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Mixed Natural Carotenoids vs. Synthetic Beta-Carotene for HPV: Why is this Distinction so Important?
Dr Elizabeth Goldspink
What are carotenoids?
They make your carrots orange, but what is the benefit to your health? Why do we include carotenoids in Papillex? Does the form matter?
Find all the answers to these questions…and more!
What Are Carotenoids?
Carotenoids, are a group of compounds that include lutein, zeaxanthin and lycopene. They are organic pigments that are naturally found in a variety of fruits and vegetables, such as carrots (as the name would suggest), tomatoes, and dark leafy vegetables such as spinach and kale.
Carotenoids are found in tomatoes too!
How Carotenoids Can Help
These compounds act as antioxidants and have shown to protect DNA from oxidative damage. The development of cancer in the human body is a multi-step and complex process, but protecting DNA from damage and mutation is important in preventing cancerous changes from occurring.
This is one of the reasons that a diet high in fruits and vegetables is linked to a decreased risk of developing a variety of diseases.
Carotenoids also help regulate immune function, and higher circulating levels of carotenoids were associated with a significant decrease in the clearance time of specific types of HPV infections, particularly during the early stages of infection (120 days and under).
Mixed Natural Carotenoids
vs. Synthetic Beta-Carotene for HPV
Our bodies
depend largely on vitamins and minerals, and the richest source of them come
from fruit, vegetables, and grains. Some nutritional supplements get their
vitamins and minerals from whole food
sources while others are made in laboratories and are termed synthetic.
Synthetic forms of vitamins are produced similarly to pharmaceutical medications. These are isolates of vitamins, lacking the complexity of the whole plant found in nature.
Supplements made from whole food concentrates contain the entire vitamin complex and are the best source of vitamins and minerals. They contain all of the cofactors that are required for healthy and optimal absorption and digestion.
These days, a large portion of the vitamins and minerals found as health food supplements are made synthetically, often lacking the accessory compounds required for absorption. A common example is beta-carotene, a powerful anti-oxidant that has been shown to protect DNA from oxidative damage and is a key ingredient in Papillex.
Beta-carotene is found naturally as a mixed carotenoid, complexed with other carotenoids including alpha-carotene, lutein, lycopene, zeaxanthin, and astaxanthin.
Carotenoids are natural fat-soluble pigments, the part that makes a carrot orange, found in fruits and vegetables. Diets rich in carotenoids have been correlated with lower disease risk. This includes plenty of colorful fruits and vegetables including carrots, tomatoes, and dark leafy vegetables such as spinach and kale!
These nutrients are potent anti-oxidants; which help to protect your cells from oxidative damage, and overtime may lead to potentially cancer-causing mutations.
A Closer Look At Lycopene
In humans, lycopene is found in the liver, adrenal glands, lungs, prostate, colon, and skin at concentrations higher than all other carotenoids.
Lycopene has been found to possess antioxidant and anticancer properties in animal and in vitro studies. Furthermore, much epidemiological research has linked high intake of lycopene-containing foods or high lycopene serum (blood) levels with reduced incidence of cancer, cardiovascular disease, and age-related eye disorders such as macular degeneration (think: Mediterranean diet). It has also been found to help protect skin against sunlight-induced oxidative damage.
Lycopene is found most abundantly in tomatoes, which gives it the red pigment, but it is also present in watermelon, apricots, green peppers, carrots, rose hips, pink grapefruit, and papillex, to name a few.
Lycopene is found in the red pigment of tomatoes
In addition to containing carotenoids, these fruits and vegetables also contain other health promoting nutrients such as folate, potassium and vitamin C. Another reason to increase your daily intake of fruits and vegetables. Remember to aim for 7-10 servings a day (1 serving = ½ cup)!
How Carotenoids Can Help Against Cancer
The development of cancer in the human body is a multi-step and complex process, but protecting DNA from damage and mutation is important in preventing cancerous changes from occurring. This is one of the reasons that a diet high in fruits and vegetables is linked to a decreased risk of developing a variety of diseases.
In a supplement
form, it is almost exclusively sold as an isolated
synthetic form.
With natural mixed carotenoids, the benefits are far greater, as
you are reaping the benefits of the antioxidant power of multiple beneficial
and synergistic compounds.
