Being Well Blog

Being informed means being empowered. Welcome to the latest information and actionable insights.

Latest Insights

How Does Birth Control Impact HPV?

How Does Birth Control Impact HPV?

Adrienne Hill-Strathy
One question we commonly get asked is how birth control may impact HPV. Birth control is commonly used by women of reproductive age to prevent pregnancy. Today, many also use birth control to support hormonal symptoms like PMS, acne, dysmenorrhea, and heavy menstrual bleeding. Many factors are often considered when choosing a birth control that is right for you. In this article, we will explore three popular birth control methods and things to consider with regard to HPV. Let’s Start With The Oral Contraceptive Pill (OCP) The OCP is a hormone modulating birth control. The OCP contains estrogen and progesterone, two hormones involved in the reproductive cycle. Individuals who menstruate often go on the OCP to prevent pregnancy as well as control hormonal symptoms like premenstrual syndrome (PMS), acne, painful periods, and heavy menstruation. The OCP is speculated to increase HPV persistence and progression. The pill may do this by altering certain genes as well as increasing the cervical maturation process which allows cell proliferation of HPV. By taking a synthetic hormone you may change the susceptibility of the cervical cells to high-risk infections. Moreover, because the OCP contains growth-stimulating hormones estrogen and progesterone, there is some risk that they can increase the risk of cervical cancer. Studies have found that long-term use (10 years or longer) of oral contraceptives has a four-fold increased risk of developing cervical cancer. A study of over 46,000 individuals found that those who are used OCP had a significantly higher rate of cervical cancer and abnormal cervical cell growth than non-users. The research does also suggests that the risk decreases after stopping the pill. HPV rates decline with time since quitting. The OCP may also lead to nutrient deficiencies associated with HPV.  The pill can deplete riboflavin, vitamin B6, folic acid, vitamin C, and zinc. We know these nutrients are important players in supporting the immune system and some have even been specifically linked to HPV. Moreover, the birth control pill is also known to alter the gut microbiome. The pill may increase leaky gut, dysbiosis, and candida overgrowth. A healthy gut is another foundation for our immune and overall health. Impairing this system can have a widespread impact on the rest of the body. Considering these impacts, it is important to support nutrient levels and gut health if taking the OCP. We recommend optimizing dietary intake of diverse fruits and vegetables, fibers, and probiotic foods as well as considering supplementation. Condoms Condoms are a favorable form of birth control when it comes to protecting against Sexually Transmitted Infections (STIs) and pregnancy. Condoms form a barrier between mucosal contacts and are found to be 98 percent effective at protecting against STIs like chlamydia and gonorrhea. However, because skin-to-skin contact can still occur with condom use, they are less effective at preventing the spread of herpes, genital warts, and HPV. That’s right. Unfortunately, HPV can still be transmitted through condom use. Nevertheless, condom use is still warranted and recommended. Some studies have found that the risk for genital warts and the grade of cervical intraepithelial neoplasia (CIN) was reduced in condom users. Condoms also protect against other STIs and infections that can contribute to co-infections and impair the vaginal microbiome. IUD The intrauterine device comes in both a hormonal and non-hormonal form. Both are inserted into the uterus for long-term, effective pregnancy prevention. The hormonal IUD delivers a small amount of progestin to the local uterine tissue. Some individuals notice side effects like changes in mood, bloating, cramping, or reduced menstruation. The IUD can also get displaced and in rare cases perforate the uterus. The hormonal release of the IUD is lower than the OCP. The IUD releases one hormone, progestin, at a dose of fewer than 20 micrograms each day. Whereas the OCP releases 1 milligram of progestin and 0.02 to 0.06 milligrams of estrogen each day. The non-hormonal option is a copper IUD that prevents pregnancy by releasing copper in the uterus that is toxic to sperm. The copper IUD will not suppress ovulation and the most common side effect is heavier menstrual bleeding. While the copper IUD has no hormonal impact, the heavier menstrual bleeding can contribute to iron deficiencies and anemia. What’s The IUD Connection with HPV? Some studies have shown that sexually active individuals with the IUD group had higher clearance rates of HPV. While others, when adjusted for other variables, found no association between IUD use and HPV infection or persistence. Research comparing the difference between the copper IUD and hormonal has found mixed results. One study found the hormonal IUD to have a lower risk of high-risk HPV than the copper IUD. Another study found the copper IUD to have a lower risk of cervical neoplasm. Overall, it is unclear how these devices are influencing cervical dysplasia and HPV infections or the mechanism of action. It is also important to note that the IUD and OCP do also not protect against other STI’s like chlamydia and gonorrhea, while condoms do. So how can you decrease your risk of HPV? You are probably thinking, what then can I use to protect myself against HPV and STI’s? Currently, condoms and engaging with fewer sexual partners are the best ways to reduce your risk of exposure to HPV. However, we understand that other factors are involved. We always recommend talking to your health practitioner to help decide what is best for you. Because most sexually active individuals carry some form of HPV and it can be transmitted through skin contact, no form of birth control can completely protect you. More importantly, you can support your whole-body system so that if you are infected, you are better equipped to defend against pathogens and viruses.
Dec 13, 2021
4 min read
Letting Go: The Shame of HPV

