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Adrienne Hill-Strathy
High-Risk HPV, 16 18 45: What You Need to Know
The family of human papillomaviruses contains a variety of over 150 different strains of HPV. These strains have evolved over time to have different ways to infiltrate and evade the immune system of individuals, causing different disease progressions.
Nearly all sexually active individuals will come into contact with a strain of HPV. It is estimated that 80% of women will contract an HPV infection at some point in their lifetime.
While most cases of HPV infections are asymptomatic, some can manifest in lesions from genital warts to cervical cancer. A few HPV strains, in particular, HPV 16, 18, and 45 have been classified as the most high-risk HPV types, accountable for approximately 70% of cervical cancers around the world.
The prevalence of high-risk HPV infections is estimated at around 22.7%. The most common of these high-risk infections to cause changes to the cervix were HPV types 16, 18, and 45.
High-Risk HPV
High-risk strains often do not cause symptoms so many are unaware that they have contracted a strain of HPV. The high-risk strains develop slowly over time, causing minor changes to the cells of the cervix, anus, or oral cavity.
High-risk strains that persist for a number of years can eventually alter the genome of an individual and increase the risk that cancer will evolve.
12 HPVs (16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, and 59) are defined by the World Health Organization (WHO) as being high-risk cancer-causing types. Together these HPV’s cause half a million cases of cervical cancer per year worldwide. These strains can also cause cancers at other sites, including the penis, vagina, and vulva and in the oral cavity.
What Makes High-risk Strains More Cancerous?
The reason high-risk strains are more likely to cause cancer is due to where the virus has evolved to infiltrate the body and specific proteins within the viral machinery.
Particular areas within the cervix lining are more susceptible to fostering cell replication than others. HPV that gains access to the transformational zone in the cervix have been linked to higher rates of cancer progression. This site has a lower density of immune cells called Langerhans cells, that provide our first line of defense in fighting off pathogens.
High-risk HPV strains are the leading cause of cervical cancer
Two viral proteins, E6 and E7, have also been found to be more active on high-risk strains of HPV. These proteins are thought to be responsible for allowing the virus to enter the upper layers of the epithelial tract. The proteins have also been found to downregulate toll-like receptors of the innate immune system, leading to greater threats to the individual's DNA.
These E6 and E7 proteins appear to be inactive or weakly active in low risk HPV types.
High-Risk HPV Strains and Cancer Rates
Despite high-risk strains increasing one’s risk of cancer, contracting a strain does not mean you are going to get cancer. The majority (90%) of individuals will clear the infection within three years and have no complications. Of the 10% of cases that become chronic only 1% will result in cervical cancer.
Women with a high-risk HPV strain have a 210-fold higher risk of developing a CIN 3 complication in 6 years as compared with negative women. This means that instead of every 9 in 10,000 women contracting cervical cancer, 210 in 10,000 with a high-risk strain will develop into cancer.
HPV Testing and mRNA E6 E7
HPV testing can detect which strain of HPV you have contracted and indicate whether you have been infected with a high-risk strain.
To provide a better understanding of the strains risk of developing into cancer, mRNA E6 and E7 testing can also be done. Testing can be done to detect the presence of these proteins within an individual.
E6 and E7 are usually expressed at low levels during a transient HPV infection. When the virus has integrated into the individual gnes, the oncogene transcripts are over-expressed, leading to the development of cervical cancer.
HPV E6 and E7 mRNA expression level are highly correlated with the severity of cervical lesions and can be tested and used as a biomarker for HPV infections that are more likely to progress to cancer.
Having more reliable and better testing for HPV has played a significant role in reducing mortality from cervical cancer in the past several years. Staying on top of your pap testing and monitoring your situation with your doctor is key to fighting off high-risk strains.
What Can You Do If You Have Contracted HPV?
In addition to regular testing, fighting off high-risk strains of HPV requires a healthy immune system. We believe implementing a healthy lifestyle is built around four foundational lifestyle therapies:
1. Nutrition and Supplementation
The gut is home to around 80% of the immune system. Consuming a fruit and vegetable-rich diet, limiting sugar and refined carbohydrate intake has been found to have a positive effect on the overall function of the immune system.
Papillex is a supplement which is designed specifically to help your body respond to HPV and is packed full of ingredients which have been researched with HPV in mind.
Building a strong immune system with good nutrition is an important factor in your body's ability to fight off viral infections
2. Psychological Stress
Prolonged stress has been found to create an imbalance in the ability of the body to fight incoming infection, by over activating areas of the immune system that exacerbate chronic illness. Engaging in daily stress management practices like meditation, exercise, and socializing can have a positive effect in improving the bodies overall resiliency.
