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What Is Human Papillomavirus?

What Is Human Papillomavirus?

Dr Elizabeth Goldspink
Are you worried about HPV? Are you unclear as to what exactly HPV is? We at Papillex understand your concerns. HPV can be scary! That’s why in this article we have covered all you need to know about HPV so you can understand the facts and feel empowered toward your health. What Is HPV? The human papillomavirus (HPV) is a viral infection. HPV has become an extremely prevalent sexually transmitted infection worldwide, now topping the charts of the most commonly sexually transmitted infection in the United States. Most people think that HPV indicates that your body is in real dire straits, and it can cause some very serious health problems, including cervical cancer and genital warts. However, HPV can also just pass through your system quietly without any symptoms. This is why it is really important that you separate the fact from fiction as you understand what it means to carry the infection. This article aims to help you understand the truth behind the human papillomavirus infection, allowing you to feel more assurance at what it means to live with the condition. Types Of HPV There are many different types of HPV; in fact, more than 100 kinds have been identified. These variations are further divided into low-risk and high-risk strains, with each type leading to potentially different health problems. For example, skin warts are caused by HPV-1 to HPV-4. Types HPV-6 and HPV-11 are the main cause of common and genital warts. Types 16 and 18 are the strains most commonly associated with cervical cancer. Transmission HPV is primarily a sexually transmitted disease. In fact, the Center for Disease Control states that HPV is the most commonly sexually transmitted infection in the United States. However, sexual intercourse is not needed to transmit the infection, with HPV being transmitted through skin-to-skin contact. Having said that, most people do tend to get the infection through direct sexual contact, whether it be through vaginal, anal or oral sex. HPV is the most prevalent STI in the United States Symptoms may not develop right away; it can be years before any health problems are seen, which makes it hard to identify the source. Anyone who is sexually active, even with one person, can get HPV. Transmission At Birth Pregnant women with HPV can also pass on the infection to their child during delivery, although this occurs very rarely. In the case that this does happen the health impact on the baby can be quite severe, with it being possible that warts develop in the throat and/or airways causing recurrent respiratory papillomatosis. Symptoms and Health Problems For most people, symptoms of HPV do not manifest themselves until the infection has developed to a later stage, and at this point it may already be too late. This is why it is important to get yourself tested for HPV at regular intervals. As mentioned previously, there are more than 100 strains of HPV, with each affecting the possible symptoms a carrier of the infection may develop. In most cases for healthy men and women, HPV will go away of its own accord and not cause any health problems. A healthy lifestyle contributes to a heightened immune system. However, for those who may have a weakened immune system, it is possible that HPV can cause health problems. Common health problems caused by the HPV virus include: Genital warts Common warts Plantar warts Laryngeal papillomas Facial warts Precancerous lesions of cervix, anus, penis, vulva, or uterus Cervical cancer Penile carcinoma in men Cancer Development Cancer formation by the HPV virus involves two proteins encoded by HPV genes, called E6 and E7. These proteins interfere with the activities of other proteins which should prevent tumors from forming in your body, however, they are instead disrupted by E6 and E7. When these tumor suppressor proteins are disrupted, cancerous cells can form and go wild in your body. This process usually takes years as abnormal cells take a long time to become so far advanced. That's why it is absolutely vital that young women test regularly for abnormal cells with a medical professional. Diagnosis, Control and Prevention How do I know if I have HPV? Testing regularly for HPV is the first positive step to keeping HPV and cervical cancer in check. There are two prominent ways in which young women are screened for cervical cancer, the HPV test and the Pap Smear test. The Pap Smear tests for changes in the cells of the cervix, while HPV testing looks for the presence of the viral infection itself. Even if you are found to have abnormal cervical cells or HPV is found to be present in your system, most men and women will not develop any health problems from having the virus. It is important that women over the age of 21 go for routine pap tests How can I stop myself from picking up HPV? As the climbing rate of HPV prevalence makes it the most common sexually transmitted infection in the US, the focus should be on prevention. Using condoms the proper way each and every time you have any sexual contact will lower your chances of HPV. However, this will not fully protect against the virus - there is always a risk that there may be contact with infected areas whether you use a condom or not. So, what else can you do to stay free from HPV? Routine Pap Tests Regular pap smear tests are strongly recommended for women over the age of 21. The recommended interval for healthy young women with no prior history of abnormal cells is once every three years. Pap smear tests are especially recommended for women who have multiple sexual partners. Routine checkups are the best way to find HPV in its early stages in order to begin preventative measures. As men can be affected by HPV as well as women, men should also go for routine checkups and be screened for symptoms such as warts or precancerous lesions in the anal or penile region. HPV Vaccinations While HPV vaccinations do not protect against all strains of the virus, Gardasil, the most commonly administered, is effective at protecting against the 2 strains of HPV that cause genital warts and the 2 that are the most high-risk when it comes to causing cancer, including cervical cancer. If sexually active men and women were not vaccinated earlier, vaccination is recommended up until age 26. Gardisil is the most commonly used vaccination, protecting against the 2 strains of HPV that cause genital warts, and the 2 strains that are the most high-risk HPV strains, commonly known to cause cancer, such as cervical cancer. How Do I Fight HPV Naturally? HPV-related health problems or diseases can be fought by a healthy immune system. Commonly when someone has an HPV infection and it goes by unnoticed, it is due to their healthy immune system keeping the virus at bay. An immune system is the first line of defense against all diseases, including HPV. Lifestyle changes such as quitting smoking, decreasing alcohol consumption, regular exercise, mindfulness, and healthy dietary changes are a few ways to keep a robust immune system ready to fight back. Papillex is a supplement that contains vitamins and nutrients which have been shown in research to support the immune system in the fight against HPV, further aiding in preventing health problems like genital warts and cervical cancer. The ingredients in Papillex were hand-picked for their immune boosting properties. Take a look at the breakdown of Papillex's ingredients. Why watch and wait when you could be proactive? Order Papillex today!
May 23, 2019
6 min read
Photodynamic Therapy for HPV: What Is It and Does It Work?

