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If Intercourse Feels Off, It Could Be Inflammation - Not You
Lovisa Alatalo
Q&A on Pain, Pleasure, and the Inflammation Connection in IC, Endometriosis, and PCOS
Is it normal that sex has started to feel uncomfortable - or even painful?It’s common, but not something you have to “push through.” Many women experience changes in comfort, lubrication, or pain with penetration or deep thrusting at some point in their lives. While many factors can contribute, emerging research suggests that inflammatory balance may play a role. When inflammation persists, it may be associated with changes in nerve sensitivity, circulation, or tissue repair — factors that can affect comfort. Understanding this connection is the first step toward relief and reconnection with pleasure.
What do you actually mean by inflammatory imabalance - and how can it affect sexual comfort? Inflammation is a normal immune response that can help us heal from sickness. Challenges can arise when low-grade inflammation persists over time. In the pelvis, that can look like:
Heightened pain signaling and nerve sensitivity, which can amplify discomfort with touch or penetration
Tissue irritation, which may affect the vaginal vestibule, bladder, or surrounding pelvic structures
Changes to local circulation and muscle tone, which may contribute to tension and guarding
Some research suggests there may be a feedback loop where discomfort and inflammation reinforce one another. Breaking that loop usually requires a multi-pronged plan (more on that below).
How are IC, Endometriosis, and PCOS part of the same story?They’re distinct conditions - and you should always work with a clinician for diagnosis and care - but each condition has been studied for potential links between inflammation and changes in pelvic or sexual comfort.
Interstitial cystitis/bladder pain syndrome (IC/BPS): Characterized by bladder-centered pain, urgency, and frequency; dyspareunia is common due to pelvic floor tension and bladder irritation. Care guidelines emphasize stepwise, multimodal support.
Endometriosis: Inflammation is thought to play a role in the biological processes underlying endometriosis and related pelvic discomfort.
PCOS: Beyond hormones and metabolism, PCOS is associated with low-grade systemic inflammation that may influence ovarian function, body composition, and even sexual wellbeing via indirect pathways (mood, energy, lubrication).
Different conditions, shared theme: inflammation can disrupt comfort and pleasure pathways.
What symptoms suggest inflammation might be part of the picture?Everyone’s experience is unique, but red flags that warrant a chat with your practitioner include:
Pain with penetration or deep thrusting
Burning, rawness, or “paper-cut” sensations at the vaginal opening
Bladder pressure, urgency, or pain that flares with intercourse
Pelvic floor tension, a feeling of “guarding,” or post-coital aching
Cycle-linked flares (Endo), urinary flares (IC), or whole-body “inflamed” days (PCOS)
These can overlap with vulvodynia/vestibulodynia (localized pain at the vestibule), which often has an immune-inflammatory component and benefits from tailored care.
Besides biology, how does this affect the mind - and relationships?Pain changes behavior. When sex hurts, our brains naturally anticipate danger, which ramps up tension, cortisol, and - you guessed it - pro-inflammatory signaling. That loop can shrink desire and make pain more likely next time. Normalizing your experience, involving your partner in the plan, and addressing both physical and nervous-system factors can help you move back toward safety and pleasure.
Where should I start if I suspect inflammation is involved?Think layers, not a single fix. Consider this framework with your clinician:
Medical assessment and pelvic-floor care
Get evaluated for endometriosis, IC/BPS, infections, dermatologic conditions, hormone status, and pelvic-floor dysfunction. Guideline-based, stepwise care for IC/BPS and individualized endometriosis plans matter. Pelvic-floor physiotherapy (for downtraining, coordination, and breath) is often a game-changer.
Nervous-system regulation
Gentle breathwork, mindfulness, and body-based therapies can help shift out of chronic “guarding.” Framing interventions around safety and comfort can reduce pain amplification.
Nutrition for inflammation balance
Prioritize a mostly plant-forward, Mediterranean-style pattern: leafy greens, colorful produce, legumes, nuts, seeds, whole grains, and omega-3-rich fish. This pattern is consistently linked with lower inflammatory tone and may support symptom control in endometriosis. If you suspect triggers (e.g., alcohol, ultra-processed foods), track and test changes with a professional - avoid extreme restriction.
For a Wellex primer on practical, anti-inflammatory grocery choices, see Immune Health Grocery Guide: Strong Foundations for Inflammation Support on our blog.
Microbiome and tissue care
A healthy vaginal microbiome supports tissue resilience; scented products, harsh washes, and frequent douching can disrupt it. If dryness is part of the picture, explore pH-appropriate lubricants and moisturizers with your clinician.
Supplement strategies (evidence-informed, not prescriptive)
Depending on your case, clinicians sometimes consider omega-3s, magnesium, curcumin, quercetin, or NAC as part of broader care. These nutrients are being studied for their role in supporting a healthy inflammatory response and oxidative balance. They are not intended to diagnose, treat, cure, or prevent any disease. Quality, dosing, and fit with medications matter. Discuss with your provider.
Q: How does this play out differently in each condition?
IC/BPS
What’s happening: Bladder and pelvic tissues are hypersensitized; flares can follow stress, diet triggers, menstruation, or intercourse.
Why sex may hurt: Pelvic-floor guarding, bladder pressure, and urethral sensitivity can all contribute.
Useful angles: Guideline-based layering - behavioral therapies, pelvic-floor physio, bladder training, targeted symptom management, and clinician-guided nutraceuticals - often works better than any single tool. Keep a flare diary to personalize triggers without over-restricting.