3. Sleep
Getting adequate rest, seven to eight hours of quality sleep per night, allows the immune system time to revitalize, balance hormones and it initiates cellular repair. Setting a regular bedtime, limiting caffeine intake in the afternoon, and eating a nutrient-dense diet are all ways we can improve our sleep quality.
4. Exercise and Movement
From improved circulation to naturally increasing the bodies white blood cell and antibody count, staying active has a range of benefits in helping support the immune system and defense against disease. We recommend talking daily walks and engaging in bi-weekly strength training and aerobic activity.
Oct 01, 2020
5 min read
A Cure For HPV? Or Too Good To Be True?
Christine Chung
Recently there has been buzz online surrounding a cure for HPV.
Is there a cure? Will it reverse the damage that’s already occurred? Do I have to go to Mexico?
Learn about HPV and whether or not there is a cure here.
What is Human Papillomavirus?
Human Papillomavirus is one of the most common viruses that affect humans and the most common sexually transmitted infection in the United States.
It affects countless men and women every year. That’s right - HPV affects men, too.
The Center for Disease Control and Prevention estimates that almost every sexually active adult will get HPV at some point in their lifetime. It can be spread by skin-to-skin contact, most commonly through sexual activity.
How does it become Cervical Cancer?
HPV causes 91% of cervical cancer. However, not all HPV infections can or will cause cancer. Only a few out of the 100+ known strains of HPV have the potential to become carcinogenic.
Most infections will present with no symptoms at all and be cleared naturally over time with a robust immune system!
However, when your immune system is weakened, or when your body is invaded by a strong strain of HPV, cell proliferation can occur. This is the growth of abnormal cervical cells, which can lead to cervical intraepithelial neoplasia (CIN), and eventually, cancer.
Is there a cure?
The short answer is no. There is no magic treatment that will completely eradicate HPV or reverse all damage. But, outcomes for HPV and cervical cancer are very good with routine screening and well-informed treatments.
How can we naturally respond to HPV?
There are many ways to naturally respond to symptoms and complications of HPV including genital warts and cervical dysplasia. The two most popular treatment options are Cryotherapy and LEEP.
Cryotherapy
Cryotherapy uses liquid nitrogen, a very cold substance, to freeze off abnormal cells from your cervix. Cryotherapy is also a commonly used procedure for wart removal. This treatment kills off the cancerous cells allowing for new growth of healthy cells in its place.
How it works: Similar to a Pap test, you will be laying down and your doctor will insert a speculum into your vagina. Instead of the brush used for Pap testing, your doctor will use a cryoprobe, holding it at certain places on your cervix to freeze the cells. The whole process should only take 5 minutes or so. You may feel some cold sensation or mild cramping.
The result: Cryotherapy is quite effective for eliminating abnormal cells with a low recurrence rate.
Loop Electrosurgical Excision Procedure (LEEP)
LEEP is another cervical cancer prevention treatment, where abnormal cervical cells are removed from your cervix using a small electrical wire loop.
How it works: Similar to a Pap, you will be lying down while your doctor inserts a speculum into your vagina. Numbing cream will be applied, and your doctor will use the wire loop to remove the cells. The electricity of the loop cauterizes the blood vessels in the area to prevent bleeding. The whole process should take about 10 minutes.
The result: Highly effective. LEEP will usually remove all the abnormal cells. One study even showed LEEP was more effective than cryotherapy.
Other treatments
Conization, or a cone biopsy, removes a cone-shaped section of the abnormal tissue for lab examination of CIN.
Surgical removal, including electrocautery, laser surgery, and excision.
Photodynamic therapy, combined with Aminolevulinic acid, has been a novel treatment generating a lot of hype in the media as the “cure to HPV”. Photodynamic therapy uses wavelengths to damage the surface layer cells affected by HPV. The treatment poses a lower risk to women looking to get pregnant in the future. However, the treatment is still in its infancy. Further quality research is needed to determine its long-term effectiveness.
You may read conflicting information about these treatments online. You and your doctor will know what’s best for you; every treatment should be specific to each case.
Vaccination
An HPV vaccine exists that protects against two strains of HPV, HPV 16 and 18, that cause genital warts and two strains that most commonly cause cervical cancer.
For the vaccine to be effective, it must be given before the virus has been contracted. Typically, it is recommended for females aged 13 to 26 and males aged 13 to 21.
