pap smear? The Papanicolaou-stained (Pap) smear was introduced in 1949 by a pathologist named George Papanicolaou. The Pap smear is now the primary screening tool used to assess abnormal cervical changes and screen for the risk of cervical cancers. The Pap smear involves taking a cell sample of the cervix and assessing for any abnormalities. By monitoring cell changes, earlier treatment and interventions can be implemented which can prevent more severe disease. While Pap testing and increased screening have resulted in a decline in cervical complications, there remains some debate over how often early screening should take place. Considering 90 percent of HPV infections will regress over time, screening can also lead to harm such as unnecessary stress on the individual, additional follow-up testing and biopsy, and the potential of unnecessary treatment.  The chances of having an abnormal Pap smear are higher in young individuals and decrease with age. Around 10% of individuals with a cervix aged 20-29 years will have an abnormal test result while only 1.6% of those aged 60-69. Of these abnormal results, 1.5% of 20–29-year-olds will have high-grade lesions that lead to further testing and biopsy. However, more than 50% of these will undergo treatment. Many of these infections would clear on their own and lead to no complication of cervical cancer. For this reason, many countries recommend screening at a later age. Here is what is recommended in Canada, the UK, and the US. Screening Guidelines Differ Depending on Country Canada The Canadian Task Force on Preventive Health Care recommends the following screening for asymptomatic individuals with a cervix without a previously abnormal test and who are sexually active. Screening is not recommended for individuals under 24. The potential harms in this group out weight the benefit of early screening. For individuals with a cervix aged 25-29 screening is weakly recommended every 3 years. The concern for cervical cancer increases in this age group, therefore there are benefits to screening. For those aged 30-69 routine screening every 3 years is strongly recommended. In this age group, the risk of cervical cancer is greater, and screening offers preventative benefits. At the age of 70 regular screening may be ceased. In Canada, the recommendations are used as guidance to be used in discussions with patients. Some women may place a higher value on avoiding cervical cancer and would want to undergo more frequent or earlier screening. While others may prefer to follow the screening guidance. United States The US Preventive Services Task Force sets the screening guidelines in the United States. The US recommendation incorporates high-risk HPV testing, which can help detect high-grade cervical lesions by identifying strains more likely to cause cervical cancers. They recommend the following: Screening begins at age 21-29 and should be followed up every 3 years with cervical cytology. In women aged 30-65, it is recommended to screen every 3 years with cervical cytology and every 5 years with high-risk human papillomavirus testing or every 5 years HPV testing in combination with cytology. The USPSTF recommends against screening in those under the age of 21 and over the age of 65 and those who have had a hysterectomy. United Kingdom The UK has its own set of recommendations through the NHS Cervical Screening Programme. The NHS has also begun including HPV testing in its assessment. Cervical samples will be tested for high-risk Human Papillomavirus to help identify individuals more at risk for developing cervical cancer and implement treatment earlier. Their screening is recommended to begin at age 25 to 65. For those aged 25-49, screening is offered every three years. For those aged 50-64 years of age, it is recommended every five years. What about for those who have had an abnormal Pap previously? Screening guidelines differ if you have previously had an abnormal Pap and HPV has been detected. If your Pap test was abnormal, you were likely referred to a gynecologist for a colposcopy. A colposcopy allows for a better view of the cervix and biopsy. Depending on your level of cell changes and health history, your doctor will recommend a treatment course of action or to watch and wait. In those that have previously tested positive for HPV or had abnormal Paps that turned normal, your doctor will likely recommend follow-up testing a year after a normal result. HPV infections can recur, so it is important to stay on top of testing to see if cell changes recur over time.  The Benefit of Early Detection Deciding when and how often to screen for cervical cancer and HPV, should be discussed with your medical doctor. Early detection has been beneficial in reducing our overall rates of cervical cancer. However, extra screening has also added anxiety and unnecessary procedures to those whose infections would have regressed within 12-36 months. Moreover, detecting infection early also allows for earlier intervention with immune supports like Papillex and lifestyle changes like an anti-inflammatory diet, stress reduction, and exercise.
May 02, 2022
4 min read
Top 5 Overlooked Foods for Supporting Immune Health

