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Acrylamide: Are You Sure You Want Fries With That?

Acrylamide: Are You Sure You Want Fries With That?

Christine Chung
There are many risky ingredients and chemicals in processed food that can increase your risk of cancer. Did you also know that the way YOU cook or process your food can also have a similar effect? Keep reading below to get the low down on HPV and how acrylamide may affect your cancer risk! What is Acrylamide? Acrylamide is an industrial chemical that can be found in dyes, paper, plastics, and can even be used in treating water sewage. These are commonly seen in products we buy, in the packaging, and adhesives used. Oh, and by the way, this chemical is also present in tobacco smoke. How does this apply? This toxic chemical can form in some foods when using high-temperature cooking methods, such as deep frying, pan frying, roasting, or baking. This comes from a combination of sugars and an amino acid called aspargine that are presently found in food. These two components separately do not have a bad effect on your health, but during high-temperature cooking, they combine and can cause some pretty negative side effects on your health. The exact temperature at which acrylamide forms in food has yet to be determined, but it has so far not been found in food prepared at temperatures below 120 degrees Celsius (248 Fahrenheit). Why Should I Avoid Fried Food? Acrylamide is yet another reason to avoid fried and processed foods since certain food preparation methods lead to the formation of chemicals that pose a potential health concern. It was first detected in certain foods in April 2002 by the Swedish National Food Authority. Acrylamide is a chemical that naturally forms in certain foods, particularly starchy foods that are rich in carbohydrates and low in protein, during processing or high-temperature cooking, such as frying, roasting, and baking but not typically when boiling and steaming even at very high temperatures. Those French fries you can’t help but get as the side of your burger? These are heavily contributing culprits to high levels of acrylamide. In fact, the highest concentrations of acrylamide are found in potato chips and French fries, and are followed by cigarette smoke. Cancer Risk The Joint Food and Agriculture Organization/WHO Expert Committee on Food Additives (JECFA) and the United States Food and Drug Administration has identified dietary exposure to acrylamide as a potential concern. Acrylamide is known to cause cancer in animals at high levels. Elevated doses can also be toxic to the nervous system of both animals and humans. An 11-year study in the journal of Cancer Epidemiology Biomarkers and Prevention found an increased risk of endometrial and ovarian cancer was associated with higher intake of acrylamide from food. Here are other organizations’ takes on acrylamide: The International Agency for Research on Cancer (IARC) classifies acrylamide as a “probable human carcinogen.” The US National Toxicology Program (NTP) has classified acrylamide as “reasonably anticipated to be a human carcinogen.” The US Environmental Protection Agency (EPA) classifies acrylamide as “likely to be carcinogenic to humans.” While adverse effects to your brain and nervous system are unlikely at the estimated average exposure to acrylamide, changes in the actual structure and function of your nerve cannot be excluded for individuals with a high dietary exposure to acrylamide. For a compound that is both genotoxic and carcinogenic, these MOEs indicate a health concern. The take-home message: Avoid fried and processed foods and your body will thank you. In addition to taking Papillex, eat a diet high in fruits and vegetables and minimize the ingestion of saturated fats, and processed foods that impair immunity and contribute to inflammation in the body. 3 Tips to Decrease your Acrylamide Burden 1. Boil or steam your vegetables. By not roasting, baking, or frying your food, this will avoid the combination of sugars and amino acids that creates acrylamide. Boiling and steaming your food, no matter what temperature, is not connected with acrylamide formation. Acrylamide does not form, or forms at lower levels in fish, meat, or dairy products. 2. Don’t overcook your vegetables. Cooking for longer periods of time, especially at higher temperatures can cause acrylamide formation. This will also help to sustain those good fibers to contribute to a happy gut. 3. Avoid fried potato products ...like French fries or potato chips, or any other fried vegetable, especially those with breading. Acrylamide is mainly found in plant-based foods, especially potatoes and grains, and even coffee! So think twice next time you choose French fries or breaded, deep-fried onion rings next time! Bonus Tips for the Fried Food Fiends! *  If you find you just can’t get away from roasted, baked, or fried potato foods, soak your potato slices raw for 15 to 30 minutes before frying – make sure to dry the slices thoroughly to prevent oil fires! *  Avoid storing potatoes in the fridge before cooking. Studies show that this may increase levels of acrylamides formed during the cooking process. *  When frying, baking, or roasting potatoes, bread, or other vegetables, try cooking them to a lighter shade and avoid burning to decrease acrylamide production. Want to know more about healthy eating? Check out our blog on healing HPV through food!
Jul 17, 2019
4 min read
Photodynamic Therapy for HPV: What Is It and Does It Work?

