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Sulfated Polysaccharides and HPV
Adrienne Hill-Strathy
Within the world of plants and fungi lie a vast array of medicinal compounds. Sulfated polysaccharides are powerful therapeutic compounds being explored for their anti-viral activity. These polysaccharides are shown to have potent anti-viral effects against viruses like the human papillomavirus (HPV) and the herpes virus (HSV).
Sulfated polysaccharides include compounds like heparin, cellulose sulfate, and dextran sulfate. Structurally, these compounds look very similar to heparan sulfate, an HPV cell-attachment factor. These compounds are found to inhibit papillomavirus and herpes infections due to their ability to block the viruses from attaching to healthy cells.
These polysaccharides also contain potent anti-inflammatory and antioxidant properties that help support cellular health and prevent tumor progression.
Where can you find these potent polysaccharides? Sulfated polysaccharides can be found in some species of medicinal mushroom as well as marine plants like red and brown algae.
Red Algae – Irish Moss (Chondrus crispus)
Irish moss is a type of seaweed or algae that is found on the Atlantic coast in Britain, Europe, and North America. The moss is rich in the sulfated polysaccharide carrageenan. You might know carrageenan from the back of your almond milk or yogurt. It is commonly used as a stabilizer and emulsifier in food products. The carrageenan found in common packaged foods is chemically processed and may even have negative health effects. However, consuming the moss in its pure form offers a range of beneficial vitamins and nutrients. Keep reading for a recipe.
In addition to its rich carrageenan content, Irish moss is also rich in other minerals like iodine, important for thyroid health. It also contains omega-3 fatty acids, which can reduce the risk of heart disease and high blood pressure. The moss also contains a carotenoid called fucoxanthin, which benefits blood sugar regulation and acts as an antioxidant, which we know is important for fighting HPV. Irish moss has been consumed for centuries and was used as a nutrient supply during times of famine.
Carrageenan acts as a potent HPV inhibitor by blocking HPV from binding to its attachment sites. Considering condom use is minimally effective in preventing HPV infection, carrageenan is being explored as a topical microbicide to be used preventatively against HSV, HIV, and HPV. The inhibitory effect appears to be strongest for HPV compared to HSV and HIV. Topical applications were found to be safe and well-tolerated, reporting no increased risk of reproductive tract infections or irritations. So far, carrageenan-containing sexual lubricants have been found to be effective at blocking HPV16.
Brown Algae – Fucoidan
Brown seaweeds contain a sulfated polysaccharide, called fucoidan. Fucoidan is a sulfated alpha L-fucan that has been found to support the immune system, reduce inflammation, and have an impact on blood pressure and infection. Animal studies have shown fucoidan to have a protective effect against liver injury by suppressing inflammatory mediators and increase the production of liver-protective enzymes. The anti-viral activity of fucoidan comes from its natural killer cell stimulation which promotes immune modulation and antitumor effects.
Brown algae also contain fucoxanthin, an antioxidant that gives algae its brown color, as well as other microminerals like iodine for thyroid health.
Fucoidan in brown seaweeds has been reported to possess anti-viral activities against viruses like HIV and HSV. The compound acts by inhibiting virus and entry and replication. More human studies are still needed to support its effects, but the compound could be used preventatively to reduce viral infections.
Lentinus Edodes- Shiitake mushroom
Shiitake mushrooms are one of the most well-known mushroom species. Medicinally, the shiitake mushroom is shown to be effective in the treatment of prostate cancer, can help lower high cholesterol, stimulates the activity of immune cells, and has antiviral and antibacterial properties.
The potent medicinal properties come from their high polysaccharide content of Beta-D-glucans. These glucans have been found to enhance the number of immune cells and have antiviral activity against the poliovirus and herpesvirus.
The beta-D-glucans found in shiitake aid in slowing tumor growth and kill viruses and other microbes.
Agaricus Blazei- Almond Mushroom
Another medicinal mushroom rich in polysaccharides is Agaricus Blazei, also called Agaricus subrufescens. Agaricus is a Brazilian basidiomycete often consumed as food or in tea to help with emotional stress, high cholesterol, diabetes, and gastric disorders.
Agaricus contains active compounds that have repeatedly been shown to activate the immune system and prevent the herpes virus from attaching to and infecting healthy cells. The compound also has anti-inflammatory and antioxidant properties, helping maintain the overall health of the cells.
Reaping the many therapeutic benefits of mushrooms isn’t as easy as eating sauteed mushrooms. Medicinal compounds must be extracted through water or alcohol-based decoctions. These powerful extracts are then taken in tinctures or powdered form.
What are the risks to consuming sulfated polysaccharides?
While generally quite safe for use, mushrooms like shiitake may cause an elevation in white blood cells, upset the stomach, and skin inflammation. Agaricus extracts can cause hypoglycemia, nausea, diarrhea, and upset stomach. Few have also reported liver damage and allergic reactions.