Top 5 Overlooked Foods for Supporting Immune Health

Adrienne Hill-Strathy
At Papillex, we are all about focusing on the factors we can control to positively impact our overall health. With that philosophy in mind, today we’re talking about food! Food plays a powerful role when it comes to supporting our immune health. The array of micronutrients we obtain from our food is necessary for the immune system to mount and sustain a response against pathogens and invaders like the human papillomavirus (HPV). Consuming a diverse, whole-food diet is number one in getting our supply of vitamins, minerals, and other phytochemicals. We’ve outlined a few of our favorite foods that can support our immune system on a daily basis.    Citrus fruits Many of us jump to citrus fruits when it comes to supporting our immune system--for good reason! Citrus fruits like grapefruit, oranges, lemons, and limes are a great source of vitamin C, magnesium, B vitamins, potassium, phosphorus, magnesium, and copper. Vitamin C in particular plays an important role in many cellular immune functions. The micronutrient has been found to help stimulate immune molecules like neutrophils, which help identify and clear away invaders. Vitamin C has been found to help decrease the severity and duration of colds and flu. Vitamin C can be depleted due to pollution, smoking, infections, and other diseases that increase oxidative stress. Studies have also shown that higher levels of Vitamin C might help reduce cellular changes due to HPV. Citrus is also a source of phenolic compounds and terpenes. These antioxidants have anti-cancer and anti-inflammatory properties. These compounds and Vitamin C work together to have a synergistic action in supporting your immunity. Consuming whole citrus fruit (not the juiced form) is also a good source of fiber. Fiber helps support a healthy gut microbiome, which is intricately connected to our immune system. Cruciferous vegetables Cruciferous vegetables are also known as the Brassica family, they include some of our favorites--broccoli, Brussel sprouts, collards, red cabbage, kale, and asparagus. These crunchy vegetables contain phytochemicals that are high in antioxidants called isothiocyanates. They are also rich in sulfur, folate, vitamin K, and vitamin B6. Regularly consuming cruciferous vegetables can help support DNA repair. Sulfur also helps recycle the antioxidant glutathione. The Brassica family also contains a rich source of sulforaphane, which is broken down into two powerful antioxidants, Indole 3 carbinol, and DIM. The compounds have been found to have anti-cancer properties and help regress cervical dysplasia. DIM is one of the ingredients found in Papillex. Cruciferous vegetables also benefit gut health due to their high fiber content, phytonutrients, and other vitamins and minerals. Lightly cooking these dense vegetables can help make them easier to digest and be utilized by the body. Ginger We have all tasted the warm, healing properties of ginger. Ginger has been used for centuries around the world in teas, dishes, and as a medicinal compound. The pungent rhizome contains the compounds gingerol, shogaol, and paradols. The anti-inflammatory and antioxidant properties of ginger have been found to benefit a range of conditions including degenerative disorders, digestive health, nausea and vomiting, diabetes, and cancer. The antimicrobial properties of ginger also help treat infectious diseases. The research suggests the anti-cancer properties of ginger come from its inhibitory effects on cell proliferation and cell death. Ginger can also suppress inflammation and DNA damage. Studies have shown that ginger can play a role in many cellular pathways that impact the prevention and treatment of cervical cancer. Garlic Garlic is another dietary staple, used for centuries for its pungent flavor and many health benefits. A superfood for many reasons, garlic is chock-full of nutrients, amino acids, and fibers. It contains calcium, iron, magnesium, selenium, zinc, and vitamins B1, A, and C. Garlic’s medicinal properties come from its concentration of sulfur-containing compounds like allicin and ajoene. Allicin helps support the immune system by reducing inflammation and stimulating immune defenses. The compound gets activated when garlic is chopped. Once in the digestive tract, allicin helps inhibit the growth of pathogens it has even been found to protect from certain bacteria like Helicobacter pylori.  The compounds found in garlic also possess anti-cancer effects. Ajoene has been found to trigger cell death in leukemic cells. Compounds in garlic have also been studied for their role in inhibiting mammary, melanoma, colon cancer cell growth. Research into its effect on liver, prostate, bladder, and lung cancer is evolving.  Garlic also supports healthy gut flora. Garlic contains a prebiotic fiber called inulin that helps feed the growth of good gut bacteria. Mushrooms We couldn’t complete our favorite immune-supporting foods without mentioning mushrooms. Regularly consuming mushrooms like shiitake and white button, offer a supply of many therapeutic compounds including polysaccharides called beta-glucans. Beta-glucans help inhibit inflammatory molecules while stimulating immune receptors and molecules to defend against pathogens and viruses. Mushrooms are also a rich source of B vitamins, which help protect the heart and regulate the nervous system. They also contain copper and potassium. A study researched participants that consumed 5 or 10 grams of shiitake mushrooms daily for a month. They found an increase in the production of T-cells and natural killer cells. Consuming mushrooms also increased the expression of receptors. The participant’s gut health was also impacted, with an increase in sIgA, a marker of healthy gut immunity. Of course, immune-supportive nutrients and phytochemicals are found across the food rainbow. Ideally, a diet rich in diverse plant and whole foods will support a healthy immune response. We hope this list offers a little extra inspiration for your next grocery haul. 
Apr 12, 2022
4 min read
How to Support Your Metabolic Health for HPV