Photodynamic Therapy for HPV: What Is It and Does It Work?

Christine Chung
Photodynamic therapy is a treatment typically used in the treatment of acne, warts, and a range of cancers, including mouth (oral), head and neck, lung, and skin cancer, and has been for a number of years now. However, PDT is now being considered a novel approach to eradicating the human papillomavirus. This follows a study conducted by scientists at the Mexico National Polytechnic Institute who found it to be effective in clearing the virus. Furthermore, it was reported that a researcher who worked on the project, Eva Ramón Gallegos, has used the method to remove HPV from 100% of a 29-women sample. So is PDT the cure for HPV that we’ve all been looking for? That remains to be seen. The latest reports are yet to be published in a peer-reviewed journal, and they were made a considerable amount of time ago now, back in February 2019. Nevertheless, PDT is worth exploring in the eradication of a virus which is the leading cause of cervical cancer in the world, and one of the most commonly transmitted sexual infections in the world. How Does PDT Work? PDT involves using a particular type of light in combination with a photosensitizing agent called aminolevulinic acid (ALA), which is applied as either a topical cream or injected into your blood to make your cells sensitive to light. Aminolevulinic acid, particularly 5-aminolevulinic acid, is an amino acid that is involved in a pathway called porphyrin synthesis in your body. When combined with the correct light wavelength, the procedure damages those surface layer cells affected by HPV, while surrounding tissue is left undamaged. Photodynamic Therapy in action for Acne In other words, ALA, makes your cells more sensitive to light, and when exposed to a certain wavelength of light, can kill cancer cells. PDT also works well for treating genital warts. The combined therapy attacks the skin cells of genital warts that continue to expand when they shouldn’t. In addition, the therapy was specific enough that it targeted these cells but left the normal, healthy skin cells alone. What Are The Benefits of PDT? Many women who suffer from HPV are of child-bearing age, so the risk of treatment to future pregnancies is a concern for this population. Luckily, photodynamic therapy poses a lower risk to current and future pregnancies. PDT is safer than other treatments during pregnancy Among other benefits, photodynamic therapy is also non-surgical, which also means there is no blood loss, no sustained damage to cervical tissue, and no reports of infertility related to treatment. Are There Any Downsides? PDT can be associated with some side effects, such as red, itchy skin, swelling, burning, or stinging at the site of treatment, however, these are relatively minor problems, especially in comparison to some of the treatments mentioned above. However, PDT can be expensive. This is dependent on the length of treatment and resistance of HPV, however, studies show that it is more cost-effective in comparison to some other treatments. How Effective Is PDT? We did the digging so you wouldn’t have to. So sit back, sip your green tea, and relax. Most clinical trials show that PDT is highly effective when compared to a placebo treatment, or a treatment where the study participants THINK they are getting PDT treatment, but in reality, they are not. When targeting CIN or HPV infections specifically to each patient, the complete remission rate is improved significantly. Keep in mind, the studies in this review were of lower quality. Studies show that with ALA-PDT, HPV can be effectively eliminated in those with latent or subclinical infections within 3 months. This is the population of people who have been diagnosed with HPV but have not or are not currently showing symptoms. Catch it early, and ALA-PDT therapy may work for you! Multiple 4-hour treatments of 5-ALA and PDT in males with genital warts show complete clinical remission after the last session. The number of sessions and strength of treatment was specified for each patient depending on HPV viral load, a number that dictates the severity of infection. By monitoring the viral load, doctors were able to keep an eye on the effectiveness of treatment, knowing when they needed to increase the intensity, or back off with treatment. Treatment effectiveness According to