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Therapeutic Effects of Polysaccharides
Jenny Henderson
Quite a few research studies in recent years have been looking at the various benefits of polysaccharides. These compounds are found in different plants, such as mushrooms and marine algae. It has long been known that medicinal mushrooms, for example, boast quite a few important functions, such as immune modulation and anticancer mechanisms. These functions are mediated by these polysaccharide molecules.
The Effects
Overall, polysaccharides from either mushrooms or seaweeds have been shown in laboratory, animal, and human studies to be:
Anti-inflammatory
Anti-cancer and anti-tumor
Antimicrobial
Antiviral
Immune modulating
Antioxidant
Antithrombotic (blood thining)
Lower high cholesterol
Support diabetes and other metabolic abnormalities
Support inflammatory conditions such as IBD
Support liver health
Support kidney health
And more!
What are polysaccharides?
Polysaccharide molecules are long, complex, branched chains strung together from individual sugar molecules such as glucose and galactose. Hence the name, ‘poly’ meaning ‘many’, and ‘saccharides’ meaning ‘sugars’. However, unlike the sugar that you might find in the kitchen or in processed foods which you might associate with poorer health outcomes, when they are part of this long complex chain, they behave completely differently. Additionally, the branches of polysaccharides can have various molecular groups attached, that enhance their therapeutic functions, such as sulfate groups. Some examples of polysaccharides are beta-glucan, fucoidan, and carrageenan.
How do they work?
Research is still in early stages and ongoing, so some of the mechanisms of how exactly these polysaccharides have their therapeutic effects are still unclear. We know that these long chains have different polarities, and that enables them to interact with many different factors within our bodies and with foreign pathogens. For example, sulfated polysaccharides can physically interfere with the Herpes Simplex virus (which causes genital herpes and cold sores) to prevent it from adhering and entering host cells. Or they can bind with immune system cells and enhance their functioning and to fight infections, and reduce runaway inflammatory responses.
Given how much positive and promising research already exists, it will not be surprising to see more and more studies being devoted to fungal and algal polysaccharides, especially in an era of high vigilance around viruses.
Harness Polysaccharides with SIMPLIX - Respond with Confidence
Sep 09, 2022
2 min read
The Mediterranean Diet: Another Fad or the Answer to a Healthy Immune System?
Victoria Gasparini
Well, it’s September, and a new season of routine, growth and adjustment is upon us. As much as the warm summer months can bring so much joy and peace to us, there is something new and fresh about the summer winding down, and the leaves starting to drop. September is a beautiful time to start a new approach to your health, as well.
To preface, this blog is not about a new, restrictive diet, but rather a lifestyle change that is adaptable and provides you with a sense of freedom in your daily life, while reaching your health goals and protecting the body against disease.
I actually don’t even like to refer to it as the mediterranean “diet” because this lifestyle plan does not actually restrict calories or major food groups, and comes with a plethora of benefits aside from weight loss (the typical goal of dieting). In fact, according to numerous epidemiological studies, the mediterranean plan can aid in protecting against chronic inflammatory diseases such as cancer, obesity, diabetes, metabolic syndrome, atherosclerosis, cognitive disorders and more. This plan is anti-inflammatory and antioxidant rich, which might be why it is so successful at protecting against diseases that are a result of underlying inflammation.
So, what is the mediterranean diet?
The adoption of the mediterranean diet as a medicinal approach to healing many of the diseases that plague the western world began when researchers realized that countries bordering the mediterranean sea such as Greece and Italy, had lower mortality rates, less chronic disease and significantly reduced incidence of cardiovascular disease.
The mediterranean diet is a plant-based eating pattern that prioritizes traditional mediterranean cuisine such as; whole grains, vegetables, fruits, legumes, fish, spices and herbs, nuts and seeds, eggs, fermented dairy and white meats, with a major emphasis on omega 3 fats. Red wine and some alcohol are welcomed in moderation, and sweets are typically enjoyed on special occasions. This diet is known for its extensive variety of fresh (and often seasonal) foods, flexibility and lack of restriction. What many find interesting is that the mediterranean plan is not just about the food we are consuming. In fact, this plan is a way of life that prioritizes physical activity like walking and biking, as well as eating and spending quality time with family and friends. It is thought that by following the principles of mediterranean diet, emphasizing the consumption of fresh, quality foods with the company of family and friends, allows the body time to register satiety and hunger-cues, a principle commonly neglected in western countries, where a fast-paced lifestyle of eating on-the-go or in front of the television is our typical way of life.