Endometriosis
What’s happening: Inflammatory lesions and adhesions can cause deep pelvic pain and dyspareunia; immune activation and neuroinflammation amplify signals.
Why sex may hurt: Deep thrusting can stretch or compress inflamed tissues; periods may heighten sensitivity.
Useful angles: A team approach - gynecology, pelvic-floor physio, pain management, mental health support, and nutrition - helps address both lesion biology and pain amplification.
PCOS
What’s happening: Low-grade systemic inflammation is frequently observed, alongside insulin resistance and hormonal shifts.
Why sex may feel “off”: Symptoms can be indirect - energy, mood, lubrication, self-image - but addressing metabolic and inflammatory drivers often supports sexual wellbeing.
Useful angles: Sleep, strength + cardio, fiber-rich carbs, omega-3s, and insulin-sensitizing strategies supervised by your clinician.
What about vulvar or vestibular pain at the entrance (burning, “paper-cut” sensation)?Localized provoked vulvodynia/vestibulodynia is a leading cause of introital pain and is increasingly understood to involve immune-inflammatory mechanisms and peripheral nerve sensitization. Targeted care can include pelvic-floor downtraining, topical therapies, desensitization under guidance, and addressing contributors like recurrent irritation. A specialist evaluation is essential.
How do I talk to my partner when sex has become stressful?Language that centers safety and teamwork helps: “My body’s been in defense mode; I want to rebuild comfort together.” Agree on non-penetrative intimacy while you heal, use generous, pH-appropriate lubrication, and keep a shared log of what feels good or aggravating. Framing changes as temporary adaptations (not rejection) protects connection while you work your plan.
What does a realistic “next-30-days” plan look like?Try stacking a few high-leverage actions:
Book: An appointment with a clinician who understands pelvic pain; ask about IC/BPS workup if bladder symptoms are present, endometriosis evaluation if cycle-linked pain dominates, or vestibulodynia assessment for entrance-pain patterns. Bring a symptom + flare diary.
Start: Daily 5–10 minutes of diaphragmatic breathing and gentle pelvic-floor drops (on the exhale) to reduce guarding; add a short walk after meals to support metabolic and inflammatory tone.
Shift: Meals toward a Mediterranean pattern; aim for two omega-3-rich seafood servings weekly and a rainbow of plants most days. See Wellex’s [Immune Health Grocery Guide] for quick, realistic swaps.
Support: Discuss evidence-informed supplements with your practitioner (e.g., omega-3, magnesium, curcumin, quercetin, NAC) and ensure they fit your case and meds.
Set: Shared intimacy goals with your partner focused on comfort, exploration, and consent; revisit weekly and celebrate small wins.
Can supplements help - and where does Wellex fit?Supplements are tools, not cures. Formulations designed to support inflammation balance, pelvic comfort, and tissue integrity can complement the foundations above and the plan you build with your clinician*. If you’re navigating IC, Endo, or PCOS, talk to your provider about whether an evidence-informed blend maps to your goals - and remember that consistency beats intensity. For deeper context on hormone processing and “why balance over detox,” read The Hidden Link Between Inflammation & Estrogen Metabolism on our blog.
Bottom line - how do I reconnect with pleasure without ignoring my body?By viewing pain as information, not identity. Partner with a clinician, support your body’s natural balance, and work toward restoring comfort through evidence-informed care. Intimacy can become enjoyable again - not by forcing, but by re-teaching your body that it’s safe to feel good.
* These statements have not been evaluated by the Food and Drug Administration. This content is not intended to diagnose, treat, cure, or prevent any disease.
References
American Urological Association (AUA). Diagnosis and Treatment of Interstitial Cystitis/Bladder Pain Syndrome (2022 Update). AUA Guideline
Moradi, M. et al. (2021). Inflammatory Mediators and Pain in Endometriosis: A Systematic Review. PubMed
Khan, K. N. et al. (2024). Endometriosis: A Comprehensive Exploration of Inflammatory Mechanisms. PMC
Jamil, A. et al. (2024). Systematic Low-Grade Chronic Inflammation and Intrinsic Mechanisms in Polycystic Ovary Syndrome. PubMed
Li, X. et al. (2021). Chronic Low-Grade Inflammation in the Pathogenesis of Polycystic Ovary Syndrome. MDPI
Bornstein, J. et al. (2022). Immune-Mediated Mechanisms in Localized Provoked Vulvodynia (Vestibulodynia). PMC
Nov 17, 2025
7 min read
When Everyone Around You Is Pregnant: Navigating the Quiet Grief of Infertility
Victoria Gasparini
You log onto Instagram and see yet another baby announcement, pastel balloons, glowing faces, tiny shoes resting on a growing bump. You love your friends. You’re happy for them. But deep down, a quiet ache blooms in your chest. Maybe it’s been months, maybe years, since you first started trying. And still, nothing.
Infertility is more than a medical diagnosis, it’s a deeply personal, often invisible grief. It’s the cycle of hope and heartbreak. It’s celebrating everyone else’s joy while quietly mourning your own. And when it feels like everyone around you is pregnant, the isolation can be suffocating.
At Wellex®, we know this pain is real. And we want to hold space for it.
The Grief No One Sees
Infertility is a grief that doesn’t always have a name. It doesn’t come with casseroles or sympathy cards. It’s a silent kind of loss- of timelines, of expectations, of the ease you thought would come with building a family. You may not even realize you're grieving, but every month that passes without a positive test can feel like another tiny loss.
