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Is Cervical Cancer Genetic?

Is Cervical Cancer Genetic?

Adrienne Hill-Strathy
Cervical cancer remains the second most common cancer among women worldwide. Certain high-risk strains of the Human Papilloma Virus (HPV) are responsible for causing cervical cancer. Around 70-90% of individuals with HPV will clear the virus 12 to 24 months after infection. However, in few individuals, the viral infection can persist and cause cellular changes to the cervix that may lead to cervical cancer. What allows some people to quickly clear the viral infection and others to develop cancer?  Several identified factors may impact an individual’s ability to clear an infection. These include frequent re-infections, immune health, hormone levels, or infections by more than one HPV type.  Genetic factors also play a role. In this article, we explore the relationship between HPV and genetics. How Do Genes Influence Cancer? Genes play a role in directing healthy cellular development by controlling cell growth and cell death.  Genes that control how our cells grow, work, and stay alive are called oncogenes. Other genes, called tumor suppressor genes, keep cell growth under control and initiate cell death at the right time. Cancer occurs when DNA mutations alter the genes that turn on oncogenes or turn off tumor suppressor genes, allowing abnormal cellular growth. Research has found that high-risk HPV contains special proteins called E6 and E7. These proteins turn off tumor suppressor genes. When these genes are deactivated, cells in the cervix can progress and lead to further gene changes and potentially cancer. Is Cervical Cancer Heritable? Research suggests that a familial predisposition to cervical cancer may be present. If your mother or sister had cervical cancer, your chances of developing cervical dysplasia or cancer are increased. Moreover, the risk increases with the increased degree of genetic relatedness. A Swedish study found that genetic heritability accounted for 27% of the underlying factors for cervical cancer development. The study also tested the role of the environment but found shared environmental factors accounted for only 0-2% of disease progression. The results showed a greater impact than other cancers like colorectal cancer, lung cancer, and melanoma. The reason for these genetic correlations is not completely understood. It could be explained by a few factors: Our genetics may impact our DNA repair pathways associated with CIN3 cervical dysplasia and HPV persistence. Genes have also been associated with supporting viral infection and cell entry. Genotypes may influence an individual’s likelihood of exposure to HPV. For example, genetics may influence an individual’s sexual or risk behaviors, thereby influencing the risk level of contracting HPV. Genetics may also influence an individual’s cervical cancer risk through HLA alleles. Seven alleles have been associated with cervical cancer, while another four showed a negative association.  Specific genotypes like BRACA have also been investigated on cervical cancer. It was found that the BRACA1 genotype was associated with a decreased risk of cervical cancer. The same variant is also associated with an increased risk of inherited breast cancer. Genetics and The Immune System Cervical cancer may also be driven by genetic factors that influence the immune system, decreasing some women’s ability to fight off infections like HPV.  The immune system is the key factor allowing HPV infections to progress from cervical dysplasia to invasive cancer. The progress from infection to cancer takes several years to decades to develop. The innate and adaptive immune responses are responsible for the regression, persistence, and progression of HPV infections. For example, women with HPV infections that evolve into high-grade lesions have a reduced immune cellular response. Genetics may also influence the number of immune cells an individual has to defend against infection. MTHFR Genetic Mutation Some people have a genetic mutation that prevents them from properly converting dietary folate into its active form (5-MTHF) by a process called “methylation”. This mutation may explain why some women with healthy diets and lifestyles struggle to clear the infection. The MTHFR mutation increases the risk of several diseases including heart disease, colon cancer, and breast cancer. Studies evaluating the association between genetic variants of MTHFR and cervical cancer show some association between the MTHFR C677T polymorphism and CIN 3. However, further studies are needed to determine the actual cause. An Emerging Field The research behind genetic predispositions to cervical cancer and cervical dysplasia is very much still evolving. As more research emerges, we may have more clarity as to what leads some to develop more severe reactions to HPV infection than others.
May 17, 2021
3 min read
Research update:  AHCC® found to clear HPV in a human clinical study conducted by Dr Judith A. Smith

Research update: AHCC® found to clear HPV in a human clinical study conducted by Dr Judith A. Smith