Photodynamic Therapy for HPV: What Is It and Does It Work?

Christine Chung
Photodynamic therapy is a treatment typically used in the treatment of acne, warts, and a range of cancers, including mouth (oral), head and neck, lung, and skin cancer, and has been for a number of years now. However, PDT is now being considered a novel approach to eradicating the human papillomavirus. This follows a study conducted by scientists at the Mexico National Polytechnic Institute who found it to be effective in clearing the virus. Furthermore, it was reported that a researcher who worked on the project, Eva Ramón Gallegos, has used the method to remove HPV from 100% of a 29-women sample. So is PDT the cure for HPV that we’ve all been looking for? That remains to be seen. The latest reports are yet to be published in a peer-reviewed journal, and they were made a considerable amount of time ago now, back in February 2019. Nevertheless, PDT is worth exploring in the eradication of a virus which is the leading cause of cervical cancer in the world, and one of the most commonly transmitted sexual infections in the world. How Does PDT Work? PDT involves using a particular type of light in combination with a photosensitizing agent called aminolevulinic acid (ALA), which is applied as either a topical cream or injected into your blood to make your cells sensitive to light. Aminolevulinic acid, particularly 5-aminolevulinic acid, is an amino acid that is involved in a pathway called porphyrin synthesis in your body. When combined with the correct light wavelength, the procedure damages those surface layer cells affected by HPV, while surrounding tissue is left undamaged. Photodynamic Therapy in action for Acne In other words, ALA, makes your cells more sensitive to light, and when exposed to a certain wavelength of light, can kill cancer cells. PDT also works well for treating genital warts. The combined therapy attacks the skin cells of genital warts that continue to expand when they shouldn’t. In addition, the therapy was specific enough that it targeted these cells but left the normal, healthy skin cells alone. What Are The Benefits of PDT? Many women who suffer from HPV are of child-bearing age, so the risk of treatment to future pregnancies is a concern for this population. Luckily, photodynamic therapy poses a lower risk to current and future pregnancies. PDT is safer than other treatments during pregnancy Among other benefits, photodynamic therapy is also non-surgical, which also means there is no blood loss, no sustained damage to cervical tissue, and no reports of infertility related to treatment. Are There Any Downsides? PDT can be associated with some side effects, such as red, itchy skin, swelling, burning, or stinging at the site of treatment, however, these are relatively minor problems, especially in comparison to some of the treatments mentioned above. However, PDT can be expensive. This is dependent on the length of treatment and resistance of HPV, however, studies show that it is more cost-effective in comparison to some other treatments. How Effective Is PDT? We did the digging so you wouldn’t have to. So sit back, sip your green tea, and relax. Most clinical trials show that PDT is highly effective when compared to a placebo treatment, or a treatment where the study participants THINK they are getting PDT treatment, but in reality, they are not. When targeting CIN or HPV infections specifically to each patient, the complete remission rate is improved significantly. Keep in mind, the studies in this review were of lower quality. Studies show that with ALA-PDT, HPV can be effectively eliminated in those with latent or subclinical infections within 3 months. This is the population of people who have been diagnosed with HPV but have not or are not currently showing symptoms. Catch it early, and ALA-PDT therapy may work for you! Multiple 4-hour treatments of 5-ALA and PDT in males with genital warts show complete clinical remission after the last session. The number of sessions and strength of treatment was specified for each patient depending on HPV viral load, a number that dictates the severity of infection. By monitoring the viral load, doctors were able to keep an eye on the effectiveness of treatment, knowing when they needed to increase the intensity, or back off with treatment. Treatment effectiveness According to