Making sure that you get an adequate amount of mixed carotenoids is very important to help regulate immune function, creating an optimal environment in your body for healing. It is also important to ensure that carotenoids are mixed, since taking a high dose of an individual carotene, especially beta-carotene, may have negative effects, as quoted by the Cancer Prevention Study Group.
This shows the importance of loading up on richly pigmented vegetables such as: peppers, tomatoes, carrots and kale. In addition, research suggests that additional support using clinically-researched nutrients can help support the body’s response to HPV.
Papillex uses only mixed carotenoids from pristine water algae. This ensures that our customers have the full spectrum
of carotenoids, from a whole food source. Our customers are guaranteed the most
potent form of antioxidants that help with healthy cell turnover and
regeneration.
What else can you do
naturally?
Carotenoids are just one of the many well researched and high quality ingredients in Papillex to help your immune system respond to your HPV infection naturally.
You should also consider making the following changes to your lifestyle:
Eat plenty of fruits and vegetables
Reduce alcohol consumption
Exercise to sweat
Drink green tea to combat HPV
Increase your daily intake of fruits and vegetables, ideally to 7-10 servings a day, and consider supplementing with Papillex.
Sep 18, 2019
4 min read
Christine Chung
What is Folic Acid?
Folate is a member of the B vitamin (B9) family, a water-soluble vitamin involved in many chemical processes in the body. Folic acid is the synthetic form of folate.
Folate is essential for the production of red and white blood cells and other important cells that help to convert food into energy and make DNA. Folate also plays an important role in the reproductive tract and is needed to maintain a healthy pregnancy.
The body cannot create folate on its own so we must obtain it through our diet or supplementation. Research on HPV has begun to highlight a strong association between folate deficiency and cervical dysplasia, emphasizing the importance of incorporating more folate-rich foods into your diet as well as taking a quality supplement.
Folate versus Folic Acid
Folate differs from folic acid in the way that the vitamin gets converted in the digestive tract. Folate is immediately converted into the active form of vitamin B9, called 5-methyl-THF (5-MTHF). Folic Acid enters the bloodstream and passes through the liver and other tissues in order to be converted.
Folic acid is thought to be better absorbed, however, it is metabolized at a slower rate, which means more can accumulate and linger in the system and may lead to excess. Folate, on the other hand, will be excreted if too much is consumed.
Folate Deficiency
Folate plays a critical role in your body so when it is lacking, it can lead to suboptimal health but it isn’t always easy to know when you are low in vitamin B9. Some symptoms include unexplained fatigue, anemia, muscle weakness, shortness of breath, difficulty focusing, brain fog, headaches, and heart palpitations.
Deficiencies in folate can cause megaloblastic anemia, which is when your blood cells form in an improper shape. This hinders their ability to function correctly in your body. Folate is especially important for pregnant women, as deficiencies can cause neural tube defects in a growing fetus.
Folate and Methylation
Without folate, the body has trouble maintaining methylation. Methylation is a biochemical process that helps support cardiovascular, neurological, and reproductive health.
The cycle of methylation begins with a methyl group (one carbon and three hydrogen molecules) converting amino acid, methionine into S’Adenosylmethionine (SAM-e). Once converted into SAM-e, this molecule travels through the body transferring methyl groups to other bodily systems. SAM-e Is finally converted to the amino acid homocysteine, which creates the antioxidant glutathione.
A deficiency in folate or B12 impairs the final stage of methylation, leading to elevated levels of homocysteine. Too much homocysteine increases the risk of heart disease and blood clots.
Methylation also regulates our genes, turning them on or off. One of the ways cancer develops is through impaired gene regulation. Not having enough folate can impair the body’s ability to regulate cell growth and increase susceptibility to cervical cancer.
MTHFR Gene Mutations
Some people have a genetic mutation that prevents them from properly converting dietary folate into its active form (5-MTHF). This mutation may explain why women with healthy diets and lifestyles struggle to clear the infection, while others who smoke and eat poorly can eliminate the infection with no problem.
Individuals with the MTHFR mutation have an increased risk of several diseases including heart disease, colon cancer, and breast cancer. Supplementing with the active form of folate (folic acid or methylated folate) can be beneficial for those with the mutation.