Adrienne Hill-Strathy
Many of you have expressed interest in the results of Dr. Judith A. Smith’s HPV study on the use of AHCC® in people with HPV. Her previous studies showed positive findings, suggesting that AHCC® may help eradicate HPV in individuals with persistent high-risk infections. We are excited to learn that a further clinical trial confirms positive findings and will soon be published. HPV and Cervical Cancer Cervical cancer represents around 10 percent of all cancers worldwide. The human papillomavirus (HPV) is the virus found to cause 99 percent of cervical cancers and is also associated with cancers of the throat, anus, vagina, vulva, and penis.  High-risk strains of HPV infect the epithelial layer of cells of the cervix. When HPV infections persist overtime (classified by positive HPV testing over two or more years), there is an increased risk of developing cervical cancer. As we understand more about the cause and progression of cervical cancer and HPV, we are also learning more ways to prevent and protect against it. Research has evaluated the use of a natural medicinal compound, AHCC® on HPV infections. What is AHCC® and how can it help eradicate HPV? What Do Your Pap Results Mean? AHCC® stands for Active Hexose Correlated Compound. It is a nutritional supplement derived from shiitake mushroom that acts as an immune modulator. The compound is safe and effective at increasing the number and activity of immune molecules including natural killer cells, dendritic cells, and cytokines, which help the body identify and fight off infections. The standardized extract of AHCC® was developed in Japan in 1992 by the company Amino Up Chemical Co. Ltd. Several studies have reported a variety of therapeutic effects from AHCC®, including antioxidant, anticancer activity, and improved immune responses. The positive findings of AHCC® in enhancing the immune response have led to the question of whether the compound could benefit people with HPV. The human research on AHCC® and HPV has been led by Dr. Judith A. Smith, Pharm D. a Professor and Director of Women’s Health Integrative Medicine Research Program in the Department of Obstetrics, Gynecology and Reproductive Sciences at McGovern Medical School. Here is what we currently know about Dr. Smith’s recent research endeavors: From Bench to Bedside In 2019, Dr. Smith published an article in the Frontiers in Oncology entitled: From Bench to Bedside: Evaluation of AHCC supplementation to Modulate the Host Immunity to Clear High-Risk Human Papillomavirus Infections. The study found clearance of high-risk HPV in vitro, in mouse models, and in two human pilot studies of 10 patients. The human trials found dosing of 1-3 grams of AHCC® daily for 3-8 months led to a 44-66.7% clearance rate of HPV infections. Dosing of 3 grams led to slightly higher clearance rates than 1 gram. This research study spurred further interest in the topic and led to a recently completed phase II trial. The New Research The most recent research study was a human double-blind, placebo-controlled trial. This means that the participants and the researchers were not aware whether the participants had supplemented with AHCC® or with placebo. The study included 50 participants, evaluated for either active treatment with a 3-gram dose of AHCC® for 6 months or a placebo. Participants were followed for 12 to 30 months. Individuals that continued to be HPV positive at the end of the 12 months, were considered treatment failures. Those that were negative after 6 months were followed for another 6 months to confirm if they remained HPV negative. This study also evaluated immune markers like CD8+ T cells or natural killer (NK) cells to monitor the physiological response to AHCC® supplementation. While the results of the study have yet to be published, Dr. Smith has confirmed reports that the results are aligned with the positive findings found in the first two pilot studies. The results of this follow-up study will be published this year. As soon as the new paper is made available, we will be the first to share it with you. What’s next? We are excited about the growing knowledge base around HPV, cervical dysplasia, and cervical cancer prevention and the use of natural medicine to play a role in responding to HPV naturally. Dr. Smith plans to extend the research to evaluate the potential of AHCC® supplementation in combination with chemotherapy for the treatment of HPV related cancers.
Mar 02, 2021
3 min read
The Life-Cycle of HPV

