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Sneak More Vegetables into Your Diet
Christine Chung
Vegetables… you either love them or hate them.
Your like or dislike of vegetables probably comes from childhood, when you
first got that weird little tree on your plate that your mom called “broccoli”,
that did not quite taste as good as cheese.
Growing into adulthood, we understand the importance of vegetables and try
our best to include those 5 to 7 servings in your daily meals.
Why does it have to be so hard? Are vegetables really that important?
Vegetable consumption may be more important that you know.
Many women with persistent HPV have been found in research to have lower than optimal
amounts of fruits and vegetable intake. Because fruits and vegetables are
jam-packed with essential vitamins, minerals, nutrients, and antioxidants, they
can help to boost your immune system and increase your body’s resilience to
HPV.
Increasing your daily intake of fruits and vegetables is a theme that will
continue to be repeated continuously in any scenario. It is, however, the simplest
way to improve your overall health, so we encourage everyone to eat 7 to 10
servings of fruits and veggies every day.
This can sound daunting at first, but once you get the ball rolling, it can
easily become a part of your daily routine! And guess what? You do not have to eat soft, tasteless green
piles of mush!
Here are a few great tips to help you achieve your daily servings of fruits
and vegetables without sacrificing your tastebuds:
Baby Spinach or Kale in your Morning Smoothie
Dark green leafy vegetables are chock-full of folate and other amazing nutrients. Surprisingly enough, these will not interfere with the flavor of your smoothie, especially with added fruit. You will hardly know there are any greens in there at all, besides the color, and you will have gotten a whole serving or 2 of vegetables out of the way before lunchtime! There are also frozen options of kale, baby spinach, and avocado, to name a few, that are pre-cut and washed, and easy to toss into your smoothie!
Make Homemade Soup
Soups are an easy and delicious way to eat your veggies, especially in the winter when you might be craving warm “comfort food” instead of cold salad.
From a Traditional Chinese Medicine perspective, you should be eating warm, cooked foods as they are easier for your body to digest, allowing for easier nutrient absorption!
Cut up a variety of vegetables, like broccoli, cauliflower, mushrooms, green beans, bell peppers, squash, kale, and boil it in broth with your seasonings of choice and enjoy! You can usually get at least 3 servings of vegetables through a serving of homemade vegetable soup.
Opt for Healthy Chips!
…kale chips, that is!
Kale chips are easy to make, and can be an alternative to chips, giving you that crispy bite and savoury taste that many people often crave!
Take a head of kale, strip the leaves from the stem, and rip the leaves into smaller pieces. Lay the kale pieces flat on a baking sheet, drizzle with extra virgin olive oil and sea salt. Let them bake in the oven at 250°C for about 20 to 30minutes, or until dry and crispy. These will soon become your favorite movie night snack!
Choose the Side Salad Option.
Eating out? As tempting as it may be to order a side of fries with your burger, choosing the side salad is a better idea for your health, contributing to your daily vegetable serving count. Not to mention, fried potatoes are very bad for you, in ways that you may not imagine! Little changes here and there can add up to a big positive change!
Bake with Vegetables.
Another easy to incorporate vegetables into your day is by baking with them.
This can mean baking veggies to make them into snacks or sides for meals, as
baking will help with high volume vegetable cooking, or you can actually make
baked goods with vegetables! Take a look online for some delicious,
veggie-based, baked goods recipes! Here is a recipe for zucchini-based
brownie that is certifiably
delicious.
Looking for extra support? Check out Papillex’s high-quality, hand-picked ingredients that contain the active components of many superfood vegetables!
Feb 19, 2020
3 min read
7 Changes to Kick the January Blahs
Christine Chung
Are you a victim of the January Blahs?
With the
beginning of a new year, January is a month of motivation, change, and new
beginnings. However, for those of us in winter-laden areas, January can also be
the greyest and coldest months of the year. It is tough to get that new year
motivation rolling when it is so cold and miserable outside.
Cue the
January Blahs.
The
bright and sparkly excitement of December has ended and here comes this
overwhelming new year with long, dark days and wind that hurts your face.
People tend to retreat indoors to the comfort of their warm homes and avoid all
outdoor activities. The gym, parks, socialization, really any walking outdoors is a foreign concept at this time.
By the
end of January, most people will have “fallen off the wagon” with respect to
their New Year’s resolutions. Granted, most people tend to set unrealistic
expectations for their goals, often getting discouraged with any fall in
progress.
Lucky for
all the citizens of snowy winter areas, we have got the top 7 tips to kick
these January Blahs and get back to your motivated, energetic self!
