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Normal Pap Smear: Could I Still Have HPV?
Adrienne Hill-Strathy
The regular Pap test can be a dread for many women. The situation is uncomfortable, and the fear of an abnormal result can be anxiety-provoking.
What’s more, the results of a Pap smear can often be confusing.
Here, we have provided a breakdown to help you better understand your Pap results and how we can use testing to better prevent complications like cervical cancer.
What Is a Pap and HPV Test?
The HPV and Pap Smear Tests are the primary ways for women to test for HPV and signs of abnormal cells.
A Pap test involves taking a sample of cells from your cervix to assess for any abnormalities. It is usually combined with a pelvic exam and sometimes an HPV test, which screens for the presence of HPV viruses in your cell tissues.
What Do Your Pap Results Mean?
The test results from a Pap smear can go one of three ways: NORMAL, UNCLEAR, ABNORMAL.
Normal: a normal Pap test suggests no abnormal cellular changes on the surface of the cervix. Pap testing will be recommended every three years.
Unclear: an unclear test indicates some mild abnormality and usually warrants a repeat Pap test. Mild abnormality could be due to a vaginal or sexually transmitted infection, changes in hormones, such as those seen in pregnancy or menopause, with certain medications, or poor test collection.
Abnormal: an abnormal pap test means that cervical cell changes were found. This does not mean that you are positive for cervical cancer but further investigation is needed.
Can You Have a Normal Pap Smear But Be Positive for HPV?
Because the Pap test and HPV test for two different things, abnormal cellular changes and the presence of HPV in your cells, it is possible for your Pap test to come back normal, but you screen positive for HPV.
This results likely means you have HPV, but the virus remains in a state of low activity and has not caused significant abnormal changes to your cervix.
HPV is typically cleared by activation of the adaptive immune system, which releases immune molecules called T-cells into the circulation to suppress viral replication. Over time, a healthy immune system should prevent HPV from further proliferating into your cervical epithelial cells and render the virus in a latent state.
A normal Pap test could therefore indicate that your immune system is actively suppressing cell proliferation, but the virus is still active.
Errors In Pap Testing
A normal Pap test could also mean the swab may not have caught the areas of abnormality on your cervix. While Pap testing is a great tool, it isn’t always perfect.
Studies find that abnormal findings increase when conventional Pap smears are replaced by liquid-based cytology (LBC). However, because most HPV infections resolve over time and cytology exams lead to costly follow-up investigations with repeat Pap smear and biopsies, HPV reflex testing is being used to identify high-risk strains.
HPV Reflex Testing
Pap and HPV testing are usually done in combination to evaluate whether the strain of HPV that is infecting a host, has a high risk of developing into cancer.
HPV reflex testing can help identify the particular HPV strain that is causing the infection.
We know that high-risk HPV types 16, 18, 31, 33, 35, 45, 52, and 58 account for about 88% of all cervical cancers worldwide. Detection of these strains within an individual can help prioritize preventative measures and screening to monitoring changes and cell development.
By performing more specific screening we can ensure that individuals at high-risk are getting proper follow ups and avoiding undue stress to minor cases that are unlikely to progress into cervical cancer.
It should be noted that HPV reflex screening is not typically included in screening guidelines but is offered as a commercial test to better screen for a patient’s risk.
What Can You Do?
If you have received a result of a normal Pap test but remain positive for HPV, it is still important for you to take steps to support your immune system and keep watch on the situation.
We recommend:
Eating a diet rich in plants and high in micronutrients.
Supplementing with herbal formulas, like Papillex, and medicinal mushrooms to support your immune system.
Developing techniques to reduce daily stressors and manage overwhelm.
Limiting the consumption of alcohol and avoiding smoking.
Getting daily exercise and movement into your day.
May 03, 2021
3 min read
Adrienne Hill-Strathy
Viruses aren’t living organisms but strands of DNA or RNA that make a home in other living organisms. By doing so, the viruses can survive.
The life-cycle of a virus includes gaining entry into a living organism, replicating, and making itself a home.
Understanding the life-cycle and how the immune system interacts with HPV can better understand why some strains develop into complications like cancer.
What Makes The HPV Life-Cycle Unique?
HPV includes a family of more than 150 types that have slight variations. HPV has adapted over time to target different tissue regions and cause different diseases.