The Life-Cycle of HPV

Adrienne Hill-Strathy
Viruses aren’t living organisms but strands of DNA or RNA that make a home in other living organisms. By doing so, the viruses can survive. The life-cycle of a virus includes gaining entry into a living organism, replicating, and making itself a home. Understanding the life-cycle and how the immune system interacts with HPV can better understand why some strains develop into complications like cancer. What Makes The HPV Life-Cycle Unique? HPV includes a family of more than 150 types that have slight variations. HPV has adapted over time to target different tissue regions and cause different diseases. Most HPV infections occur around the mouth or genitals. Some infections cause visible growths like warts and others are asymptomatic. In addition to the type of HPV strain, symptoms also depend on the individuals' immune system. The immune system influences how quickly the virus is identified and eliminated from the body. Most HPV infections will complete their life-cycle without causing disease or symptoms at all. Infection Stage Infection occurs when the HPV gains entry into skin tissue, called epithelial cells. Epithelial cells line the surface of the body and can be classified into three shapes: squamous, columnar, and cuboidal. When it comes to testing for HPV and cell abnormality, squamous cells are the ones that typically develop abnormalities. Squamous cells are found in body tissue which forms the very surface of the skin. During a Pap smear, a swab is taken from this layer to examine for abnormalities. The cells meet the rest of the body through a layer called the basement membrane. This basement layer is where the HPV virus attaches and enters the cell. Once the virus has accessed the cell it can then use the cell to replicate. Squamous Cells Diagram Replication: Depending on the strain of HPV and the body the virus makes a home in, the life-cycle will have different outcomes. The virus may remain relatively silent. In this case, the virus doesn’t move beyond the basement membrane to cause disease. The virus may also begin to replicate, releasing its viral particles deeper into the host. When the virus replicates deeper into the skin tissue it is called a productive infection. Productive Infections Infections can be classified into grades CIN 1 (deregulated) to 3 (high-grade neoplasia). Persistent high-grade infections at CIN2 or CIN3 can further lead the virus to integrate into the individuals' genes. This puts the individual at greater risk of developing cancer. Some areas within the cervix lining are more susceptible to infection. HPV that gain access to the transformational zone in the cervix have been linked to higher rates of cancer progression. Two viral proteins, E6 and E7, have also been found on high-risk strains of HPV. These proteins are thought to be responsible for stimulating cell cycle entry into the upper epithelial layers and linked to cancerous changes. Latency In most cases, HPV will not reach a cancerous state. The majority (80-90%) of HPV infections will clear on their own. Even high-risk strains will likely be cleared by a local immune response. The virus gets inactivated through interaction with our immune system. In a healthy immune system, active infections will stimulate immune cells called CD4+ T cells. The presence of CD4+ T cells activates more immune molecules to overtake the virus. A compromised or weak immune system appears to increase HPV infections. In viral latency, viral particles continue to exist within the basement membrane in an inactive state. However, the virus can get reactivated following a change in immune status. What Makes Certain HPV Subtypes More Carcinogenic? In order for cancer to develop, the virus has to go undetected by the immune system over a prolonged period. Certain subtypes of HPV, like HPV-16 and 18 are more powerful carcinogens. What makes the virus carcinogenic is its ability to invade the cell layer for longer periods of time allowing changes in the gene expression of the underlying tissue. It is thought that the presence of E6 and E7 proteins on high-risk strains allows for cervical abnormalities to occur. How Can You Assist Your Immune System? It is clear from the research that a healthy immune system is key to preventing HPV infections from reaching a cancerous state. Diet and lifestyle create the foundation for a healthy immune system. Some important factors in supporting your overall health include: Optimizing nutrition and supplementation: Consuming fruit and vegetable-rich diet, limiting sugar and refined carbohydrate intake has a positive effect on the immune system. Managing psychological stress: Prolonged stress can imbalance the ability of the body to fight incoming infections. Engaging in daily stress management practices like meditation, exercise, and socializing can have a positive effect in improving the body's overall resiliency. Getting good quality sleep: Getting adequate rest, or seven to eight hours of quality sleep per night allows the immune system time to revitalize. Adequate sleep balances hormones and initiates cellular repair. Setting a regular bedtime, limiting caffeine intake in the afternoon, and eating a nutrient-dense diet are all ways to improve your sleep quality. Engaging in regular exercise and movement: From improved circulation to naturally increasing the immune cells, staying active has a range of benefits in helping support health and prevent disease. We recommend taking daily walks and engaging in bi-weekly strength training and aerobic activity.
Mar 01, 2021
4 min read
Green Tea Extract and Cervical Cancer/Warts