1. Self-compassion and kindness
Pay attention to the internal monologue that is constantly playing in your head. You might be shocked by how harsh and unforgiving you are with yourself. Embrace imperfection and start practicing self-kindness, compassion, and forgiveness. Self-care is a great place to start! Draw yourself a bath, relax with a good book, or treat yourself to spa day!
2. Become reacquainted with nature
Research shows that a leisurely forest walk in comparison with urban walks decreases cortisol (the stress hormone), lowers blood pressure, improves mood, and lowers anxiety. Don’t have access to a forest? Get outside anyway! Listen to the sounds, observe the sights, and reflect.
3. Laugh more
In addition to boosting your immune system, laughter also reduces stress, stimulates the release of endorphins, the feel good neurotransmitters, helps relieve pain, and may ease blood pressure. Laugh it up, it’s good for you!
4. Set proper goals
The reason why most New Year’s
Resolutions don’t tend to last is because of improper goal setting. Most people
set unrealistic goals for themselves, which sets you up for failure. Setting
specific, slightly challenging goals have been proved time after time to be the
best method of goal setting.
Making sure they are not too easy, and ensuring specificity (i.e. How many servings of vegetables is your daily target? How many kilometres do you want to run within 30 minutes by March?) is the key to good goal setting. Check out this TEDtalk by venture capitalist John Doerr who has a goal-setting system that has been employed by large companies like Google and Intel to differentiate success from failure.
5. Hold yourself accountable
This is a way to keep yourself on track for your goal. Connect with like-minded friends, fellow members of your gym, or join a program where they have large networks of accountability groups! When others can hold you responsible, you are more likely to stick to the goals at hand.
6. Get some light
Many studies have shown that light therapy can treat Seasonal Affective
Disorder (SAD). SAD is a mood disorder that is related to changes in season. Light
therapy is a new, popular method of treatment for SAD. The research shows that
10,000 lux of light for 30 minutes per day early in the morning can treat and prevent symptoms of SAD.
Those who received light therapy noticed improvements in energy, mood,
fatigue, and cognitive function! This study compared light therapy to a
commonly used antidepressant, fluoxetine. The results showed that light therapy had no significant
difference of efficacy compared to fluoxetine. Both groups saw significant improvements in mood.
Something as simple as light was
able to provide the same benefit as a pharmaceutical medication!
How do you get this specific amount of bright light every morning? Companies like Verilux have light machines specific to treating SAD, providing the therapeutic amount of lux with timers to ensure your daily dose of light.
7. Top up your Vitamin D
Vitamin D is quite commonly
deficient in those who live in winter-heavy countries, like Canada. Research
has linked Vitamin D deficiencies to lower mood, worsened cognitive
performance, decreased immune function, among other more serious concerns.
Studies have shown that improving
Vitamin D levels was significantly associated with improvements in depression scales, concluding that Vitamin D is an
important consideration for the January Blahs.
Want to learn more about optimizing your health?
Check out our blogs for more health and wellness tips!
Jan 08, 2020
3 min read
“Mexican Scientist Cures HPV!” Fact or Fiction?
Christine Chung
This headline has been quite popular in the media as of late.
Scientific sources have been publishing information about this topic, as well as reputable, and not so reputable news outlets.
Is it really true?
Have scientists in Mexico really discovered the cure to a virus that is rapidly become the most common sexually transmitted infection in the United States?
Sadly, the short answer is no.
A team of highly-trained scientists from Mexico have claimed “cure HPV” using a fairly new technology called Photodynamic Therapy (PDT) combined with Aminolevulinic acid (ALA), a gel that helps the therapy work better, to kill cancer cells.
Read below to learn more about PDT, ALA, and whether or not this is the end-all treatment for HPV.
ALA and Photodynamic Therapy (PDT)
PDT is commonly used as a treatment for cancer, using a particular type of light in combination with a specific photosensitizing agent, ALA.
ALA, particularly 5-aminolevulinic acid, is an amino acid that is involved in a special pathway called porphyrin synthesis in your body. Aminolevulinic acid is the special addition used in combination to specific wavelengths to treat cancers with overgrowths of the skin.
How does ALA-PDT work?
The combined therapy attacks the skin cells of genital warts that continue to expand when they shouldn’t. In addition, the therapy was specific enough that it targeted these cells but left the normal, healthy skin cells alone.
What else is PDT used for? PDT has also been used for acne, precancerous lesions, such as actinic keratosis, and melanomas of the skin.
Can I get ALA-PDT from my doctor?
ALA-PDT has only recently been introduced and accepted for use in some countries, especially in Mexico City, for cervical cancers, precancerous lesions, and HPV-related symptoms, such as genital warts.
Does it actually work?
Most clinical trials show that PDT is highly effective when compared to placebo treatment. When targeting CIN or HPV infections specifically to each patient, the complete remission rate is improved significantly. However, most of the studies included were of lower quality, so they may not be quite as reputable.