Additionally, the mediterranean plan can be adaptable, and can account for cultural foods that are also rich in omega 3s, antioxidants and phytonutrients.
How can the mediterranean diet help with HPV
Studies have found a link between adherence to the mediterranean diet and a reduction in inflammatory cytokines and proteins, suggesting an immuno-modulatory function of the diet. In fact, a review looking at the relationship between the mediterranean diet and cancer risk, found that a mediterranean plan played a direct role in slowing the progression of high-risk HPV, and thereby preventing cervical cancer development, as well as an indirect protective role against the active infection turning into a cervical cancer diagnosis.
Steps to get you started on a mediterranean diet plan
Convinced yet? Let’s get you started.
Adopt variety.
The best part about starting a plan like this is the variety of foods that are welcome on a daily basis. We always recommend colourful fruits and vegetables, leafy and dark greens, and seasonal fruits and veggies (If you’re in North America, have you tried the peaches lately?). Luckily, variety does not just come in the form of fresh produce, but can be found in other goodies like cheeses (hard cheeses like parmesan and dips like a greek-yogurt based tzatziki). Goat and sheep-based dairy products are also often better tolerated, so give those a try too. Fish, white meats like chicken and turkey (ground, sliced, whole), and even coffee and red wine, in moderation. When finding foods to stock your fridge with, always focus on the quality of the product vs. the calorie count. High quality, minimally processed foods are a staple in the mediterranean diet plan.
Set movement goals
I know that it isn’t always easy to meet your exercise goals, but the mediterranean plan stresses the importance of movement, rather than hours in the gym. So, instead of taking the elevator, take the stairs. Park further away at the grocery store, walk on the treadmill while you answer emails, get out in nature and walk amongst the trees, mountains or by the water if you can. Meet a friend for a walk, do an online 20 minute yoga class, even jog on the spot between work meetings to get blood flowing. Whatever you can do, is always better than doing nothing at all.
I like to plan my days with short, 10-20 minute movement breaks. When it's scheduled, you are more likely to follow through. You will also notice an increase in energy and focus during the day when you prioritize movement.
Be Social
A crucial part of the mediterranean plan is eating with friends and family. Building strong relationships and breaking bread with those you love, is actually beneficial to the immune system and our ability to fight disease. A review on socialization and the immune system found that positive social experiences can reduce inflammation and enhance our antiviral responses. So, here is your sign to call up some friends and family and get together for a meal.
Interested in other ways to enhance your immune system and fight HPV? Follow us on instagram!
Sep 05, 2022
4 min read
So, You've Had an Abnormal Pap, Now What?
Victoria Gasparini
In 2022, an estimated 14,100 women in the United States have been or will be diagnosed with cervical cancer, caused by HPV. In 2020, over 600,000 women were diagnosed across the globe. While the HPV vaccine has drastically reduced cervical cancer rates as a direct result of preventing high-risk HPV, there are still approximately 4300 deaths per year in the United States alone, from cervical cancer.
Take comfort knowing that most HPV cases do not cause cancer, and that many strains of HPV can be controlled and suppressed naturally by supporting the body’s immune system and encouraging adequate viral clearance. The high risk strains of HPV are 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 66 and 68. HPV 16 and 18 are typically the higher risk types and are responsible for most types of HPV-related cancers.
What to do after receiving an abnormal pap smear
The Pap smear involves taking a cell sample of the cervix and assessing for any abnormalities. By monitoring cell changes, earlier treatment and interventions can be implemented which can prevent more severe disease. If you receive an abnormal pap smear result, it is best to talk to your doctor about what your next steps are. This may include more frequent screenings, among other possible solutions. Unfortunately, from a conventional standpoint, the advice is typically to “watch and wait” at this point in the diagnosis.
Fortunately, more and more research is finding that there are ways to control and manage HPV naturally, with dietary and lifestyle changes. Let’s dive into your post-diagnosis plan, below.