Green Tea Extract and Cervical Cancer/Warts

Christine Chung
The Greatness of Green Tea Green Tea Extract is one of the many great ingredients in Papillex™. Green Tea, also known by its Latin name Camellia sinensis, is high in compounds called polyphenols. Polyphenols are naturally occurring chemicals abundant in plants that have beneficial properties to human health. The polyphenols found in green tea are specifically beneficial in boosting the immune system in people with HPV. Two polyphenols, in particular, epigallocatechin gallate (EGCG) and polyphenol E are effective in the treatment of cervical lesions and warts caused by HPV. These master players, EGCG and polyphenol E, are antioxidants that help protect cells from oxidative stress and fight inflammation. EGCG is also associated with relaxation and keeping you alert. It is now recognized for the prevention of several conditions including autoimmune disease, heart disease, neurodegenerative disorders, and Alzheimer’s.  What does the research say? A handful of studies have begun investigating the use of green tea extract on HPV clearance, preventing cervical cancer, and eliminating genital warts caused by HPV. Green tea has been shown to influence a variety of mechanisms that are favorable towards preventing and treating HPV-related lesions. Most notably, green tea extract has been found to play a role in regulating immune molecules called T cells. T cells are important immune system modulators. EGCG from green tea extract has been found to increase the production of T regulatory cells, helping regulate and balance the immune response.  How do these compounds impact HPV? A review investigating the potential mechanism of action of green tea extract on HPV cells found that EGCG and polyphenol E specifically stopped the spread of HPV-related cancer cells by halting cervical epithelial and cancer cell growth. The study also found the compounds had a greater effect on squamous cells and less in adenocarcinoma cells. EGCG was also found to have a stronger growth inhibition than polyphenol E.  One study conducted in South Korea of 51 patients evaluated the use of green tea extracts, polyphenol E and EGCG, in a form of ointment or capsule in patients with mild to severe cervical dysplasia. The local ointment was applied to half the participants twice a week. The patients that received the oral treatment took 200 mg capsules every day for 8-12 weeks. The findings showed an overall reduction of 69% of cervical dysplasia lesions in patients who received green tea extracts, compared to only 10% improvement in the group with no green tea treatment. The participants in the ointment application had a slightly better response. How is green tea extract used to clear HPV warts? Warts are another pesky symptom of HPV. Green tea extract has been studied as a treatment option for both plantar warts and genital warts caused by HPV.  A study in the British Journal of Dermatology has found the topical treatment of green tea to be both effective and safe. The study used an ointment containing 10% green tea catechins and evaluated over 1000 adults with external genital and perianal warts. The participants that used the ointment containing green tea extract were found to be 2-folds more effective than the participants without green tea in their ointment. The green tea cleared existing warts and prevented recurrence 12 weeks after treatment. All of this promising research shows that green tea extract can serve as a worthwhile natural therapy for men and women with HPV associated cervical lesions (CIN) or warts. Is it safe for me to take? Green tea has an excellent safety profile in moderate doses, both orally and topically, and is associated with many health benefits ranging from heart health to anti-cancer properties.  The efficacy and safety of this topical green tea extract were confirmed by one of the few clinical trials available, including 397 adults with HPV genital warts. People who applied the treatment 3 times a day had complete clearance of warts in 16 weeks. So, do I just drink a lot of tea? Now you may be wondering, how many cups of green tea do I need to be drinking to benefit from these positive effects?  Unfortunately, to get enough of the green tea catechins to have an actual effect on prevention and healing, you would need to drink a ridiculous amount of green tea every day. Something in the 20 to 30 cup-per-day range! Nevertheless, the data does suggest that regular and high consumption of green tea may contribute to the prevention of cervical cancer.  To obtain the optimal dose, we recommend consuming green tea extract as a supplement. Luckily, there are many high-quality products, including Papillex™, that can provide you with a therapeutic dose to help your body naturally rid of HPV. What about topical application? The FDA approved a topical cream called Veregen®, a standardized extract of green tea leaves, containing 85% catechins, most abundant being EGCG. The compound is also being evaluated for its use in skin cancers like basal cell carcinoma. The topical cream can be applied in a thin layer twice daily to affected areas.   How Can Papillex Help? Attaining the therapeutic daily dosage of green tea can be a challenge without supplementation. Papillex has made it easy for you, combining high-quality therapeutic level extracts of EGCG from green tea containing in combination with several ingredients that work together to boost the immune system to respond to HPV naturally. Papillex is a simple and effective way to support your body and immune health.
Jan 15, 2021
4 min read
Could your rash be a symptom of HPV?

