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“Mexican Scientist Cures HPV!” Fact or Fiction?
Christine Chung
This headline has been quite popular in the media as of late.
Scientific sources have been publishing information about this topic, as well as reputable, and not so reputable news outlets.
Is it really true?
Have scientists in Mexico really discovered the cure to a virus that is rapidly become the most common sexually transmitted infection in the United States?
Sadly, the short answer is no.
A team of highly-trained scientists from Mexico have claimed “cure HPV” using a fairly new technology called Photodynamic Therapy (PDT) combined with Aminolevulinic acid (ALA), a gel that helps the therapy work better, to kill cancer cells.
Read below to learn more about PDT, ALA, and whether or not this is the end-all treatment for HPV.
ALA and Photodynamic Therapy (PDT)
PDT is commonly used as a treatment for cancer, using a particular type of light in combination with a specific photosensitizing agent, ALA.
ALA, particularly 5-aminolevulinic acid, is an amino acid that is involved in a special pathway called porphyrin synthesis in your body. Aminolevulinic acid is the special addition used in combination to specific wavelengths to treat cancers with overgrowths of the skin.
How does ALA-PDT work?
The combined therapy attacks the skin cells of genital warts that continue to expand when they shouldn’t. In addition, the therapy was specific enough that it targeted these cells but left the normal, healthy skin cells alone.
What else is PDT used for? PDT has also been used for acne, precancerous lesions, such as actinic keratosis, and melanomas of the skin.
Can I get ALA-PDT from my doctor?
ALA-PDT has only recently been introduced and accepted for use in some countries, especially in Mexico City, for cervical cancers, precancerous lesions, and HPV-related symptoms, such as genital warts.
Does it actually work?
Most clinical trials show that PDT is highly effective when compared to placebo treatment. When targeting CIN or HPV infections specifically to each patient, the complete remission rate is improved significantly. However, most of the studies included were of lower quality, so they may not be quite as reputable.
Which situations would ALA-PDT be beneficial?
Studies show that with ALA-PDT, HPV can be effectively eliminated in those with latent or subclinical infections (currently with no symptoms), within 3 months. This is the population of people who have been diagnosed with HPV but have not or are not currently showing symptoms.
The current research does show that those with CIN responded very well to PDT.
How does it compare to other therapies?
ALA-PDT also poses a very low risk to fertility, current, and future pregnancies. It is also fairly minimally-invasive, as it is a non-surgical procedure involving no blood loss, no damage to the cervical tissue, and no reports of infertility. In these situations, ALA-PDT may be a treatment of interest for you.
This therapy can also be more cost-effective than some other, more invasive procedures. If your case is more resistant to PDT, it may end up costing more in the long run.
Reported side effects include: red, itchy skin, swelling, burning or stinging at the site of treatment.
The Bottom Line
Current research on available clinical trials show that PDT combined with ALA could possibly be effective in the treatment for HPV and associated conditions - but more, higher quality research needs to be done.
Infections of early or late stage, with or without CIN, and even infections progressed into cervical cancer are all potentially treatable by ALA-PDT.
Trials are all new and of varying qualities, but the research available is all we have to determine the benefits of this new therapy.
The News Headlines
The work that is currently publicized in the media is in regards to Mexican scientists who have claimed to use ALA-PDT to eradicate HPV completely in 29 women.
While the reports are interesting, especially with the currently available information on ALA-PDT, their findings have not been published yet and are unlikely to be a be-all-end-all cure for HPV.
Be careful of the credibility of information out there. Keep in mind the source of information before making decisions about your health and treatment.
How Does Papillex Come Into All This?
By boosting your natural immunity and replacing missing and low nutrients, Papillex™ can help you to create an environment inhospitable to HPV and its common symptoms, cervical dysplasia and genital warts.
Dec 18, 2019
3 min read
HPV, Broccoli, and its secret Ingredient - Sulphoraphane
Dr Elizabeth Goldspink
Your childhood was probably filled with memories of your parents always telling you to eat your greens, broccoli being one of the main greens that many children will scrunch their face at.
But...did you know that broccoli has many branches of super metabolites that can radically change your health?
Discover why your mom was right, and why you shouldn’t give up eating broccoli any time soon!
What’s the Deal with Broccoli?
Broccoli belongs to the cabbage family, part of a larger family called the Brassicas. The brassica family of cruciferous vegetables also includes common power greens including kale, Brussels sprouts, Swiss chard, and cabbage.
This group of vegetables contains phytochemicals that have high antioxidant activity called isothiocyanates.
Broccoli, however, goes one step further.
Broccoli is very high in vitamin K, vitamin C, vitamin A, folate, vitamin B6, and manganese, and also contains sulforaphanes and indoles. These are also strong antioxidants, but they have the added benefit of detoxification, anti-cancer properties, and many other health benefits. The American Cancer Society even stands behind broccoli, recommending consumption to decrease the risk of cancer.
Sulforaphane and Indoles
Broccoli’s therapeutic claim to fame is in its active ingredients: Sulforaphane.
These compounds are found in most cruciferous vegetables including cabbage, Brussels sprouts, cauliflower and arugula.
However, broccoli sprouts are by far the richest source of sulforaphane. After consumption, sulforaphane will then break down into 2 even more powerful metabolites: indole-3-carbinol (I3C) and diindolylmethane (DIM).