Letting Go: The Shame of HPV

Adrienne Hill-Strathy
Shame is the intensely painful feeling or experience of believing that we are flawed, and therefore unworthy of love and belonging (Brene Brown, 2012). We all have known and have experienced the discomforting wash of shame at some point in our lives. Under our shame often lies our rooted beliefs and experiences that tell us we are bad. Shame differs from guilt in that our guilt tells us we did something bad, our shame tells us that we are bad. Shame is intense and can lead to secrecy, silence, and judgment. STI’s and Shame From a young age, we have been taught to fear sexually transmitted infections (STIs). Sexual health education, media, and society have all painted the picture that STIs are dirty and disgusting - by that logic, if we catch one, we must be dirty and disgusting, too.  Because HPV is an STI, we often feel ashamed of our diagnosis.  Holding onto shame can prevent us from living a healthy life, and can contribute to stress and unhealthy behaviors that impair our immune system. Letting go of the shame associated with HPV may be foundational to our healing. In this article, we share a few ways you can reframe your narrative to understand that HPV isn’t something to be ashamed about. By releasing our shame, we make space to empower ourselves and others. How to Let go of Shame To let go of the shame of HPV, it is important to clarify a few things about the virus, how it is contracted, and how prevalent it is - with this information, we can begin to change our narrative. Creating a new narrative: the truth about HPV HPV is a virus.  As humans, we are naturally exposed to viruses and other pathogens that live in our environment - this is a part of life. Strains of the HPV family have an affinity for skin tissue in and around the genital or mouth areas. The virus is passed on through skin-to-skin contact with an infected individual. HPV is so common that an estimated 80 percent of women will contract a strain of HPV in their lifetime.  Once infected, the virus makes a home within the human tissue cells. In most cases, the immune system will identify and suppress the virus activity over time leading to no symptoms or complications. In some cases, the virus may proliferate and slowly cause cellular dysplasia that can lead to cervical cancer over many years. Given the large number of HPV strains and high transmission rate of the virus, the best way to avoid exposure includes abstaining from sexual activities or limiting your number of sexual partners. Sexual activity is a significant part of the human experience.  Asking you to suppress your sexuality would be like asking you to stay in your house for the rest of your life to avoid catching a cold. We can aim to prevent infection by avoiding risk factors, but we don’t want to miss out on life! Instead of staying at home, our body has an innate system called the immune system, which we rely on to support and protect us from infection and disease. We can take preventative action by making sure this system is up and running efficiently to protect us against viruses. Now that we understand a little more about the virus, it is time to foster a little empathy. Fostering empathy for yourself: If the root of our shame lies in our feelings of being unworthy of love and belonging, letting go of shame requires a healthy dose of empathy. Empathy involves showing compassion and kindness to ourselves, which can feel unnatural and uncomfortable at first. Imagine talking to yourself like you would talk to a young child or a close friend. How would you speak to them in a similar situation? I would imagine it is different from how you talk to yourself, because we are often harshest to ourselves. Remind yourself that you are not to blame, you are not unworthy, and you are deserving of care. Self-compassion and empathy is a continuous practice.  Name it to tame it One of the most powerful tools we can use to reduce our shame is to talk about it. When we can name our shame, we tame our shame.  So many women suffer the HPV diagnosis in silence but find that when they do speak up they can connect with so many others who are experiencing the same thing. Speaking up about our shame is a vulnerable and emotional risk. With that risk lies the power of vulnerability - it creates space for others to feel less afraid, less alone, and less ashamed. When we don’t talk about these things, we can unintentionally breed shame. Try opening up to someone you trust. Turn to a trusted friend, family member, or counselor - someone who can hold space for you and just listen. We know that talking to a partner can be scary and intimidating, but have found that many who have opened up about their sexual health with their partners often find it brings them closer. Speaking your truth also allows for a chance to practice being your most honest and authentic self. Shame has a powerful weight on each of us, and we all experience it at some point. Often, the shame associated with HPV is rooted in our misunderstanding of the virus and the narrative we have created around contracting sexually transmitted infections.  Remember that shame also does not help you and it does not help others. Be kind to yourself and show yourself compassion - your vulnerability can give others the courage and strength to let go of shame as well. Sources: https://www.ted.com/talks/brene_brown_listening_to_shame?language=en
Jul 26, 2021
4 min read
AHCC® and Genital Warts