While the vaccine protects against a few of the high-risk and common strains, it is important to keep in mind that the vaccination does not protect against all HPV strains. Several other high-risk strains exist and are being detected in patients that have been vaccinated, so routine screenings are still recommended.
HPV Vaccines typically take place between the ages of 13 and 26
Are new vaccines on the way?
A new immune-based vaccine was recently developed that may be effective in treating women with existing HPV and precancerous changes on the cervix.
The therapeutic vaccine injects a specific protein that triggers the immune system to attack high-risk HPV which is known to cause cervical cancer.
A randomized controlled trial that followed women for over two years post-vaccination found that those who received the vaccine were more than twice as likely to see their CIN eliminated compared to those who received placebo.
The vaccine shows promising evidence that it may not only eliminate the lesions but also the HPV infection. However, research is still in its infancy and more long-term trials are needed to determine the safety and effectiveness of treatment.
Consult your doctor to work out the best plan of action for you to stay healthy
Natural Methods to Fight HPV
Most HPV infections can be easily cleared by a strong, healthy immune system. Immunity can be heavily supported and improved through our daily lifestyle choices, including:
Eat plenty of fruits and vegetables – fruits and vegetables contain many essential vitamins and nutrients to keep your body functioning at its best! These food groups are specifically high in antioxidants, which may help neutralize bad molecules floating around in your body. The food we eat also plays a crucial role in supporting our gut health, where nearly 70% of our immune system is housed.
Quit smoking – smoking significantly increases your risk for HPV-related cancers, and even second-hand smoke exposure increases your risk. While cutting down your cigarette count will still have an effect, nothing is quite as good as quitting entirely.
Reduce alcohol consumption – high consumption of alcohol is related to several negative outcomes, including a reduction of immune function.
Drink green tea – green tea has been shown in many studies to have immune benefits and anti-cancer effects, some specific to HPV.
Exercise to sweat – movement is important to improve your circulation for immune benefits and general well-being, while sweating will help release toxins from within your body.
Get adequate sleep – getting 7 to 8 hours of high-quality sleep is important to regulate your bodily functions, including your circadian rhythm. All of these factors have a distinct effect on your ability to fight infections.
Keep a positive mindset – positivity has several health benefits, including stress reduction which will keep your immune system strong.
Supplement your diet appropriately – for some people, it can be difficult to get the nutrition they need to keep their immune system working at 100%. Papillex is a supplement specifically designed to help both women and men respond to HPV naturally and give their immune systems the support it needs.
Could Medicinal Mushrooms be the Cure?
Promising new research on the benefits of a shiitake mushroom compound called Active Hexose Correlated Compound (AHCC) could help eradicate persistent HPV infections. Two small human clinical research trials have been conducted by Dr. Judith A. Smith, Pharm D., an associate professor in the Department of Gynecologic Oncology and Reproductive Medicine at the University of Texas.
The studies have found daily intake of 1-3 grams of AHCC eradicated the virus in 44-66.7% of patients with high-risk HPV status after 3-7 months.
Medicinal mushrooms have been used for centuries in traditional medicine to support the immune system and fight viral infections and cancers. You can learn more about AHCC for HPV here.
While the trials have been successful so far, more research is needed to determine if it is effective. Patients should talk with their doctors before starting any supplementation.
The Ultimate Cure-All?
It seems we are always looking for the ultimate cure-all - that one thing that will do the trick and solve our problems. Unfortunately, a magic pill rarely exists, and instead, a more nuanced and multi-faceted approach is needed. This nuanced approach applies when we talk about curing HPV.
Sep 15, 2020
6 min read
How Many Types of HPV Are There?
Adrienne Hill-Strathy
There are over 150 different HPV strains that have been identified in humans.
Different strains have evolved over time through evolution into five sub-groups, each with unique ways to infiltrate and cause disease in an individual.
Some strains cause minor papilloma’s on the surface of the skin, while others have no symptoms but have the ability to slowly develop into cancers.
The most widely studied HPV sub-group is classified as Alpha types. Alpha types are more researched because they are typically associated with cervical cancer. The alpha types can be divided into high-risk and low-risk strains.
Broadly speaking, we can classify HPV strains into low and high-risk
Low-Risk Strains
Low-risk strains often cause common warts on the surface of the skin. These strains of HPV are considered low-risk because they rarely develop into cancer.
HPV strains 6 and 11 are the most common low-risk HPV strains, causing 90% of genital warts.
Genital warts are soft, fleshy, cauliflower-like growths that can grow in genital areas including the anus and penis. These warts can be painful, itchy, annoying, and, worst of all, highly persistent. Warts generally show up a few weeks or months after sexual contact with an infected partner.