Sulforaphane has been widely studied as a very powerful anti-cancer agent. It is also very effective in glucose control in Type 2 Diabetic patients, and great at regulating bowel movements.
I3C is also well known for it’s anti-cancer properties. It is used in other clinical scenarios, such as hormone balancing, as it is a phytoestrogen, detoxification, liver supporting, and immune supporting.
DIM is similarly known for anti-cancer and detoxification properties.
These compounds have been researched for its ability to help protect our bodies from free radicals, repair damaged DNA, and help protect against cancers including cervical cancer. This is why broccoli sprout extract is a key ingredient in Papillex.
Broccoli Metabolites and HPV
There are many studies supporting these broccoli metabolites and the management of HPV and HPV-related symptoms.
Epidemiological studies show that I3C supplementation may be beneficial in treating CIN and other conditions related to HPV. In a study, I3C supplementation showed even faster regression rates than the non-treatment group, even though the other subjects in the study who were not taking I3C had less HPV-positive findings.
Sulforaphane was shown to induce cell death and cervical cancer cells. It was able to accomplish this through the suppression of a certain gene (EZH2) activated by HPV, that is commonly targeted by cancer drugs. Broccoli can be so powerful!
DIM helps detoxify your body, which has general health benefits. Some early animal studies show that DIM can slow cervical dysplasia in mice.
So Broccoli Sprout, Anyhow, Anywhere?
Reaping the benefits of broccoli’s active ingredient is not as simple as taking any broccoli sprout supplement.
The body’s ability to take up nutrients, vitamins and minerals is called bioavailability and varies greatly from person to person and from nutrient to nutrient.
There are many things that influence how much of a given nutrient your body can absorb; its source, your gut microbiota, and other foods you eat alongside.
For example, some vitamins must undergo a chemical conversion in order to be activated while others might require the presence of dietary fats to be absorbed.
In the case of broccoli, the active ingredient sulphoraphane, must be first converted before it’s available for use.
Cruciferous vegetables store the precursor to sulphoraphane, a molecule called glucoraphanin, and only in the presence of an enzyme myrosinase is it converted into sulphoraphane.
Therefore, in order to get active sulphoraphane from our diet, a chemical reaction between the enzyme myrosinase and the precursor glucoraphanin must occur.
Raw vs. Cooked
You must be careful in cooking cruciferous vegetables. While the raw form of broccoli can have 10 times more sulforaphane than cooked broccoli, large quantities of raw cruciferous vegetables can become goitergens, harmful to the thyroid.
Flash steaming broccoli for 1-3 minutes at a medium heat is generally a good way to keep all those sulforaphanes, but also prevent harm to your thyroid.
Sprouts tend to be more easily digestible - a fun new addition to your salads!
Not All Supplements Are Created Equal…
Most of the nutritional supplements that are marketed as broccoli sprout extracts only contain glucoraphanin, and not the myrosinase enzyme necessary for the conversion to sulphoraphane.
While the bacteria in our gut can help with this chemical reaction, it is inefficient in many people, and therefore provides little benefit.
Papillex uses brassinase, a specialized broccoli powder extract that contains active myrosinase and sulphoraphane. This combination provides all the necessary building blocks to ensure the conversion to active sulphoraphane. Papillex guarantees its biovailability directly to your cells.
Sources
Ishita Ahuja, Jens Rohloff, and Atle Magnar Bones. Defence mechanisms of Brassicaceae: implications for plant-insect interactions and potential for integrated pest management. A review. Agron. Sustain. Dev. 2010 30(2):311-48.
Vermeulen M, Klöpping-Ketelaars IW, van den Berg R, Vaes WH. Bioavailability and kinetics of sulforaphane in humans after consumption of cooked versus raw broccoli. J Agric Food Chem. 2008 Nov 26;56(22):10505-9.
Schor, Jacob, ND, FABNO. “Broccoli: Alternatives to Eating It Raw.” Natural Medicine Journal. N.p., Oct. 2011. Accessed 20 June 2017.
Dec 11, 2019
4 min read
Christine Chung
There is no shame around HPV. At least, there shouldn’t be.
Yet many women who have HPV feel shameful about it and are worried about sharing the information with future partners, at the risk of being judged.
You’re not alone.
HPV is Growing
HPV
is now considered to be the most common
sexually transmitted infection in the US. It can be transmitted through any
skin-on-skin contact with the affected area, including oral and anal sex, as
well as intimate touching.
There are over 100 different strains of HPV identified, but most do not carry a significant risk. Only a few high-risk strains have a small possibility to cause cancers.
HPV 16 and 18 are the high-risk strains that cause 70% of cervical cancers. This risk is the reason why routine gynecological exams are recommended. Cervical cancer progression is preventable if caught early enough and appropriate measures are taken.
The Social Stigma Around HPV
In a survey of over 2,000 women, there was a wide range of stigmas associated with HPV, including shame, fear, and promiscuity. Almost 40% of the surveyed women were worried about what others may think of them if they had known of their HPV diagnosis.
Marcia Cross, an
actress most known for her role on Desperate Housewives appeared publicly on
television to end the shame surrounding HPV. She was diagnosed with anal
cancer, likely as a result of HPV transmission from her husband’s throat cancer,
caused by the same strain of HPV.
On an
episode of CBS This Morning, she
said:
"I know that there are people who are ashamed, you have cancer. Should you then also feel ashamed like you did something bad because it took up residence in your anus?"