Methylation is also impacted by diet in general. Studies have found the degree of methylation in the body to correlate with the volume of fruit and vegetables participants consumed. The findings suggest that dietary modifications to include more folate in the diet can reduce the risk of cervical dysplasia.
Benefits of Folic Acid
The average adult is recommended to take 400mcg of folate daily. Although folate is best known for preventing neural tube defects in fetuses, new research is showing its benefits in cancer prevention including breast, bladder, cervical, ovarian, and pancreatic cancers.
Because folate is involved in reducing homocysteine, folate intake can influence heart disease. Recent research is showing benefits in reducing the risk of Autism Spectrum Disorder, Dementia and Alzheimer’s, and depression.
Food Sources of Folate
We recommend aiming for your daily dose of folate from food, before supplementing. Food sources of folate include:
Dark green leafy vegetables (i.e. kale, spinach),
Broccoli,
Black-eyed peas,
Liver,
Asparagus,
Brussels sprouts,
Avocado,
Broccoli,
Green peas,
Fortified Grains*.
*Because of the utmost importance of folate adequacy, the Canadian government, along with other governments have mandated folate fortification to many grains, like breakfast cereals, white flour, and pastas.
Folic Acid’s Role in HPV Management
Folate is one of several key nutrients that have been studied in relation to HPV.
Folate’s role in HPV is likely related to the methylation cycle mentioned above, which ensures your genes function normally.
Current research has highlighted the relationship between low levels of folate in the blood and high-risk HPV infection through the promotion of cervical dysplasia development.
Studies have found that individuals with a folate deficiency have an increased risk of positive HPV status, as well as an increased risk of progression to cervical and oral cancer. Whereas women with higher plasma folate and B12 levels with HPV-16 positivity were 60-75% less likely to be diagnosed with moderate cervical dysplasia.
There has been extensive research on the role of folate in HPV. We highlighted some key research below:
A 2003 study by Hernandez et al. showed that women with the highest levels of blood folate levels from either food or supplements have lower rates of cervical dysplasia from HPV.
A 2016 case-control study by Zhao et al. that included 271 controls and 214 women with both high and low-grade HPV lesions, found that low blood folate levels in women were coupled with a higher risk of cervical cancer from HPV.
A large analysis of studies, or a meta-analysis, showed an increased risk of cervical cancer among Asian populations with low blood folate levels.
A study by Bai et al. showed that a folate deficiency was associated with an increased risk of squamous cell carcinoma of the cervix and cervical intraepithelial neoplasia (CIN) in subjects who were HPV 16 positive.
In an Indian population, improving folate and vitamin B12 status may have a beneficial impact on the prevention of cervical cancer.
Scientific evidence shows that folic acid likely plays a protective role in HPV progression to cervical cancer.
Folate is one of the many key protective nutrients in Papillex. A daily serving of Papillex contains the equivalent of 5 ounces of poultry liver, 4 cups of chickpeas, or 40 spears of asparagus.
Should I Supplement Folic Acid?
It is estimated that 5 to 40 percent of the female population has a folate deficiency globally.
Ideally, we would obtain our folate from food sources like dark leafy greens, vegetables, fruits, nuts, and seafood. However, it can be difficult to get the recommended amount of folate from food alone. As mentioned, a person’s genetics may also make it difficult to convert dietary folate into its active form.
Folic acid supplementation of 400mcg per day is safe. The highest level of daily intake of folate that poses no risk of adverse health effects was set at 1,000 micrograms per day. Folic acid is also a water-soluble vitamin and does not accumulate in fat tissue. Therefore, excess intake will be excreted into the urine and out of the body.
Supplementation with folic acid is often recommended for pregnant women to prevent neural tube defects and prevent megaloblastic anemia.
Supporting HPV Naturally
Many doctors choose to implore a “watch and wait” tactic, as it is difficult to begin treatment without further progression of abnormal cells. Some people wait years before seeing this progression, and most surgical interventions do not have an immense effect on the early stages of cell changes.
Even if you eat the healthiest possible diet, you may still have several nutritional deficiencies which can harm the health of your immune system. This is why in addition to a diet high in richly pigmented fruits and vegetables, it’s important to supplement your diet with clinically supported nutritional supplements.