Could your rash be a symptom of HPV?

Adrienne Hill-Strathy
You’ve recently noticed a rash developing on your skin, making you wonder, is this HPV? HPV infections reside within the skin tissue and are transmitted through skin to skin contact. There are over 150 different viral strains of HPV that have evolved to infiltrate different areas within the skin and mucous membranes and are associated with different symptoms and progress to different diseases. Most HPV Infections are Asymptomatic Most HPV infections are silent. A person will contract an infection without having any visible symptoms. In about 90 percent of patients, a healthy immune system will typically develop an immune response to regress the virus within a period of 1 to 2 years. A small number of people suffer from persistent HPV infections and have an increased risk of developing cancer. However, these infections take many years to develop and through early detection and pap screening, complications rarely develop into malignancies. HPV Symptoms Typically, if symptoms do develop, they will either cause visible papilloma’s or warts on the surface of the skin or cause chronic infections that persist within the cell tissue and are only detected through clinical examination like a pap smear. HPV symptoms may include: Genital warts Skin warts Cancerous or precancerous changes in the cells of the cervix, detected during a pap test. Genital Warts Some low-risk strains of HPV can cause visible symptoms on the skin like common warts, genital warts, and plane warts. Genital warts are also known as condylomata acuminate. They are usually caused by HPV types 6 and 11. The warts appear as a soft, fleshy, cauliflower-like growths that grow in genital areas including the anus and penis. They can be painful, itchy, annoying, and, worst of all, highly persistent. Genital warts may also cause swelling in the genital area and lead to itching and discomfort. In women, warts often grow on the vulva, the walls of the vagina, or in between the external genitals and the anus. In men, they usually occur on the tip or shaft of the penis. Other Warts Caused By HPV Other warts caused by the HPV infection include plane warts, which tend to show up as small nodules on the hands or face. Plane warts can cause a mild rash on the hands of face during viral regression, but it is uncommon. Common warts typically show up as irregular shaped rough nodules that occur in multiples. These warts are also most commonly found on the fingers or hands, often featuring small black dots of clotted blood vessels. How Do I Get Rid of Warts? Each individual’s immune system responds differently to HPV, so each of us will have a different reaction to the virus as well. HPV strains that cause warts are classified as low-risk strains because they rarely develop into serious complications like cancer. Most warts will be cleared naturally by a healthy immune system. Implementing a healthy diet and lifestyle as well as incorporating natural treatments like green-tea extract, found in Papillex, has also been found to improve wart clearance. Rashes Although HPV affects the skin tissue, rashes are not typically a symptom of an HPV infection. As mentioned, some plane warts may present with a rash during viral regression but otherwise it is not a common symptom of an HPV infection. A rash likely indicates another skin infection, irritation, or sexually transmitted disease and requires further examination by your doctor.
Jan 01, 2021
3 min read
HPV Keeps Coming Back!

HPV Keeps Coming Back!