Because seaweeds contain iodine, there is a risk of consuming too much iodine and disrupting thyroid function. Sea vegetables like algae may also be exposed to environmental contaminants like arsenic and mercury. Make sure to purchase these supplements from a reputable source. Algae should not be taken with anticoagulant drugs like warfarin and heparin.
Given the immune stimulatory effects of sulfated polysaccharides, supplements should be taken with caution in individuals with autoimmune or immune system conditions. We always recommend seeking advice from a health care provider before starting any supplement or treatment.
Image from: https://divascancook.com/how-to-make-sea-moss-gel-recipe/
How to reap the benefits of Irish Moss
Irish moss can be bought in raw form or cultured into a gel. The moss can then be used topically or ingested. If taken orally, add 1 heaping tablespoon into a smoothie with frozen mangoes and dates.
2 oz of raw Irish moss
1700 ml of spring water
To make:
Wash moss thoroughly in filtered water.
Soak 2 ounces of dried Irish Moss on the counter in 1700 ml filtered water for one day.
Simmer on low until a gel is formed.
Irish moss has minimal taste, so it is perfect to blend into smoothies, juices, and soups or strews.
Store in the refrigerator for up to 2-3 weeks or kept frozen.
Nov 15, 2021
5 min read
The Nutrient Connection – How Micronutrients Could be at The Root of Your HPV.
Adrienne Hill-Strathy
When many of us think of the health benefits of food proteins, fats, and carbohydrates come to mind. These macronutrients make up the general composition of our foods but within them lie additional health-promoting compounds called micronutrients.
Micronutrients include trace minerals and vitamins that support the normal growth and development of living organisms. Without them, body systems like the immune system, nervous system, and digestive system can become impaired.
Many individuals are deficient in micronutrients. This can be due to low intake of dietary sources like fruits and vegetables and high intake of processed and nutrient-poor foods. Additionally, it is thought that the micronutrient quality of our fresh food has declined in recent years due to industrial agricultural production.
This micronutrient deficiency may be at the root of why some people struggle to eradicate HPV infections compared to others who clear the virus more easily. Several micronutrients have been specifically found to be low in individuals with HPV and cervical dysplasia - we’ll outline them below.
Portrait of female gatherer gathering organic vegetables with a wicker basket at orchard
The Key Players
Folate – Vitamin B9
Most people know of folate as an important nutrient for fetal development that should be taken during pregnancy. In addition to supporting a healthy pregnancy, Folate also plays a role in DNA production and red and white blood cell formation, and also plays an important role in HPV.
When folate levels are low, the body has trouble maintaining a process called methylation. Methylation helps support cardiovascular, neurological, and reproductive health. When the process is impaired, it can increase levels of an inflammatory compound called homocysteine. This compound can increase the risk of heart disease and impact gene regulation that helps regulate cancer cell growth.
There is a strong association found between folate deficiency and cervical dysplasia. Several studies have found that high blood levels are associated with a lower risk of cervical dysplasia and HPV and increased risk with low blood folate. Studies have also demonstrated that supplementation with folate may reduce the risk of cervical cancer.
Low dietary intake of folate may not be solely to blame for deficiencies. Some individuals have SNP’s in their genetic pathway that prevents them from converting dietary folate into its active form. These individuals may have higher levels of homocysteine and an increased risk of disease.
How to get your dose? Foods that contain folate include leafy greens, brussel sprouts, broccoli, and chickpeas. Folate can also be supplemented. The recommended daily intake of folate is 400 micrograms.
Lycopene and Carotenoids- Vitamin A
Vitamin A is derived from dietary intakes of those red, orange, and green-colored vegetables rich in lycopene and carotenoids. This vitamin also appears to play a role in cervical health.
Studies evaluating dietary intake and blood levels of Vitamin A found higher intake was associated with a reduced risk of cervical cancer. Whereas low dietary intake of carotenoids is associated with an increased risk of persistent HPV infections.
How to get your daily dose? To get more lycopene and carotenoids into the diet, aim for 6-8 servings of leafy greens, orange, red and yellow vegetables per day.
Foods rich in lycopene and carotenoids include: carrots, squash, tomatoes, broccoli, and red peppers. A dosage of 3000 mcg per day is recommended. Please note that Vitamin A should not be taken if pregnant, as excess stores can build up and cause birth defects.
Selenium
Selenium is another trace mineral that we must obtain from our diet. Selenium is important for thyroid function, reproductive health, and keeping the immune system running.
Many individuals are low in selenium due to the reduced soil quality of our foods. Low levels have been found to increase rates of cervical dysplasia. Selenium deficiency is thought to allow viral strains to mutate and progress.
How to get your daily dose? Selenium is found in high doses in brazil nuts. 3 nuts per day are adequate to reach the daily recommended dose of 200 mcg. Oysters have also been found to contain selenium.