Marcia Cross and many other celebrities and high-profile individuals are coming out to the public about their HPV diagnosis. There should be no shame attached to any medical conditions that result from HPV. The stigma associated with HPV prevents people from seeking out attention from their healthcare providers or friends and family because of the fear of judgment.
This doesn’t have to be the case.
What can you do naturally?
There are options. Most HPV infections are cleared by a strong, healthy immune system. You will most likely clear the infection and any symptoms with a robust immune system. And your immune system can be naturally well supported in a number of evidence-based ways:
Consume plenty of fruits and vegetables
Quit smoking
Reduce alcohol consumption
Drink green tea
Exercise to sweat
In addition, Papillex is a clinically-researched, nutrient-rich supplement designed to increase your body’s ability to respond to HPV naturally. By optimizing your natural immunity and replacing missing and low nutrients, Papillex™ helps you create an environment inhospitable to HPV and its common symptoms, such as cervical dysplasia and genital warts.
Nov 13, 2019
2 min read
Sugar and HPV: The Case Against Sugar
Christine Chung
Sugar: the most enticing, delicious sweetener, tempting you into a life of obesity, diabetes, and other chronic illnesses. We all now know that sugar is the real bad guy in our foods…but why? And what’s the deal with sugar in HPV?
What’s the Deal With Sugar?
Most people know that “sugar is bad for you” and that reducing its intake is one of the cornerstones to a healthier lifestyle. But what is it exactly about sugar that impacts our health so negatively?
For starters, the sheer volume of consumption by the average North American has skyrocketed. The estimated annual per capita consumption in the 1850s was about 25 pounds. This increased to about 120 pounds of sugar per capita by the 1950s. With the introduction of other processed forms of sugar, such as high fructose corn syrup, to virtually all refined foods, modern sugar consumption has grown to about 40 teaspoons of added sugar per person, per day!
In addition to the staggering quantity consumed, sugar contains many empty calories, is very energy dense, and has shown to have very harmful, deleterious effects on our immune system.
Key Definitions
*Empty calories: what do we mean by empty calories? This sweetener contains virtually no minerals, vitamins, or other micronutrients. It is just a very refined carbohydrate, and does very little in the ways of nourishing our bodies.
*Energy dense: a little sugar adds up to a lot of extra calories. Only 1 teaspoon (= 5 grams) of sugar has about 16 Calories. This may not seem like much, but it adds up quickly (i.e. multiply that by 40 = an additional 640 Calories a day).
*Effects on immune system: excess consumption can have adverse effects on your immune system. In one study, the consumption of 100g (25 teaspoons) in the form of either sucrose, glucose, or fructose by healthy volunteers caused a temporary decrease in the ability of their neutrophils (specialized immune cells) to engulf bacteria. This suggests that reducing your intake of sweeteners (including refined carbohydrates like white bread and pasta) can be helpful in preventing and fighting infections.
High fructose corn syrup (HFCS) is a common sweetener found in sodas, candies, fruit-flavoured drinks and pre-packaged foods… in other words, it is found in virtually all processed foods. Take a few minutes to look at the ingredients labels in your cabinets and fridge. HFCS has been known to impact the body’s functions which prevent it from healing and repairing. Stopping the body from healing is the last thing you want to do if diagnosed with HPV. Although fructose is a naturally occurring sugar found in fruits and vegetables, it is the refined forms of fructose used primarily as a food additive that’s being discussed. In fact, the highest source of fructose and HFCS in the North American diet comes from sodas and other sugary drinks.
In terms of calories and chemical structure, sugars are very similar to one another, the body appears to metabolize fructose very differently than the rest. In animal models, high fructose diets cause the development of obesity, insulin resistance, diabetes mellitus, and dyslipidemia.
How Important Is Blood Sugar Control?
If you have cervical cancer, intraepithelial neoplasia, or are at high risk for developing any of the above, studies suggest that controlling blood sugar levels may help improve outcomes.
The Diabetes Connection
The rates for type 2 diabetes are on the rise. Once considered “late onset” or “adult diabetes” because it historically predominantly affected older populations in the past, this disease is now presenting itself in younger and younger people.
Being overweight and obese, the “Standard American Diet” consisting of highly processed, high sugar, and low fruit and vegetable intake, combined with a sedentary lifestyle are major contributing factors to this trend.
Blood sugar levels that are higher than normal but not yet high enough to be diagnosed as type 2 diabetes, also called “prediabetes”, is a warning sign that serious changes to diet and lifestyle need to be taken to prevent progression of the disease.
It is currently estimated that six million Canadians have prediabetes.
Diseases by Diabetes
Having type 2 diabetes increases the risk of developing heart disease and stroke. In fact, according to the Canadian Diabetes Foundation, up to 80% of people with diabetes will die as a result of heart attack or stroke. New research suggests that high blood sugar may also be a contributing factor in poor cervical cancer prognosis, and that obesity and abnormal blood glucose could be risk factors in the development of pre-neoplastic lesions of the cervix.
Research published in the journal Gynecological Oncology reported that high glucose levels were associated with a greater risk for recurrence and mortality in non-diabetic women with locally advanced cervical cancer treated with radiation and/or concurrent chemotherapy.
Preventing Diabetes
The good news is that achieving stable blood glucose control is possible. Depending on the severity of your dysglycemia, this may involve much more dedication to your personal health. Even with the help of medication, the key to glucose control is healthy diet and exercise, which are also key for optimal health.