Adrienne Hill-Strathy
Contracting a strain of HPV is very common. You may have had it as a child in the form of a pesky plantar wart on the bottom of your foot or a small nodule that developed on your finger. In early adulthood, HPV is commonly contracted through sexual contact, with 80% of women contracting a strain within her lifetime. The common occurrence of HPV and its often-invisible symptoms may make you wonder, what happens after you’ve been infected, and can a virus reactivate? Here we breakdown a little more about HPV, HPV testing, how the virus enters latency, and whether infection can come back. We also provide some tips to help you maintain optimal immune health. What is HPV? The human papillomavirus includes a diverse group of over 150 viruses that infiltrate the body through our skin tissue and use the machinery of our cells to replicate their viral code. Depending on the strain and the immune system, an HPV infection may present a range of symptoms from visible papilloma, or warts, on the skin surface or genitals to no symptoms at all. Few high-risk strains may develop into complications like cervical cancer years after infection. HPV is typically considered a lifelong infection, once you have contracted a viral strain the DNA lives within your cells. However, the HPV virus can get deactivated and stop producing its viral load, referred to as viral latency. For more information on HPV, check out our article on What Is HPV? for an in-depth guide to HPV. HPV Testing HPV testing is done to evaluate the active presence and strain of HPV in a host. The screening tools for cervical cancer typically classify infection on the following levels: First HPV-positive results: this is a common result and most new infections will likely revert to a negative within 6 to 12 months but require follow-up. HPV-positive, cytology negative- patients with positive HPV status but negative cytology are at an increased risk of developing cervical cancer. A patient with the result will be recommended to be followed and repeat HPV and cytology in 12 months. Recurrent HPV-positive- often a positive HPV screen will be followed by an HPV negative. This suggests the immune system has made the HPV infection latent. The HPV infection can still recur upon reactivation due to a weakened immune system. Persistent HPV positive- a persistent HPV infection, that has been positive for over 12 months, is likely to develop into a CIN 2 infection within five to seven years. The infection should be closely monitored for potential progression. Persistent HPV-positive, low-risk cytology and negative colposcopy- In the situation, patients may still be at risk of disease progression, and active surveillance is still needed. Viral Latency The majority (80-90%) of HPV infections will enter a state of latency. Latency refers to a virus remaining in a resting state without producing its viral code so symptoms or complications don’t develop. In a healthy immune system, active infections will initiate an immune response through CD4+ T cells. Once these cells are activated more immune molecules accumulate at the site of infiltration and overtake the viral gene expression. A compromised or weak immune system seems to be the hallmark of HPV infections, where the failure to develop effective cell-mediated immunity to clear or control the infection results in persistent infection and increases the probability that the cells progress to cancer. Recurrence of Latent Infections Because the HPV particles continue to exist within the bottom layer of the epithelial cells, the virus can get reactivated following a change in immune status. Maintaining viral latency requires one to maintain a healthy immune system. When this fails or is compromised the virus can begin replicating again and may lead to symptoms or progress to complications like cervical cancer. Can I Get Re-infected? If you have contracted a strain of HPV in the past, you are not immune from catching further infections. The 150 different strains of HPV all have slightly different DNA and mechanisms of infiltrating an individual. It is estimated that 75-85% of females and males carry a strain of HPV. Therefore, engaging in sexual activity can expose an individual to further HPV infections and complications. Even women in long-term monogamous relationships can get re-infected. Research is looking to evaluate whether exposure to HPV viruses, particularly HPV 16 and 18, which cause the most cases of cervical cancer, can lead to natural protection against additional HPV strains. Thus far, there has been a lack of sufficient data on naturally acquired immunity and whether the previous infection can reduce rates of recurrence. Maintaining a healthy immune system Regardless of the strain of HPV, you have contracted, the key to silencing the virus and keeping it in its latency state depends on the health of the immune system. The immune system is multi-faceted, which means supporting it is complex as well. First, reducing risk factors like smoking, prolonged oral contraceptive use, assessing coinfections, and immune-related diseases is key to ensuring adequate immune functioning. Second, implementing a healthy diet, rich in diverse plant-based foods and good-quality proteins, reducing stress, getting good quality sleep, and engaging in regular exercise is also important to support our body and immune health. Lastly, supplementation can help replenish nutritional deficiencies that are essential for proper immune function. Papillex includes a range of nutrients known to be low in patients with persistent HPV infections and a number of herbs that help optimize our immune system.
Dec 01, 2020
4 min read
HPV And Fertility: What's The Impact?

HPV And Fertility: What's The Impact?