How to Support Your Metabolic Health for HPV

Adrienne Hill-Strathy
What do you know about Metabolic health? If the answer is not much, that’s okay! Today we’re talking about how your metabolic health supports our overall health and wellbeing. Our metabolic health not only impacts our energy, but our memory, mood, skin, fertility, sexual health, and immune system. By understanding the basics of how our body uses energy and how we can support it, we can optimize our ability to defend against the persistence of viral infections like the human papillomavirus (HPV). Let’s dive in. What is Metabolic Health and Why Should you Care? Metabolism is the process by which we convert food into energy. When our metabolism is healthy, we have energy, normal blood pressure, blood sugar regulation, and limited inflammation. When our metabolic process becomes impaired our cells don’t function optimally and we are more vulnerable to developing disease. It is important to pay attention to our metabolic health because poor metabolic health underlies many chronic diseases, including persistent HPV infections. Unfortunately, poor metabolic health is more common than you think--you likely know friends or family members with diabetes, hypertension, obesity, or high cholesterol. It is estimated that 88% of the American population shows some signs of metabolic dysfunction. Around 33% of adults in the United States have metabolic syndrome. Metabolic syndrome is characterized by increased blood pressure, high blood sugar, excess body fat around the waist, and abnormal cholesterol and triglyceride levels. Metabolic syndrome is associated with an increase in chronic inflammation and oxidative stress, two factors that increase the risk of cancer and persistent HPV infections. Where Things Can Become Imbalanced The modern lifestyle is largely to blame for the high rates of metabolic dysfunction. Our diets are higher in processed and sugary foods, we are more sedentary than ever, get less quality sleep, and many of us live with chronic daily stressors that cause further hormonal and metabolic imbalance. All these factors and more, make it important to be aware of our metabolic health and how we can actively work to support it. One of the main ways our metabolism can become impaired is through our diet. When the body is taxed with large amounts of dietary carbohydrates, it can throw off our hormone balance and metabolism.   Blood sugar is one of our best markers to monitor metabolic health daily. Glucose is the primary fuel source for our cells. We obtain glucose when we break down carbohydrates and proteins from the diet. Glucose then signals the pancreas to secrete a hormone called insulin. Insulin is responsible for shuttling the glucose into our cells to be used as energy. The body stores some of this glucose in the muscles and liver for a backup energy supply. Some glucose also is stored in fat cells and processed by triglycerides. One of the impacts high blood sugars can have over time is a process called insulin resistance. Insulin resistance occurs when our cells become desensitized to insulin, preventing glucose from getting into our cells. Instead, the sugar remains elevated in the bloodstream. Excess glucose in the bloodstream leads to inflammation, oxidative stress, and can harden blood vessels over time. For optimal health, we want steady blood glucose and insulin levels over time. How Does Metabolic Health Impact HPV? You might wonder, how does this all play into HPV? Well, turns out the health of our cells influences many of the factors that put us at risk for HPV. As we’ve mentioned, inflammation and oxidative stress are increased when metabolism is dysfunctional. Metabolic dysfunction can also throw off our hormones and immune system. We know the immune system is so important for HPV clearance so when the system is impaired, it will be harder for the body to defend against viral invaders. Research has found some associations between poor metabolic health and HPV. A study looking at the relationship between blood glucose levels and cervical cancer cases found higher blood sugar was associated with a poorer prognosis of cervical cancer. There is also some evidence that suggests individuals with diabetes require more treatment for genital warts from HPV. How do I Assess my Metabolic Health? We typically measure our metabolism using five biomarkers: blood sugar, triglycerides, high-density lipoprotein (HDL) cholesterol, blood pressure, and waist circumference. Your doctor has probably screened you for some of these at some point. Many metabolic assessments are included in regular screening and medical check-ups. Obtaining regular blood pressure screening and labs is the best way to assess metabolic health over time. Basic blood tests to help assess your metabolic health: Cholesterol Panel: A cholesterol panel is commonly used to assess cardiovascular risk. The panel measures cholesterol levels and triglycerides. Triglycerides are a part of lipid or fat, when elevated they can be a sign of prediabetes. High sugar and carbs intake can impact cholesterol levels. HbA1c: This measure captures a 2–3-month average blood sugar level and is used to assess risk for developing type 2 diabetes. Fasting insulin and fasting glucose: these measures can be used to calculate HOMA-IR, a measure of how well your cells are responding to insulin. What to do to support our metabolic health Supporting our metabolic health is just like training a muscle. It is the consistent things we do every day that add up to the overall picture of metabolic health. Supporting our metabolic health involves making smart dietary choices, getting adequate sleep, managing stress, engaging in physical activity, and reducing exposure to environmental toxins. Reduce intake of refined carbohydrates: these can quickly spike blood sugar and insulin levels, leading to a crash later in the day. Pair carbohydrates with proteins, fats, and fiber to reduce glucose spike: Always combine starches with protein, fat, and fiber to help maintain a level blood sugar. If you plan to eat something sugary, have it after your meal instead of on an empty stomach to lower the glucose spike. Eat fiber-rich foods: Fiber helps slow the breakdown of glucose into the bloodstream. Fibers also help feed the beneficial microbes that live in the gut. Supporting the gut microbiome can help improve insulin sensitivity and our response to glucose-rich foods. Engage in regular exercise: Exercise can help regulate our blood sugar levels and improve our insulin response. Aim for 150 minutes per week or 30 minutes on most days. Even taking a 10–15-minute brisk walk after meals have been found to help regulate blood sugar levels. Get 7-8 hours of adequate sleep per night: Sleep can also play a role in our metabolic health. Poor sleep can lead to less clearance of glucose from our blood stream and higher insulin levels. When we don’t get good sleep, we may be more likely to make poor dietary choices and crave simple carbohydrates. Meditation and Stress management: Stress can also impair our metabolism and throw off our insulin levels. When we are stressed, we produce more of the hormone cortisol. Cortisol can attract glucose stored in the muscles and liver into the bloodstream, increasing blood glucose levels. It also shuts off insulin production. As a result, we have more sugar floating in the bloodstream. Meditation is a great way to help reduce your overall stress.
Mar 29, 2022
5 min read
Oral HPV and Oropharyngeal Cancer