Which situations would ALA-PDT be beneficial?
Studies show that with ALA-PDT, HPV can be effectively eliminated in those with latent or subclinical infections (currently with no symptoms), within 3 months. This is the population of people who have been diagnosed with HPV but have not or are not currently showing symptoms.
The current research does show that those with CIN responded very well to PDT.
How does it compare to other therapies?
ALA-PDT also poses a very low risk to fertility, current, and future pregnancies. It is also fairly minimally-invasive, as it is a non-surgical procedure involving no blood loss, no damage to the cervical tissue, and no reports of infertility. In these situations, ALA-PDT may be a treatment of interest for you.
This therapy can also be more cost-effective than some other, more invasive procedures. If your case is more resistant to PDT, it may end up costing more in the long run.
Reported side effects include: red, itchy skin, swelling, burning or stinging at the site of treatment.
The Bottom Line
Current research on available clinical trials show that PDT combined with ALA could possibly be effective in the treatment for HPV and associated conditions - but more, higher quality research needs to be done.
Infections of early or late stage, with or without CIN, and even infections progressed into cervical cancer are all potentially treatable by ALA-PDT.
Trials are all new and of varying qualities, but the research available is all we have to determine the benefits of this new therapy.
The News Headlines
The work that is currently publicized in the media is in regards to Mexican scientists who have claimed to use ALA-PDT to eradicate HPV completely in 29 women.
While the reports are interesting, especially with the currently available information on ALA-PDT, their findings have not been published yet and are unlikely to be a be-all-end-all cure for HPV.
Be careful of the credibility of information out there. Keep in mind the source of information before making decisions about your health and treatment.
How Does Papillex Come Into All This?
By boosting your natural immunity and replacing missing and low nutrients, Papillex™ can help you to create an environment inhospitable to HPV and its common symptoms, cervical dysplasia and genital warts.
Dec 18, 2019
3 min read
HPV, Broccoli, and its secret Ingredient - Sulphoraphane
Dr Elizabeth Goldspink
Your childhood was probably filled with memories of your parents always telling you to eat your greens, broccoli being one of the main greens that many children will scrunch their face at.
But...did you know that broccoli has many branches of super metabolites that can radically change your health?
Discover why your mom was right, and why you shouldn’t give up eating broccoli any time soon!
What’s the Deal with Broccoli?
Broccoli belongs to the cabbage family, part of a larger family called the Brassicas. The brassica family of cruciferous vegetables also includes common power greens including kale, Brussels sprouts, Swiss chard, and cabbage.
This group of vegetables contains phytochemicals that have high antioxidant activity called isothiocyanates.
Broccoli, however, goes one step further.
Broccoli is very high in vitamin K, vitamin C, vitamin A, folate, vitamin B6, and manganese, and also contains sulforaphanes and indoles. These are also strong antioxidants, but they have the added benefit of detoxification, anti-cancer properties, and many other health benefits. The American Cancer Society even stands behind broccoli, recommending consumption to decrease the risk of cancer.
Sulforaphane and Indoles
Broccoli’s therapeutic claim to fame is in its active ingredients: Sulforaphane.
These compounds are found in most cruciferous vegetables including cabbage, Brussels sprouts, cauliflower and arugula.
However, broccoli sprouts are by far the richest source of sulforaphane. After consumption, sulforaphane will then break down into 2 even more powerful metabolites: indole-3-carbinol (I3C) and diindolylmethane (DIM).
Sulforaphane has been widely studied as a very powerful anti-cancer agent. It is also very effective in glucose control in Type 2 Diabetic patients, and great at regulating bowel movements.
I3C is also well known for it’s anti-cancer properties. It is used in other clinical scenarios, such as hormone balancing, as it is a phytoestrogen, detoxification, liver supporting, and immune supporting.
DIM is similarly known for anti-cancer and detoxification properties.
These compounds have been researched for its ability to help protect our bodies from free radicals, repair damaged DNA, and help protect against cancers including cervical cancer. This is why broccoli sprout extract is a key ingredient in Papillex.
Broccoli Metabolites and HPV
There are many studies supporting these broccoli metabolites and the management of HPV and HPV-related symptoms.
Epidemiological studies show that I3C supplementation may be beneficial in treating CIN and other conditions related to HPV. In a study, I3C supplementation showed even faster regression rates than the non-treatment group, even though the other subjects in the study who were not taking I3C had less HPV-positive findings.
Sulforaphane was shown to induce cell death and cervical cancer cells. It was able to accomplish this through the suppression of a certain gene (EZH2) activated by HPV, that is commonly targeted by cancer drugs. Broccoli can be so powerful!