Vitamin C
Who doesn’t love vitamin C? A powerful antioxidant that plays a role in many functions in the body. Vitamin C is important for immune system function, which is why we have all associated oranges and lemons with preventing colds and flu. Vitamin C also supports collagen production, iron absorption, and fuels and protects our cells.
Studies have found that higher intake of Vitamin C was associated with lower rates of HPV persistence compared to lower intake. Dietary supplements of Vitamin C were also found to reduce the risk of Cervical dysplasia in high-risk HPV infections.
How to get your daily dose? Foods like kiwis, red peppers, broccoli, citrus fruits, apples, and strawberries are high in vitamin C. The recommended daily intake is 75 to 90 milligrams. However, intake of up to 2000 mg a day is considered safe.
Vitamin E
Finally, Vitamin E deserves a mention - this vitamin is another powerful antioxidant found to protect against DNA damage and oxidative stress. Vitamin E may have anti-cancer effects.
A meta-analysis reviewing the relationship between vitamin E intake and blood levels of vitamin E has found the higher levels of vitamin E, the lower level of cervical dysplasia.
How to get your dose? Vitamin E is found in foods like sunflower seeds, almonds, peanuts, pumpkin, beet greens, spinach, and red bell pepper. The recommended daily intake is 15 milligrams per day.
Receiving our nutrients from foods is always the best method, however, it isn’t always easy to get our daily dose. That is why Papillex formulated its supplement with this research in mind to provide one supplement to meet all of your needs!
Sep 06, 2021
4 min read
Green Tea Extract and Cervical Cancer/Warts
Christine Chung
The Greatness of Green Tea
Green Tea Extract is one of the many great ingredients in Papillex™.
Green Tea, also known by its Latin name Camellia sinensis, is high in compounds called polyphenols. Polyphenols are naturally occurring chemicals abundant in plants that have beneficial properties to human health.
The polyphenols found in green tea are specifically beneficial in boosting the immune system in people with HPV. Two polyphenols, in particular, epigallocatechin gallate (EGCG) and polyphenol E are effective in the treatment of cervical lesions and warts caused by HPV.
These master players, EGCG and polyphenol E, are antioxidants that help protect cells from oxidative stress and fight inflammation. EGCG is also associated with relaxation and keeping you alert. It is now recognized for the prevention of several conditions including autoimmune disease, heart disease, neurodegenerative disorders, and Alzheimer’s.
What does the research say?
A handful of studies have begun investigating the use of green tea extract on HPV clearance, preventing cervical cancer, and eliminating genital warts caused by HPV. Green tea has been shown to influence a variety of mechanisms that are favorable towards preventing and treating HPV-related lesions.
Most notably, green tea extract has been found to play a role in regulating immune molecules called T cells. T cells are important immune system modulators. EGCG from green tea extract has been found to increase the production of T regulatory cells, helping regulate and balance the immune response.
How do these compounds impact HPV?
A review investigating the potential mechanism of action of green tea extract on HPV cells found that EGCG and polyphenol E specifically stopped the spread of HPV-related cancer cells by halting cervical epithelial and cancer cell growth. The study also found the compounds had a greater effect on squamous cells and less in adenocarcinoma cells. EGCG was also found to have a stronger growth inhibition than polyphenol E.
One study conducted in South Korea of 51 patients evaluated the use of green tea extracts, polyphenol E and EGCG, in a form of ointment or capsule in patients with mild to severe cervical dysplasia. The local ointment was applied to half the participants twice a week. The patients that received the oral treatment took 200 mg capsules every day for 8-12 weeks.
The findings showed an overall reduction of 69% of cervical dysplasia lesions in patients who received green tea extracts, compared to only 10% improvement in the group with no green tea treatment. The participants in the ointment application had a slightly better response.
How is green tea extract used to clear HPV warts?
Warts are another pesky symptom of HPV. Green tea extract has been studied as a treatment option for both plantar warts and genital warts caused by HPV.
A study in the British Journal of Dermatology has found the topical treatment of green tea to be both effective and safe. The study used an ointment containing 10% green tea catechins and evaluated over 1000 adults with external genital and perianal warts. The participants that used the ointment containing green tea extract were found to be 2-folds more effective than the participants without green tea in their ointment. The green tea cleared existing warts and prevented recurrence 12 weeks after treatment.
All of this promising research shows that green tea extract can serve as a worthwhile natural therapy for men and women with HPV associated cervical lesions (CIN) or warts.
Is it safe for me to take?
Green tea has an excellent safety profile in moderate doses, both orally and topically, and is associated with many health benefits ranging from heart health to anti-cancer properties.
The efficacy and safety of this topical green tea extract were confirmed by one of the few clinical trials available, including 397 adults with HPV genital warts. People who applied the treatment 3 times a day had complete clearance of warts in 16 weeks.
So, do I just drink a lot of tea?
Now you may be wondering, how many cups of green tea do I need to be drinking to benefit from these positive effects?