Papillex is a compound that contains high-quality, natural sources of nutrients that have been shown to support beneficial results in eliminating HPV infections. It contains ingredients that nutritionally support the immune system which will help the body to better respond to genital warts, cervical dysplasia, and other HPV-related disorders naturally.
Aug 07, 2019
6 min read
Vitamin D: The “Sunshine Vitamin”
Dr Elizabeth Goldspink
Vitamin D comes from the sun. Vitamin D is also a key player in maintaining overall health, supporting immune function, regulating inflammation, bone health, and many other essential body processes.
Unfortunately, many people are deficient in this crucial vitamin.
Most people in countries in the northern latitudes do not achieve their adequate dose, especially during the winter. Did you know that low Vitamin D levels can also affect your HPV status?
This blog covers the basics of HPV and how Vitamin D can be vital to your health and wellbeing.
Vitamin D: The Sunshine Vitamin
There are two main natural sources of Vitamin D, food and sunshine, with the sun being most people’s primary source of Vitamin D. This is why it can be more difficult to get the appropriate dose of Vitamin D in winter months when daylight shortens in cooler climates.
Ultraviolet light is absorbed into the skin, strikes the skin, and triggers Vitamin D synthesis, so sunshine is crucial!
Vitamin D is a fat-soluble vitamin as well as a hormone. It is best known for its crucial role in bone health. Without it, the body would not be able to absorb calcium, magnesium, or phosphate from food - which are essential minerals for bone strength. Without adequate calcium absorption, the body “borrows” calcium from the bones, increasing the risk of bone thinning, which may lead to osteoporosis and fracture. Vitamin D helps maintain normal blood levels of phosphorus, magnesium, and calcium for other body functions.
Vitamin D is so vital to bone health that governments mandated the fortification of certain food products, such as milk and milk alternatives to prevent severe deficiencies. Diseases caused by severe deficiency, such as rickets in children and osteomalacia in adults, were common before this fortification.
Vitamin D-eficient Symptoms
It isn’t always obvious when your body is in need of more Vitamin D. While the symptoms are often subtle, low levels of vitamin D can present with:
Low immune function – have you noticed you’re getting sick or run down more often than usual?
Fatigue – it can be as simple as an increased difficulty of getting out of bed in the morning.
Bone loss or pain – new and random aches and pains should be assessed by your primary healthcare provider.
Muscle pain and weakness – not able to crush it at the gym like usual? Having difficulty recovering?
Low mood or depression – often this is a key symptom of Seasonal Affective Disorder, where those who have dark, cold, long winters are deficient in vitamin D, leading to decreased pleasure or interest in doing things they used to love, low mood, and depression.
Impaired skin healing – with low vitamin D, it can be harder to heal something as small as a papercut or a skin blemish scar.
Hair loss – hair thinning or hair loss can be caused by low vitamin D levels
Can I test if I’m deficient?
Vitamin D levels can be checked through a blood test. The most common test is the 25-hydroxyvitamin D or 25(OH)D. It reflects vitamin D produced inside the body from both foods, sun, and supplements. Ranges above 20-30 ng/mL are considered sufficient for bone and overall health in healthy individuals. Levels over 50 ng/mL can be associated with adverse effects.
Getting tested can give a general indicator of your status and whether it might be useful to supplement. We always recommend talking to your doctor to get their take on what would be best for you.
What’s the connection between Vitamin D and HPV?
So now that you know the importance of vitamin D, how does this relate to your HPV status?
New research on Vitamin D is constantly emerging, increasing what we know about the many benefits this vitamin has for our health. Low levels have been linked to insulin resistance and diabetes, inflammation, impaired immunity, and certain autoimmune conditions, and cancer. As more research is conducted, the potential benefits of this “sunshine vitamin” are rapidly expanding.
The main connection between Vitamin D and HPV is in the immune system. An HPV prognosis can single-handedly be affected by the strength of your immunity, and Vitamin D is an essential part of keeping a robust immune system. A study in the United States links low vitamin D status to increased risk of developing a high-risk HPV infection among sexually active women.
Optimal Vitamin D levels have been found to play a positive role in both the adaptive and innate immune systems. Vitamin D has been found to boost the expression of white blood cells, which are the immune molecules known for fighting off infections and managing inflammation. Low levels of Vitamin D have also been associated with autoimmune diseases such as multiple sclerosis, lupus, diabetes, and rheumatoid arthritis.