And when others announce their pregnancies, it can feel like your grief is being highlighted in high definition. It’s not that you’re bitter. It’s that you’re human. You’re allowed to feel joy for them and sadness for you. Those emotions can coexist.
You Are Not Alone
One in six people struggle with infertility. But it doesn’t always feel that way when you’re the only one not showing up with a baby bump to brunch. That sense of loneliness can be crushing, especially if you’re going through it silently.
If you’ve felt like skipping the baby shower. If you’ve left the grocery store crying because you passed the diaper aisle. If you’ve wondered what’s wrong with your body, you are not alone.
There is no shame in struggling to conceive. And while it may feel like everyone else’s path is linear and effortless, know that behind many smiles are stories untold- miscarriages, failed rounds of IVF, years of waiting, heartbreak and healing.
How to Cope When It Feels Like Too Much
There’s no perfect guidebook for navigating the emotions that come with infertility. But there are some steps that might help soften the edges of this pain:
1. Set boundaries, unapologetically. If you need to skip the baby shower, do it. If you need to mute social media accounts, do it. Protect your peace- this is not selfish. It’s self-preservation.
2. Find your people. Whether it’s a therapist, a support group, or even a trusted friend who gets it, don’t go through this alone. You deserve to be witnessed, to be heard, and to be supported.
3. Honor your emotions. You don’t have to “stay positive” all the time. You don’t need to be hopeful if today you’re not. Anger, jealousy, exhaustion- all of it is valid. Feel it, express it, and let it move through you.
4. Explore holistic support — when and if it feels right. There are gentle, natural ways to support your reproductive health- from nutrition and targeted supplements to stress management, sleep, and hormone balance. At Wellex, we believe in supporting the body as a whole, helping you feel grounded in your journey, whatever the outcome.
5. Reconnect with your body on your terms. Infertility can make your body feel like the enemy. Try to shift that narrative. Gentle movement, nourishing meals, journaling, even acupuncture or womb massage, these aren’t just wellness practices, they’re rituals of reconnection. You are not broken. You are worthy. You are whole.
Your Path is Still Sacred
It’s okay if your journey looks different. It’s okay if your motherhood story hasn’t unfolded yet or if it takes a different form entirely. You are not behind. You are not less-than. You are not forgotten.
And you are allowed to grieve, to be angry, to feel joy, to have hope, to feel hopeless- all in the same breath.
At Wellex®, we see you. We honor your story. And we’re here to support you, not just physically, but emotionally and spiritually too.
Because your path matters. Your pain matters. You matter.
Apr 28, 2025
3 min read
What’s the Best Lube for Vaginal Health?
Victoria Gasparini
If you’re like most people, you probably haven’t put much thought into what lube you choose. You may not realize that the lubricant you select for enjoyment can affect your vaginal well-being and potentially heighten your chances of developing different vulvovaginal issues if not selected thoughtfully. Given the vast array of lubricants available, including flavored and warming varieties, it's essential to understand how specific components and traits can enhance or interfere with your body's natural equilibrium.
pH and Vaginal Health: Why staying balanced matters
The vagina is a delicate ecosystem, naturally kept in balance by a slightly acidic pH level between 3.8 and 4.5. This acidity supports a healthy vaginal microbiome, promoting beneficial bacteria (like lactobacillus) while inhibiting the growth of harmful bacteria and yeast. When you use a lubricant with a pH that’s too high (alkaline) or too low (acidic), it can really throw off this balance, leading to symptoms like itching, irritation, or even infections like bacterial vaginosis (BV), and UTI’s.
What to look for:
Opt for pH-balanced lubricants: Look for a lube that lists a pH close to 4.0 to 4.5, especially for regular use. Lubes outside this range can disrupt vaginal acidity, compromising natural defenses.
Save the exciting lubes for external use: Many of us don’t know that flavored or warming lubes are often pH-adjusted for external application rather than internal use. If you enjoy them, limit their use to areas outside the vaginal canal to prevent pH imbalance.
Keeping your lube’s pH in mind not only ensures more comfortable intimacy but also helps protect vaginal health in the long term by maintaining that important balance.
Osmolarity: Why proper hydration is key
Osmolarity (say that 5 times fast!) refers to the concentration of particles (like salts and sugars) in a solution, and it affects how water flows in and out of our cells. Lubricants with high osmolarity (above 400 mOsm/kg) can draw water out of vaginal cells, causing dryness or irritation. On the other hand, low-osmolarity lubes (well below 250 mOsm/kg) can cause cells to absorb too much water, leading to a sticky or uncomfortable sensation. Ideally, you want a lube that’s isotonic—closely matching the natural osmolarity of vaginal tissues (around 250-400 mOsm/kg)—to keep cells comfortable and hydrated.
How to Choose the Right Osmolarity:
Go isotonic: Check for lubricants marketed as “isotonic” or with osmolarity close to 250-400 mOsm/kg. This ensures that the lube won’t disturb vaginal cells or cause moisture imbalances.
Beware of sugary ingredients: Lubes with added sugars can increase osmolarity and make dryness or irritation worse. Avoid ingredients like glycerin if you’re prone to irritation, as these can lead to “hyperosmotic” effects, which pull water out of cells, leaving tissues feeling dry and uncomfortable.
By choosing a lube with the right osmolarity, you can help maintain natural moisture and reduce the risk of post-use discomfort or irritation. This keeps intimacy enjoyable without impacting vaginal health.