First and foremost, go visit your doctor to have your blood sugar levels tested. Next, under the supervision of your physician, increase your intake of vegetables, fruits, and lean protein, while cutting out processed, refined foods (including white flower, white pasta, white bread, fast food, TV dinners, etc.), sugar, and fried food consumption.
Increasing your daily physical activity is critical as well: 20-30 minutes daily of brisk walking is an excellent start, and can have a tremendously positive impact on your health. Try incorporating HIIT workouts 1 or 2 times per week to really optimize your physical health!
Whether you have high blood sugar levels or not, these diet and lifestyle modifications can help improve overall health.
The bottom line: cut back on sugar and other refined carbohydrate consumption, increase your daily intake of fruits and vegetables, your body will thank you.
Sep 25, 2019
5 min read
Mixed Natural Carotenoids vs. Synthetic Beta-Carotene for HPV: Why is this Distinction so Important?
Dr Elizabeth Goldspink
What are carotenoids?
They make your carrots orange, but what is the benefit to your health? Why do we include carotenoids in Papillex? Does the form matter?
Find all the answers to these questions…and more!
What Are Carotenoids?
Carotenoids, are a group of compounds that include lutein, zeaxanthin and lycopene. They are organic pigments that are naturally found in a variety of fruits and vegetables, such as carrots (as the name would suggest), tomatoes, and dark leafy vegetables such as spinach and kale.
Carotenoids are found in tomatoes too!
How Carotenoids Can Help
These compounds act as antioxidants and have shown to protect DNA from oxidative damage. The development of cancer in the human body is a multi-step and complex process, but protecting DNA from damage and mutation is important in preventing cancerous changes from occurring.
This is one of the reasons that a diet high in fruits and vegetables is linked to a decreased risk of developing a variety of diseases.
Carotenoids also help regulate immune function, and higher circulating levels of carotenoids were associated with a significant decrease in the clearance time of specific types of HPV infections, particularly during the early stages of infection (120 days and under).
Mixed Natural Carotenoids
vs. Synthetic Beta-Carotene for HPV
Our bodies
depend largely on vitamins and minerals, and the richest source of them come
from fruit, vegetables, and grains. Some nutritional supplements get their
vitamins and minerals from whole food
sources while others are made in laboratories and are termed synthetic.
Synthetic forms of vitamins are produced similarly to pharmaceutical medications. These are isolates of vitamins, lacking the complexity of the whole plant found in nature.
Supplements made from whole food concentrates contain the entire vitamin complex and are the best source of vitamins and minerals. They contain all of the cofactors that are required for healthy and optimal absorption and digestion.
These days, a large portion of the vitamins and minerals found as health food supplements are made synthetically, often lacking the accessory compounds required for absorption. A common example is beta-carotene, a powerful anti-oxidant that has been shown to protect DNA from oxidative damage and is a key ingredient in Papillex.
Beta-carotene is found naturally as a mixed carotenoid, complexed with other carotenoids including alpha-carotene, lutein, lycopene, zeaxanthin, and astaxanthin.
Carotenoids are natural fat-soluble pigments, the part that makes a carrot orange, found in fruits and vegetables. Diets rich in carotenoids have been correlated with lower disease risk. This includes plenty of colorful fruits and vegetables including carrots, tomatoes, and dark leafy vegetables such as spinach and kale!
These nutrients are potent anti-oxidants; which help to protect your cells from oxidative damage, and overtime may lead to potentially cancer-causing mutations.
A Closer Look At Lycopene
In humans, lycopene is found in the liver, adrenal glands, lungs, prostate, colon, and skin at concentrations higher than all other carotenoids.
Lycopene has been found to possess antioxidant and anticancer properties in animal and in vitro studies. Furthermore, much epidemiological research has linked high intake of lycopene-containing foods or high lycopene serum (blood) levels with reduced incidence of cancer, cardiovascular disease, and age-related eye disorders such as macular degeneration (think: Mediterranean diet). It has also been found to help protect skin against sunlight-induced oxidative damage.
Lycopene is found most abundantly in tomatoes, which gives it the red pigment, but it is also present in watermelon, apricots, green peppers, carrots, rose hips, pink grapefruit, and papillex, to name a few.
Lycopene is found in the red pigment of tomatoes
In addition to containing carotenoids, these fruits and vegetables also contain other health promoting nutrients such as folate, potassium and vitamin C. Another reason to increase your daily intake of fruits and vegetables. Remember to aim for 7-10 servings a day (1 serving = ½ cup)!
How Carotenoids Can Help Against Cancer
The development of cancer in the human body is a multi-step and complex process, but protecting DNA from damage and mutation is important in preventing cancerous changes from occurring. This is one of the reasons that a diet high in fruits and vegetables is linked to a decreased risk of developing a variety of diseases.
In a supplement
form, it is almost exclusively sold as an isolated
synthetic form.
With natural mixed carotenoids, the benefits are far greater, as
you are reaping the benefits of the antioxidant power of multiple beneficial
and synergistic compounds.
Making sure that you get an adequate amount of mixed carotenoids is very important to help regulate immune function, creating an optimal environment in your body for healing. It is also important to ensure that carotenoids are mixed, since taking a high dose of an individual carotene, especially beta-carotene, may have negative effects, as quoted by the Cancer Prevention Study Group.
This shows the importance of loading up on richly pigmented vegetables such as: peppers, tomatoes, carrots and kale. In addition, research suggests that additional support using clinically-researched nutrients can help support the body’s response to HPV.