Adrienne Hill-Strathy
HPV is now considered the most common sexually transmitted infection among North Americans. The Center of Disease Control estimates that nearly everyone who is sexually active will have contracted a strain of HPV at some point in their lives. With HPV being highly prevalent in the young female population and infertility now affecting one-fifth of couples trying to conceive worldwide, many wonder whether contracting HPV will negatively impact fertility. Here, we outline the link and potential risks between HPV and fertility as well as some tips on what you can do about it. The HPV Fertility Link Most HPV infections do not pose fertility risks, but in some cases, they can. A healthy immune system will typically clear an HPV infection within a few years. Leaving the cervix and reproductive system in health to conceive and carry a baby. However, in the small percentage of HPV infections that do progress to cellular changes, lesions on the cervix, and inflammation have been associated with premature labor and low birth weight. Recent research on HPV infections and fertility is finding a correlation between HPV infections and reduced fertility through a higher number of premature ruptures of the membrane and spontaneous abortions. However, before you go sound your alarm bells, remember these studies are correlation-based, not causation. Many other factors can be contributing to this decline in fertility that was not identified in the study. More research is needed to make any conclusions that HPV does indeed reduce fertility. Does Treatment of Cervical Dysplasia Affect Fertility? Although most HPV infections will go away on their own, some require treatment that may affect the ability to conceive or reach full term in pregnancy. Cryotherapy, cone biopsy and LEEP procedures remove cells on the cervix and change your cervical mucus production. Procedures may also cause stenosis, or narrow the cervix, making it more difficult for sperm to reach the egg and get fertilized. The cervix may also weaken during treatment, leading to cervical insufficiency when your cervix widens and thins before coming to full term. Most women do not ever reach the stage of cervical cancer or require treatment. Cell progression is caught easily in pap tests, and preventative measures can be taken. The recommendation for disease control and prevention is to get one pap test every three years to keep an eye on your cervical cells, and more frequently if you have ever had an abnormal pap test. Can You Give HPV to Your Baby? There is a very low risk of transmission of a pregnant woman’s HPV infection to a child. One study followed 153 pregnant women through their pregnancies, some of which had previous HPV infections, and some with newly diagnosed HPV diagnoses through their pregnancies. Most pregnancies continue to full-term with no complications and babies are born with no signs of being carried by someone with an HPV infection. HPV Infection in Men There is growing interest in the impact of HPV in men and on male fertility in particular. Studies have found HPV infections are associated with reduced sperm quality, altering both motility and concentration of sperm. It was also found that HPV infection decreased cell count of normal-shaped cells and increased levels of ani-sperm antibodies. Nevertheless, research on the impact of HPV on male fertility is still developing and more research is needed to make any conclusions. What Can You Do About It? Fertility is impacted by a number of factors including hormones, stress, diet, age, lifestyle, etc. We know that taking proactive steps to protect and support your overall health and immune system will not only help fight off an HPV infection but foster a healthy home for a new life. Making lifestyle changes like eating better, exercising, sleeping well, keeping your stress levels low, cutting out smoking, alcohol consumption, and other toxic components of your life, will not only help you clear an HPV infection but also benefit fertility. Can I Take Papillex while Pregnant? Papillex is a great supplement for you prior to pregnancy. It will help keep your immune system robust, fighting the HPV infection. Papillex also contains supportive compounds like folic acid that helps with neural development and protects against birth defects. As well as vitamin C and E for a healthy immune system. However, Papillex is not recommended during pregnancy due to the mixed carotenoids in the ingredient formula. While beta-carotene, great against HPV, has not been associated with any complications in pregnancy, high doses of vitamin A have been. It is always important to consult your healthcare practitioner when taking any new supplements, especially if you are pregnant. For more information, head to our HPV and Pregnancy article.
Nov 01, 2020
3 min read
Superfoods and Juice Recipes to Fight Cervical Cancer