How Lube Choice Can Affect Your Pap Smear
Pap smears are one of the most effective tools in early detection of cervical cell changes and HPV-related abnormalities. However, certain lubricants can interfere with these tests. Some lubes contain ingredients that can leave a thin, almost invisible film on the cervix, which might obscure results or make the test harder to interpret accurately. While this doesn’t mean you can’t use lube, it’s helpful to keep the following tips in mind when preparing for a Pap smear.
What to Do Before a Pap Smear:
Choose a simple, water-based lube: If you’re using lube close to the time of your appointment, opt for a water-based, pH-balanced option. Avoid using any lubricants the day of the appointment if possible, as even small traces can influence the test results.
Speak with your healthcare provider: Some clinics provide their own pH-safe, water-based lubricants that won’t affect the Pap smear, so check with your provider if you’re concerned. They can recommend the best approach for your appointment.
Being mindful of lube choice around Pap smears can ensure you get the most accurate results, giving you and your healthcare provider a clearer picture of your cervical health.
Does Lubricant Affect HPV? Indirectly, Yes
While lubricants don’t directly alter or prevent HPV transmission, maintaining a healthy vaginal environment can support your body’s natural defenses against viruses. When the vaginal microbiome is balanced and cells are healthy and hydrated, the immune system can better protect against infections, including HPV. Choosing a pH-balanced, isotonic lube that doesn’t irritate or disrupt cells is a small way to support overall vaginal health, helping your body create a naturally resilient environment.
Remember that the HPV vaccine and regular screenings are your best protection against high-risk HPV strains, but using a high-quality lube that supports vaginal health is another simple way to help your body function optimally.
Key Takeaways for Choosing the Best Lube
With all this in mind, here’s a checklist for choosing a lube that keeps your body balanced and comfortable:
Go for pH-balanced options: Aim for a pH between 4.0 and 4.5 to support your natural acidity and protect the microbiome.
Select an isotonic lube: Look for osmolarity between 250-400 mOsm/kg for proper cell hydration without causing dryness or discomfort.
Prepare for your pap smear: Stick with simple, water-based, pH-friendly lubes and avoid using any lubricants on the day of your appointment.
Skip unnecessary additives: Avoid ingredients like glycerin, parabens, and fragrances, which can irritate sensitive vaginal tissue and upset pH or osmolarity balance.
Our Top Suggestions
When factoring in all the above requirements, there’s actually only two lubricants on the market that we would suggest.
IRIS
Good Clean Love
Making the Right Choice Matters
Choosing the right lubricant might seem like a small detail, but it can make a big difference in how you feel and in supporting your vaginal health. By selecting a lube that’s pH-balanced, isotonic, and free from irritating additives, you’re prioritizing both comfort and long-term well-being. It’s an empowering choice that keeps intimacy enjoyable and protects your health—one small decision that goes a long way.
Dec 03, 2024
4 min read
Victoria Gasparini
So, you’ve been told you have HPV.
Maybe you heard terms like “high-risk” or “low-risk,” or maybe you kind of zoned out after hearing the diagnosis and now aren’t quite sure what type you have or how concerned you should be. If you’re feeling anxious or confused, you’re not alone. HPV diagnoses are common, and naturally, they come with a lot of questions. Some may worry right away about cancer risks, while others simply want to understand the types of HPV and how they affect health. Let’s break it down so you can feel informed and empowered.
There’s power in prevention, and knowing what type of HPV you have is a good first step to understanding your risks and preventing the development of more serious HPV-related cancers. Unfortunately, many of us don’t have the luxury of time with our medical doctors, or we just simply don’t know what questions we should be asking. Don’t worry, we’ve got you covered.
Let’s start with the basics
HPV, or human papillomavirus, is one of the most common viral infections, spread primarily through skin-to-skin contact. There are over 200 known strains of HPV, which can be categorized into two main types: high-risk and low-risk. Most HPV infections are harmless and may even clear up on their own. However, certain strains are more likely to lead to health issues, which is why it’s essential to know what type you may have.
High-risk vs. low-risk HPV: What’s the difference?
High-Risk HPV: These strains are associated with a higher chance of leading to certain cancers, including cervical, anal, oropharyngeal (throat), and genital cancers. The most common high-risk strains are HPV-16 and HPV-18, which are responsible for the majority of cervical cancer cases. If you are reading this and have been told you have one of the above strains, please keep reading so we can walk you through this.
Low-Risk HPV: These strains do not typically lead to cancer but can cause benign conditions like genital warts. HPV-6 and HPV-11 are common low-risk strains known to cause warts but aren’t linked to cancer.
Being told you have high-risk HPV can be scary, but it’s important to remember that “high-risk” doesn’t automatically mean you’ll get cancer. Most high-risk HPV infections never progress to cancer, especially with regular screenings and proactive health measures.
Why knowing your HPV-type matters
Knowing whether you have a high- or low-risk HPV strain is valuable for guiding your health decisions. For high-risk HPV strains, regular follow-up appointments and screenings like Pap smears or HPV tests are crucial. These screenings help monitor any potential cellular changes that could, if left unchecked, progress over time.
For low-risk strains, your doctor might recommend managing symptoms (like warts) if they arise. Knowing your strain can also help you understand which preventive measures may be best suited for you.
What about CIN-1, CIN-2, or CIN-3?
Understanding your HPV type is an important first step, but it’s also helpful to know about CIN, or cervical intraepithelial neoplasia. When it comes to HPV, CIN is another term that may come up, especially if you’ve had an abnormal Pap smear. CIN levels, like HPV types, tell us more about what’s happening in the body and help doctors decide on the best course of action.