The hormone has also been found to play a role in managing chronic inflammation, a key factor in nearly every chronic disease. Vitamin D manages inflammation through modulating cytokine production and proliferation. Cytokines are the immune systems chemical messenger systems that tell the rest of the immune system when to respond and react.
Vitamin D’s Anti-Cancer Effects
Another study outlined the importance of Vitamin D in the steroid hormone pathway, which regulates calcium. It explained the anti-proliferative, pro-apoptotic, anti-angiogenic effect of Vitamin D in cancer prevention.
In easier terms, Vitamin D was effective in decreasing cancer cell growth and increasing cell death of existing cancer cells. This study found a significant connection between blood levels of Vitamin D and HPV positive status. Vitamin D has proven anti-inflammatory functions, therefore the deficiency of Vitamin D and its metabolites could possibly relate to HPV persistence and other related cervical intraepithelial neoplasia.
Getting Your Vitamin D
The best way to get Vitamin D is through sun exposure. You need bare skin exposed to sunlight when it’s at its highest so that you can get enough ultraviolet B, or UVB, rays. 10 to 30 minutes per day around 11am to 3pm is optimal. Fair-skinned individuals may spend less time, while those with darker skin tones may need to spend longer. Darker skin tones will have decreased production of Vitamin D in the skin due to increased skin pigments which block UV light absorption.
Other factors that may affect Vitamin D synthesis in your skin from the sun include season, time of day, latitude, cloud cover, pollution, skin tone, clothing, sunscreen, and age. Except in summer months, the skin can make little if any Vitamin D from the sun if you live at latitudes above 37 degrees north. This includes all of Canada and most of the United States. Those ages 65 and up have decreased production of vitamin D with increasing age.
Although sunscreen is important for protecting the skin against harmful effects of the sun, such as skin cancer, sunscreen blocks your skin’s ability to produce vitamin D. Try sitting in the sun, sunscreen-free for 10 minutes, then generously applying sunscreen or cover-up after filling up your vitamin D stores!
To supplement or not to supplement?
For those who live in places with long, dark winters, or grey seasons (we’re looking at you, Canada!), supplementation is recommended. You should see your primary healthcare provider to get bloodwork to guide dosing and supplementation - supplementing too much vitamin D has been known to cause stomach pain and kidney dysfunctions. When picking your supplement, make sure it is in the active form of cholecalciferol.
Food sources may help with your Vitamin D levels as well. Food sources highest in Vitamin D include: canned sardines, salmon, tuna, sunflower seeds, liver, eggs, mushrooms, and fortified milk.
What else can you do naturally?
Most HPV infections are easily cleared by a strong, healthy immune system. You will likely clear the infection with no symptoms with a robust immune system. Your immune system can be supported in a number of natural ways:
Eat plenty of fruits and vegetables – fruits and vegetables contain many essential vitamins and nutrients to keep your body functioning at its best! These food groups are specifically high in antioxidants, which may help neutralize bad molecules floating around in your body.
Quit smoking – smoking single-handedly increases your risk for HPV-related cancers, even second-hand smoke exposure. While cutting down your cigarette count will still affect, nothing is quite as good as quitting entirely.
Reduce alcohol consumption – high consumption of alcohol is related to several negative risks, including a decrease in immune functioning.
Drink green tea – green tea has been shown in many studies to have immune-boosting benefits and anti-cancer effects, some specific to HPV.
Exercise to sweat – We recommend at least 20-30 minutes of light aerobic walking or cycling each day and 2-3 sessions of resistance training.
Get adequate sleep – getting 7 – 8 hours of high-quality sleep is important to regulate your bodily functions, including your circadian rhythm. All of these factors have a distinct effect on your ability to fight infections.
Jul 24, 2019
7 min read
Acrylamide: Are You Sure You Want Fries With That?
Christine Chung
There are many risky ingredients and chemicals in processed food that can increase your risk of cancer. Did you also know that the way YOU cook or process your food can also have a similar effect?
Keep reading below to get the low down on HPV and how acrylamide may affect your cancer risk!
What is Acrylamide?