AHCC® and Genital Warts

Adrienne Hill-Strathy
Genital Warts are one symptom of the Human Papillomavirus (HPV). Warts are caused by specific strains of the HPV family. These strains cause soft, fleshy, and often irritating growths around the genital areas. If you have developed genital warts, you are probably wondering, “how do I get rid of them?” and “what does this mean for my health?” In this blog, we break down all things genital warts, as well as provide information about a new medicinal mushroom compound called AHCC®. AHCC® has been found to support the immune system and eradicate viral infections like HPV.  What are Genital Warts? Genital warts usually appear on the vulva, vagina, scrotum, or penis a few weeks to two to three months after exposure to an HPV infection. The warts tend to be soft, fleshy, skin-colored, or appear as white bumps. They may grow in singles or multiples, sometimes appearing as a cauliflower-like growth. While genital warts can be itchy, annoying, and persistent, they are harmless. How Did I Contract Genital Warts? The HPV family includes over 100 different viruses that commonly infect humans. The virus is so common because it is easily transmitted through skin-to-skin contact.  Genital warts can be transmitted through sexual interaction with the vagina, anus, oral sex, or hand contact. Transmission can even occur through individuals without visible warts or symptoms. Given the ease of transmission, it is estimated that 80 percent of people will be exposed to an HPV infection at some point in their lifetime. The risk of developing complications depends on the viral strain of HPV that you have contracted.  What are the complications of contracting genital warts? Fortunately, the strains of HPV that cause genital warts do not cause cancer. The strains of HPV associated with warts are considered low-risk. HPV tends to arise two to three months after infection and can last anywhere from a few weeks to a few years. High-risk strains that are often asymptomatic can eventually progress into cancer. It is important to note that contracting one strain of HPV does not make you immune to contracting other strains of HPV. Even if you have low-risk HPV, you can still be exposed to high-risk strains and should follow your physicians’ recommendations and receive regular testing. You can also pass the infection on to another person even once the warts have gone away. Can genital warts be treated? If you have recently noticed an outbreak of genital warts - what can you do to get rid of them? HPV and genital warts can be treated. Viruses and other pathogens that affect humans are suppressed by the immune system. Immune molecules such as natural killer cells, cytokines, and macrophages play a role in identifying and eliminating these foreign invaders. One way to naturally enhance the function and production of the immune system is through medicinal mushrooms. AHCC® and genital warts Active hexose correlated compound, or AHCC®, is a medicinal mushroom extract with immune-modulating and antioxidant activities. AHCC® has been researched for its use in supporting immune function in cancer treatment, viral infections, and enhancing immune function. Studies have found AHCC® to increase the natural killer cell and cytokine production, allowing for greater activation of the immune system. AHCC® also enhances T-cell and macrophage production, helping eradicate and eliminate invaders. AHCC® has been clinically researched as immune support for people suffering from persistent high-risk HPV infections. Dr. Judith A. Smith, of the University of Texas, has led two clinical trials of the use of AHCC® in people with HPV. The studies have evaluated a dose of 1 and 3 grams of AHCC® daily in high-risk HPV-infected individuals. The results of both studies have found AHCC® to have statistical significance in eradicating HPV infections compared to placebo.   No research studies have specifically evaluated AHCC® on genital warts. However, the underlying immune system support is important for clearing viral infections because it is the first to respond to and identify threats to the body for elimination.  What else can I do? There are certain lifestyle changes you can make to reduce your risk of infection: Quit Smoking and reduce alcohol: Smoking cigarettes impacts nearly every tissue in the body. No safe limit is recommended for use.  Reduce alcohol intake: Drinking alcohol can suppress the immune system. If you choose to drink, aim for less than 2-3 glasses per week.  Long-term use of oral contraceptives: Oral contraceptives have been linked to an increased risk of cervical cancer. Amp up your diet: Eating a nutrient-dense diet full of fruits and vegetables. Individuals who consumed more vegetables are less likely to have HPV.  Green tea extract: Green tea extract has also been shown to inhibit the development of HPV warts and cervical lesions.
Jun 28, 2021
4 min read
How To Prepare For a Colposcopy Exam