Oral HPV and Oropharyngeal Cancer

Adrienne Hill-Strathy
The human papillomavirus (HPV) is commonly known for its association with cervical cancer and genital warts. But, HPV is also a risk factor for several types of cancers including oropharyngeal cancer. Oropharyngeal cancer includes cancers that affect the back of the tongue, soft palate, tonsils, and side of the throat. In recent years, we have seen a rise in oropharyngeal cancers, highlighting the need for proactive management to address oral HPV. Here, we break down what you need to know about oral HPV and how you can support your immune system to defend against it. What are the Prevalence Rates of Oral HPV? It is estimated that around 7 percent of Americans aged 14 to 69 have detectable HPV in their oral tissue. The prevalence of oral HPV is higher in men than in women, 10.1% compared to 3.6%. The rates of oral cancers have increased between 2003 and 2013 by about 3.4% per year. Rising rates of HPV are thought to be due to rising rates of HPV infection in the population mostly due to changes in sexual behavior. Today, the average person has a greater number of sexual partners and it is more common to engage in oral sex. Oral sex is thought to be the main contributor to the increasing rates of oropharyngeal HPV. A study of oral HPV in men found infection rates increased with prevalence and increased frequency of oral sex. There were also increasing rates in men who smoked, were in non-monogamous relationships, and had a partner with oral or genital HPV. How Is HPV Transmitted? HPV is highly transmittable and is mainly contracted through skin-to-skin or oral contact. Touching the genitals or engaging in oral sex with an infected individual can be enough to transmit HPV. Because HPV is so easily transmitted, most sexually active individuals will contract some strain of HPV in their lifetime. The CDC estimates that 90% of men and 80% of women will be infected with a strain of HPV. Now, we know what you are thinking—“oh no, am going to get cancer?” If I have Oral HPV, Am I Going to Get Cancer? Like genital HPV, most individuals that contract oral HPV will not progress to oropharyngeal cancer. It takes many years for oropharyngeal cancers to develop from an HPV infection. Between the time of infection and cancer development, the immune system often clears the HPV and renders it dormant within the cells. Nevertheless, there is still risk if HPV remains persistent over time. The most common strain of HPV found in oral infections is HPV-16. HPV-16 is a high-risk strain that can cause cancers if it proliferates over time. Approximately 1 percent of men and women are infected by HPV-16. What are the Symptoms of Oral HPV? Like other forms of HPV, in the early stages, oral HPV infections often cause no symptoms at all. Oral HPV that is progressing into oropharyngeal cancers may cause symptoms including: Difficulty swallowing Lump on the neck or in the cheek. Chronic hoarseness Sore throat that doesn’t go away White or red patches on the tonsils Jaw pain or swelling Unintentional weight loss If you notice any of these symptoms or changes, please contact your doctor. How Do you Know if you Have Oral HPV? Oral HPV is not included in regular screening guidelines and practices. There is no test to detect for early signs of HPV cellular changes in the throat like we do with the Pap Smear. However, HPV testing can be done to detect tissue samples for the presence of HPV. For these reasons, many individuals will not know that they have been infected with oral HPV until it has progressed into a cancerous state. Addressing the immune system and limiting risk factors can help reduce overall risk and prevent complications. How to Limit Infection and Complications of HPV Reduce the number of sexual partners: Reducing sexual behavior (vaginal sex, oral sex) is one way to reduce and prevent infection rates. Because HPV is transmitted through sexual contact and touch, limiting sexual partners will lead to less possible exposure to HPV. Using protection can partially help protect against HPV but it is not 100 percent effective. Quit smoking: Smoking puts individuals at greater risk for cancers, especially those in the respiratory pathway, and is associated with an increased risk of oropharyngeal cancers. Not all oropharyngeal cancers are related to HPV. Tobacco, alcohol use, and poor lifestyle habits alone can also cause oropharyngeal cancers. Together the combination of smoking and oral HPV can significantly increase one’s risk. Reduce alcohol intake: Alcohol use is another risk factor for oral cancers. Reducing alcohol consumption and drinking mindfully when needed can help support overall health and the risk of HPV complications. Support the immune system: The immune system is thought to be the hallmark of whether an HPV infection continues to persist over time or is eradicated. You can support your immune system by getting adequate sleep, eating 7-8 servings of vegetables a day, engaging in moderate exercise, managing stressors, getting sunlight, and forming healthy relationships. You can learn more about supporting your immune system here on wellex.co. Four Towering yellow and white pills, daily supplement dose. Can Papillex help with Oral HPV? Papillex was formulated to help correct nutrient deficiencies associated with persistent HPV, and to provide immune-supporting nutrients and herbs. Since the HPV strains that cause cellular changes of the cervix are the same strains that contribute to oropharyngeal cancer, the ingredients in Papillex can help support the immune system response to oral HPV.
Mar 15, 2022
4 min read
The Pros and Risks of LEEP