Like most HPV infections, genital warts will usually be cleared by a strong, healthy immune system. Taking supplements like green tea extract, found in papillex, can also help improve wart clearance.
High-Risk Strains
High-risk strains of HPV have a higher likelihood of developing into cancers.
High-risk strains often do not cause symptoms so many are unaware that they have contracted a strain of HPV. The high-risk strains develop slowly overtime, causing minor changes to the cells of the cervix, anus, or oral cavity. High-risk strains that persist for a number of years increase the risk that cancer will evolve.
12 HPVs (16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, and 59) are defined by the World Health Organization (WHO) as being high-risk cancer causing types. Together these HPV’s cause half a million cases of cervical cancer per year worldwide. HPV-16 and 18 are the most common strains associated with cervical cancer, causing about 70% of cervical cancers.
These strains can also cause cancers at other sites, including the penis, vagina, and vulva and in the oral cavity.
The reason high-risk strains are more likely to cause cancer is thought to be due to where the virus has evolved to infiltrate the body and specific proteins within the viral machinery.
Particular areas within the cervix lining are more susceptible to fostering cell replication than others. HPV that gain access to the transformational zone in the cervix have been linked to higher rates of cancer progression.
Viral proteins identified as E6 and E7, have been found to be responsible for stimulating cell cycle entry into the upper epithelial layers and linked to cancerous changes.
Despite high-risk strains increasing one’s risk of cancer, contracting a strain does not mean you are going to get cancer. The majority of individuals will clear the infection within a few years and have no complications.
Transmission and Infection Rates
The variety of HPV strains and the transmissibility of the virus means most individuals will pick up one strain of HPV in their lifetime.
HPV is one of the most easily transmitted sexually transmitted diseases. The virus can be contracted just through skin contact with an infected individual. Because the virus lives within the skin cells, even protected sexual contact can lead to transmission from areas that aren’t covered by a barrier.
Getting Regular Pap Tests
Getting regular pap tests is important to monitor any potential infections and complications. Cell progression is caught easily in pap tests, and awareness is key to taking preventative measures to clear the virus.
The recommendation for disease control and prevention is to get one pap test every three years to keep an eye on your cervical cells, and more frequently if you have ever had an abnormal pap test.
It is essential to go for regular pap smear tests if you are a young woman, even if you display no symptoms
How Can I Protect Myself Against HPV?
The most important thing you can do to protect yourself from HPV complications is maintaining your overall health. A healthy immune system is the hallmark of HPV infections, where the failure to develop effective cell-mediated immunity to clear or control the infection results in persistent infection and increases the probability that the cells progress to cancer.
We can support and build our immune system by making healthy choices every day. Some important factors in supporting your overall health include:
Optimizing Nutrition and Supplementation
Consuming a fruit and vegetable-rich diet, limiting sugar and refined carbohydrate intake has been found to have a positive effect on the overall function of the immune system.
Managing Psychological Stress
Prolonged stress has been found to create an imbalance in the ability of the body to fight incoming infection, by over activating areas of the immune system that exacerbate chronic illness. Engaging in daily stress management practices like meditation, exercise, and socializing can have a positive effect in improving the bodies overall resiliency.
Getting Good Quality Sleep
Getting adequate rest, seven to eight hours of quality sleep per night, allows the immune system time to revitalize, balance hormones and it initiates cellular repair. Setting a regular bedtime, limiting caffeine intake in the afternoon, and eating a nutrient-dense diet are all ways we can improve our sleep quality.
Engaging in Regular Exercise and Movement
From improved circulation to naturally increasing the bodies white blood cell and antibody count, staying active has a range of benefits in helping support the immune system and defense against disease. We recommend talking daily walks and engaging in bi-weekly strength training and aerobic activity.
Sep 01, 2020
4 min read
What to Expect in a Colposcopy Exam
Adrienne Hill-Strathy
If you are reading this, you may have recently been referred by your doctor to get a colposcopy.
Colposcopies are rarely talked about so can evoke some distress and confusion for patients upon referral.
Here we hope to provide some details about the procedure, what to expect, and why it’s a great step to help you get on top of your reproductive health.
What Is a Colposcopy Exam?
A colposcopy, pronounced kol-POS-kuh-pee, is typically referred to patients following an abnormal Pap smear.
Abnormal Paps suggest some cell changes have occurred on the cervix, vagina, or vulva. The device, called a colposcope offers a way to get a closer look at what is going on internally.
How Does the Procedure Work?
Colposcopies are typically performed by gynecologists.