How To Prepare For a Colposcopy Exam

Adrienne Hill-Strathy
Scheduling a colposcopy exam can come with a flood of anxieties - will it be uncomfortable? What if you receive an abnormal Pap? What comes next? If you’re feeling these concerns, you are not alone. We are here to equip you with a few ways to prepare your body, mind, and cervix for your next appointment.  If you have never had a colposcopy before, here is a little bit about what you can expect in the exam.  How To Prepare For Your Next Colposcopy Appointment Pre-Appointment: Feeling prepared for your appointment can reduce some of your anxieties and fears, we recommend: Scheduling your Pap appointment at an appropriate date and time can be helpful to reduce the stress leading up to the exam. Aim to schedule the appointment for the morning so you won’t increase your anxiety by spending the entire day thinking about it. It can also help to pick a day when you have fewer commitments. With less to do that day, you can schedule some time to do something nice for yourself after your appointment. Write a note for the appointment including important information and any questions you may have. For example: The last date of your period and cycle length Any medications you are taking Additional diagnosis Plans to conceive Remind your doctor of your unique situation. Jot down any questions you might have about your appointments, test results, and procedures. Knowing when and what is being tested over the coming months and year can help you plan and feel more prepared.  Take some time to get into your body. Doing something that engages your physical body or senses can help get you out of your mind and into your body. We recommend: Try a morning meditation Go for a walk Practice yoga Listen to relaxing music Inhale some essential oils Release your fears. Writing or speaking about your fears can be a helpful way of releasing them from inside of us. Take a few minutes to notice and acknowledge the thoughts you are having. Are they true? Are they helpful? Can you reframe your thinking? Create a mantra. Creating a mantra to repeat to yourself when anxious thoughts arise is another helpful technique to release anxiety. Something as simple as, “I am healthy, I am strong, I trust myself” can help bring us back into an empowered mindset.  At the Appointment: Share your questions, anxieties, and fears with your doctor. Most doctors understand the stress of the situation and voicing your fears can help them reassure you about the process and your health.  Bring a token with you. During the appointment, it can be helpful to have something you can hold in your hands to ease anxiety. You may want to bring a crystal, stress ring, or bracelet.  Use touch to calm the mind. Use your finger or hands to gently massage the back of your neck or wrist areas. These areas contain pressure points that can help bring us back to the present and increase feelings of relaxation.  Be your own advocate. Often, we look to authority to guide us instead of looking within. Remember that your doctors see many patients every day and despite caring for your health, they don’t live and experience your body as you do. You know your body and know what feels right or wrong. You are the best advocate for your health - so, voice something if you feel it is needed. After the Appointment: You did it! A colposcopy is hard, so be proud of showing up and making it through. Give yourself a hug and reward yourself with something you enjoy. Take a quiet bubble bath with candles, buy yourself flowers, release the tension with a sweaty yoga class, or schedule a catch-up with your most supportive friends. Do what makes you feel best. Schedule your follow-up appointments and reflect on where you want to be at that time. Are there elements of your lifestyle you want to focus on changing between now and then? Make a list of things you can do to support yourself through this time.  Obtain your results online. Many offices now offer online results. For some, it may be helpful to review your results at home before your appointment. Take time to think of any questions or concerns and allow yourself to enter your next appointment feeling informed. Unfortunately, we sometimes have to go to uncomfortable appointments because it is important for our health. In these times, we need a little extra self-care and grounding. We hope these tips provide some value and stress relief for your next visit but keep in mind that you are your own expert - your best guide is to look within!
Jun 14, 2021
4 min read
Research update:  AHCC® found to clear HPV in a human clinical study conducted by Dr Judith A. Smith