DIM helps detoxify your body, which has general health benefits. Some early animal studies show that DIM can slow cervical dysplasia in mice.
So Broccoli Sprout, Anyhow, Anywhere?
Reaping the benefits of broccoli’s active ingredient is not as simple as taking any broccoli sprout supplement.
The body’s ability to take up nutrients, vitamins and minerals is called bioavailability and varies greatly from person to person and from nutrient to nutrient.
There are many things that influence how much of a given nutrient your body can absorb; its source, your gut microbiota, and other foods you eat alongside.
For example, some vitamins must undergo a chemical conversion in order to be activated while others might require the presence of dietary fats to be absorbed.
In the case of broccoli, the active ingredient sulphoraphane, must be first converted before it’s available for use.
Cruciferous vegetables store the precursor to sulphoraphane, a molecule called glucoraphanin, and only in the presence of an enzyme myrosinase is it converted into sulphoraphane.
Therefore, in order to get active sulphoraphane from our diet, a chemical reaction between the enzyme myrosinase and the precursor glucoraphanin must occur.
Raw vs. Cooked
You must be careful in cooking cruciferous vegetables. While the raw form of broccoli can have 10 times more sulforaphane than cooked broccoli, large quantities of raw cruciferous vegetables can become goitergens, harmful to the thyroid.
Flash steaming broccoli for 1-3 minutes at a medium heat is generally a good way to keep all those sulforaphanes, but also prevent harm to your thyroid.
Sprouts tend to be more easily digestible - a fun new addition to your salads!
Not All Supplements Are Created Equal…
Most of the nutritional supplements that are marketed as broccoli sprout extracts only contain glucoraphanin, and not the myrosinase enzyme necessary for the conversion to sulphoraphane.
While the bacteria in our gut can help with this chemical reaction, it is inefficient in many people, and therefore provides little benefit.
Papillex uses brassinase, a specialized broccoli powder extract that contains active myrosinase and sulphoraphane. This combination provides all the necessary building blocks to ensure the conversion to active sulphoraphane. Papillex guarantees its biovailability directly to your cells.
Sources
Ishita Ahuja, Jens Rohloff, and Atle Magnar Bones. Defence mechanisms of Brassicaceae: implications for plant-insect interactions and potential for integrated pest management. A review. Agron. Sustain. Dev. 2010 30(2):311-48.
Vermeulen M, Klöpping-Ketelaars IW, van den Berg R, Vaes WH. Bioavailability and kinetics of sulforaphane in humans after consumption of cooked versus raw broccoli. J Agric Food Chem. 2008 Nov 26;56(22):10505-9.
Schor, Jacob, ND, FABNO. “Broccoli: Alternatives to Eating It Raw.” Natural Medicine Journal. N.p., Oct. 2011. Accessed 20 June 2017.
Dec 11, 2019
4 min read
Christine Chung
A
Natural Approach to HPV
Watching and waiting to see if your HPV progresses into something more serious can be stressful and cause frustration. Papillex contains ingredients that research has shown to help the immune system respond to HPV naturally. It also contains replenishing nutrients that tend to be deficient in cases of persistent HPV infections.
Low levels of dietary carotenoids have been shown in women with HPV and are associated with an increased risk of persistent HPV infections. The risk is increased by 50% for high-risk HPV. High levels of vegetable consumption, specifically have been shown to decrease HPV persistence by 54%. Increased levels of lycopene in the blood are also associated with a decreased risk of CIN 1, 3, and cervical cancer.
Eat Your Vegetables!
One study showed higher dietary intakes of dark green and deep yellow vegetables and fruit were associated with an almost 50% decreased relative risk of CIN 3. This shows the importance of loading up on colorful vegetables such as peppers, tomatoes, carrots, mangos, sweet potatoes, spinach, and kale to support homeostasis and a healthy microbiome. A daily serving of Papillex™ contains the equivalent of 3/4 cup of frozen cooked spinach, 3 cups of raw carrots, or 2.5 cups of raw cantaloupe daily.
Indole-3-carbinol, DIM, and sulforaphane are powerful metabolites found in broccoli family vegetables that support the body in the repair of DNA damage and have been shown to lower the risk of cancer. Small human trials suggest indole-3-carbinol (I3C) supplementation may be beneficial in treating conditions related to HPV. One study showed a statistically significant regression of CIN in patients treated with oral I3C, despite a higher prevalence of positive HPV findings in treatment groups.
Sulforaphane
Specifically was shown to stop the growth of cancer cells by causing cell death. These important ingredients are found in cabbage, broccoli, broccoli sprouts, Brussels sprouts, cauliflower, and kale. To garner the same benefit as a daily serving of Papillex™, you would need to eat one head of broccoli, 2 cups of Brussels sprouts, or 2.8 cups of raw cabbage per day…that’s a lot of crunchy greens!