The Pros and Risks of LEEP

Adrienne Hill-Strathy
If you have previously had an abnormal Pap or tested positive for the human papillomaviruses (HPV), your doctor might have recommended a procedure to help clear the abnormal cells. Several conventional interventions are available to address HPV and cervical changes. These procedures aim to remove abnormal tissue and cells in order to prevent progression into cancer. An HPV diagnosis can be confusing. Adding a potential surgical procedure into the mix may add to your concern, confusion, and anxiety. We hear you; we would want to know the risks, potential harms, and procedural effectiveness as well. Here, we lay out the pros and cons of LEEP and other common conventional treatments for cervical dysplasia so you can be better informed about your options and what is best for your health. First, a bit about HPV HPV is the most common sexually transmitted infection around the world. So common that up to 80 percent of sexually active individuals will contract HPV at some point in their lives. Out of the hundreds of different strains of HPV, around 15 have been identified as high-risk. These high-risk strains are associated with cellular changes on the cervix. If these cell changes persist over time, there is a risk that they may lead to cervical cancer. If you have contracted HPV, do not worry. Up to 90 percent of individuals that contract an infection will clear it within about two years. In individuals that fail to clear the infection, there is an increased risk of developing persistent cell changes that may progress into cervical cancer. Cervical cell changes are monitored using Pap testing. Interventions have been developed to address cell changes before they can occur in individuals who have had abnormal Pap tests and persistent high-grade cervical intraepithelial neoplasia (CIN). Depending on your situation, your gynecologist may recommend a LEEP, conization, cryotherapy, or laser. Here we lay out the pros and cons of each of these procedures. LEEP- Loop electrosurgical excision procedure The LEEP is an excision method used to remove abnormal cellular changes from the surface of the cervix. LEEP is typically recommended in cases of CIN2/3 or persistent CIN 1. During the procedure, you will assume a similar position as you would for a regular pelvic exam. A thin wire loop with an electric current will be inserted into the vagina to remove cells from the cervix.   Pros of LEEP LEEP can be performed in-office. It is quick and generally painless with local anesthesia. The procedure generally takes only 10 minutes. LEEP removes less tissue than other methods, leaving less scarring and changes to the cervix than other methods. The tissue removed during the procedure can be used to confirm the degree of cellular changes. Risks of LEEP LEEP can cause cramping and light bleeding during and after the procedure. The procedure increases the risk of infection, cervical scarring, and changes in sexual function. It is associated with an increased risk of preterm labor and low birth weight. The risk of preterm delivery increases with the depth of LEEP exceeding 10 mm. Effectiveness of LEEP The recurrence rate of CIN 2, 3 after treatment varies depending on one’s age, the severity of the disease, the treatment. The five-year recurrence rate of LEEP is estimated at around 8.1%. Cold Knife Conization Cold knife conization is another surgical excision method used to remove abnormal tissue from the cervix using a scalpel or laser knife. This procedure allows your doctor to further examine the cervical tissue to determine cancerous changes. Conization is used to treat cervical dysplasia and very early cervical cancer. The procedure involves the removal of a cone-shaped portion of the cervix to remove a cervical lesion and the transformation zone. Conization may be used when there are conflicting Pap smear and biopsy findings, there is severe dysplasia, or in the early stages of cervical cancer. Pros of Conization Conization also allows for histologic review of extracted tissue to assess HPV infection and cervical changes. The cone biopsy is used to effectively diagnose abnormalities of the cervix and treat the early stages of cervical cancer. Risks of Conization Side effects of cone biopsy include risk of infection, cramping, and bleeding during and after the procedure. Conization has a higher hemorrhage rate compared to LEEP. The procedure removes more tissue than LEEP and therefore a greater risk of scarring and damage to the cervix. Conization is also associated with an increased risk of preterm labor and low birth weight. Effectiveness of Conization Conization has been found to have the lowest recurrence rate compared to other procedures. The five-year risk of recurrence is estimated at around 4%. Cryotherapy or Laser Cryotherapy and laser are ablative methods used to destroy abnormal cervical tissue. Cryotherapy uses a freezing gas or liquid nitrogen to remove precancerous cells on the cervix. With laser surgery, carbon dioxide is used to destroy abnormal cervical cells. Pros of Cryotherapy or Laser The procedure is quick and can be done in-office, usually taking between 10 and 15 minutes. The risk of preterm labor is not increased as it is with excision methods. Removes less tissue than excision methods. Risks of Cryotherapy or Laser Tissue isn’t available for histologic evaluation, so cells cannot be examined for degree of changes. Can cause mild cramping during the procedure. The procedure may cause vaginal bleeding and lead to infection. Cryosurgery can cause scarring of the cervix, cervical stenosis, which may lead to risks to getting pregnant, staying pregnant, and vaginal delivery.  Effectiveness of Cryotherapy or Laser Cryotherapy was to be least effective at reducing cervical cancer long-term. It was found to have the highest risk of recurrence of CIN 2/3 and invasive cancer after treatment compared to other methods. While each procedure carries some risk, there are benefits to each procedure in reducing rates of cervical dysplasia and cancer. We recommend talking to your doctor about your options and what is best suited for your unique situation. Following any procedure, your doctor will schedule a follow-up Pap smear to monitor cell changes over time. It is important to remember that while the procedures are effective at removing abnormal cellular tissue, they do not remove or suppress HPV activity. Without suppressing the underlying infection, cellular changes can always return, so it is important to continue to monitor the cervix. This continued HPV activity is why supporting the immune system still plays a pivotal role in addressing HPV and preventing long-term complications of the virus.
Mar 04, 2022
5 min read
Topical Herbs for HPV and Genital Warts