Papillex uses only mixed carotenoids from pristine water algae. This ensures that our customers have the full spectrum
of carotenoids, from a whole food source. Our customers are guaranteed the most
potent form of antioxidants that help with healthy cell turnover and
regeneration.
What else can you do
naturally?
Carotenoids are just one of the many well researched and high quality ingredients in Papillex to help your immune system respond to your HPV infection naturally.
You should also consider making the following changes to your lifestyle:
Eat plenty of fruits and vegetables
Reduce alcohol consumption
Exercise to sweat
Drink green tea to combat HPV
Increase your daily intake of fruits and vegetables, ideally to 7-10 servings a day, and consider supplementing with Papillex.
Sep 18, 2019
4 min read
Christine Chung
A
Natural Approach to HPV
Watching and waiting to see if your HPV progresses into something more serious can be stressful and cause frustration. Papillex contains ingredients that research has shown to help the immune system respond to HPV naturally. It also contains replenishing nutrients that tend to be deficient in cases of persistent HPV infections.
Low levels of dietary carotenoids have been shown in women with HPV and are associated with an increased risk of persistent HPV infections. The risk is increased by 50% for high-risk HPV. High levels of vegetable consumption, specifically have been shown to decrease HPV persistence by 54%. Increased levels of lycopene in the blood are also associated with a decreased risk of CIN 1, 3, and cervical cancer.
Eat Your Vegetables!
One study showed higher dietary intakes of dark green and deep yellow vegetables and fruit were associated with an almost 50% decreased relative risk of CIN 3. This shows the importance of loading up on colorful vegetables such as peppers, tomatoes, carrots, mangos, sweet potatoes, spinach, and kale to support homeostasis and a healthy microbiome. A daily serving of Papillex™ contains the equivalent of 3/4 cup of frozen cooked spinach, 3 cups of raw carrots, or 2.5 cups of raw cantaloupe daily.
Indole-3-carbinol, DIM, and sulforaphane are powerful metabolites found in broccoli family vegetables that support the body in the repair of DNA damage and have been shown to lower the risk of cancer. Small human trials suggest indole-3-carbinol (I3C) supplementation may be beneficial in treating conditions related to HPV. One study showed a statistically significant regression of CIN in patients treated with oral I3C, despite a higher prevalence of positive HPV findings in treatment groups.
Sulforaphane
Specifically was shown to stop the growth of cancer cells by causing cell death. These important ingredients are found in cabbage, broccoli, broccoli sprouts, Brussels sprouts, cauliflower, and kale. To garner the same benefit as a daily serving of Papillex™, you would need to eat one head of broccoli, 2 cups of Brussels sprouts, or 2.8 cups of raw cabbage per day…that’s a lot of crunchy greens!
Studies have found that individuals with a folate deficiency have an increased risk of positive HPV status, as well as an increased risk of progression to cervical and oral cancer.
There may be a relationship between low levels of folate in the blood and high-risk HPV infection. Folate rich foods include: dark green leafy vegetables (such as: spinach, asparagus and Brussels sprouts), nuts and beans, and liver. A daily serving of Papillex contains the equivalent of 5 ounces of poultry liver, 4 cups of chickpeas, or 40 spears of asparagus.
Vitamin C Is Correlated With Lower Prevalence of HPV
Vitamin C is a powerful antioxidant. Research studies conclude that individuals with higher Vitamin C levels have a lower HPV viral load, and decreased frequency of the development of oral and cervical cancer.
Foods highest in Vitamin C include: yellow bell peppers, guavas, dark green vegetables (especially kale and turnip greens), kiwi and broccoli. A daily serving of Papillex™ contains the equivalent of 1/2 yellow pepper, 1 guavas or 2 cups of kale.
Anti-viral Antioxidants
Green tea
has long been known as a powerful anti-viral and anti-infective plant that stimulates the immune system. Green tea is often used topically for genital warts and cervical dysplasia.
Orally, green tea intake has been associated with slowed progression and decreased risk of cancer through its strong antioxidant effects.
A daily serving of Papillex™ contains the equivalent of 2.5 cups of green tea with a guaranteed low level of caffeine. For those who are sensitive to caffeine, no need to worry!
Vitamin E
Vitamin E has been shown through clinical studies to inhibit cancer cell growth and support the immune system through its powerful antioxidant capabilities.
Low levels of Vitamin E have been seen in cervical cancer patients and higher rates of HPV-16 and 18 in research. Foods high in Vitamin E include cooked spinach, almonds, roasted sunflower seeds, avocados and fish. A daily serving of Papillex™ contains the equivalent of 32 cups of cooked spinach, 3 cups of whole almonds, or 28 whole avocados. WOW!
Selenium
Individuals with cervical dysplasia have been reported to have low levels of selenium, an essential trace mineral. In recent animal studies, selenium has also been shown to increase cell death in HPV-infected cells.
It can be difficult to supply the body with selenium, as many of our soils are depleted of this essential mineral. Foods that are generally higher in selenium include brazil nuts, oysters, tuna, and sunflower seeds. A daily serving of Papillex™ contains the equivalent of 3 oysters, 4 ounces of tuna, or 3 brazil nuts.
Medicinal Magic
Astragalus
A powerful immune modulator has been used for centuries to promote resilience in the body. Recent studies have shown the herb's impact on the growth of abnormal cervical cells.