Research update: AHCC® found to clear HPV in a human clinical study conducted by Dr Judith A. Smith

Adrienne Hill-Strathy
Many of you have expressed interest in the results of Dr. Judith A. Smith’s HPV study on the use of AHCC® in people with HPV. Her previous studies showed positive findings, suggesting that AHCC® may help eradicate HPV in individuals with persistent high-risk infections. We are excited to learn that a further clinical trial confirms positive findings and will soon be published. HPV and Cervical Cancer Cervical cancer represents around 10 percent of all cancers worldwide. The human papillomavirus (HPV) is the virus found to cause 99 percent of cervical cancers and is also associated with cancers of the throat, anus, vagina, vulva, and penis.  High-risk strains of HPV infect the epithelial layer of cells of the cervix. When HPV infections persist overtime (classified by positive HPV testing over two or more years), there is an increased risk of developing cervical cancer. As we understand more about the cause and progression of cervical cancer and HPV, we are also learning more ways to prevent and protect against it. Research has evaluated the use of a natural medicinal compound, AHCC® on HPV infections. What is AHCC® and how can it help eradicate HPV? What Do Your Pap Results Mean? AHCC® stands for Active Hexose Correlated Compound. It is a nutritional supplement derived from shiitake mushroom that acts as an immune modulator. The compound is safe and effective at increasing the number and activity of immune molecules including natural killer cells, dendritic cells, and cytokines, which help the body identify and fight off infections. The standardized extract of AHCC® was developed in Japan in 1992 by the company Amino Up Chemical Co. Ltd. Several studies have reported a variety of therapeutic effects from AHCC®, including antioxidant, anticancer activity, and improved immune responses. The positive findings of AHCC® in enhancing the immune response have led to the question of whether the compound could benefit people with HPV. The human research on AHCC® and HPV has been led by Dr. Judith A. Smith, Pharm D. a Professor and Director of Women’s Health Integrative Medicine Research Program in the Department of Obstetrics, Gynecology and Reproductive Sciences at McGovern Medical School. Here is what we currently know about Dr. Smith’s recent research endeavors: From Bench to Bedside In 2019, Dr. Smith published an article in the Frontiers in Oncology entitled: From Bench to Bedside: Evaluation of AHCC supplementation to Modulate the Host Immunity to Clear High-Risk Human Papillomavirus Infections. The study found clearance of high-risk HPV in vitro, in mouse models, and in two human pilot studies of 10 patients. The human trials found dosing of 1-3 grams of AHCC® daily for 3-8 months led to a 44-66.7% clearance rate of HPV infections. Dosing of 3 grams led to slightly higher clearance rates than 1 gram. This research study spurred further interest in the topic and led to a recently completed phase II trial. The New Research The most recent research study was a human double-blind, placebo-controlled trial. This means that the participants and the researchers were not aware whether the participants had supplemented with AHCC® or with placebo. The study included 50 participants, evaluated for either active treatment with a 3-gram dose of AHCC® for 6 months or a placebo. Participants were followed for 12 to 30 months. Individuals that continued to be HPV positive at the end of the 12 months, were considered treatment failures. Those that were negative after 6 months were followed for another 6 months to confirm if they remained HPV negative. This study also evaluated immune markers like CD8+ T cells or natural killer (NK) cells to monitor the physiological response to AHCC® supplementation. While the results of the study have yet to be published, Dr. Smith has confirmed reports that the results are aligned with the positive findings found in the first two pilot studies. The results of this follow-up study will be published this year. As soon as the new paper is made available, we will be the first to share it with you. What’s next? We are excited about the growing knowledge base around HPV, cervical dysplasia, and cervical cancer prevention and the use of natural medicine to play a role in responding to HPV naturally. Dr. Smith plans to extend the research to evaluate the potential of AHCC® supplementation in combination with chemotherapy for the treatment of HPV related cancers.
Mar 02, 2021
3 min read
The Life-Cycle of HPV