While knowing your HPV type can indicate whether your strain is high-risk or low-risk, CIN levels give us another layer of information by grading any changes in the cervical cells. Let’s take a look at what these different CIN levels mean and how they relate to your health.
Understanding CIN grading
If you’ve been told you have CIN-1, CIN-2, or CIN-3, these terms describe the degree of cell changes detected in the cervix.
If you’re feeling a bit lost - here’s a breakdown:
CIN-1: Mild cellular changes, often due to low-risk HPV types or early high-risk HPV infections. CIN1 usually requires regular monitoring, as most cases clear up naturally with time as the immune system fights the virus.
CIN-2: Moderate cell changes, usually associated with high-risk HPV types. CIN-2 lesions can sometimes go away on their own, particularly in younger women. Your doctor may recommend regular follow-ups or, in some cases, treatment to remove abnormal cells.
CIN-3: These are typically more severe cell changes with the most advanced form of cervical dysplasia. CIN-3 is still not cancer but has a higher chance of progressing to cervical cancer if untreated. We know this sounds scary, but there are various options to prevent the progression of these cellular changes into cervical cancer. CIN-3 usually requires treatment to prevent any further changes, which is a discussion you will have with your healthcare provider.
Knowing both your HPV type and CIN level helps you and your healthcare provider make informed choices about monitoring, treatment, and prevention. This knowledge empowers you to take control of your health, as you’ll know exactly what to watch for and how to approach the situation.
Not all HPV leads to cancer
Now that you have a better idea of what your HPV type and grading mean, let’s talk about the elephant in the room - the cancer risk. One of the biggest fears after an HPV diagnosis is the risk of cancer. But it’s important to know that having HPV doesn’t mean cancer is inevitable. In fact, the body’s immune system clears most HPV infections within 1-2 years without causing any long-term issues. Cancer develops only in a small percentage of high-risk cases, often when the virus persists over many years without detection or treatment.
Here’s where regular screening comes in: Pap smears and HPV tests detect cellular changes early on, well before they have a chance to develop into anything more serious. If any changes are detected, your healthcare provider can recommend treatment options to prevent them from progressing.
Protecting Your Health with HPV
There’s a lot you can do to stay empowered and protected when it comes to HPV:
Get regular screenings: If you have a high-risk strain, keep up with your recommended screenings. Early detection is one of the most effective ways to prevent HPV from leading to more severe health issues. If you haven’t already, talk to your doctor about the HPV vaccine and whether this is the right option for you.
Boost your immunity: A healthy immune system is your best defense against HPV. Focus on a nutrient-rich diet, high in antioxidants, cruciferous veggies, deeply pigmented fruits and berries, whole & high fibre grains. Get regular exercise and manage your response to stress to support your body’s natural ability to fight off infections. By supporting our immune system through these means, we give our body the tools to clear HPV on its own.
Stay educated and informed: The more you know about your HPV status, the better equipped you’ll be to make decisions about your health. Understanding your strain, its risks, and preventive measures allows you to take control of your wellness journey.
Knowledge is power
An HPV diagnosis can feel overwhelming, but remember, knowledge is power. By understanding your HPV-type, staying up to date on screenings, and exploring preventive options, you’re taking steps to protect your health. HPV is common, and with regular care and attention, most people can manage it without it ever becoming a serious concern. This journey is about education and empowerment—taking small, informed actions to support your well-being.
Nov 19, 2024
5 min read
Make Movember Count: HPV-Related Cancers Affect Men, Too
Victoria Gasparini
It’s grow time, gentlemen! Movember brings us an opportunity to raise awareness of various conditions affecting men, notably prostate and testicular cancer. Over the years, we have also begun focusing on how mental health disorders impact men, too. While these conditions are extremely important, and still require us to lean in and learn more, a lesser-known but rapidly rising concern is HPV-related oropharyngeal cancer. The truth is, this type of throat cancer has seen a significant increase in men due to HPV, but awareness lags far behind. This Movember, let’s not shy away from talking about this any longer.
The cancers we don’t talk about enough
Men’s health issues like prostate and testicular cancer get much of the spotlight—and rightly so. But oropharyngeal cancer deserves our attention too. HPV-related oropharyngeal cancer is actually increasing faster in men than in women, largely due to how HPV, especially the high-risk HPV-16 strain, can spread through oral contact. This growing rate of HPV-related cancer in the throat, base of the tongue, and tonsils is a call to action to know the risks, take steps to prevent them, and spread the word. There is no better time to do this than in Movember.
The silent cancer
While HPV is commonly discussed in the context of cervical cancer, the virus doesn’t discriminate based on gender. For men, the virus can stay dormant for years, causing cellular changes over time that may eventually lead to oropharyngeal cancer. Because of this, men may be unaware of the risks they carry, highlighting the need for everyone—regardless of gender—to understand HPV’s impact.
The silent progression of oropharyngeal cancer cells is one reason HPV can be so concerning. Without symptoms, many men have no idea they’re carrying the virus or that they may be at risk. While women are keeping up with their pap smears and HPV screening, it can be more difficult for men to be adequately screened and assessed for HPV related cancers, especially of the throat. The signs of oropharyngeal cancer, such as a persistent sore throat, difficulty swallowing, or a lump in the neck, often only appear once the cancer has progressed. This delay in diagnosis can make the disease more challenging to treat effectively.