During the exam, you will be asked to remove your clothes from the waist down. Your feet are placed into two stirrups and a speculum is used to view the vagina and cervix.
A solution of acetic acid is applied to the area using cotton swabs to make it easier to observe any cellular changes. The acid can burn slightly upon application and may cause slight discomfort.
The physician will then move the colposcope into view, depicting an image of the cervix on a digital screen. Many physicians will offer you the option to take a look at the screen, but you can also choose to look away if you wish.
Here, the physician can visualize the cervix and observe any changes in color, discharge, irritation, etc. Depending on the observation, the physician may decide to take a swab or biopsy of the cervix for further examination of cell changes.
There are two types of biopsies, one taken from the outside of the cervix and another from the inside opening. The biopsy may cause mild discomfort but is generally quick and painless.
What Happens Next?
Because abnormal cell changes depicted on the cervix will usually be cleared by a healthy immune system within two years, most patients will be asked to monitor the situation by getting a follow up Pap test done every six months.
If a biopsy was taken, a follow up appointment will be made to discuss the results, next steps, and if further intervention is warranted.
What can you do?
Although the procedure and fear of an abnormal Pap test can be anxiety provoking, be proud that you are taking proactive care of your reproductive health. Understanding your risks makes you more prepared to prevent more severe outcomes later in life.
Instead of watching and waiting between follow up Pap tests, why not take actionable steps to naturally support your immune system in clearing off the virus?
Adopting a healthly lifestyle, diet, implementing stress management techniques and supplementing with products like Papillex, that replenish the nutrients that have been found to be low in people with persistent HPV infections, can effectively help your immune system respond naturally to HPV and leave you in a better state of overall wellness.
Jun 01, 2020
2 min read
Epithelial Cell Abnormality: All You Need To Know
Christine Chung
You go for your normally scheduled pap test, but this time things are different. You get your test results, and you see ABNORMAL.
You, along with 8% of Canada’s female population, are wondering the same thing. What does this mean?
In this blog post, we break down what you need to know about the Pap smear, the possible results, and what it means to have epithelial cell abnormality.
First, let’s break down what an epithelial cell is.
What is an Epithelial Cell?
Epithelial cells are found on the surface layers of the body such as the skin, respiratory tract, urinary tract, and organs. The cells create a barrier between the inside and outside of the body, protecting it from invaders like viruses, bacteria, and other pathogens.
Epithelial tissue is one of the four major tissue groups and can be found lining many parts of the digestive system, the epidermis, the oral cavity, many of the body’s glands, and the cervix.
There are three types of epithelial cells: squamous, cuboidal, and columnar. Squamous cells are what we commonly examine when it comes to Pap testing and cell abnormality. Squamous cells are found in the esophagus, mouth, and vagina, protecting the body against wear and abrasion.
Different layers of Epithelial Cells
What Is An Epithelial Cell Abnormality?
An Epithelial Cell Abnormality is when an epithelial cell has undergone abnormal cellular changes, which could indicate cancerous or pre-cancerous cells. When abnormal cells are found on the cervix, this is also known as cervical dysplasia.
Epithelial cell abnormality and cervical dysplasia are detected through a Pap test.
Normal vs Abnormal Cervix Cells Taken from a Pap Smear
What is the Pap Test?
The Pap test or Pap smear was invented in the 1920s by a gynecologist named George Papanicolaou. While researching, Papanicolaou discovered certain cellular smears taken from the vagina and cervix and viewed under the microscope differed in epithelial cellular normality. His discovery revealed early detection of cancerous cells in women presenting without any current symptoms.
The Pap test has now become part of routine physical examination for individuals with female reproductive parts to detect and monitor the presence of precancerous or cancerous cells on the cervix that may progress into cervical cancer.
The test results from a Pap smear can go one of three ways: NORMAL, UNCLEAR, ABNORMAL.
Normal: Indicates no cellular changes or precancerous activity was found.
Unclear: Often warrants a repeat Pap test. This indicates that your cells could be mildly abnormal, due to a vaginal or sexually transmitted infection, changes in hormones, or poor test collection.
Abnormal: An abnormal Pap test means that some level of cervical cell changes were found. It does not mean that you have cervical cancer but further testing is recommended.