The Life-Cycle of HPV

Adrienne Hill-Strathy
Viruses aren’t living organisms but strands of DNA or RNA that make a home in other living organisms. By doing so, the viruses can survive. The life-cycle of a virus includes gaining entry into a living organism, replicating, and making itself a home. Understanding the life-cycle and how the immune system interacts with HPV can better understand why some strains develop into complications like cancer. What Makes The HPV Life-Cycle Unique? HPV includes a family of more than 150 types that have slight variations. HPV has adapted over time to target different tissue regions and cause different diseases. Most HPV infections occur around the mouth or genitals. Some infections cause visible growths like warts and others are asymptomatic. In addition to the type of HPV strain, symptoms also depend on the individuals' immune system. The immune system influences how quickly the virus is identified and eliminated from the body. Most HPV infections will complete their life-cycle without causing disease or symptoms at all. Infection Stage Infection occurs when the HPV gains entry into skin tissue, called epithelial cells. Epithelial cells line the surface of the body and can be classified into three shapes: squamous, columnar, and cuboidal. When it comes to testing for HPV and cell abnormality, squamous cells are the ones that typically develop abnormalities. Squamous cells are found in body tissue which forms the very surface of the skin. During a Pap smear, a swab is taken from this layer to examine for abnormalities. The cells meet the rest of the body through a layer called the basement membrane. This basement layer is where the HPV virus attaches and enters the cell. Once the virus has accessed the cell it can then use the cell to replicate. Squamous Cells Diagram Replication: Depending on the strain of HPV and the body the virus makes a home in, the life-cycle will have different outcomes. The virus may remain relatively silent. In this case, the virus doesn’t move beyond the basement membrane to cause disease. The virus may also begin to replicate, releasing its viral particles deeper into the host. When the virus replicates deeper into the skin tissue it is called a productive infection. Productive Infections Infections can be classified into grades CIN 1 (deregulated) to 3 (high-grade neoplasia). Persistent high-grade infections at CIN2 or CIN3 can further lead the virus to integrate into the individuals' genes. This puts the individual at greater risk of developing cancer. Some areas within the cervix lining are more susceptible to infection. HPV that gain access to the transformational zone in the cervix have been linked to higher rates of cancer progression. Two viral proteins, E6 and E7, have also been found on high-risk strains of HPV. These proteins are thought to be responsible for stimulating cell cycle entry into the upper epithelial layers and linked to cancerous changes. Latency In most cases, HPV will not reach a cancerous state. The majority (80-90%) of HPV infections will clear on their own. Even high-risk strains will likely be cleared by a local immune response. The virus gets inactivated through interaction with our immune system. In a healthy immune system, active infections will stimulate immune cells called CD4+ T cells. The presence of CD4+ T cells activates more immune molecules to overtake the virus. A compromised or weak immune system appears to increase HPV infections. In viral latency, viral particles continue to exist within the basement membrane in an inactive state. However, the virus can get reactivated following a change in immune status. What Makes Certain HPV Subtypes More Carcinogenic? In order for cancer to develop, the virus has to go undetected by the immune system over a prolonged period. Certain subtypes of HPV, like HPV-16 and 18 are more powerful carcinogens. What makes the virus carcinogenic is its ability to invade the cell layer for longer periods of time allowing changes in the gene expression of the underlying tissue. It is thought that the presence of E6 and E7 proteins on high-risk strains allows for cervical abnormalities to occur. How Can You Assist Your Immune System? It is clear from the research that a healthy immune system is key to preventing HPV infections from reaching a cancerous state. Diet and lifestyle create the foundation for a healthy immune system. Some important factors in supporting your overall health include: Optimizing nutrition and supplementation: Consuming fruit and vegetable-rich diet, limiting sugar and refined carbohydrate intake has a positive effect on the immune system. Managing psychological stress: Prolonged stress can imbalance the ability of the body to fight incoming infections. Engaging in daily stress management practices like meditation, exercise, and socializing can have a positive effect in improving the body's overall resiliency. Getting good quality sleep: Getting adequate rest, or seven to eight hours of quality sleep per night allows the immune system time to revitalize. Adequate sleep balances hormones and initiates cellular repair. Setting a regular bedtime, limiting caffeine intake in the afternoon, and eating a nutrient-dense diet are all ways to improve your sleep quality. Engaging in regular exercise and movement: From improved circulation to naturally increasing the immune cells, staying active has a range of benefits in helping support health and prevent disease. We recommend taking daily walks and engaging in bi-weekly strength training and aerobic activity.
Mar 01, 2021
4 min read
HPV Keeps Coming Back!