Unfortunately, to get enough of the green tea catechins to have an actual effect on prevention and healing, you would need to drink a ridiculous amount of green tea every day. Something in the 20 to 30 cup-per-day range! Nevertheless, the data does suggest that regular and high consumption of green tea may contribute to the prevention of cervical cancer.
To obtain the optimal dose, we recommend consuming green tea extract as a supplement. Luckily, there are many high-quality products, including Papillex™, that can provide you with a therapeutic dose to help your body naturally rid of HPV.
What about topical application?
The FDA approved a topical cream called Veregen®, a standardized extract of green tea leaves, containing 85% catechins, most abundant being EGCG. The compound is also being evaluated for its use in skin cancers like basal cell carcinoma. The topical cream can be applied in a thin layer twice daily to affected areas.
How Can Papillex Help?
Attaining the therapeutic daily dosage of green tea can be a challenge without supplementation. Papillex has made it easy for you, combining high-quality therapeutic level extracts of EGCG from green tea containing in combination with several ingredients that work together to boost the immune system to respond to HPV naturally.
Papillex is a simple and effective way to support your body and immune health.
Jan 15, 2021
4 min read
Christine Chung
Remember when your mom told you to eat your apples and oranges to fight colds and flu? She was onto something!
Vitamin C does it all - boosting energy, improving skin quality and mood, supporting iron absorption, and functions as an antioxidant and immune support.
Vitamin C, also known as ascorbic acid, is a water-soluble vitamin that plays an important role in human health. Vitamin C is an essential vitamin for humans, as we are unable to make it on our own. This makes it very important to get enough of this crucial vitamin through our diets or supplementation.
Vitamin C is most known for its role in fighting colds and flu. However, this vitamin is also essential for maintaining the structure and function of our skin tissues. It is involved in the creation of collagen for your skin and fuel for your cells and neurotransmitters. It is also a strong antioxidant, meaning it neutralizes toxic substances in your body.
This powerful vitamin is also an important player in supporting HPV infections.
Benefits of Vitamin C
The mechanism behind many of these benefits comes from Vitamin C’s role in managing oxidative stress. Oxidation occurs when the body breaks down proteins and cells, creating free radicals. These free radicals contribute to cellular damage. Vitamin C (an antioxidant) combats oxidative stress by neutralizing free radicals.
These antioxidant effects help protect connective tissue and form collagen layers in our skin tissues. Vitamin C also supports the immune system by neutralizing pathogens and inflammation which helps immune cells perform their job effectively.
New research sheds light on the connection between Vitamin C status and cancer risk. The study found that Vitamin C from fruits and vegetables was associated with a lower risk of cancer by decreasing the formation of carcinogens in your body.
Vitamin C levels are a good way to measure a healthy lifestyle and can be associated with heart health and decreased risk of strokes.
Let’s not forget the good old-fashioned common cold. Many people take Vitamin C at high doses to prevent colds, or shorten the duration and decrease the intensity of colds. Vitamin C has an anti-histaminic effect at high doses, which is likely to help with colds as well as allergies.
Vitamin C Deficiency
Vitamin C deficiency is famous for causing scurvy back in the days where men would be on ships for long periods, or during times of war and famine. Surprisingly enough, scurvy has been seen more recently in some university student populations.
The most common cause of Vitamin C deficiency is due to poor diet, alcoholism, anorexia, or smoking. Because Vitamin C is widely obtained from fruits and vegetables, it takes several months of poor nutrient intake for severe deficiency to develop.
Vitamin C deficiency can present with symptoms such as fatigue, malaise, and inflammation of gums.
Because vitamin C is an important component of collagen production, deficiency can result in skin conditions like keratosis pilaris, where rough, bumpy skin appears on the back of the upper arms and thighs. Skin may also appear dry, damaged, and bruise easily.
Vitamin C deficiency may also lead to slow-healing wounds, joint pain and it may contribute to iron-deficient anemia by reducing the absorption of iron from plant-based foods and negatively affecting iron.
How much Vitamin C do I need?
Vitamin C can be easily obtained through eating a fruit and vegetable-rich diet.
The recommended daily intake of Vitamin C is about 75 to 90mg. One kiwi contains about 75mg of vitamin C, an orange 83mg, and Brussel sprouts 70mg of vitamin C. Taking an additional 500mg in supplement form can provide an added positive effect.
The Vitamin is considered quite safe, the tolerable upper intake of vitamin C is around 2000mg a day for adults.
Food Sources
Food sources of Vitamin C includes:
Citrus fruits, including lemons, oranges, grapefruit, kiwi)
Bell peppers (specifically red and green)
Broccoli
Strawberries
Brussels sprouts
Tomatoes
Cantaloupe
* It’s important to remember that Vitamin C content may be decreased with heat and prolonged storage.
Remember that significant amounts of vitamin C in food are lost during high-temperature cooking, and during prolonged warming (i.e. keeping meals warm at 75°C for 4 hours). To get the most vitamin C intake from food, cook foods at lower temperatures and for shorter durations if possible, or opt for raw versions of foods when applicable.