Topical Herbs for HPV and Genital Warts

Adrienne Hill-Strathy
Genital warts are a common symptom of low-risk strains of the Human Papillomavirus (HPV). Genital warts are typically harmless, however, they can cause discomfort, irritation, and distress. A lot of people are interested in natural herbs and nutrients to support their bodies against low-risk strains and warts from HPV. Herbal therapies offer attractive treatments for HPV given their strong safety profile and wide therapeutic index. Here we share some of the best ingredients and evidence to support the use of topical herbal therapies on viral infections. It should be noted that many of the studies included in the review do not specifically review HPV but other viral infections like the Herpes Simplex Virus (HSV) and influenza. The antiviral actions work similarly on the HPV, but more research is needed on topical herbal products to fully understand their use. The Ingredients Turkey tail Turkey tail is a medicinal mushroom know to have immune-modulating and energizing effects. The mushroom grows in a multicolored array on fallen trees in wooded areas of North America. The compound has been taken orally for centuries to treat respiratory conditions and has been used as an adjunctive in cancer treatment. The mushroom was found to have antiviral activities against influenza and HSV viruses in cell studies. The active compounds in turkey tail include polysaccharides called PSP and PSK. These compounds appear to act on the immune system and can inhibit the growth of cancer cells. Most people tolerate turkey tail well. The compound is considered safe, though it may cause mild gastrointestinal side effects like heartburn, constipation, and nausea when taken orally. Lemon balm Also known as Melissa officinalis, this herb comes from the mint family and has a lemon scent to it. Commonly used to improve mood, calm anxiety, and improve cognitive function, lemon balm also has antiherpetic and antiviral effects on the HSV family. Studies have found topical application of lemon balm to provide therapeutic action against recurrent herpes infections and cold sores. In one study, participants applied either lemon balm or a placebo to affected areas four times a day for five days. At the end of the five days, the participants that used the lemon balm had fewer symptoms of itching, burning, and redness. The lemon balm group also had faster healing than the placebo group. Echinacea root Echinacea is a commonly used herb for treating colds, flu, and other viral infections. The plant has anti-inflammatory, immunomodulatory, and antioxidant properties that have been used for centuries to treat various ailments. Studies find echinacea to benefit the immune system to combat viruses. Specifically, echinacea has been found to have antiviral activities against the HSV. Topically, echinacea has been found to help improve skin hydration, reduce acne and improve eczema symptoms and skin repair. Green tea extract Commonly known for its energy-boosting properties, green tea also has powerful antioxidant activity that protects against free radical damage. Green tea has been studied for its antiviral activity against Herpes Simplex Virus (HSV). Topical application was found to have an anti-herpetic effect when applied hours after the virus inoculated. We also love to supplement green tea extract orally, for high-risk HPV. Licorice Licorice has been used for many centuries for a wide variety of conditions. Today the herb is used to help with conditions like acid reflux, hot flashes, and viral infections. Licorice has also been found to have anti-inflammatory and anti-microbial properties for skin conditions. One study showed improvements in eczema with topical use of licorice root extract. The Licorice was also found to have antiviral activities against HSV-1 in vitro. Red algae Red algae are one of the oldest groups of eukaryotic algae. This mineral-rich marine plant contains a therapeutic compound called carrageenan, which has been studied for its use on HPV. Another compound in red algae called griffithsin has been found to interfere with HPV entry into cells. Together griffithsin and carrageenan have powerful antiviral activities and may help clear warts caused by HPV. Peppermint essential oil Peppermint oil is extracted from the leaves of the peppermint plant. The oil has been used as an aide in several conditions. Peppermint is a commonly used antiseptic and anti-inflammatory that can be applied topically to help alleviate pain. The oil may also help alleviate skin itching. Research evaluating the use of peppermint oil on viruses has found it to have strong antiherpetic activity against HSV-1 and HSV-2. Further studies have confirmed an inhibitory effect on HSV infections. Vitamin C Most of us are familiar with the powerful immune and antioxidant properties of vitamin C. Vitamin C is also a skin supportive vitamin, helping stimulate collagen production. Topical use of vitamin C on recurrent herpes infections was found to shorten the persistence of scabs in 2.5 days. The active compounds in vitamin C work by stimulating mucolytic and antimicrobial activities. Aloe Vera Aloe vera is commonly known for its wound-healing effects, applied topically to relieve sunburns and help heal wounds. Aloe vera’s therapeutic activity comes from its concentration of glycerin extract which forms a protective mucilage over damaged tissues. Aloe when applied topically has also been found to have antiviral activity on the herpes simplex virus. Our new topical formula combines all these and more into a plant-powered solution to genital warts. Together these ingredients can help promote skin healing and target viral activity. Interested in testing it out? We are looking for customer feedback. We will send you a free product exchange for your honest feedback and experience. Contact customerservice@wellex.co to let us know you are interested in testing our newest product.
Feb 21, 2022
4 min read
The Best AHCC®