Studies have found that individuals with a folate deficiency have an increased risk of positive HPV status, as well as an increased risk of progression to cervical and oral cancer.
There may be a relationship between low levels of folate in the blood and high-risk HPV infection. Folate rich foods include: dark green leafy vegetables (such as: spinach, asparagus and Brussels sprouts), nuts and beans, and liver. A daily serving of Papillex contains the equivalent of 5 ounces of poultry liver, 4 cups of chickpeas, or 40 spears of asparagus.
Vitamin C Is Correlated With Lower Prevalence of HPV
Vitamin C is a powerful antioxidant. Research studies conclude that individuals with higher Vitamin C levels have a lower HPV viral load, and decreased frequency of the development of oral and cervical cancer.
Foods highest in Vitamin C include: yellow bell peppers, guavas, dark green vegetables (especially kale and turnip greens), kiwi and broccoli. A daily serving of Papillex™ contains the equivalent of 1/2 yellow pepper, 1 guavas or 2 cups of kale.
Anti-viral Antioxidants
Green tea
has long been known as a powerful anti-viral and anti-infective plant that stimulates the immune system. Green tea is often used topically for genital warts and cervical dysplasia.
Orally, green tea intake has been associated with slowed progression and decreased risk of cancer through its strong antioxidant effects.
A daily serving of Papillex™ contains the equivalent of 2.5 cups of green tea with a guaranteed low level of caffeine. For those who are sensitive to caffeine, no need to worry!
Vitamin E
Vitamin E has been shown through clinical studies to inhibit cancer cell growth and support the immune system through its powerful antioxidant capabilities.
Low levels of Vitamin E have been seen in cervical cancer patients and higher rates of HPV-16 and 18 in research. Foods high in Vitamin E include cooked spinach, almonds, roasted sunflower seeds, avocados and fish. A daily serving of Papillex™ contains the equivalent of 32 cups of cooked spinach, 3 cups of whole almonds, or 28 whole avocados. WOW!
Selenium
Individuals with cervical dysplasia have been reported to have low levels of selenium, an essential trace mineral. In recent animal studies, selenium has also been shown to increase cell death in HPV-infected cells.
It can be difficult to supply the body with selenium, as many of our soils are depleted of this essential mineral. Foods that are generally higher in selenium include brazil nuts, oysters, tuna, and sunflower seeds. A daily serving of Papillex™ contains the equivalent of 3 oysters, 4 ounces of tuna, or 3 brazil nuts.
Medicinal Magic
Astragalus
A powerful immune modulator has been used for centuries to promote resilience in the body. Recent studies have shown the herb's impact on the growth of abnormal cervical cells.
In an in vitro study, an Astragalus injection into cells slowed down the bad cell growth and regulated immune cells. The study concluded that on a cellular level, Astragalus can reduce the survival of infected cells, the effect increasing with higher doses.
Reishi
The Reishi mushroom has been celebrated for its antiviral properties over thousands of years. Clinical studies have shown that the use of these medicinal mushrooms has dramatically impacted the clearance rate of HPV, both vaginal and oral. Extracts of Reishi, or Ganoderma lucidum stopped the growth of HPV-infected cells by stopping the cell cycle and causing cell death in transformed cervical cells.
Papillex can be an excellent way to support your body during the “watch and wait” period between pap smears. It contains therapeutic dosages of clinically research ingredients that help support the immune system when concerned with HPV.
Why watch and wait, when you can be proactive? Order Papillex today!
Aug 21, 2019
4 min read
Vitamin D: The “Sunshine Vitamin”
Dr Elizabeth Goldspink
Vitamin D comes from the sun. Vitamin D is also a key player in maintaining overall health, supporting immune function, regulating inflammation, bone health, and many other essential body processes.
Unfortunately, many people are deficient in this crucial vitamin.
Most people in countries in the northern latitudes do not achieve their adequate dose, especially during the winter. Did you know that low Vitamin D levels can also affect your HPV status?
This blog covers the basics of HPV and how Vitamin D can be vital to your health and wellbeing.
Vitamin D: The Sunshine Vitamin
There are two main natural sources of Vitamin D, food and sunshine, with the sun being most people’s primary source of Vitamin D. This is why it can be more difficult to get the appropriate dose of Vitamin D in winter months when daylight shortens in cooler climates.
Ultraviolet light is absorbed into the skin, strikes the skin, and triggers Vitamin D synthesis, so sunshine is crucial!