Superfoods and Juice Recipes to Fight Cervical Cancer

Christine Chung
Human beings are naturally programmed to eat foods that are healing and beneficial for our bodies. However, we all know that it isn’t always easy to follow this inner wisdom. When we really tap in and listen, healthy eating can become second nature – it’s truly conscious eating. Knowing the value of the foods you eat, as well as where they’ve come from and how to best infuse your body with the nutrients it needs, helps you help your body and allows you to thrive.  Excellent HPV Protection Properties So, which foods should we be packing our kitchens with to protect against HPV & cervical cancer? In general, stocking up on green leafy vegetables like spinach and romaine lettuce (packed with lutein and carotenoids), broccoli and cabbage (which have indole-3-carbinol) plus foods rich in antioxidants, vitamins C, E, and A (oranges, grapefruit, raspberries, carrots, and kale) offer protection from cancer by preventing the growth of free radicals in your body. Free radicals One way a healthy diet can positively impact health is by stabilizing free radicals in the body. Free radicals are molecules that contain an unpaired electron in their atomic structure. This electron is highly reactive in the body, damaging cell membranes, DNA, proteins, carbohydrates, and lipids. The body naturally produces free radicals during normal metabolic processes. However, we can also obtain free radicals from external sources like exposure to cigarette smoke, air pollutants, and chemicals. Cancers often stem from free radical diseases, as defects and oncogene activation get initiated by free radical reactions. Antioxidants, on the other hand, are molecules that can donate an electron to a rampaging free radical and neutralize it, reducing its capacity to cause damage. Consuming a plant and animal-rich diet, supplies the body with these antioxidants. Vitamin C, for example, is one antioxidant found in both animals and plants. It cannot be made by the body so we need to obtain it from our diet. The compounds from vitamin C reduce oxidative reactions in the body, helping maintain balance and reduce disease. Top 3 Superfoods The super foods we’ve included on this list are known for their exceptional HPV & cervical cancer fighting nutrients. Green Tea Green tea has also been shown to suppress urokinase, a type of enzyme that is thought to play a key role in the spread of cancer cells. Epigallocatechin gallate, or EGCG, and polyphenols E showed the inhibition of cervical dysplasia and cancer cell growth in cell studies. These studies actually show EGCG stopping the cancer cells right in their path and inducing cell death. Green tea extracts in ointment topically AND capsule forms were also shown to treat cervical lesions!  Papaya Papaya is one of the best sources of vitamin C, and carotenoids. Papaya’s nutrient combo has been associated with lower HPV infection rates and lower risk of cervical lesions. Low levels of carotenoids, found in many fruits and vegetables, was associated with increased risk of persistent HPV infections. Vitamin C levels were also seen to be significantly lower in cervical cancer patients with high positive rates of HPV 16 and 18, the cancer-causing strains of HPV.  Turmeric In recent years western medicine has started to pay attention to this extraordinary root. The compound found in turmeric that induce self-destruction of harmful cells is called Curcumin. Curcumin contains a class of compounds called curcuminoids that act by suppress regulatory molecules and signaling pathways involved in upregulating cancers and other diseases. Curcumin has been shown in research to not only eliminate HPV infections, but also help treat cervical cancer. It has been previously seen to have protective effects against cancer in HPV and non-HPV related cancers. Recipes Incorporating HPV fighting superfoods into your diet can be easy and delicious, which is why we’ve included three of our favourite easy recipes that will allow you to incorporate more of these ingredients into your day to day menu. If you don’t have all of the ingredients, creativity is key when it comes to keeping things fresh in the kitchen – so sub in what you do have and challenge yourself to add at least one of these foods into your life daily. So, here's a few of our favourites :) Papaya Coconut Green Smoothie This smoothie requires only a few ingredients. The papaya provides a boost of those HPV fighting carotenoids and vitamin C, while the kale is rich in antioxidants called quercetin and kaempferol. Add in some coconut milk and flakes for some extra creaminess and help keep you full. Frozen papaya Coconut milk Coconut flakes Fresh Kale Image via Loving it Vegan Matcha Green Tea Smoothie Drink this smoothie in the morning for a perfect hint of caffeine or it works as an afternoon pick. The subtle green tea flavor gives you cancer-fighting benefits of EGCG and a dose of vitamin C and carotenoids from the mango. Spinach provides an extra hit of folic acid another important vitamin in protecting against HPV infections. Mango (fresh or frozen) Frozen Bananas Handfuls Baby Spinach Matcha Green Tea Powder Coconut Milk Carrot & Turmeric Tonic Juicing can also be a great and delicious option to get in your daily nutrients. This juice provides a delicious mixture of carotenoids from carrots and cancer-fighting curcuminoids from turmeric. Lemons are full of vitamin C, folate and antioxidants. The ginger adds a flavourful bite and naturally reduces inflammation in the body and stimulates the immune system. Golden Delicious Apple Turmeric Ginger Lemon Carrots Cucumber
Oct 15, 2020
4 min read

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