In an in vitro study, an Astragalus injection into cells slowed down the bad cell growth and regulated immune cells. The study concluded that on a cellular level, Astragalus can reduce the survival of infected cells, the effect increasing with higher doses.
Reishi
The Reishi mushroom has been celebrated for its antiviral properties over thousands of years. Clinical studies have shown that the use of these medicinal mushrooms has dramatically impacted the clearance rate of HPV, both vaginal and oral. Extracts of Reishi, or Ganoderma lucidum stopped the growth of HPV-infected cells by stopping the cell cycle and causing cell death in transformed cervical cells.
Papillex can be an excellent way to support your body during the “watch and wait” period between pap smears. It contains therapeutic dosages of clinically research ingredients that help support the immune system when concerned with HPV.
Why watch and wait, when you can be proactive? Order Papillex today!
Aug 21, 2019
4 min read
Christine Chung
What is Folic Acid?
Folate is a member of the B vitamin (B9) family, a water-soluble vitamin involved in many chemical processes in the body. Folic acid is the synthetic form of folate.
Folate is essential for the production of red and white blood cells and other important cells that help to convert food into energy and make DNA. Folate also plays an important role in the reproductive tract and is needed to maintain a healthy pregnancy.
The body cannot create folate on its own so we must obtain it through our diet or supplementation. Research on HPV has begun to highlight a strong association between folate deficiency and cervical dysplasia, emphasizing the importance of incorporating more folate-rich foods into your diet as well as taking a quality supplement.
Folate versus Folic Acid
Folate differs from folic acid in the way that the vitamin gets converted in the digestive tract. Folate is immediately converted into the active form of vitamin B9, called 5-methyl-THF (5-MTHF). Folic Acid enters the bloodstream and passes through the liver and other tissues in order to be converted.
Folic acid is thought to be better absorbed, however, it is metabolized at a slower rate, which means more can accumulate and linger in the system and may lead to excess. Folate, on the other hand, will be excreted if too much is consumed.
Folate Deficiency
Folate plays a critical role in your body so when it is lacking, it can lead to suboptimal health but it isn’t always easy to know when you are low in vitamin B9. Some symptoms include unexplained fatigue, anemia, muscle weakness, shortness of breath, difficulty focusing, brain fog, headaches, and heart palpitations.
Deficiencies in folate can cause megaloblastic anemia, which is when your blood cells form in an improper shape. This hinders their ability to function correctly in your body. Folate is especially important for pregnant women, as deficiencies can cause neural tube defects in a growing fetus.
Folate and Methylation
Without folate, the body has trouble maintaining methylation. Methylation is a biochemical process that helps support cardiovascular, neurological, and reproductive health.
The cycle of methylation begins with a methyl group (one carbon and three hydrogen molecules) converting amino acid, methionine into S’Adenosylmethionine (SAM-e). Once converted into SAM-e, this molecule travels through the body transferring methyl groups to other bodily systems. SAM-e Is finally converted to the amino acid homocysteine, which creates the antioxidant glutathione.
A deficiency in folate or B12 impairs the final stage of methylation, leading to elevated levels of homocysteine. Too much homocysteine increases the risk of heart disease and blood clots.
Methylation also regulates our genes, turning them on or off. One of the ways cancer develops is through impaired gene regulation. Not having enough folate can impair the body’s ability to regulate cell growth and increase susceptibility to cervical cancer.
MTHFR Gene Mutations
Some people have a genetic mutation that prevents them from properly converting dietary folate into its active form (5-MTHF). This mutation may explain why women with healthy diets and lifestyles struggle to clear the infection, while others who smoke and eat poorly can eliminate the infection with no problem.
Individuals with the MTHFR mutation have an increased risk of several diseases including heart disease, colon cancer, and breast cancer. Supplementing with the active form of folate (folic acid or methylated folate) can be beneficial for those with the mutation.
Methylation is also impacted by diet in general. Studies have found the degree of methylation in the body to correlate with the volume of fruit and vegetables participants consumed. The findings suggest that dietary modifications to include more folate in the diet can reduce the risk of cervical dysplasia.
Benefits of Folic Acid
The average adult is recommended to take 400mcg of folate daily. Although folate is best known for preventing neural tube defects in fetuses, new research is showing its benefits in cancer prevention including breast, bladder, cervical, ovarian, and pancreatic cancers.
Because folate is involved in reducing homocysteine, folate intake can influence heart disease. Recent research is showing benefits in reducing the risk of Autism Spectrum Disorder, Dementia and Alzheimer’s, and depression.
Food Sources of Folate
We recommend aiming for your daily dose of folate from food, before supplementing. Food sources of folate include:
Dark green leafy vegetables (i.e. kale, spinach),
Broccoli,
Black-eyed peas,
Liver,
Asparagus,
Brussels sprouts,
Avocado,
Broccoli,
Green peas,
Fortified Grains*.
*Because of the utmost importance of folate adequacy, the Canadian government, along with other governments have mandated folate fortification to many grains, like breakfast cereals, white flour, and pastas.
Folic Acid’s Role in HPV Management
Folate is one of several key nutrients that have been studied in relation to HPV.
Folate’s role in HPV is likely related to the methylation cycle mentioned above, which ensures your genes function normally.
Current research has highlighted the relationship between low levels of folate in the blood and high-risk HPV infection through the promotion of cervical dysplasia development.