Vitamin C’s Role In HPV
Vitamin C’s antioxidant and immune support properties explain Vitamin C’s important role in HPV clearance.
Vitamin C may be useful in preventing and treating a wide range of conditions. Many studies are showing that this Vitamin may even help treat and prevent cervical dysplasia due to HPV infection.
Persistent HPV and Vitamin C
A study in the Journal of Infectious Diseases found that the risk of type-specific persistent HPV infection was lower among women reporting the highest intake of Vitamin C in the study, compared to those reporting the lowest intake.
CIN and Vitamin C
Another study in the International Journal of Gynecological Cancer looked at whether dietary supplements, such as Vitamin C and multivitamins, were associated with cervical intraepithelial neoplasia (CIN), and found that dietary supplements may reduce the risk of CINs in women with high-risk HPV infections.
Natural sources of vitamin C include citrus fruit, cantaloupe, broccoli, Brussels sprouts, cauliflower, and potatoes as well as through supplements like Papillex. Relief of HPV symptoms is another amazing reason to increase your daily intake of fruits and vegetables, and to try taking Papillex!
Vitamin C for Genital Warts
The immune-boosting properties of Vitamin C, along with its propensity for wound healing and creating healthy skin tissue also makes it an important ingredient in treating HPV complications like genital warts.
Studies have found oral intake of 1000mg of Vitamin C per day shortens the time of genital wart remission and marginally decreased the rate of recurrence compared to controls.
Obtaining Your Daily Dose
Obtaining a healthy level of Vitamin C can be as simple as adopting a healthy lifestyle and eating a diet rich in a variety of fruits and vegetables.
For example, having a kiwi with your breakfast, a serving of broccoli at lunch, and fresh tomato sauce at dinner can naturally replenish your body’s stores of Vitamin C. Remember, consistency is key. Eating fruits and vegetables throughout the day regularly is the best way to support our natural stores.
Supplementing with Papillex also offers a serving of 100 percent the daily value of Vitamin C.
Dec 15, 2020
5 min read
Three Antiviral Plants to Fight Infection Naturally
Christine Chung
Plants have been credited with having antiviral and immune-stimulating properties dating back centuries. Herbal medicine was used regularly in Ancient Egypt and China as natural remedies for all sorts of ailments.
Today, studies show that many plants not only have antiviral properties but can also increase the body’s endurance and resistance to a range of biological, chemical, and physical stressors.
Unlike prescription medicines, whose list of potential side effects can be long – antiviral herbal plants and adaptogens often have little to no side effects.
Antiviral Adaptogens
Adaptogens represent one category of herbs that help the body adapt to a variety of stressors. Adaptogens help strengthen the body's resilience to stress on a cellular level.
What makes adaptogens unique is that they:
Cause no harm or additional stress on the body.
Help the body adapt to many and varied environmental and psychological stresses.
Do not have a specific action on the body. They support all major systems like the nervous system, hormonal system, and immune system.
Adaptogens benefit the immune system by stimulating a specific white blood cell called a macrophage.
Macrophages are the first line of defense in eating up or destroying pathogens in the blood and clearing invaders from our system.
Supplementing adaptogens have been found to inhibit viral replication by interfering with the early events of viral adsorption and entry into target cells.
Natural Antivirals For HPV
Are you looking for a natural treatment for HPV?
Below, we have highlighted three antiviral herbs that are key ingredients in our clinically-researched, nutrient-rich supplement designed to optimize your body’s ability to respond to HPV naturally.
Camelia Sinensis - Green Tea Extract
Green tea (Camelia sinensis) has long been known to be a powerful antiviral that benefits the immune system.
Green tea is often used topically for genital warts, and can also be used topically in treatments of cervical dysplasia.
Orally, green tea intake has been associated with a decreased risk of cancer due to its powerful antioxidants. It contains polyphenols, catechins, and flavonoids, which are protective anti-cancer compounds.
Green tea extract provides antiviral activities through active compounds called epigallocatechingallate (EGCG), which have been found to play a critical role in cancer chemoprevention, diabetes, neurodegenerative diseases, stroke, and other biochemical disorders.
In viral infections, EGCG has been found to inhibit the early stage of infections, through attachment, entry and membrane fusion by interfering with viral membrane proteins.
Astragalus
Astragalus root could be your best friend when you’re looking to stop a virus from multiplying.
This powerful immune modulator has been used for centuries to promote resilience in the body. Recent studies have shown this herb’s impact on halting the growth of abnormal cells.
Astragalus does this by stimulating the immune system through enhancing the activity of our natural killer cells and killer t-cells. These immune molecules attack and neutralize invading pathogens in the body.
Astragalus also plays a role in the adaptive immune response. It stimulates the production of white blood cells, antibodies, and production of interferons, which respond to viral invaders.