The Best AHCC®

Adrienne Hill-Strathy
As we’ve increased our understanding of the health benefits of mushrooms, the market for mushroom supplement products has increased as well. One potent mushroom called AHCC, found to be effective in supporting HPV eradication, has seen a boom in interest and availability. Several retailers are now selling AHCC covering a wide range of quality and price points. As a consumer, we understand it can be confusing to know what AHCC you should buy. How do you know which AHCC is best and what is the difference between the products? Here is a simple guide to purchasing AHCC. What is AHCC? AHCC stands for Active Hexose Correlated Compound, a highly-researched mushroom extract derived from the shiitake mushroom species. Over 30 clinical research studies have supported the use, effectiveness, and safety profile of AHCC®. The medicinal mushroom extract has been found to have powerful anti-viral activity against HPV as well as other viruses like influenza. It has been researched as an adjunct in cancer treatment. The compound works by stimulating the production of immune molecules that play a role in responding to infections and tumor growth. Studies show that it can increase the number of readily available natural killer cells, dendritic cells, and cytokines. The gentle and modulating action of mushrooms also makes them general immune supports to promote overall wellbeing. Where does AHCC come from? The compound was created by a Japanese company called Amino Up Chemical Co. Amino Up was founded in the 1970’s, they have since been manufacturing innovative nutritional compounds. In 1989 the company debuted the Lentinula Edodes Extract, also called AHCC. The magic in these mushrooms comes down to their unique manufacturing process. No other mushroom extract is processed in the same way as Amino Up. The company uses an extensive screening process to extract the special strain of mycelia used in AHCC. Mycelia are the part of the mushroom that grows below ground. They look like root-like hairs that grow on wood or soil. Once harvested, the roots are taken to the manufacturing plant to be broken down into tiny molecules. Through cultivation, sterilization, and decomposition, the compound is concentrated and freeze-dried. The final extract is made into a powder or capsule form. Throughout the process, the company ensures the safety and efficacy of every batch. Make sure it is the real thing Look out, some retailers are not selling the real AHCC. Instead of selling the proprietary extract from Amino Up, some retailers have packaged mushroom blends or other forms of shiitake mushroom. You will know the difference if the product is labeled Active Hexose Correlated Compound or AHCC with a registered ® or ™ label. Only AHCC that has been extracted from the Japanese manufacturers can be labeled with the registered trademark. The problem with using the non-AHCC products is that their therapeutic ingredients are not what have been included in the clinical research on AHCC. So, you may save money on a more affordable product, but it likely won’t have the intended impact. How has Papillex made our product more affordable? You might note that other suppliers are selling AHCC for a higher price. If the product contains pure AHCC® and has a trademark symbol, it has come from the same manufacturer and is the same therapeutic product. The difference is only the branding and potentially some added ingredients. Check your labels and look for AHCC® proprietary blend, the dosage, and if they have added other ingredients or fillers.   At Papillex, our goal has always been impact over profit. We wanted to make AHCC as accessible as possible, which is why we lowered our profit margins. We decided to sell AHCC® for $53, instead of over $100. AHCC® by Papillex Our AHCC product contains 60 capsules of 500 mg of pure AHCC per capsule. We add nothing else, no fillers, additives, or preservatives. Ingredient quality is top on our priority list and our products are verified with a certificate of analysis, including microbial testing, heavy metal testing, physical testing, and ingredient identification testing. So, you can be confident in what you’re taking. We added AHCC to our HPV toolbox to optimize your body’s ability to respond to HPV naturally. Our Papillex™ product aims to optimize nutrient levels found to be low in individuals with HPV infections. It also supplies immune-boosting ingredients to support the immune system. Taking AHCC® alongside Papillex™ creates a synergistic effect. Taking the two together offers more support than either of them taken alone. How to Dose AHCC®: The clinically researched dosage of AHCC for HPV is 1-3grams per day. (3 x 500 mg capsules taken twice daily) for 6 months. Papillex™: For acute infections, we recommend 2 capsules twice daily. For maintenance reduce dosage to 2 capsules daily.
Feb 07, 2022
4 min read
Lifestyle Tips to Heal and Suppress HPV