Pap Smear Tests Are Essential For Detecting HPV
Breaking down the Abnormal Pap Test Results
The Pap test is a screening test that reports different grades of abnormality. The following table displays the severity of these results from lowest to highest:
Degree of Severity
Pap Test Result
0
Normal
1
ASC-US
2
LSIL
3
ASC-H
4
HSIL
5
AIS
6
Squamous Carcinoma
Abnormal Result Breakdown
Here is a breakdown of abnormal Pap test results:
Atypical Squamous Cells of Undetermined Significance (ASC-US) The most common of all abnormal Pap test findings. ASC-US means the squamous cells of the cervix look abnormal. This is likely due to an HPV infection. Usually, the cells return to normal on their own, but your doctor will likely recommend monitoring to be safe.
Atypical Glandular Cells (AGC) This type of result is unique from the others listed here as they relate to glandular cells instead of squamous cells. Cervical mucus and mucus in the uterus are produced by these glandular cells. An AGC result indicates that there are abnormalities in the cervix’s glandular cells and raises concerns about pre-cancerous or cancerous cells. Further testing and monitoring will be recommended.
Low-grade Squamous Intraepithelial Lesions (LSIL) This indicates mild cervical dysplasia, abnormal tissue potentially signifying early stages of cancerous processes. These changes are likely due to an HPV infection. Often these changes return to normal over time but require monitoring. This could also be known as cervical intraepithelial neoplasia, or CIN 1.
Atypical Squamous Cells (ASC-H) Atypical squamous cells are another form of cell abnormality that has a high possibility of being HSIL. Further testing must be completed to know for sure.
High-grade Squamous Intraepithelial Lesions (HSIL) This result indicates moderate to severe dysplasia. An HPV infection is present and spreading, causing more serious changes. This is still not cancer, but it has a higher risk of progression into cancer if untreated. With adequate support and treatment, it may go back to normal findings. A CIN 2 or 3 classification would fit here.
Adenocarcinoma In Situ (AIS) This finding indicates an advanced lesion was found with a high risk to develop into cancer without proper treatment. This is a stage where it is critical to prevent cervical cancer progression. A CIN 3 classification would fit here.
Squamous Carcinoma: A positive screening for squamous carcinoma indicates cancer. Squamous cell cervical cancer makes up 80% of all cervical cancers. At this stage, precancerous cells have progressed to cancer and require further treatment of surgery, radiation, chemotherapy, or other immunotherapies. A diagnosis of squamous is quite rare. Women who receive regular Pap tests will catch cervical cell changes before cancer develops and are very unlikely to ever unknowingly reach this stage.
Discuss with your healthcare professional how to proceed following abnormal cell results.
What does Cervical Intraepithelial Lesion (CIN) mean?
The Pap test cannot tell the exact severity of cervical cellular changes. A cervical biopsy taken through colposcopy is needed to find out whether precancer or cancer is actually present. Cervical biopsy results are reported as Cervical Intraepithelial Lesion (CIN) on a grade of 1, 2, or 3.
CIN 1: indicates mild, low-grade changes in the cells. CIN 1 often will go away on its own without treatment.
CIN 2: is used for moderate cellular changes. This is a higher-risk for progression into a pre-cancerous stage.
CIN 3: indicates more severe (high-grade) changes, with a higher likelihood to progress to cancer and may be classified as precancer.
A healthy ldiet and ifestyle helps your immune system
Frequently Asked Questions:
What is an HPV test?In individuals with abnormal Pap test or females above the age of 30, the Pap test may be combined with an HPV test. The HPV test screens for the presence of the HPV virus, which causes cervical cancer. HPV is very common and can be present without any signs of cervical abnormality. It is often tested to determine which strain of HPV you have contracted. Because some strains have a higher chance of progressing to cancer, knowing the specific strain and viral presence can help your doctor monitor your risk.
How often do I need to get a Pap test?Pap smears have now been recommended for sexually active females between the ages 25-69 to be performed once every 3 years. If you have had an abnormal Pap your doctor will repeat your Pap every 6- 12 months until they are clear.
What should I do following an abnormal Pap?Following an abnormal result, your primary healthcare provider will refer you for colposcopy. A colposcopy allows for closer examination of the cervix using a microscope. A cervical biopsy may also be taken for more accurate detection of cell types. Read more on what you can expect in a colposcopy appointment.
How are abnormal cervical cells treated?Depending on the severity of cervical abnormality your doctor will recommend monitoring or treatment. Treatment usually includes an excisional and ablative treatment where cervical tissue is removed or destroyed. Loop electrosurgical excision procedure (LEEP) and Conization are the two most common excisional treatments. LEEP uses a thin wire loop that carries an electric current to remove abnormal cells. Conization removes a cone-shaped piece of the cervix that contains abnormal cells. Cryotherapy and laser are the two most common ablative treatments.