Ganoderma Lucidum - Reishi Mushrooms
Ganoderma lucidum, more commonly known as Reishi mushroom, has been celebrated for its antiviral properties for more than 2000 years.
Reishi mushroom is a powerful anti-inflammatory and is tied to longevity, improved immune function, and mental clarity. Perhaps that’s why they’ve adopted the nickname “King of mushrooms.” Clinical studies have shown that the use of these medicinal mushrooms has dramatically impacted the clearance rate of HPV, both genital and oral.
Reishi is considered an adaptogenic herb. It contains proteins effective against viruses like herpes simplex and HPV by inhibiting viral replication and adsorption into target cells.
Papillex Supplement
Want to learn more about Papillex™? Check out the What is Papillex page to get the full list of our high potency ingredients.
Sources:
Lyu, Ling, et al. “Effects of Astragalus injection on cervical immortalized epithelial cell growth and its cell cycle regulation mechanism.” Journal of Hainan Medical University 22.4 (2016): 17-20.
Donatini, Bruno. “Control of Oral Human Papillomavirus (HPV) by Medicinal Mushrooms, Trametes versicolor and Ganoderma lucidum: A Preliminary Clinical Trial.” International journal of medicinal mushrooms 16.5 (2014).
Hernandez-Marquez, Eva, et al. “Inhibitory activity of Lingzhi or Reishi medicinal mushroom, Ganoderma lucidum (Higher Basidiomycetes) on transformed cells by Human Papillomavirus.” International journal of medicinal mushrooms 16.2 (2014).
Nov 15, 2020
3 min read
Why Healing the Gut Is the Key to a Healthy Immune System
Adrienne Hill-Strathy
Why Nutrition Is So Important
Nutrition
plays an essential role in maintaining proper function of the immune system.
The majority of the immune cells within the human body are found within lymphatic tissue surrounding the intestines, called the gut-associated lymphoid tissue (GALT).
The
location of the immune system near the digestive tract plays an important role.
This allows us to use food to synthesize molecules that are needed for the immune system to function and to help us quickly identify pathogens and invaders.
Eating a nutrient-rich and diverse diet helps ensure that we have the right inputs to form the immune system.
The close
proximity of the immune system to the digestive tract also leaves it vulnerable
to exposure to foods and invaders that may cause harm to the body.
Make the right decisions when it comes to nutrition to help your immune system.
Leaky Gut Syndrome
Modern
diets, low in vegetables and fiber and high in sugar, processed foods, gluten
and dairy, have been found to increase cross-reactions between the immune
system and the digestive system, referred to as leaky gut.
Leaky gut
occurs when the lining of the gastrointestinal tract becomes more porous and
permeable, allowing food particles and external invaders that normally would
flow through the gut to get into the blood stream.
As the immune system comes into contact with these particles, it tags them as invaders.
This
on-going activation between the immune system has been found to induce chronic
inflammation and contribute to chronic disease.
What to Eat to Improve Gut Health and Immune Function?
Improving the function of the gut and the immune system depends on adequate nutrition and fiber from a healthy diet.
The aim is
to eat food that nourishes the gut, ensures the integrity of the gut lining,
and promotes balance within the macrobiotic gut flora.
We can do
this in one of two ways.
Limiting Foods Like:
Sugar
Sugar and processed foods have been found to decrease the balance of beneficial bacteria in your gut. Consuming a diet high in levels of glucose, fructose, and sucrose has been found to create an imbalance of bad gut bacteria.
Limiting consumption of refined sugars as well as natural sugars can support the growth of beneficial bacteria over other species.
Help your gut create good bacteria by reducing your sugar intake!
Gluten
Gluten is a substance present in
cereal grains that gives food shape and maintains a chewy texture.
Gluten also contains a protein in it called zonulin. Research has found that zonulin is the only human protein discovered to date that is known to reversibly regulate intestinal permeability by modifying intercellular tight-junctions in the gut lining.
By increasing the permeability of
the gut lining, greater interaction between the immune system and GI system can
occur, contributing to the pathogenesis of autoimmune diseases.
Limiting
consumption of gluten-containing grains is a common approach to healing
intestinal permeability and restoring immune function.
Fuel Up On
Fiber
Fiber is a structural component found in many plant foods like broccoli, brussels sprouts, oats, and apples.
Fiber isn’t digested fully by the intestines but helps bulk our stools and promote digestion to eliminate wastes. Eating more fiber can also be a great way to help feed gut-friendly bacteria, promoting beneficial gut flora.
Probiotics
Probiotics are microorganisms that
provide benefit to the host.
Our bodies contain trillions of
micro-organisms that facilitate enzymatic processes in the body.
Maintaining a proper balance of
beneficial probiotic bacteria is found to have a wide range of health benefits, including weight loss, improved
mood, and limiting overall inflammation.
Consuming foods like sauerkraut, kimchi, miso, and kefir can provide beneficial probiotics to the gut. A probiotic supplement can also help naturally increase beneficial gut bacteria.