This isn’t to create fear, but rather to serve as a reminder to us all, that the effects of high risk HPV go beyond what we typically hear discussed in the health and wellness space, and they highlight the importance of awareness and prevention - beyond just the month of November.
It's not all bad news
The truth is, HPV-related oropharyngeal cancer is mostly preventable. Explore options with your family physician to help protect yourself, including a discussion around vaccination and routine healthcare check-ups to help with early detection.
At Papillex, we have always believed in the power of education as a form of prevention. Learning about HPV-related risks and advocating for regular screenings can help save lives. Additionally, supporting your body through adequate nutrition such as a diet high in antioxidants, minerals like zinc and magnesium, lots of fruits and veggies, whole-food sources of protein and complex carbohydrates are all excellent ways to support the body in addition to adequate prevention and screening measures.
Mustache or not, let’s spread awareness this Movember
Supporting men’s health goes beyond just growing a mustache. This Movember, let’s start meaningful conversations around HPV-related oropharyngeal cancer and other cancers affecting men.
Here are some impactful ways to get involved:
Talk about HPV-related cancers with friends and family
Okay, so it’s not your typical dinner table conversation - but talking about HPV-related cancers helps to break the stigma and can be the reason your friend or family member gets tested. You can play a role in saving the life of someone you love and that is worth the initial awkward conversation starter.
Encourage regular health screenings
Regular check-ups can catch issues earlier on, whether it's related to prostate cancer, testicular cancer, or HPV-related oropharyngeal cancer. Remember, the most concerning part of oropharyngeal cancers is the latency of symptoms. The silent symptoms mean that the disease is progressing without us knowing, which means intervention is often too late. This is why regular health screenings are so important.
We suggest requesting screenings from your physician. There is currently no standard screening for HPV in men, which makes this a bit of a challenge. Because of this, it is important to know your risks and talk with your doctor about prevention strategies. Have your physician assess for lesions on the oropharynx as well.
Break the silence around men’s health
Men’s health shouldn’t be a hidden topic. By starting conversations and breaking stigmas, we can encourage more men to take proactive steps in their healthcare. This requires us all, women too - to get educated, encourage the men in our lives and advocate for better screening and more research and funding to go into HPV related cancers.
Let’s make this Movember count
Movember is a powerful reminder that men’s health deserves our attention, too. Oropharyngeal cancer and other HPV-related health concerns affect men worldwide, yet few of us are talking about it. By raising awareness, supporting prevention, and encouraging screenings, we can make a difference. This Movember, let’s stand together in support of men’s health. Each conversation, each act of support, and each step toward prevention matters.
Nov 12, 2024
4 min read
Victoria Gasparini
HPV is one of the most common sexually transmitted infections, affecting 80% of sexually active women. In fact, most sexually active men and women will contract some strain of HPV at some point in their lives. Unlike many STI’s, HPV does not have a known cure. Because of this, the typical advice around sexual abstinence with sexually transmitted infections is likely not sustainable.
If you’ve tested positive for HPV, the best thing you can do for both you and your sexual partners health is educate yourself on safe sex, while addressing the infection and practicing methods to reduce viral transmission. With that being said, here are 3 tips you can take to practice safer sex with HPV, and reduce your risk of spread.
Talk to your doctor about getting vaccinated against HPV.
Both you and your partner may benefit from the protection of vaccination. The HPV vaccine prevents from many dominant strains of the virus, which reduces your risk of commonly associated cancers like cervical, anal, and oropharyngeal. The HPV vaccine also protects against occurrence of genital warts. Vaccination is NOT a substitute for regular screening, and therefore all people with a cervix need to keep up with their regular pap tests. Vaccination is a personal decision that should be discussed with your healthcare provider.
Use protection each time you engage in sexual activity
Keep in mind, HPV can be spread through any kind of sexual activity including vaginal, anal and oral sex. Though not 100% effective at stopping the spread of STD’s, condoms and dental dams can drastically reduce your risk of spreading HPV to your partner when engaging in sexual activity. It is important to know that HPV spreads through skin cells, so condoms do not provide complete protection.
Get tested. Regularly.
Early detection of HPV and any other STI’s is crucial to your health. Both you and your partner(s) should consider getting tested and staying in the know on your sexual health. Consider getting tested with each new sexual partner, as well as maintaining regular screening as recommended by your physician. A pap smear can help identify pre-cancerous and other cell changes of the cervix that may put you at risk for cervical cancer. The HPV test identifies the virus that can be responsible for these cell changes. Discuss your testing options with your physician.
Manage HPV with lifestyle and dietary changes
If you have chronically occurring genital warts, bumps, lesions or sores, you should check with your doctor before engaging in sexual activity. Though these often go away on their own, your doctor may be able to provide you with some options to speed recovery. There are also many dietary and lifestyle changes that can help clear or suppress the virus, making it less likely to spread infection through sexual activity. In addition to these changes, products like Papillex, AHCC and our new supplement for HSV, Simplix, may speed up the healing process.
In addition to common prevention methods, foundational lifestyle approaches like adequate sleep hygiene, a reduction in stress, and adding antioxidants through food and supplementation are tried and true ways to suppress HPV.
Jul 11, 2022
2 min read
Oral HPV and Oropharyngeal Cancer
Adrienne Hill-Strathy
The human papillomavirus (HPV) is commonly known for its association with cervical cancer and genital warts. But, HPV is also a risk factor for several types of cancers including oropharyngeal cancer. Oropharyngeal cancer includes cancers that affect the back of the tongue, soft palate, tonsils, and side of the throat.