Studies have found that individuals with a folate deficiency have an increased risk of positive HPV status, as well as an increased risk of progression to cervical and oral cancer. Whereas women with higher plasma folate and B12 levels with HPV-16 positivity were 60-75% less likely to be diagnosed with moderate cervical dysplasia.
There has been extensive research on the role of folate in HPV. We highlighted some key research below:
A 2003 study by Hernandez et al. showed that women with the highest levels of blood folate levels from either food or supplements have lower rates of cervical dysplasia from HPV.
A 2016 case-control study by Zhao et al. that included 271 controls and 214 women with both high and low-grade HPV lesions, found that low blood folate levels in women were coupled with a higher risk of cervical cancer from HPV.
A large analysis of studies, or a meta-analysis, showed an increased risk of cervical cancer among Asian populations with low blood folate levels.
A study by Bai et al. showed that a folate deficiency was associated with an increased risk of squamous cell carcinoma of the cervix and cervical intraepithelial neoplasia (CIN) in subjects who were HPV 16 positive.
In an Indian population, improving folate and vitamin B12 status may have a beneficial impact on the prevention of cervical cancer.
Scientific evidence shows that folic acid likely plays a protective role in HPV progression to cervical cancer.
Folate is one of the many key protective nutrients in Papillex. A daily serving of Papillex contains the equivalent of 5 ounces of poultry liver, 4 cups of chickpeas, or 40 spears of asparagus.
Should I Supplement Folic Acid?
It is estimated that 5 to 40 percent of the female population has a folate deficiency globally.
Ideally, we would obtain our folate from food sources like dark leafy greens, vegetables, fruits, nuts, and seafood. However, it can be difficult to get the recommended amount of folate from food alone. As mentioned, a person’s genetics may also make it difficult to convert dietary folate into its active form.
Folic acid supplementation of 400mcg per day is safe. The highest level of daily intake of folate that poses no risk of adverse health effects was set at 1,000 micrograms per day. Folic acid is also a water-soluble vitamin and does not accumulate in fat tissue. Therefore, excess intake will be excreted into the urine and out of the body.
Supplementation with folic acid is often recommended for pregnant women to prevent neural tube defects and prevent megaloblastic anemia.
Supporting HPV Naturally
Many doctors choose to implore a “watch and wait” tactic, as it is difficult to begin treatment without further progression of abnormal cells. Some people wait years before seeing this progression, and most surgical interventions do not have an immense effect on the early stages of cell changes.
Even if you eat the healthiest possible diet, you may still have several nutritional deficiencies which can harm the health of your immune system. This is why in addition to a diet high in richly pigmented fruits and vegetables, it’s important to supplement your diet with clinically supported nutritional supplements.
Papillex is a compound that contains high-quality, natural sources of nutrients that have been shown to support beneficial results in eliminating HPV infections. It contains ingredients that nutritionally support the immune system which will help the body to better respond to genital warts, cervical dysplasia, and other HPV-related disorders naturally.
Aug 07, 2019
6 min read
Vitamin D: The “Sunshine Vitamin”
Dr Elizabeth Goldspink
Vitamin D comes from the sun. Vitamin D is also a key player in maintaining overall health, supporting immune function, regulating inflammation, bone health, and many other essential body processes.
Unfortunately, many people are deficient in this crucial vitamin.
Most people in countries in the northern latitudes do not achieve their adequate dose, especially during the winter. Did you know that low Vitamin D levels can also affect your HPV status?
This blog covers the basics of HPV and how Vitamin D can be vital to your health and wellbeing.
Vitamin D: The Sunshine Vitamin
There are two main natural sources of Vitamin D, food and sunshine, with the sun being most people’s primary source of Vitamin D. This is why it can be more difficult to get the appropriate dose of Vitamin D in winter months when daylight shortens in cooler climates.
Ultraviolet light is absorbed into the skin, strikes the skin, and triggers Vitamin D synthesis, so sunshine is crucial!
Vitamin D is a fat-soluble vitamin as well as a hormone. It is best known for its crucial role in bone health. Without it, the body would not be able to absorb calcium, magnesium, or phosphate from food - which are essential minerals for bone strength. Without adequate calcium absorption, the body “borrows” calcium from the bones, increasing the risk of bone thinning, which may lead to osteoporosis and fracture. Vitamin D helps maintain normal blood levels of phosphorus, magnesium, and calcium for other body functions.
Vitamin D is so vital to bone health that governments mandated the fortification of certain food products, such as milk and milk alternatives to prevent severe deficiencies. Diseases caused by severe deficiency, such as rickets in children and osteomalacia in adults, were common before this fortification.
Vitamin D-eficient Symptoms
It isn’t always obvious when your body is in need of more Vitamin D. While the symptoms are often subtle, low levels of vitamin D can present with:
Low immune function – have you noticed you’re getting sick or run down more often than usual?
Fatigue – it can be as simple as an increased difficulty of getting out of bed in the morning.
Bone loss or pain – new and random aches and pains should be assessed by your primary healthcare provider.
Muscle pain and weakness – not able to crush it at the gym like usual? Having difficulty recovering?
Low mood or depression – often this is a key symptom of Seasonal Affective Disorder, where those who have dark, cold, long winters are deficient in vitamin D, leading to decreased pleasure or interest in doing things they used to love, low mood, and depression.
Impaired skin healing – with low vitamin D, it can be harder to heal something as small as a papercut or a skin blemish scar.