Vitamin D is a fat-soluble vitamin as well as a hormone. It is best known for its crucial role in bone health. Without it, the body would not be able to absorb calcium, magnesium, or phosphate from food - which are essential minerals for bone strength. Without adequate calcium absorption, the body “borrows” calcium from the bones, increasing the risk of bone thinning, which may lead to osteoporosis and fracture. Vitamin D helps maintain normal blood levels of phosphorus, magnesium, and calcium for other body functions.
Vitamin D is so vital to bone health that governments mandated the fortification of certain food products, such as milk and milk alternatives to prevent severe deficiencies. Diseases caused by severe deficiency, such as rickets in children and osteomalacia in adults, were common before this fortification.
Vitamin D-eficient Symptoms
It isn’t always obvious when your body is in need of more Vitamin D. While the symptoms are often subtle, low levels of vitamin D can present with:
Low immune function – have you noticed you’re getting sick or run down more often than usual?
Fatigue – it can be as simple as an increased difficulty of getting out of bed in the morning.
Bone loss or pain – new and random aches and pains should be assessed by your primary healthcare provider.
Muscle pain and weakness – not able to crush it at the gym like usual? Having difficulty recovering?
Low mood or depression – often this is a key symptom of Seasonal Affective Disorder, where those who have dark, cold, long winters are deficient in vitamin D, leading to decreased pleasure or interest in doing things they used to love, low mood, and depression.
Impaired skin healing – with low vitamin D, it can be harder to heal something as small as a papercut or a skin blemish scar.
Hair loss – hair thinning or hair loss can be caused by low vitamin D levels
Can I test if I’m deficient?
Vitamin D levels can be checked through a blood test. The most common test is the 25-hydroxyvitamin D or 25(OH)D. It reflects vitamin D produced inside the body from both foods, sun, and supplements. Ranges above 20-30 ng/mL are considered sufficient for bone and overall health in healthy individuals. Levels over 50 ng/mL can be associated with adverse effects.
Getting tested can give a general indicator of your status and whether it might be useful to supplement. We always recommend talking to your doctor to get their take on what would be best for you.
What’s the connection between Vitamin D and HPV?
So now that you know the importance of vitamin D, how does this relate to your HPV status?
New research on Vitamin D is constantly emerging, increasing what we know about the many benefits this vitamin has for our health. Low levels have been linked to insulin resistance and diabetes, inflammation, impaired immunity, and certain autoimmune conditions, and cancer. As more research is conducted, the potential benefits of this “sunshine vitamin” are rapidly expanding.
The main connection between Vitamin D and HPV is in the immune system. An HPV prognosis can single-handedly be affected by the strength of your immunity, and Vitamin D is an essential part of keeping a robust immune system. A study in the United States links low vitamin D status to increased risk of developing a high-risk HPV infection among sexually active women.
Optimal Vitamin D levels have been found to play a positive role in both the adaptive and innate immune systems. Vitamin D has been found to boost the expression of white blood cells, which are the immune molecules known for fighting off infections and managing inflammation. Low levels of Vitamin D have also been associated with autoimmune diseases such as multiple sclerosis, lupus, diabetes, and rheumatoid arthritis.
The hormone has also been found to play a role in managing chronic inflammation, a key factor in nearly every chronic disease. Vitamin D manages inflammation through modulating cytokine production and proliferation. Cytokines are the immune systems chemical messenger systems that tell the rest of the immune system when to respond and react.
Vitamin D’s Anti-Cancer Effects
Another study outlined the importance of Vitamin D in the steroid hormone pathway, which regulates calcium. It explained the anti-proliferative, pro-apoptotic, anti-angiogenic effect of Vitamin D in cancer prevention.
In easier terms, Vitamin D was effective in decreasing cancer cell growth and increasing cell death of existing cancer cells. This study found a significant connection between blood levels of Vitamin D and HPV positive status. Vitamin D has proven anti-inflammatory functions, therefore the deficiency of Vitamin D and its metabolites could possibly relate to HPV persistence and other related cervical intraepithelial neoplasia.
Getting Your Vitamin D
The best way to get Vitamin D is through sun exposure. You need bare skin exposed to sunlight when it’s at its highest so that you can get enough ultraviolet B, or UVB, rays. 10 to 30 minutes per day around 11am to 3pm is optimal. Fair-skinned individuals may spend less time, while those with darker skin tones may need to spend longer. Darker skin tones will have decreased production of Vitamin D in the skin due to increased skin pigments which block UV light absorption.
Other factors that may affect Vitamin D synthesis in your skin from the sun include season, time of day, latitude, cloud cover, pollution, skin tone, clothing, sunscreen, and age. Except in summer months, the skin can make little if any Vitamin D from the sun if you live at latitudes above 37 degrees north. This includes all of Canada and most of the United States. Those ages 65 and up have decreased production of vitamin D with increasing age.