the evidence, the percentage strength of the aminolevulinic acid may impact effectiveness. Comparing 2 different studies, one clinical trial used a 20% aminolevulinic acid gel and showed a high complete response rate, meaning no more symptoms for the patients with HPVafter 3 treatments. Even after 1 year, follow-up tests showed very low levels of recurrence of symptoms in patients. Another study of higher quality used a 3% aminolevulinic acid gel with photodynamic therapy. Their results were generally positive for use in the treatment of HPV symptoms, however, they were not significantly different from the placebo group (recall: study participants THINK they are getting PDT treatment, but in reality, they are not). This study was of higher quality, so perhaps the other study was not as accurate. A third clinical trial from Mexico used a 6% aminolevulinic acid gel with photodynamic therapy. They were looking into eliminating HPV-16and HPV-18 and associated cervical intraepithelial neoplasia (CIN) in Mexican women. They found that at this percentage, HPV infections were successfully eliminated, with or without CIN progression. Specifically, in groups of people with cervical intraepithelial neoplasia, PDT showed to be very promising. CIN precancerous lesions, including carcinomas and early invasive cancer of the cervix, responded very well to photodynamic therapy. Improving HPV outcomes Well, newer studies are showing the effectiveness of using different analyses and numbers to track and guide the effectiveness of treatment. Researchers and doctors are keeping tabs on the HPV viral load to measure the effectiveness of treatment. This helps the treatment team to know if the current treatment is working if the dose should be increased, or if the treatment is working so well that they can start to use lower doses. PDT has been shown to significantly lower viral load after treatment. The better the treatment, the lower the viral load! They can also keep track using polymerase chain reaction assays (PCR) to give a grade of HPV, measuring the status of the HPV infection. DNA detection with genotype identification has also been used in this patient setting. The only thing you really need to know about this technique is that it can help find some precancerous or HPV lesions that are unnoticed. Using these techniques, one clinical trial saw two cases of anal warts cleared with no detectable HPV at the end of treatment or at 1 year after treatment. Mechanisms of Action ALA-PDT also works by downregulating the expression of the human papilloma virus E6/E7 oncogene, the gene responsible for producing precancerous and cancer cells associated with HPV. It also upregulates tumor suppressors, including p53, something that’s usually produced in your body to prevent tumors from growing. ALA-PDT causes apoptosis of H8 cells, which is very important. H8 cells are HPV-16 immortalized cervical epithelial cells. These cells are highly studied in HPV, as they activate the E6/E7 oncogenes and otherwise hide in plain sight by acting and functioning as normal human skin cells. One study found that by downregulating the E6/E7 oncogene and upregulating tumor suppressor, they were able to cure HPV infection-associated diseases and prevent progression into cervical cancer. The higher the dose of treatment, the higher the level of cell death of H8 cells. That’s a win in our books! In summary: Current research on available clinical trials show that PDT combined with ALA is very effective in the treatment for HPV and associated conditions. Infections of early or late stage, with or without CIN, and even infections progressed into cervical cancer are all potentially treatable by ALA-PDT. Trials are all new and of varying qualities, but the research available is all we have to determine the benefits of this new therapy. What else can you do? Lifestyle modifications, a healthy diet, and supplementation are key in maintaining a robust immune system to help clear the HPV infection. Even with the PDT, ensuring adequate wellness and a fully supported immune system will work in conjunction with the treatment to fight the battle against HPV! Discover the innate benefits in each Papillex ingredient and what exactly it does to support your immune system so you stay HPV-symptom free!
May 21, 2019
6 min read

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