First things first, know that you aren’t alone.
HPV is one of the most common sexually transmitted infections, affecting 80% of sexually active women. In fact, most sexually active men and women will contract some strain of HPV at some point in their lives. It is not uncommon to have an abnormal pap smear during routine testing. It is, however, important to do what you can to get HPV under control.
Talk to your doctor about follow-ups, strains and risk.
While Pap testing and increased screening have resulted in a decline in cervical complications, there remains some debate over how often early screening should take place. Considering 90 percent of HPV infections will regress over time, screening can also lead to harm such as unnecessary stress on the individual, additional follow-up testing and biopsy, and the potential of unnecessary treatment.
The chances of having an abnormal Pap smear are higher in young individuals and decrease with age. Around 10% of individuals with a cervix aged 20-29 years will have an abnormal test result while only 1.6% of those aged 60-69. Of these abnormal results, 1.5% of 20–29-year-olds will have high-grade lesions that lead to further testing and biopsy. However, more than 50% of these will undergo treatment. Many of these infections would clear on their own and lead to no complication of cervical cancer.
Depending on where you live and your unique, individual case - your screening guidelines may differ. It is best to work with your physician to develop a plan that is right for you. Find out the screening guidelines in your country here.
Adopt a healthy immunity plan.
At Papillex, we dive into the research on building your immune system to help prevent and clear infections like HPV. Here are some of our favorite, evidence-based tips for building and adopting a healthy immunity plan to help you take control of HPV.
Find movement that you enjoy
Consistency is key when it comes to exercise and movement - so if it does not come naturally, know that you probably won’t stick with it. Try finding a daily movement you enjoy such as walking outdoors, weight lifting, kayaking, swimming, hiking, rock climbing - anything that gets you up and going.
Eat a wide array of colorful vegetables and fruits.
The more variety you consume with regards to veggies and fruits, the better. Nutrients like carotenoids, sulforaphane, folate, vitamin C, selenium and more, have all been shown to boost immunity and increase clearance of HPV.
While all foods are welcome in a healthy, balanced diet, it is best to focus on anti-inflammatory, antioxidant and phytonutrient-rich foods, with limited intake of starches and sugars. You can find out more about diet and HPV here.
Practice mindfulness
Addressing stressors in our lives is often the biggest barrier to healing, and also often the most important barrier to knock down. The connection between stress and persistent infections is clear which is what makes mindfulness such an integral part of your healing. Studies continuously find a connection between stress and its impact on immunity, which is supported in pathogenesis and persistence of HPV infections. You cannot always control stressful events from occurring, but you can manage perceived stress through methods of talk therapy, finding good friends to chat with, getting adequate sleep and nutrients, and getting outside in nature. Reducing perceived stressors can help with HPV disease management and progression and is an important part of any HPV treatment plan. Other things you can do to manage stress include, positive self-talk and reinforcement, surrounding yourself with positive people, trying acupuncture and/or massage, and more. Click here for more stress-management tips.
The most important thing you can do for yourself after receiving an abnormal pap smear, is to be gentle with yourself. HPV is not your fault. It is a virus that can be managed and controlled. Holding onto shame can prevent us from living a healthy life, and can contribute to stress and unhealthy behaviors that impair our immune system. Letting go of the shame associated with HPV may be foundational to our healing. Be kind to yourself.
For more tips on managing HPV, follow us on instagram @papillex.
Aug 22, 2022
4 min read
Getting Creative: Can We Detect HPV In Sanitary Pads?
Victoria Gasparini
In the United States, among other countries, we have a growing public health dilemma. People are not showing up to their regular pap screenings. Because of this, an alarming 52% of cervical cancers are detected in advanced stages. Because early detection of cervical cancer cells via pap smear significantly decreases risk of fatality, detecting cervical cancers in advanced stages is putting us at not only a tragic and incomprehensible disadvantage for fighting disease, but also a preventable one.
But, it's not as simple as reminding our friends and families to head to the doctor. In the United States, we have disparities comparable to lower income nations - preventing Americans from attending their regular screenings, such as income, location and other social determinants. In fact, some research suggests your zip code has more impact on your health outcomes, than any other factors.