In recent years, we have seen a rise in oropharyngeal cancers, highlighting the need for proactive management to address oral HPV. Here, we break down what you need to know about oral HPV and how you can support your immune system to defend against it.
What are the Prevalence Rates of Oral HPV?
It is estimated that around 7 percent of Americans aged 14 to 69 have detectable HPV in their oral tissue. The prevalence of oral HPV is higher in men than in women, 10.1% compared to 3.6%.
The rates of oral cancers have increased between 2003 and 2013 by about 3.4% per year. Rising rates of HPV are thought to be due to rising rates of HPV infection in the population mostly due to changes in sexual behavior. Today, the average person has a greater number of sexual partners and it is more common to engage in oral sex.
Oral sex is thought to be the main contributor to the increasing rates of oropharyngeal HPV. A study of oral HPV in men found infection rates increased with prevalence and increased frequency of oral sex. There were also increasing rates in men who smoked, were in non-monogamous relationships, and had a partner with oral or genital HPV.
How Is HPV Transmitted?
HPV is highly transmittable and is mainly contracted through skin-to-skin or oral contact. Touching the genitals or engaging in oral sex with an infected individual can be enough to transmit HPV. Because HPV is so easily transmitted, most sexually active individuals will contract some strain of HPV in their lifetime. The CDC estimates that 90% of men and 80% of women will be infected with a strain of HPV.
Now, we know what you are thinking—“oh no, am going to get cancer?”
If I have Oral HPV, Am I Going to Get Cancer?
Like genital HPV, most individuals that contract oral HPV will not progress to oropharyngeal cancer. It takes many years for oropharyngeal cancers to develop from an HPV infection. Between the time of infection and cancer development, the immune system often clears the HPV and renders it dormant within the cells.
Nevertheless, there is still risk if HPV remains persistent over time. The most common strain of HPV found in oral infections is HPV-16. HPV-16 is a high-risk strain that can cause cancers if it proliferates over time. Approximately 1 percent of men and women are infected by HPV-16.
What are the Symptoms of Oral HPV?
Like other forms of HPV, in the early stages, oral HPV infections often cause no symptoms at all. Oral HPV that is progressing into oropharyngeal cancers may cause symptoms including:
Difficulty swallowing
Lump on the neck or in the cheek.
Chronic hoarseness
Sore throat that doesn’t go away
White or red patches on the tonsils
Jaw pain or swelling
Unintentional weight loss
If you notice any of these symptoms or changes, please contact your doctor.
How Do you Know if you Have Oral HPV?
Oral HPV is not included in regular screening guidelines and practices. There is no test to detect for early signs of HPV cellular changes in the throat like we do with the Pap Smear. However, HPV testing can be done to detect tissue samples for the presence of HPV.
For these reasons, many individuals will not know that they have been infected with oral HPV until it has progressed into a cancerous state. Addressing the immune system and limiting risk factors can help reduce overall risk and prevent complications.
How to Limit Infection and Complications of HPV
Reduce the number of sexual partners: Reducing sexual behavior (vaginal sex, oral sex) is one way to reduce and prevent infection rates. Because HPV is transmitted through sexual contact and touch, limiting sexual partners will lead to less possible exposure to HPV. Using protection can partially help protect against HPV but it is not 100 percent effective.
Quit smoking: Smoking puts individuals at greater risk for cancers, especially those in the respiratory pathway, and is associated with an increased risk of oropharyngeal cancers. Not all oropharyngeal cancers are related to HPV. Tobacco, alcohol use, and poor lifestyle habits alone can also cause oropharyngeal cancers. Together the combination of smoking and oral HPV can significantly increase one’s risk.
Reduce alcohol intake: Alcohol use is another risk factor for oral cancers. Reducing alcohol consumption and drinking mindfully when needed can help support overall health and the risk of HPV complications.
Support the immune system: The immune system is thought to be the hallmark of whether an HPV infection continues to persist over time or is eradicated. You can support your immune system by getting adequate sleep, eating 7-8 servings of vegetables a day, engaging in moderate exercise, managing stressors, getting sunlight, and forming healthy relationships. You can learn more about supporting your immune system here on wellex.co.
Four Towering yellow and white pills, daily supplement dose.
Can Papillex help with Oral HPV?
Papillex was formulated to help correct nutrient deficiencies associated with persistent HPV, and to provide immune-supporting nutrients and herbs. Since the HPV strains that cause cellular changes of the cervix are the same strains that contribute to oropharyngeal cancer, the ingredients in Papillex can help support the immune system response to oral HPV.
Mar 15, 2022
4 min read
Adrienne Hill-Strathy
We know that the Human Papillomavirus (HPV) causes 98% of all cancers of the cervix. HPV is also linked to anal, vulva, and other cancers of the genital tract. With that said, not everyone who contracts HPV will develop complications.
Most cases of HPV will spontaneously regress on their own within 2-3 years. In the small few where HPV doesn’t revert and becomes chronic, it can lead to progressive cellular changes over time which can sometimes lead to cancer. So, what makes one person more susceptible to persistent HPV infections than another?
Let’s explore a few root factors that could be at play. Addressing these root causes can help support the body to clear HPV and prevent cervical and other HPV-related cancers.
Nutrient Deficiencies
Nutrients form the backbone and catalysts for many reactions and processes in the body. Today, many individuals are deficient in important nutrients, and these deficiencies make it difficult for the body ecosystem to function optimally. Studies have found several nutrients to be correlated with HPV infections.