Acrylamide is an industrial chemical that can be found in dyes, paper, plastics, and can even be used in treating water sewage. These are commonly seen in products we buy, in the packaging, and adhesives used.
Oh, and by the way, this chemical is also present in tobacco smoke.
How does this apply?
This toxic chemical can form in some foods when using high-temperature cooking methods, such as deep frying, pan frying, roasting, or baking.
This comes from a combination of sugars and an amino acid called aspargine that are presently found in food. These two components separately do not have a bad effect on your health, but during high-temperature cooking, they combine and can cause some pretty negative side effects on your health.
The exact temperature at which acrylamide forms in food has yet to be determined, but it has so far not been found in food prepared at temperatures below 120 degrees Celsius (248 Fahrenheit).
Why Should I Avoid Fried Food?
Acrylamide is yet another reason to avoid fried and processed foods since certain food preparation methods lead to the formation of chemicals that pose a potential health concern.
It was first detected in certain foods in April 2002 by the Swedish National Food Authority. Acrylamide is a chemical that naturally forms in certain foods, particularly starchy foods that are rich in carbohydrates and low in protein, during processing or high-temperature cooking, such as frying, roasting, and baking but not typically when boiling and steaming even at very high temperatures.
Those French fries you can’t help but get as the side of your burger? These are heavily contributing culprits to high levels of acrylamide. In fact, the highest concentrations of acrylamide are found in potato chips and French fries, and are followed by cigarette smoke.
Cancer Risk
The Joint Food and Agriculture Organization/WHO Expert Committee on Food Additives (JECFA) and the United States Food and Drug Administration has identified dietary exposure to acrylamide as a potential concern.
Acrylamide is known to cause cancer in animals at high levels. Elevated doses can also be toxic to the nervous system of both animals and humans.
An 11-year study in the journal of Cancer Epidemiology Biomarkers and Prevention found an increased risk of endometrial and ovarian cancer was associated with higher intake of acrylamide from food.
Here are other organizations’ takes on acrylamide:
The International Agency for Research on Cancer (IARC) classifies acrylamide as a “probable human carcinogen.”
The US National Toxicology Program (NTP) has classified acrylamide as “reasonably anticipated to be a human carcinogen.”
The US Environmental Protection Agency (EPA) classifies acrylamide as “likely to be carcinogenic to humans.”
While adverse effects to your brain and nervous system are unlikely at the estimated average exposure to acrylamide, changes in the actual structure and function of your nerve cannot be excluded for individuals with a high dietary exposure to acrylamide.
For a compound that is both genotoxic and carcinogenic, these MOEs indicate a health concern.
The take-home message: Avoid fried and processed foods and your body will thank you.
In addition to taking Papillex, eat a diet high in fruits and vegetables and minimize the ingestion of saturated fats, and processed foods that impair immunity and contribute to inflammation in the body.
3 Tips to Decrease your Acrylamide Burden
1. Boil or steam your vegetables.
By not roasting, baking, or frying your food, this will avoid the combination of sugars and amino acids that creates acrylamide. Boiling and steaming your food, no matter what temperature, is not connected with acrylamide formation. Acrylamide does not form, or forms at lower levels in fish, meat, or dairy products.
2. Don’t overcook your vegetables.
Cooking for longer periods of time, especially at higher temperatures can cause acrylamide formation. This will also help to sustain those good fibers to contribute to a happy gut.
3. Avoid fried potato products
...like French fries or potato chips, or any other fried vegetable, especially those with breading. Acrylamide is mainly found in plant-based foods, especially potatoes and grains, and even coffee! So think twice next time you choose French fries or breaded, deep-fried onion rings next time!
Bonus Tips for the Fried Food Fiends!
* If you find you just can’t get away from roasted, baked, or fried potato foods, soak your potato slices raw for 15 to 30 minutes before frying – make sure to dry the slices thoroughly to prevent oil fires!
* Avoid storing potatoes in the fridge before cooking. Studies show that this may increase levels of acrylamides formed during the cooking process.
* When frying, baking, or roasting potatoes, bread, or other vegetables, try cooking them to a lighter shade and avoid burning to decrease acrylamide production.
Want to know more about healthy eating? Check out our blog on healing HPV through food!
Jul 17, 2019
4 min read
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