Because of this, public health experts have to get creative in finding ways to detect HPV that are cheap and effective, and don’t require the same kind of testing that is currently available, albeit inaccessible to some.
Are sanitary pads the cheap and effective solution to this public health dilemma?
Maybe.
A 2003, small study with 17 participants found that 100% of cervical cancer participants had HPV detected in their menstrual pads. After this study, little was done with this information in the United States. However, in India, where access to pap smears is much less available - they’ve begun using sanitary pads as a way of detecting HPV and cervical cancer risk.
In the world's first trial of its kind, women in the community-based study are packaging up used sanitary pads, and shipping them on dry ice to the National Institute of Research in Reproductive and Child Health Laboratory in Mumbai, India to test for HPV.
Another group of researchers in China, took used menstrual pads and were able to successfully identify HPV in 94.2% of them. In fact according to the Washington Post, the DNA analysis used on these menstrual pads was more accurate in identifying HPV and multi-strain cervical cancers than other cervical tests available.
Does this replace the need for pap smears?
Not yet, at least.
Despite our best efforts, HPV is still a heavily stigmatized infection. Additionally, some patients find cervical screenings to be invasive and uncomfortable. Public health experts have to adopt out-of-the-box thinking when it comes to preventing advanced cervical cancers, and promoting HPV screening to the public. HPV screening via sanitary pads may be an innovative and less invasive way to encourage others to maintain regular screenings. However, because this approach is not currently practiced throughout the United States, it does not replace the need for regular pap smears. Not yet, at least.
What do you think? Send me a DM on instagram to chat!
Aug 08, 2022
2 min read
Red Algae for Cold Sores and Herpes
Jenny Henderson
Marine algae, or seaweed, families are often distinguished from each other very broadly by their colour. There are green algae, brown algae, and red algae. Quite a bit of research has been devoted to these groups because they seem to poses a variety of compounds that have a lot of promise in medicine. It seems that these marine plants that some cultures have been eating for centuries have real potential therapeutic benefits, some of which could be of real interest for those suffering with cold sores and herpes.
What makes red algae special?
The red and brown algae have been of special interest for many of their potential actions. These include being anti-inflammatory, immune modulating, antiviral, anticancer, anticoagulant, antioxidant, and more. One of the their main features are compounds called sulfated polysaccharides (SPs). These large, complex molecules have the ability to physically interact and influence various immune factors and microbes to have a desired health outcome. There is a huge variety of SPs from many species of algae, and it seems that any one of them seems to carry the potential to be of great medicinal importance. Fucoidan is one such compound from brown algae for example, and the some examples of researched red algae include Gigartina skotssbergii and Chondrus crispus.
How can red algae help cold sores and herpes?
When it comes to the Herpes Simplex Virus (HSV), laboratory studies have shown benefit there too. HSV is highly prolific, common, and easily transmissible human virus that can cause cold sores (HSV-1) as well as genital herpes (HSV-2). Since it effects so many people, and because it is so contagious (even when the infected person has no symptoms), any substance that has the potential to modify its life cycle will be of interest. SP’s are one such group of substances.
SP’s from red algae appear to be have multiple mechanisms against viruses such as HSV:
They can have a direct virucidal action, meaning they may damage the virus itself
Inhibit the virus’s ability to enter healthy cells
Inhibit its ability to replicate
Improve the host immune response
As more and more research is being conducted on these impressive compounds from algae, it will not be surprising to see further benefits being uncovered. The seaweeds themselves are considered safe, as many of them are consumed by humans as part of traditional diets, and the SP’s themselves appear to have an excellent safety profile.
Simplix harnesses the power of marine algae | Respond with Confidence
References
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6680640/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3528127/
Aug 05, 2022
2 min read
New Study Finds AHCC Supplementation Clears High-Risk HPV Infections
Victoria Gasparini
The incidence of HPV is rising rapidly, with an estimated 79 million Americans infected with the virus and nearly 80% of the population expected to have a strain of HPV in their lifetime. With over 100 strains identified in humans, about 15 of them are considered high risk and are associated with many cancers such as cervical, oropharyngeal and anal. While vaccination has been successful in preventing many cases of HPV, it is not an effective treatment for those who already have the infection.