Persistent HPV infections are more common in individuals with low levels of folate (B9), vitamin A, vitamin C, vitamin E, and selenium. With these deficiencies, there is also an increased risk of progression to cervical cancer. HPV rates decline in individuals with higher levels of these nutrients.
The underlying action of these nutrients is to help support healthy immune function through inhibiting cancer cell growth and their powerful antioxidant activities.
Nutrient deficiencies can be corrected by consuming a diet rich in diverse whole foods, especially fruits and vegetables. We like to aim for 8 to 10 servings per day with at least one serving coming from green leafy vegetables.
Nutrient levels can also be corrected through supplementation. Papillex™ was formulated with this research in mind. Our nutritional supplement offers the daily recommended serving of micronutrients known to support HPV.
The Vaginal Microbiome
Within our body’s ecosystem exists separate micro-ecosystems including the vaginal microbiome. The vagina is home to trillions of microorganisms – bacteria, fungi, and viruses. These organisms play a role in the health and function of the vagina. When certain species overgrow or get depleted, health complications can occur.
The vaginal microbiome is largely populated by the Lactobacillus species. Studies find that HPV is more common in individuals with lower levels of Lactobacillus. In individuals with cervical dysplasia levels of unhealthy microbes like Prevotella, Sneathia, and Clostridiales are increased. Research also seems to indicate that HPV infection can disrupt the vaginal microflora, allowing the virus to persist.
Screening for vaginal infections like bacterial vaginosis, candida, and trichomonas vaginalis can help detect if there is an underlying imbalance and inform how to treat it. If you notice any changes in vaginal symptoms such as irritation, redness, pain, or changes to discharge, contact your doctor.
Taking care of your vaginal health is just like taking care of your overall health - eat a nutrient-rich diet, reduce sugar intake and processed food, and fill up on those pre-biotics and probiotics. Maintain proper hygiene practices by avoiding douches and soaps, using organic, scent-free personal care products, and cotton underwear. Safe sex practices are also important to your overall wellbeing - wearing condoms can reduce exposure to other bacteria and sexually transmitted infections as well as maintain vaginal pH.
Inflammation
Inflammation is a natural immune response to repair tissue damage and defend the body against invaders. However, unchecked and chronic inflammation is at the root of many chronic diseases.
It is helpful to think of the body as one interconnected ecosystem when considering the impact of inflammation on cervical health. When inflammation is out of balance, it can contribute to the body’s vulnerability to tissue damage.
Research has found inflammation and oxidative stress to play a role in HPV persistence. The HPV virus is better able to infiltrate into the cells when the tissue is inflamed. Chronic inflammation also helps cells proliferate over time, allowing for those cervical cell changes to occur. In addition, the HPV itself is also inflammatory and its cellular process further induces inflammation at the local site.
Reducing inflammation is another whole-body approach. Dietary factors play a role in supplying the body with antioxidants, known to balance inflammatory oxidative processes. Antioxidants are best obtained from eating a diverse diet of whole foods. We also recommend reducing exposure to inflammatory triggers like cigarette smoke, alcohol, and processed foods (trans fats and refined carbohydrates) as well as managing blood sugar through consuming adequate protein, fats, and complex carbohydrates to keep inflammation down. In addition to dietary changes, getting 7-8 hours of good quality sleep per night is crucial for the immune system.
Genetics
Certain genetic factors have also been explored for their role in HPV. Studies suggest there is a familial predisposition to cervical cancer. More specifically, research indicates that individuals whose mother or sister had HPV have an increased chance of developing cervical dysplasia and cervical cancer.
This increased risk could be due to several factors. Certain genes were found to be associated with HPV risk as well as HLA alleles. A person’s genotype may also influence risk behaviors that influence HPV.
Our genes may also impact our DNA repair and detoxification pathways. Associations between the MTHFR gene and cervical cancer may also exist. MTHFR plays a role in converting dietary folate into folic acid to be used in detoxification and cellular repair pathways. An MTHFR mutation increases the risk of several diseases including heart disease, colon cancer, and breast cancer. Some evidence suggests there is a link between genetic variants of MTHFR and cervical cancer, but more research is needed. Increasing dietary folate through intake of leafy green vegetables, beans, and supplementation, can help support this pathway.
Hormones
Hormones also play an important role as the chemical messengers that act throughout the body. Hormones were first thought to play a role in HPV infections following findings that HPV infections were more common in individuals on oral contraceptive pills and after having multiple pregnancies. The sex hormone, estrogen, is thought to explain why rates of cervical dysplasia increase in these groups.
Reducing exposure to xenoestrogens, estrogens found outside the body can help reduce this risk. Consider non-hormonal methods of birth control as a way to reduce risk. Again, diet and lifestyle factors play a role in supporting healthy hormone production and function. A diet rich in cruciferous vegetables (broccoli, cabbage, and kale) can help support estrogen detoxification and clearance. Intake of phytoestrogens like flaxseed and soy can help support a healthy hormone balance.
Why lifestyle is key
The good thing is most of these factors are modifiable through lifestyle practices. The daily choices you make can influence your likelihood of developing cervical cancer or other HPV complications.
As we have said, supporting the body against invaders like HPV is a whole systems approach. Focusing on a nutrient-rich diet, reducing stress and exposure to harmful chemicals, and targeted supplementation can help address many of the underlying root causes that lead one to develop complications of HPV.
Jan 03, 2022
5 min read
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