Although sunscreen is important for protecting the skin against harmful effects of the sun, such as skin cancer, sunscreen blocks your skin’s ability to produce vitamin D. Try sitting in the sun, sunscreen-free for 10 minutes, then generously applying sunscreen or cover-up after filling up your vitamin D stores!
To supplement or not to supplement?
For those who live in places with long, dark winters, or grey seasons (we’re looking at you, Canada!), supplementation is recommended. You should see your primary healthcare provider to get bloodwork to guide dosing and supplementation - supplementing too much vitamin D has been known to cause stomach pain and kidney dysfunctions. When picking your supplement, make sure it is in the active form of cholecalciferol.
Food sources may help with your Vitamin D levels as well. Food sources highest in Vitamin D include: canned sardines, salmon, tuna, sunflower seeds, liver, eggs, mushrooms, and fortified milk.
What else can you do naturally?
Most HPV infections are easily cleared by a strong, healthy immune system. You will likely clear the infection with no symptoms with a robust immune system. Your immune system can be supported in a number of natural ways:
Eat plenty of fruits and vegetables – fruits and vegetables contain many essential vitamins and nutrients to keep your body functioning at its best! These food groups are specifically high in antioxidants, which may help neutralize bad molecules floating around in your body.
Quit smoking – smoking single-handedly increases your risk for HPV-related cancers, even second-hand smoke exposure. While cutting down your cigarette count will still affect, nothing is quite as good as quitting entirely.
Reduce alcohol consumption – high consumption of alcohol is related to several negative risks, including a decrease in immune functioning.
Drink green tea – green tea has been shown in many studies to have immune-boosting benefits and anti-cancer effects, some specific to HPV.
Exercise to sweat – We recommend at least 20-30 minutes of light aerobic walking or cycling each day and 2-3 sessions of resistance training.
Get adequate sleep – getting 7 – 8 hours of high-quality sleep is important to regulate your bodily functions, including your circadian rhythm. All of these factors have a distinct effect on your ability to fight infections.
Jul 24, 2019
7 min read
Photodynamic Therapy for HPV: What Is It and Does It Work?
Christine Chung
Photodynamic therapy is a treatment typically used in the treatment of acne, warts, and a range of cancers, including mouth (oral), head and neck, lung, and skin cancer, and has been for a number of years now.
However, PDT is now being considered a
novel approach to eradicating the human papillomavirus.
This follows a study conducted by scientists at the Mexico National Polytechnic Institute who found it to be effective in clearing the virus.
Furthermore, it was reported that a researcher who worked on the project, Eva Ramón Gallegos, has used the method to remove HPV from 100% of a 29-women sample.
So is PDT the cure for HPV that we’ve all been looking for?
That remains to be seen.
The latest reports are yet to be
published in a peer-reviewed journal, and they were made a considerable amount
of time ago now, back in February 2019.
Nevertheless, PDT is worth exploring in the eradication of a virus which is the leading cause of cervical cancer in the world, and one of the most commonly transmitted sexual infections in the world.
How Does
PDT Work?
PDT involves using a particular type of light in combination with a photosensitizing agent called aminolevulinic acid (ALA), which is applied as either a topical cream or injected into your blood to make your cells sensitive to light.
Aminolevulinic acid, particularly
5-aminolevulinic acid, is an amino acid that is involved in a pathway called porphyrin synthesis in your body.
When combined with the correct light wavelength, the procedure damages those surface layer cells affected by HPV, while surrounding tissue is left undamaged.
Photodynamic Therapy in action for Acne
In other words, ALA, makes your cells
more sensitive to light, and when exposed to a certain wavelength of light, can
kill cancer cells.
PDT also works well for treating genital warts. The combined therapy attacks the skin cells of genital warts that continue to expand when they shouldn’t. In addition, the therapy was specific enough that it targeted these cells but left the normal, healthy skin cells alone.
What Are
The Benefits of PDT?
Many women who suffer from HPV are of child-bearing age, so the risk of treatment to future pregnancies is a concern for this population. Luckily, photodynamic therapy poses a lower risk to current and future pregnancies.
PDT is safer than other treatments during pregnancy
Among other benefits, photodynamic therapy is also non-surgical, which also means there is no blood loss, no sustained damage to cervical tissue, and no reports of infertility related to treatment.
Are There
Any Downsides?
PDT can be associated with some side effects, such as red, itchy skin, swelling, burning, or stinging at the site of treatment, however, these are relatively minor problems, especially in comparison to some of the treatments mentioned above.
However, PDT can be expensive.
This is dependent on the length of treatment and resistance of HPV, however, studies show that it is more cost-effective in comparison to some other treatments.