HPV Keeps Coming Back!

Adrienne Hill-Strathy
Contracting a strain of HPV is very common. You may have had it as a child in the form of a pesky plantar wart on the bottom of your foot or a small nodule that developed on your finger. In early adulthood, HPV is commonly contracted through sexual contact, with 80% of women contracting a strain within her lifetime. The common occurrence of HPV and its often-invisible symptoms may make you wonder, what happens after you’ve been infected, and can a virus reactivate? Here we breakdown a little more about HPV, HPV testing, how the virus enters latency, and whether infection can come back. We also provide some tips to help you maintain optimal immune health. What is HPV? The human papillomavirus includes a diverse group of over 150 viruses that infiltrate the body through our skin tissue and use the machinery of our cells to replicate their viral code. Depending on the strain and the immune system, an HPV infection may present a range of symptoms from visible papilloma, or warts, on the skin surface or genitals to no symptoms at all. Few high-risk strains may develop into complications like cervical cancer years after infection. HPV is typically considered a lifelong infection, once you have contracted a viral strain the DNA lives within your cells. However, the HPV virus can get deactivated and stop producing its viral load, referred to as viral latency. For more information on HPV, check out our article on What Is HPV? for an in-depth guide to HPV. HPV Testing HPV testing is done to evaluate the active presence and strain of HPV in a host. The screening tools for cervical cancer typically classify infection on the following levels: First HPV-positive results: this is a common result and most new infections will likely revert to a negative within 6 to 12 months but require follow-up. HPV-positive, cytology negative- patients with positive HPV status but negative cytology are at an increased risk of developing cervical cancer. A patient with the result will be recommended to be followed and repeat HPV and cytology in 12 months. Recurrent HPV-positive- often a positive HPV screen will be followed by an HPV negative. This suggests the immune system has made the HPV infection latent. The HPV infection can still recur upon reactivation due to a weakened immune system. Persistent HPV positive- a persistent HPV infection, that has been positive for over 12 months, is likely to develop into a CIN 2 infection within five to seven years. The infection should be closely monitored for potential progression. Persistent HPV-positive, low-risk cytology and negative colposcopy- In the situation, patients may still be at risk of disease progression, and active surveillance is still needed. Viral Latency The majority (80-90%) of HPV infections will enter a state of latency. Latency refers to a virus remaining in a resting state without producing its viral code so symptoms or complications don’t develop. In a healthy immune system, active infections will initiate an immune response through CD4+ T cells. Once these cells are activated more immune molecules accumulate at the site of infiltration and overtake the viral gene expression. A compromised or weak immune system seems to be the hallmark of HPV infections, where the failure to develop effective cell-mediated immunity to clear or control the infection results in persistent infection and increases the probability that the cells progress to cancer. Recurrence of Latent Infections Because the HPV particles continue to exist within the bottom layer of the epithelial cells, the virus can get reactivated following a change in immune status. Maintaining viral latency requires one to maintain a healthy immune system. When this fails or is compromised the virus can begin replicating again and may lead to symptoms or progress to complications like cervical cancer. Can I Get Re-infected? If you have contracted a strain of HPV in the past, you are not immune from catching further infections. The 150 different strains of HPV all have slightly different DNA and mechanisms of infiltrating an individual. It is estimated that 75-85% of females and males carry a strain of HPV. Therefore, engaging in sexual activity can expose an individual to further HPV infections and complications. Even women in long-term monogamous relationships can get re-infected. Research is looking to evaluate whether exposure to HPV viruses, particularly HPV 16 and 18, which cause the most cases of cervical cancer, can lead to natural protection against additional HPV strains. Thus far, there has been a lack of sufficient data on naturally acquired immunity and whether the previous infection can reduce rates of recurrence. Maintaining a healthy immune system Regardless of the strain of HPV, you have contracted, the key to silencing the virus and keeping it in its latency state depends on the health of the immune system. The immune system is multi-faceted, which means supporting it is complex as well. First, reducing risk factors like smoking, prolonged oral contraceptive use, assessing coinfections, and immune-related diseases is key to ensuring adequate immune functioning. Second, implementing a healthy diet, rich in diverse plant-based foods and good-quality proteins, reducing stress, getting good quality sleep, and engaging in regular exercise is also important to support our body and immune health. Lastly, supplementation can help replenish nutritional deficiencies that are essential for proper immune function. Papillex includes a range of nutrients known to be low in patients with persistent HPV infections and a number of herbs that help optimize our immune system.
Dec 01, 2020
4 min read
HPV And Fertility: What's The Impact?