What we currently know is that having high risk HPV alone is just one factor that puts us at risk for the development of cancer. It is important to emphasize that HPV is just one contributing factor, as the risk of cancer development occurs in combination with other factors such as smoking, stress, immune dysfunction and inadequate nutrition.
Because of the lack of available treatment options for HPV, our approach at Papillex is to provide research-backed products to help with symptom-management and immune health, while providing you with the latest research on dietary and lifestyle medicine to help you feel your best while managing HPV.
With new research emerging, we are excited to announce a brand new study on the use of AHCC in the clearance of HPV. AHCC is one of the most thoroughly researched nutraceuticals for immune health, and has been widely used by traditional health practitioners for centuries in the clearance of many viral infections like the common cold, flu’s and even HPV. Before we discuss the results of the study, here’s a quick background about AHCC.
What is AHCC
AHCC® stands for active hexose correlated compound, a nutritional supplement derived from the medicinal mushroom, shiitake. After being used for many years in Traditional Chinese Medicine and medical practices in countries like Japan, AHCC® is recently being adopted globally for its immune-modulating activities. Several clinical research studies have found the compound to be effective as both a therapeutic and preventative immune support.
How Does AHCC Clear HPV?
In a brand new randomized, double-blind, placebo-controlled study, of women over the age of 30 with persistent high-risk HPV who took AHCC once daily for 6 months (followed by 6 months of placebo) found that nearly 64% of women in the study were HPV negative after just 6 months of treatment, whereas in the placebo group, only about 10% were HPV negative after 12 months.
This groundbreaking study concludes that AHCC is an effective way to support the immune system for the clearance of high-risk HPV infections and was extremely well-tolerated with no significant side-effects reported.
It is believed that AHCC helps to suppress cytokine IFN-beta to less than 20pg/ml which results in the clearance of HPV in patients.
AHCC Dosage for HPV
The dose in the study was 3g daily, while other studies have found benefits for cancer patients at 3-6g daily.
Two clinical trials have shown that even just 1g of AHCC is effective, but that 3g was slightly more affectatious in clearing HPV as well as providing adequate immune support.
At papillex, our AHCC comes in 500mg capsules and should be taken on an empty stomach, 30 minutes before eating, which will help increase the absorption of the compound into the bloodstream.
What if I already take Papillex?
You can add AHCC to your Papillex routine. While Papillex is a wonderful way to correct nutritional deficiencies associated with HPV, AHCC is a powerful immune-modulating compound that provides additional support in helping to clear viral infections.
Is AHCC right for you?
Despite the incredible safety profile for AHCC, we are unique individuals. We always recommend chatting with your health provider before starting a supplement routine. Naturopathic doctors and functional medicine practitioners are more thoroughly trained in the use of nutritional and herbal medicine and may be able to better answer your questions about supplementation.
Jul 25, 2022
3 min read
Fucoidan for Cold Sores and HSV
Jenny Henderson
Human beings have always had a relationship with the seas, so it’s not surprising that marine ecosystems harbour medicinal and therapeutic factors that can be beneficial to us. Seaweeds are an excellent example of one such source of therapeutics that has been getting some attention from researchers.
As a group, the various seaweeds (aka marine algae) that have been studied, have shown great potential for supporting immune health, reducing inflammation, supporting gut health, being anti-cancer, supporting diabetes and cardiovascular health, and fighting viruses. Even as a food source, many coastal cultures have long consumed seaweeds in their diets for their richness in protein, minerals, and complex carbohydrates.
What makes marine algae so special?
Marine algae and seaweeds contain several different compounds that appear to have therapeutic potential. Of particular interest to us are a group of compounds called polysaccharides. These are complex branched molecular chains that have the ability to physically interact with various immune factors in the body to exert their benefits. They can increase the activity of specialized immune cells, or interfere with the ability of a virus to attach and penetrate cells. One of the most promising polysaccharides is a sulfated polysaccharide called Fucoidan.
What does Fucoidan do?
Quite a bit of research has focused on the various actions of Fucoidan. It can be found in several species of seaweeds, such as Undaria pinnatifida (Wakame), and Laminaria japonica (Kombu).