How can I naturally support my body to clear HPV?A healthy diet and lifestyle are key to supporting your immune system eradicate the virus. Making lifestyle changes such as eating more fruits and vegetables, exercising daily, sleeping at least 7-8 hours a night, cutting out smoking, and excessive alcohol consumption. By making sustainable changes to support your overall health you will also help your immune system clear HPV.
We developed the Papillex supplement for this very reason, to boost your immune system and best prepare your body to regress those abnormal cells back to normal cervical cells. Papillex contains high-quality, fine-tuned ingredients hand-picked specifically to fight HPV infections.
May 15, 2020
6 min read
HPV Complications Including Genital Warts
Christine Chung
HPV Complications
Read below as we cover the WHO, WHAT, WHEN, WHERE, WHY, and HOW of HPV and its complications.
The WHO
HPV can affect both men and women alike. The rising rates of HPV have been more of a concern for the anatomically female population due to the severe consequence of cervical cancer, 80% of which have been attributed to an HPV infection.
Severe cancer-linked complications in men are rarer than that of women, which is why prevention and treatment have been heavily focused on women.
Most men have no symptoms, so the diagnosis of HPV is quite difficult. It can only be made when external genital warts are seen. Grade school boys are now being included in a school-based mandate to vaccinate against HPV to decrease transmission.
The WHAT
HPV causes a number of lower risk and higher risk complications to the body. These include:
Common warts
Genital warts
Plantar warts
Facial warts
Pre-cancerous lesions of cervix, anus, penis, vulva, or uterus
Cervical cancer
Penile carcinoma
The diseases caused by HPV may lead to certain secondary conditions or disorders. These are termed HPV complications.
Most HPV viruses do not cause any serious complications, as the infections are self-limiting and regress spontaneously within a period of 1 to 2 years in about 90 percent of patients. Only a small number of people suffer from persistent HPV infections and have an increased risk of developing cancer.
HPV can feel isolating, but don't worry, you're not alone
HPV complications include:
Cancer: Persistent HPV infections caused by high-risk types, mainly type 16 and 18, may progress into malignancies.
Cervical Carcinoma (the most common complication associated with malignancies)
Genital Carcinoma
Vulvar Carcinoma
Anal Carcinoma
Penile Carcinoma (rare cancer associated with HPV)
Genital warts in the urinary tract may become enlarged leading to difficulties in urination. In pregnancy, warts on the vaginal wall may lead to obstruction during vaginal delivery. Genital warts may become ulcers or open sores. Ulcers can lead to infections of the rectum, anus, urethra, and even mouth or throat.
Warts in the throat, or laryngeal papillomatosis can occur in newborns, from delivery when born to through vaginal delivery to women with warts.
This rare condition requires urgent attention.
The WHEN
HPV has an estimated incubation period from HPV infection to genital wart development anywhere from 2 weeks to 8 months. The majority of genital warts appear 2 to 3 months after infection.
Most people clear an HPV infection naturally with a healthy immune system in 1 to 2 years. Some people may stay infected for years. It will take about 10 to 30 years from the time of infection to see a cancerous tumor form.
It is important to get routine checkups and pap tests to stop the cervical cell changes in their path before they progress further into cancer.
The WHERE
Complications most likely arise in the genital, anal, and oral areas of both men and women. HPV mostly affects a woman’s cervix, causing cervical dysplasia and abnormal cell changes that may lead to cancer if untreated.
The WHY
There are over 150 different known strains of HPV. Some of these are high risk and some are low risk. About 14 of these strains are specifically linked to higher rates of cancer and are termed “high risk”.
We need to support each other through illnesses like HPV
HPV 6 and 11 cause 90% of genital warts linked to HPV, but are considered “low risk” strains because they rarely develop into cancer.
HPV 16 and 18 cause an estimated 70% of all cervical cancers. These two strains are widely known as the highest risk strains of HPV.
The HOW
HPV is easily spread from sexual skin-to-skin contact with a partner who has HPV. You can get it when your vulva, vagina, cervix, penis, or anus touches someone else’s affected area, genitals, mouth, or throat. This can occur during sex, including oral and anal sex.
It can spread even if there is no ejaculation. It is possible that open-mouthed kissing with a partner who has an oral HPV infection may cause transmission, but the jury is still out on that one.
What Now?
If you're concerned about HPV, you can learn more about HPV testing in our in-depth article.
If you want a way to respond naturally to HPV, why not check out our product, Papillex?
Feb 05, 2020
3 min read
Recover From An Abnormal Pap Smear. Fast.