Miso Soup is a tasty way to get some probiotics into your diet.
Diet Can Help Our Overall Immune Health
What we eat
has many implications for the outcomes of many diseases as well as our
susceptibility to infections and symptoms from viruses.
Modifying
our diet and lifestyle to incorporate more foods that support the gut
environment and limiting our intake of foods that can cause harm, is an
important step in supporting our overall immune health.
Mar 26, 2020
3 min read
Top 5 Ways to Protect Your Immune System against Coronavirus and other Viral Infections
Adrienne Hill-Strathy
How Your Body Fights Viruses: Mounting an Immune Response to Coronavirus, HPV, the Herpes Virus (cold sores), and more.
With the COVID-19 virus currently surrounding us, many of us are looking for natural ways to support our immune system.
The way the body fights off infections like COVID-19, HPV, and even cold sores caused by the herpes virus, are similar. Ensuring optimal function and balance of the immune system through nutrition, stress reduction, exercise and supplementation help the body respond to all viral invaders.
So, what leads one person to develop
symptoms caused by a virus and not another?
The answer lies in the unique functioning
of our immune systems.
How Our Immune Systems Fend Off Foreign Invaders
The immune system
can be divided into the innate and the adaptive responses.
The innate
response gets activated initially, launching immune molecules to rapidly
eliminate pathogens.
The innate
immune system includes natural killer cells (NK).
NK cells
are important at limiting the early phases of viral infections and attacking
self-cells that have become malignant.
The adaptive
immune system steps in second, when the innate needs assistance, providing
a more specific and amplified response to neutralize pathogens.
The immune
system usually does a good job of identifying what a self-molecule is versus a
foreign invader, preventing attack from disease. However, a number of factors
can limit the immune system’s ability to properly do its job:
Age:
Naturally, the immune response deteriorates with age. As we get older the body
produces fewer immune molecules to help fight off infections.
Disease: The immune system is linked to other systems in the body, like the nervous system, gastrointestinal system and endocrine system. In order to maintain balance, the other systems also need to be healthy. When something is compromised in the body, energy expenditure to the immune system will be impaired.
Inflammation: Lifestyle factors, like diet and stress, also play a role in our bodies ability to tag unwanted pathogens and produce immune molecules to them. If these systems are compromised, more energy will be needed to direct immune molecules elsewhere, weakening the immune response.
There are a
number of ways we can naturally support the immune system. The approach to
fighting off viruses like COVID-19 is the same as how we prevent against HPV
and other viruses.
Naturally Support Your Immune System
Eat a fruit and vegetable-rich diet
What we put into our bodies directly
interacts with our immune system through the gut-associated lymphoid system. Eating
a diet rich in fruits and vegetables is needed for all cells, including immune
cells to function properly.
A number of dietary interventions have been found to improve measures of gut health or reduce gut inflammation:
The Mediterranean diet, rich in
vegetables, fruit, nuts, legumes, fish and healthy dietary fats has been found
to reduce chronic inflammation.
Consuming probiotic-rich foods has
also been found to reduce inflammation and enhance the barrier function of the
gut.
Incorporating more fruit and veg into your diet can help your immune system.
Avoid or limit sugar and refined and processed foods
Simple
refined carbs include white sugar, white bread, white flour
and white pasta. Opt for whole grains
instead; the more complex the carbohydrate, the healthier it is for you.
Simple
switches like white rice to brown rice or quinoa, white bread to multigrain and
white flour to sweet potato can make all the difference, not to mention helping
keep you full and satisfied!
Reduce Stress
One of the
most important factors in optimizing proper immune system functioning is stress reduction.
Modern
humans rarely face stimuli that require us to fight-or-flee as our ancestors
had in times of predation. Instead, we are faced with numerous daily stressors,
leading to chronic stress.
The change
in immune activation has been found to down-regulate specific immune responses
in the body causing immunosuppression. The longer in duration and intensity a stressor
lasts, the greater the level of immunosuppression.
We can
reduce daily stressors through mindful activities like mediation,
spending time with loved ones, exercising, and journaling.
Meditating and exercising can help to reduce the impact of daily stressors.
Supplement with anti-viral herbs like Astragalus
Herbs can provide
added support to the immune system.
Astragalus,
a dried root, used as an adaptogen, has been found to help the body adapt to
physical, mental and emotional stress.
Astragalus
does this by stimulating the immune system through enhancing the activity of
our natural killer cells and killer
t-cells.
These immune molecules attack and neutralize invading pathogens in the body.
Astragalus
also plays a role in the adaptive immune response, stimulating production of
white blood cells, antibodies, and production of interferons, which respond to
viral invaders.
Check out our blog article to learn more about the immune boosting benefits of astragalus
Astragalus can help our bodies adapt to different kinds of stress.
Supplement with anti-viral medicinal mushrooms like Reishi (Ganoderma lucidum)
Medicinal mushrooms have been traditionally used in response to a variety of viral infections for centuries. They help prevent viral diseases, help the body overcome existing infections, and speed up recovery.