How Effective
Is PDT?
We did the digging so you wouldn’t have to. So sit back, sip your green tea, and relax. Most clinical trials show that PDT is highly effective when compared to a placebo treatment, or a treatment where the study participants THINK they are getting PDT treatment, but in reality, they are not.
When targeting CIN or HPV infections specifically to each patient, the complete remission rate is improved significantly. Keep in mind, the studies in this review were of lower quality. Studies show that with ALA-PDT, HPV can be effectively eliminated in those with latent or subclinical infections within 3 months.
This is the population of people who have been diagnosed with HPV but have not or are not currently showing symptoms.
Catch it early, and ALA-PDT therapy may work for you!
Multiple 4-hour treatments of 5-ALA and PDT in males with genital warts show complete clinical remission after the last session. The number of sessions and strength of treatment was specified for each patient depending on HPV viral load, a number that dictates the severity of infection.
By monitoring the viral load, doctors were able to keep an eye on the effectiveness of treatment, knowing when they needed to increase the intensity, or back off with treatment.
Treatment effectiveness
According to the evidence, the percentage strength of the aminolevulinic acid may impact effectiveness.
Comparing 2 different studies, one clinical trial used a 20% aminolevulinic acid gel and showed a high complete response rate, meaning no more symptoms for the patients with HPVafter 3 treatments. Even after 1 year, follow-up tests showed very low levels of recurrence of symptoms in patients.
Another study of higher quality used a 3% aminolevulinic acid gel with photodynamic therapy. Their results were generally positive for use in the treatment of HPV symptoms, however, they were not significantly different from the placebo group (recall: study participants THINK they are getting PDT treatment, but in reality, they are not). This study was of higher quality, so perhaps the other study was not as accurate.
A third clinical trial from Mexico used a 6% aminolevulinic acid gel with photodynamic therapy. They were looking into eliminating HPV-16and HPV-18 and associated cervical intraepithelial neoplasia (CIN) in Mexican women. They found that at this percentage, HPV infections were successfully eliminated, with or without CIN progression.
Specifically, in groups of people with cervical intraepithelial neoplasia, PDT showed to be very promising. CIN precancerous lesions, including carcinomas and early invasive cancer of the cervix, responded very well to photodynamic therapy.
Improving HPV outcomes
Well, newer studies are showing the effectiveness of using different analyses and numbers to track and guide the effectiveness of treatment. Researchers and doctors are keeping tabs on the HPV viral load to measure the effectiveness of treatment. This helps the treatment team to know if the current treatment is working if the dose should be increased, or if the treatment is working so well that they can start to use lower doses.
PDT has been shown to significantly lower viral load after treatment. The better the treatment, the lower the viral load!
They can also keep track using polymerase chain reaction assays (PCR) to give a grade of HPV, measuring the status of the HPV infection. DNA detection with genotype identification has also been used in this patient setting. The only thing you really need to know about this technique is that it can help find some precancerous or HPV lesions that are unnoticed.
Using these techniques, one clinical trial saw two cases of anal warts cleared with no detectable HPV at the end of treatment or at 1 year after treatment.
Mechanisms of Action
ALA-PDT also works by downregulating the expression of the human papilloma virus E6/E7 oncogene, the gene responsible for producing precancerous and cancer cells associated with HPV.
It also upregulates tumor suppressors, including p53, something that’s usually produced in your body to prevent tumors from growing.
ALA-PDT causes apoptosis of H8 cells, which is very important. H8 cells are HPV-16 immortalized cervical epithelial cells.
These cells are highly studied in HPV, as they activate the E6/E7 oncogenes and otherwise hide in plain sight by acting and functioning as normal human skin cells. One study found that by downregulating the E6/E7 oncogene and upregulating tumor suppressor, they were able to cure HPV infection-associated diseases and prevent progression into cervical cancer. The higher the dose of treatment, the higher the level of cell death of H8 cells. That’s a win in our books!
In summary:
Current research on available clinical trials show that PDT
combined with ALA is very effective in the treatment for HPV and associated
conditions.
Infections of early or late stage, with or without CIN, and even infections progressed into cervical cancer are all potentially treatable by ALA-PDT. Trials are all new and of varying qualities, but the research available is all we have to determine the benefits of this new therapy.
What else can you do?
Lifestyle modifications, a healthy diet, and supplementation
are key in maintaining a robust immune system to help clear the HPV infection.
Even with the PDT, ensuring adequate wellness and a fully supported immune
system will work in conjunction with the treatment to fight the battle against
HPV!
Discover the innate benefits in each Papillex ingredient and what exactly it does to support your immune system so you stay HPV-symptom free!
May 21, 2019
6 min read
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