Christine Chung
Watch and Wait…or Take Action? How One Doctor Supports Patients to Recover Faster from an Abnormal Pap Smear
To celebrate Cervical Cancer Awareness Month, Dr. Amy Kroeker, ND shares her perspective on managing abnormal Paps, and shares a remarkable case of cervical dysplasia that has a happy ending.
If you have ever had an abnormal Pap and heard this phrase, you’re not alone. And, if you are anything like me, you don’t like waiting.
Cervical dysplasia is caused by the HPV virus which causes normal cervical cells to change form into abnormal cells prone to becoming precancerous or cancerous cells. It is standard medical advice to “watch and wait” when first diagnosed with an abnormal PAP (ie. cervical dysplasia). However, what exactly are we waiting for…and what are we watching? It’s not like we can see our own cervix to check up on it.
In my practice, I’ve always found this advice to be excruciating to the female psyche. For 6 months, women are asked to wait, and then the PAP is re-done to see if the cells have converted back to normal cells or continued to progress towards abnormal pre-cancerous or cancerous cells.
It is assumed that since the abnormal cells are caused by a virus, that your body may be able to fight the virus off in this amount of time and allow the cells to heal. If they do not, then treatment (often by laser) is required.
But wait, if these cells are caused by a virus, isn’t there more we can do to help our bodies fight this virus off? Aren’t there a lot of natural remedies that can help boost our immune systems?
Case Study of a 26 year-old female
A few years ago, I had a patient with a memorable case of HPV-induced cervical dysplasia. A 26-year-old woman who wanted to boost her own body’s immune system to reverse the abnormal cells. Her gynecologist gave her 6 weeks before doing a laser removal of the cells. At the time, I thought it wouldn’t work. Natural medicine is all about focusing on prevention and I didn’t believe we could reverse abnormal cells in that time frame.
I made sure my patient knew there were risks to waiting but since her gynecologist had agreed to wait 6 more weeks, and she was determined to use those 6 weeks to their full advantage, I did some research and came up with a plan to support her own body’s immune system with diet, vitamins, and anti-viral and hormone balancing nutrients.
What was the result?
A clean PAP. That case, and the research I did for it became my protocol to give women back control during the “watch and wait” phase. I don’t suggest ever delaying treatment once needed and recommended by your doctor or gynecologist but during the “watch and wait” phase I prefer to take action to provide an environment supportive of the best possible outcome.
The following are some of the tips I recommend to help boost the immune system while waiting:
#1: Diet
Emphasize eating vegetables and fruits (at least 7-10 servings per day) to boost antioxidants and increase immune system function. Research shows that high levels of vegetable consumption are associated with a 54% decrease in HPV persistence. Specifically, consume at least one serving per day of a cruciferous vegetable such as broccoli, kale, cauliflower, or Brussel sprouts and at least one serving of dark green leafy vegetables or bright orange/red vegetables at every meal.
There are lower rates of HPV infections reported among women with higher intake of carotenes, lutein, zeaxanthin, and vitamin C, and these vitamins and antioxidants are found in brightly colored vegetables and fruits.
Lignans, a nutrient found in high concentrations in ground flaxseeds, help to lower levels of free estrogen in circulation. Consuming 2 tbsp per day can help improve the hormone balance necessary for the ovaries, uterus, and cervix to function optimally.
As for what foods to avoid; avoid processed foods, foods with added sugar, alcohol, and coffee. These foods create unnecessary stress on the body and hormonal systems and we need to create space in the diet for more nutrient dense foods.
#2: Supplements
There are a lot of different nutrients with
research showing they help the immune system or help the body fight viruses
like HPV. These supplements are individualized for each patient so I always
recommend working with a licensed naturopathic doctor or functional medicine
doctor to tailor a program specific to you. However, I consider the following
nutrients since they have the most research.
Folic acid – ideally in the active form
Vitamin C – higher doses, if possible, from food or supplements
Vitamin A – higher doses but if you go above 10,000 IU daily then you need to work with a doctor for liver safety
I also like to use a product that contains reishi mushroom, mixed carotenoids, broccoli sprout extract or DIM, and green tea extract – these are all found in the supplement Papillex. I have yet to find a better blend of ingredients combined in one formula for the support of cervical dysplasia.
So, next time you are told to “watch and wait” after an abnormal PAP, seek out a licensed naturopathic doctor or functional medicine doctor so you can support your body while it tries to heal and repair from the HPV virus. Why feel helpless while waiting? Take action!
Dr. Amy Kroeker, ND practices from her clinic in Winnipeg, Canada. Learn more about Amy at https://www.amykroekernd.com/about
Jan 22, 2020
4 min read
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