The biochemical mechanisms of antiviral herbs include
improving the virus-specific and nonspecific immune response (including
improved antibody production) and direct antiviral activity (mostly by
inhibiting their ability to multiply).
As traditional medicine and recent research have proven, medicinal
mushrooms can help against many viral infections, including:
parainfluenza and rhinoviruses (the common cold)
influenza (the flu)
herpes simplex (HSV-1 and HSV-2)
human papillomavirus (HPV)
herpes zoster or shingles (Varicella zoster virus)
mononucleosis (Epstein-Barr virus)
cytomegalovirus
hepatitis viruses, and many other viral infections.
Reishi mushrooms can help protect against many viral infection.
If you are already supplementing with Papillex, you are getting both of these anti-viral herbs, Astragalus and Reishi, in a daily dose.
A Multi-Faceted Natural Response
Together,
the diet, lifestyle, and targeted supplementation factors listed above can have
a profound impact on our total body function.
They can
help us reduce the severity of symptoms of a variety of viruses.
During
challenging times like these, it is important for us to remember that we have
the ability to optimize our immune system response to viruses, naturally.
Mar 19, 2020
5 min read
Mealtime Makeover: 7 Steps to Better Eating Habits for a Healthier Life
Christine Chung
For many, mealtimes are no longer rituals that invite you to slow down
and enjoy food in the company of loved ones.
Instead, meals are a true reflection of our fast-paced multitasking society - rushed, unfocused, and filled with negative thoughts. The focus has shifted to quick fixes, like takeout and processed foods, and this shift has a negative impact on overall health and well-being.
The effect your diet has on overall health should not be underestimated. It is one of the most important ways to help support your immune system against viruses and other types of infection.
Food is Supposed to Nourish, Strengthen and Heal.
As Hippocrates, the Father of
Modern Medicine once wisely stated, "Let
food be thy medicine, and medicine be thy food". Taking the time to
reconnect with the ritual of mealtime and to focus on food while we are eating
it is a great step toward better health. Simply relaxing and focusing on your
food can have tremendous positive health benefits.
Struggling to wrap your mind around this concept? Unsure of where to start? We did the homework for you.
Here are 7 key steps you need to take to improve your mealtime habits:
Practice Gratitude.
Being thankful in general has shown to have immense benefits for your health. Practicing gratitude for your meal also has equally positive benefits. It is the first step of honing your focus on your meal and calming down, changing your mindset to that of digestion. Being thankful for your meals can really help you appreciate the taste and nourishment of your food to a higher degree.
Chew your food.
This seems simple enough, but few of us actually do enough of it. Digestion begins in the mouth where our teeth mechanically break down large food particles into smaller ones, and our saliva begins the process of further breaking down food into particles that can be absorbed by our gut. Chew your food until it's a paste - it should be more liquid than solid to help the digestion process.
Don’t Drink Ice Cold Water with Meals.
Cold temperatures delay your digestion. Especially in cold months, we want to focus on warm, cooked foods to help rev up your gut to get digesting. Drinking cold water can freeze up your gut and slow digestion, leaving food feeling heavy and sluggish.
Take Time Off To Eat
Stop multitasking, even at work. Especially at work. Turn off your computer monitor, turn your phone to silent, stop working, and just eat. Take fifteen minutes to focus solely on the task of eating. Trust us, it's worth it. You'll feel better, and when you feel better, you can be more productive after you eat.
Take time out for your meals or you may not notice them!
Focus on Your Food
Ever noticed how easy it is to eat an entire box of cookies in front of the television without even realizing it? That's because you weren't focusing on the task at hand: eating. Be mindful of the smell, flavor, and texture of your food. You'll feel more satisfied with your meal. Avoid watching TV with meals, as it can distract you from your meal. The bright colors of cartoons, the intensity of action, the fear from thrillers – all of these actions will prevent your body from fully focusing on digesting.
Try To Eat at the Same Time Every Day.
Having regular mealtimes will keep your blood levels more steady, which helps control cravings and keeps energy levels consistent. Eating at the same time every day also lets your body anticipate meals and prepare for the task of digestion, making it more efficient.
Stop Eating When You Feel Satisfied, Not Stuffed.
Many of us as kids were taught to clean our plates, even if we were full. We need to retrain ourselves to stop eating when we no longer feel hungry. Eastern traditions dating back to Confucius suggest eating only until you feel approximately 80% full. You'll feel satisfied and no longer hungry, but won't feel the unpleasant sleepy side effects of overeating.
Working
on these 7 steps will send you on a more positive journey with food. Nourishing
your body is the most important when fighting HPV. Without proper digestion,
your body will never have the fuel it needs to support your immune system.
Looking for some extra support? Check out the ingredients in Papillex and see if it’s the right fit for you!
Mar 04, 2020
3 min read
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