As an anti-cancer compound, Fucoidan has been found to prevent tumor growth and mediate some of the effects of chemotherapy. It can also stimulate the immune system to attack tumors, as well as viruses. It is a potent antioxidant that is able to prevent damage to cells, and keep excess inflammation from doing the same as an anti-inflammatory. Additionally, it can support the body against metabolic problems by acting as a blood thinner and helping correct high cholesterol.
Can Fucoidan help with herpes and cold sores?
The virus that causes genital herpes and cold sores is called the Herpes Simplex virus (HSV), and it’s a highly transmissible and very common infection globally. Antiviral medications exist to treat HSV, but there is concern about resistance and side effects. Thus far the research data has been very supportive of the antiherpetic potential of Fucoidan for cold sores and HSV. In controlled laboratory and animal studies, brown seaweed Fucoidans have been shown to prevent HSV from infecting cells, directly interfere with the virus (virucidal), and also prevent viral replication.
Is Fucoidan safe to use?
Seaweeds that contain naturally-occuring Fucoidan are safe to eat, and are a common part of many culture’s diets, especially in Asia. According to the data available, there are no safety concerns when it comes to extracted Fucoidan. Some minor side effects are possible, such as nausea, but these are uncommon. As always we recommend that you speak to a qualified health care practitioner before starting any new medicinal supplements.
Harness Fucoidan's potential for HSV | Respond with Confidence with SIMPLIX
References
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6551690/
https://www.mdpi.com/1660-3397/17/3/183
https://www.jstage.jst.go.jp/article/cpb/52/9/52_9_1091/_pdf
https://pubmed.ncbi.nlm.nih.gov/31826428/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7230360/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6836154/
Jul 18, 2022
2 min read
Victoria Gasparini
HPV is one of the most common sexually transmitted infections, affecting 80% of sexually active women. In fact, most sexually active men and women will contract some strain of HPV at some point in their lives. Unlike many STI’s, HPV does not have a known cure. Because of this, the typical advice around sexual abstinence with sexually transmitted infections is likely not sustainable.
If you’ve tested positive for HPV, the best thing you can do for both you and your sexual partners health is educate yourself on safe sex, while addressing the infection and practicing methods to reduce viral transmission. With that being said, here are 3 tips you can take to practice safer sex with HPV, and reduce your risk of spread.
Talk to your doctor about getting vaccinated against HPV.
Both you and your partner may benefit from the protection of vaccination. The HPV vaccine prevents from many dominant strains of the virus, which reduces your risk of commonly associated cancers like cervical, anal, and oropharyngeal. The HPV vaccine also protects against occurrence of genital warts. Vaccination is NOT a substitute for regular screening, and therefore all people with a cervix need to keep up with their regular pap tests. Vaccination is a personal decision that should be discussed with your healthcare provider.
Use protection each time you engage in sexual activity
Keep in mind, HPV can be spread through any kind of sexual activity including vaginal, anal and oral sex. Though not 100% effective at stopping the spread of STD’s, condoms and dental dams can drastically reduce your risk of spreading HPV to your partner when engaging in sexual activity. It is important to know that HPV spreads through skin cells, so condoms do not provide complete protection.
Get tested. Regularly.
Early detection of HPV and any other STI’s is crucial to your health. Both you and your partner(s) should consider getting tested and staying in the know on your sexual health. Consider getting tested with each new sexual partner, as well as maintaining regular screening as recommended by your physician. A pap smear can help identify pre-cancerous and other cell changes of the cervix that may put you at risk for cervical cancer. The HPV test identifies the virus that can be responsible for these cell changes. Discuss your testing options with your physician.
Manage HPV with lifestyle and dietary changes
If you have chronically occurring genital warts, bumps, lesions or sores, you should check with your doctor before engaging in sexual activity. Though these often go away on their own, your doctor may be able to provide you with some options to speed recovery. There are also many dietary and lifestyle changes that can help clear or suppress the virus, making it less likely to spread infection through sexual activity. In addition to these changes, products like Papillex, AHCC and our new supplement for HSV, Simplix, may speed up the healing process.
In addition to common prevention methods, foundational lifestyle approaches like adequate sleep hygiene, a reduction in stress, and adding antioxidants through food and supplementation are tried and true ways to suppress HPV.
Jul 11, 2022
2 min read
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