HPV And Fertility: What's The Impact?

Adrienne Hill-Strathy
HPV is now considered the most common sexually transmitted infection among North Americans. The Center of Disease Control estimates that nearly everyone who is sexually active will have contracted a strain of HPV at some point in their lives. With HPV being highly prevalent in the young female population and infertility now affecting one-fifth of couples trying to conceive worldwide, many wonder whether contracting HPV will negatively impact fertility. Here, we outline the link and potential risks between HPV and fertility as well as some tips on what you can do about it. The HPV Fertility Link Most HPV infections do not pose fertility risks, but in some cases, they can. A healthy immune system will typically clear an HPV infection within a few years. Leaving the cervix and reproductive system in health to conceive and carry a baby. However, in the small percentage of HPV infections that do progress to cellular changes, lesions on the cervix, and inflammation have been associated with premature labor and low birth weight. Recent research on HPV infections and fertility is finding a correlation between HPV infections and reduced fertility through a higher number of premature ruptures of the membrane and spontaneous abortions. However, before you go sound your alarm bells, remember these studies are correlation-based, not causation. Many other factors can be contributing to this decline in fertility that was not identified in the study. More research is needed to make any conclusions that HPV does indeed reduce fertility. Does Treatment of Cervical Dysplasia Affect Fertility? Although most HPV infections will go away on their own, some require treatment that may affect the ability to conceive or reach full term in pregnancy. Cryotherapy, cone biopsy and LEEP procedures remove cells on the cervix and change your cervical mucus production. Procedures may also cause stenosis, or narrow the cervix, making it more difficult for sperm to reach the egg and get fertilized. The cervix may also weaken during treatment, leading to cervical insufficiency when your cervix widens and thins before coming to full term. Most women do not ever reach the stage of cervical cancer or require treatment. Cell progression is caught easily in pap tests, and preventative measures can be taken. The recommendation for disease control and prevention is to get one pap test every three years to keep an eye on your cervical cells, and more frequently if you have ever had an abnormal pap test. Can You Give HPV to Your Baby? There is a very low risk of transmission of a pregnant woman’s HPV infection to a child. One study followed 153 pregnant women through their pregnancies, some of which had previous HPV infections, and some with newly diagnosed HPV diagnoses through their pregnancies. Most pregnancies continue to full-term with no complications and babies are born with no signs of being carried by someone with an HPV infection. HPV Infection in Men There is growing interest in the impact of HPV in men and on male fertility in particular. Studies have found HPV infections are associated with reduced sperm quality, altering both motility and concentration of sperm. It was also found that HPV infection decreased cell count of normal-shaped cells and increased levels of ani-sperm antibodies. Nevertheless, research on the impact of HPV on male fertility is still developing and more research is needed to make any conclusions. What Can You Do About It? Fertility is impacted by a number of factors including hormones, stress, diet, age, lifestyle, etc. We know that taking proactive steps to protect and support your overall health and immune system will not only help fight off an HPV infection but foster a healthy home for a new life. Making lifestyle changes like eating better, exercising, sleeping well, keeping your stress levels low, cutting out smoking, alcohol consumption, and other toxic components of your life, will not only help you clear an HPV infection but also benefit fertility. Can I Take Papillex while Pregnant? Papillex is a great supplement for you prior to pregnancy. It will help keep your immune system robust, fighting the HPV infection. Papillex also contains supportive compounds like folic acid that helps with neural development and protects against birth defects. As well as vitamin C and E for a healthy immune system. However, Papillex is not recommended during pregnancy due to the mixed carotenoids in the ingredient formula. While beta-carotene, great against HPV, has not been associated with any complications in pregnancy, high doses of vitamin A have been. It is always important to consult your healthcare practitioner when taking any new supplements, especially if you are pregnant. For more information, head to our HPV and Pregnancy article.
Nov 01, 2020
3 min read

Example subheading

Subscribe & Save

  • Savings of up to 20% off
  • Plus Enjoy Free Shipping to US / CA
  • Switch or Pause anytime
  • Peace of Mind