the evidence, the percentage strength of the aminolevulinic acid may impact effectiveness. Comparing 2 different studies, one clinical trial used a 20% aminolevulinic acid gel and showed a high complete response rate, meaning no more symptoms for the patients with HPVafter 3 treatments. Even after 1 year, follow-up tests showed very low levels of recurrence of symptoms in patients. Another study of higher quality used a 3% aminolevulinic acid gel with photodynamic therapy. Their results were generally positive for use in the treatment of HPV symptoms, however, they were not significantly different from the placebo group (recall: study participants THINK they are getting PDT treatment, but in reality, they are not). This study was of higher quality, so perhaps the other study was not as accurate. A third clinical trial from Mexico used a 6% aminolevulinic acid gel with photodynamic therapy. They were looking into eliminating HPV-16and HPV-18 and associated cervical intraepithelial neoplasia (CIN) in Mexican women. They found that at this percentage, HPV infections were successfully eliminated, with or without CIN progression. Specifically, in groups of people with cervical intraepithelial neoplasia, PDT showed to be very promising. CIN precancerous lesions, including carcinomas and early invasive cancer of the cervix, responded very well to photodynamic therapy. Improving HPV outcomes Well, newer studies are showing the effectiveness of using different analyses and numbers to track and guide the effectiveness of treatment. Researchers and doctors are keeping tabs on the HPV viral load to measure the effectiveness of treatment. This helps the treatment team to know if the current treatment is working if the dose should be increased, or if the treatment is working so well that they can start to use lower doses. PDT has been shown to significantly lower viral load after treatment. The better the treatment, the lower the viral load! They can also keep track using polymerase chain reaction assays (PCR) to give a grade of HPV, measuring the status of the HPV infection. DNA detection with genotype identification has also been used in this patient setting. The only thing you really need to know about this technique is that it can help find some precancerous or HPV lesions that are unnoticed. Using these techniques, one clinical trial saw two cases of anal warts cleared with no detectable HPV at the end of treatment or at 1 year after treatment. Mechanisms of Action ALA-PDT also works by downregulating the expression of the human papilloma virus E6/E7 oncogene, the gene responsible for producing precancerous and cancer cells associated with HPV. It also upregulates tumor suppressors, including p53, something that’s usually produced in your body to prevent tumors from growing. ALA-PDT causes apoptosis of H8 cells, which is very important. H8 cells are HPV-16 immortalized cervical epithelial cells. These cells are highly studied in HPV, as they activate the E6/E7 oncogenes and otherwise hide in plain sight by acting and functioning as normal human skin cells. One study found that by downregulating the E6/E7 oncogene and upregulating tumor suppressor, they were able to cure HPV infection-associated diseases and prevent progression into cervical cancer. The higher the dose of treatment, the higher the level of cell death of H8 cells. That’s a win in our books! In summary: Current research on available clinical trials show that PDT combined with ALA is very effective in the treatment for HPV and associated conditions. Infections of early or late stage, with or without CIN, and even infections progressed into cervical cancer are all potentially treatable by ALA-PDT. Trials are all new and of varying qualities, but the research available is all we have to determine the benefits of this new therapy. What else can you do? Lifestyle modifications, a healthy diet, and supplementation are key in maintaining a robust immune system to help clear the HPV infection. Even with the PDT, ensuring adequate wellness and a fully supported immune system will work in conjunction with the treatment to fight the battle against HPV! Discover the innate benefits in each Papillex ingredient and what exactly it does to support your immune system so you stay HPV-symptom free!
May 21, 2019
6 min read

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