Lifestyle Tips to Heal and Suppress HPV

Adrienne Hill-Strathy
Healing HPV involves a mind-body connection. Health requires us to address all areas of our physical, mental, and energetic wellbeing. HPV can be a tricky infection in that it never completely goes away once the virus makes a home inside our cells. The immune system then plays a role in monitoring the infection and suppressing its activity. In a healthy response, HPV will become inactive and the virus will reside in a dormant state within the skin cells. Unfortunately, HPV can be reactivated. If the immune system is compromised, the infection can resurface and proliferate again. It is important to establish and maintain healthy lifestyle practices to support the immune system, promote overall health, and keep the virus in an inactive state. Here, we outline a few daily practices that can help manage daily stressors. Managing stress Create a grounding routine We know stress can significantly impair the immune system and make us more susceptible to viral infections and flu. Regardless of how much we try to limit daily stressors, we will always experience challenges and fluctuating emotions. It is important to incorporate daily practices that help to calm the nervous system, process what you are experiencing, and check in to assess your needs. Morning grounding techniques offer a place to connect with yourself and start the day feeling calm and in control. Mornings will look different for each of us, so explore and find what works best for you. You may consider starting the day with a short meditation, stretch, breathwork, journaling or read some inspiring passages from a book. It can also be helpful to write down some daily intentions or three things you are grateful for in your life. Find something that you enjoy and can stick to. Meditation Meditation has been used for thousands of years to manage stress and heal physical ailments. The benefits of meditation include reduced inflammation and improved gut health. Meditation activates our parasympathetic nervous system which is involved in the rest and digest response. Meditation can improve the absorption of nutrients, promote better sleep, and help manage mental health disorders[1]. To begin a meditation practice, it can be helpful to use a guided program or app. We love calm (www.calm.com) and insight timer (insighttimer.com). To meditate on your own: Set a timer for 5-20 minutes. Find a comfortable seated position in a quiet and calm environment. Close your eyes. Focus on your breath. Count each inhale and exhale up to 10. Thoughts will continue to arise throughout the practice, take a moment to notice them, allow them to pass, and then come back to focus on your breath. Try doing a “body scan”. Turn your focus to each part of your body, working your way from the top of your head, down your abdomen, into your toes. Notice any sensations, textures, tension, or energies as you go. As you finish the practice, take note of how you feel. Breathwork The breath helps to ground you to the present moment. Breathwork practices can be used as a simple way to relax the mind and activate the parasympathetic nervous system. Breathwork it can be done in any situation or environment without disturbance because we always have our breath with us. Repeat the following breathing exercise at least 4 times or until you feel your body relax. This practice is helpful in times of acute stress, for example, before a stressful presentation. A simple breathwork routine includes: (box diagram) Inhale 4 counts Hold Exhale 8 counts Hold Other stress reduction tips Spend time in nature. Phone a friend. Talk to a therapist or counselor. Limit your phone and media usage. Reduce your caffeine intake. Journal. Create mantras. Get enough sleep. Adopting a healthy diet We know that diet plays an essential role in supporting our overall health and preventing disease. Most of us also live busy, hectic lives. This means there isn’t always time to prepare the perfect healthy salad or homecooked meal. Planning ready-to-go healthy meals can be the make or break it between grabbing a sugary candy bar or a nutritious homemade bowl for lunch. Some tips to make mealtime easier and healthier: Make a plan. As simple as it sounds, planning can go a long way when it comes to meal prep. Having a sense of your week, when you will be busy, and what foods will nourish you can make the process a lot easier. Take 10-15 minutes each week to plan what dishes you are going to make for the week. Pinterest, Instagram, cookbooks, blogs, etc. offer endless recipe ideas. We love to keep a recipe index, saving healthy recipes we plan to make so when your inspiration runs low you have something to turn to. Set aside time each week to cook and prepare food. Cooking doesn’t need to be a daily task when we plan and organize our time. We recommend setting aside at least two times a week to meal prep to keep food fresh and add variety. Make double the portions. Meal prepping a large batch can help reduce time in the kitchen later. When you cook a meal, try to make a little extra. This way you will have leftovers that can be eaten for lunch or another dinner. If you have a lot leftover, freeze some extra so that later you will have an easy meal ready to be thawed and cooked. For example, buy double the serving of chicken breasts, marinate them with some lemon juice, oil, and spices. Cook one batch and place the other in the freezer. In the morning before starting the day, take the chicken out of the freezer. It’s then easy to pop in the oven to roast later in the day! Cut up veggies and put them center stage in your fridge. Next time you open the fridge for a little snack, they are right there and easy to grab. You will surely find yourself snacking on some healthy veggies. Add an extra handful of greens. Another healthy tip we love is to add a handful of green into your dishes. Whether it’s a smoothie or warm bowl of soup, try adding a handful of spinach, kale, or cilantro to your meal. Not only will it amp up the taste, but it’ll amp up your micronutrient levels as well. Nuts, grains and berries Getting better sleep Sleep is crucial to our health and immune system. As our body has time to rest and renew, the immune system gets activated. The body uses sleep to enhance the formation of immune molecules that defend against bacteria and viruses and builds a stronger immune system for the future. During sleep we also release a hormone called melatonin, which acts as a free radical scavenger, repairing damaged cells[2]. The recommended amount of sleep According to the National Sleep Foundation, adults need around 7 to 9 hours of quality sleep per night[3]. Tips to get better sleep: Take time to wind down: It is important to take time to wind down in the evening, perhaps with a nice warm Epsom salt bath and unplugging from technology. Giving yourself enough time to read a book in bed as your body starts to drift off into sleep. Implement a bedtime routine: Going to bed and waking up at roughly the same time every day is the most effective way to regulate your circadian rhythm. Ideally, going to bed around 10-11 P.M. once the sun has set and rising around 6 or 7 A.M. when the sun is rising helps regulate our circadian rhythm and naturally induces sleep. Avoid stimulants and alcohol: Limit caffeine intake in the afternoon and avoid alcohol intake to avoid disrupting REM sleep. Opt for herbal teas like chamomile, passionflower, or lemon balm to promote relaxation. Keep your environment dark and cool: Our body temperature drops when we fall asleep. Sleeping in a cooler room of 67 to 68 degrees F (20 C) can trick your body into sleep mode by creating conditions that mimic the body’s natural sleep cycle. Adopting healthy lifestyle practices doesn’t have to be complicated. Remember that it is the little things that you do consistently that add up to bigger changes. It’s also helpful to keep in mind that change doesn’t happen overnight, so stick with it and have patience. If you struggle, try scaling the changes back a little bit before challenging yourself again. Slowly you will notice healthy becomes a habit. [1] Black, D. S., O’Reilly, G. A., Olmstead, R., Breen, E. C., & Irwin, M. R. (2015). Mindfulness Meditation and Improvement in Sleep Quality and Daytime Impairment Among Older Adults With Sleep Disturbances. JAMA Internal Medicine, 175(4), 494. https://doi.org/10.1001/jamainternmed.2014.8081 [2] Srinivasan, V., Maestroni, G. J. M., Cardinali, D. P., Esquifino, A. I., Perumal, S. R. P., & Miller, S. C. (2005). Melatonin, immune function and aging. Immunity & Ageing, 2(1), 17. https://doi.org/10.1186/1742-4933-2-17 [3] https://www.sleepfoundation.org/excessive-sleepiness/support/how-much-sleep-do-babies-and-kids-need
Jan 17, 2022
7 min read

Example subheading

Subscribe & Save

  • Savings of up to 20% off
  • Plus Enjoy Free Shipping to US / CA
  • Switch or Pause anytime
  • Peace of Mind