Hair loss – hair thinning or hair loss can be caused by low vitamin D levels
Can I test if I’m deficient?
Vitamin D levels can be checked through a blood test. The most common test is the 25-hydroxyvitamin D or 25(OH)D. It reflects vitamin D produced inside the body from both foods, sun, and supplements. Ranges above 20-30 ng/mL are considered sufficient for bone and overall health in healthy individuals. Levels over 50 ng/mL can be associated with adverse effects.
Getting tested can give a general indicator of your status and whether it might be useful to supplement. We always recommend talking to your doctor to get their take on what would be best for you.
What’s the connection between Vitamin D and HPV?
So now that you know the importance of vitamin D, how does this relate to your HPV status?
New research on Vitamin D is constantly emerging, increasing what we know about the many benefits this vitamin has for our health. Low levels have been linked to insulin resistance and diabetes, inflammation, impaired immunity, and certain autoimmune conditions, and cancer. As more research is conducted, the potential benefits of this “sunshine vitamin” are rapidly expanding.
The main connection between Vitamin D and HPV is in the immune system. An HPV prognosis can single-handedly be affected by the strength of your immunity, and Vitamin D is an essential part of keeping a robust immune system. A study in the United States links low vitamin D status to increased risk of developing a high-risk HPV infection among sexually active women.
Optimal Vitamin D levels have been found to play a positive role in both the adaptive and innate immune systems. Vitamin D has been found to boost the expression of white blood cells, which are the immune molecules known for fighting off infections and managing inflammation. Low levels of Vitamin D have also been associated with autoimmune diseases such as multiple sclerosis, lupus, diabetes, and rheumatoid arthritis.
The hormone has also been found to play a role in managing chronic inflammation, a key factor in nearly every chronic disease. Vitamin D manages inflammation through modulating cytokine production and proliferation. Cytokines are the immune systems chemical messenger systems that tell the rest of the immune system when to respond and react.
Vitamin D’s Anti-Cancer Effects
Another study outlined the importance of Vitamin D in the steroid hormone pathway, which regulates calcium. It explained the anti-proliferative, pro-apoptotic, anti-angiogenic effect of Vitamin D in cancer prevention.
In easier terms, Vitamin D was effective in decreasing cancer cell growth and increasing cell death of existing cancer cells. This study found a significant connection between blood levels of Vitamin D and HPV positive status. Vitamin D has proven anti-inflammatory functions, therefore the deficiency of Vitamin D and its metabolites could possibly relate to HPV persistence and other related cervical intraepithelial neoplasia.
Getting Your Vitamin D
The best way to get Vitamin D is through sun exposure. You need bare skin exposed to sunlight when it’s at its highest so that you can get enough ultraviolet B, or UVB, rays. 10 to 30 minutes per day around 11am to 3pm is optimal. Fair-skinned individuals may spend less time, while those with darker skin tones may need to spend longer. Darker skin tones will have decreased production of Vitamin D in the skin due to increased skin pigments which block UV light absorption.
Other factors that may affect Vitamin D synthesis in your skin from the sun include season, time of day, latitude, cloud cover, pollution, skin tone, clothing, sunscreen, and age. Except in summer months, the skin can make little if any Vitamin D from the sun if you live at latitudes above 37 degrees north. This includes all of Canada and most of the United States. Those ages 65 and up have decreased production of vitamin D with increasing age.
Although sunscreen is important for protecting the skin against harmful effects of the sun, such as skin cancer, sunscreen blocks your skin’s ability to produce vitamin D. Try sitting in the sun, sunscreen-free for 10 minutes, then generously applying sunscreen or cover-up after filling up your vitamin D stores!
To supplement or not to supplement?
For those who live in places with long, dark winters, or grey seasons (we’re looking at you, Canada!), supplementation is recommended. You should see your primary healthcare provider to get bloodwork to guide dosing and supplementation - supplementing too much vitamin D has been known to cause stomach pain and kidney dysfunctions. When picking your supplement, make sure it is in the active form of cholecalciferol.
Food sources may help with your Vitamin D levels as well. Food sources highest in Vitamin D include: canned sardines, salmon, tuna, sunflower seeds, liver, eggs, mushrooms, and fortified milk.
What else can you do naturally?
Most HPV infections are easily cleared by a strong, healthy immune system. You will likely clear the infection with no symptoms with a robust immune system. Your immune system can be supported in a number of natural ways:
Eat plenty of fruits and vegetables – fruits and vegetables contain many essential vitamins and nutrients to keep your body functioning at its best! These food groups are specifically high in antioxidants, which may help neutralize bad molecules floating around in your body.
Quit smoking – smoking single-handedly increases your risk for HPV-related cancers, even second-hand smoke exposure. While cutting down your cigarette count will still affect, nothing is quite as good as quitting entirely.
Reduce alcohol consumption – high consumption of alcohol is related to several negative risks, including a decrease in immune functioning.
Drink green tea – green tea has been shown in many studies to have immune-boosting benefits and anti-cancer effects, some specific to HPV.
Exercise to sweat – We recommend at least 20-30 minutes of light aerobic walking or cycling each day and 2-3 sessions of resistance training.
Get adequate sleep – getting 7 – 8 hours of high-quality sleep is important to regulate your bodily functions, including your circadian rhythm. All of these factors have a distinct effect on your ability to fight infections.
Jul 24, 2019
7 min read
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