Most HPV infections occur around the mouth or genitals. Some infections cause visible growths like warts and others are asymptomatic.
In addition to the type of HPV strain, symptoms also depend on the individuals' immune system. The immune system influences how quickly the virus is identified and eliminated from the body. Most HPV infections will complete their life-cycle without causing disease or symptoms at all.
Infection Stage
Infection occurs when the HPV gains entry into skin tissue, called epithelial cells. Epithelial cells line the surface of the body and can be classified into three shapes: squamous, columnar, and cuboidal.
When it comes to testing for HPV and cell abnormality, squamous cells are the ones that typically develop abnormalities.
Squamous cells are found in body tissue which forms the very surface of the skin. During a Pap smear, a swab is taken from this layer to examine for abnormalities.
The cells meet the rest of the body through a layer called the basement membrane. This basement layer is where the HPV virus attaches and enters the cell. Once the virus has accessed the cell it can then use the cell to replicate.
Squamous Cells Diagram
Replication:
Depending on the strain of HPV and the body the virus makes a home in, the life-cycle will have different outcomes.
The virus may remain relatively silent. In this case, the virus doesn’t move beyond the basement membrane to cause disease.
The virus may also begin to replicate, releasing its viral particles deeper into the host. When the virus replicates deeper into the skin tissue it is called a productive infection.
Productive Infections
Infections can be classified into grades CIN 1 (deregulated) to 3 (high-grade neoplasia). Persistent high-grade infections at CIN2 or CIN3 can further lead the virus to integrate into the individuals' genes. This puts the individual at greater risk of developing cancer.
Some areas within the cervix lining are more susceptible to infection. HPV that gain access to the transformational zone in the cervix have been linked to higher rates of cancer progression.
Two viral proteins, E6 and E7, have also been found on high-risk strains of HPV. These proteins are thought to be responsible for stimulating cell cycle entry into the upper epithelial layers and linked to cancerous changes.
Latency
In most cases, HPV will not reach a cancerous state. The majority (80-90%) of HPV infections will clear on their own. Even high-risk strains will likely be cleared by a local immune response.
The virus gets inactivated through interaction with our immune system.
In a healthy immune system, active infections will stimulate immune cells called CD4+ T cells. The presence of CD4+ T cells activates more immune molecules to overtake the virus.
A compromised or weak immune system appears to increase HPV infections.
In viral latency, viral particles continue to exist within the basement membrane in an inactive state. However, the virus can get reactivated following a change in immune status.
What Makes Certain HPV Subtypes More Carcinogenic?
In order for cancer to develop, the virus has to go undetected by the immune system over a prolonged period.
Certain subtypes of HPV, like HPV-16 and 18 are more powerful carcinogens. What makes the virus carcinogenic is its ability to invade the cell layer for longer periods of time allowing changes in the gene expression of the underlying tissue.
It is thought that the presence of E6 and E7 proteins on high-risk strains allows for cervical abnormalities to occur.
How Can You Assist Your Immune System?
It is clear from the research that a healthy immune system is key to preventing HPV infections from reaching a cancerous state.
Diet and lifestyle create the foundation for a healthy immune system. Some important factors in supporting your overall health include:
Optimizing nutrition and supplementation: Consuming fruit and vegetable-rich diet, limiting sugar and refined carbohydrate intake has a positive effect on the immune system.
Managing psychological stress: Prolonged stress can imbalance the ability of the body to fight incoming infections. Engaging in daily stress management practices like meditation, exercise, and socializing can have a positive effect in improving the body's overall resiliency.
Getting good quality sleep: Getting adequate rest, or seven to eight hours of quality sleep per night allows the immune system time to revitalize. Adequate sleep balances hormones and initiates cellular repair. Setting a regular bedtime, limiting caffeine intake in the afternoon, and eating a nutrient-dense diet are all ways to improve your sleep quality.
Engaging in regular exercise and movement: From improved circulation to naturally increasing the immune cells, staying active has a range of benefits in helping support health and prevent disease. We recommend taking daily walks and engaging in bi-weekly strength training and aerobic activity.
Mar 01, 2021
4 min read
Adrienne Hill-Strathy
HPV is very widespread amongst the population. It is estimated that 80 percent of women will contract a strain of HPV in their lifetime. Most of these infections are silent, causing no visible symptoms or side effects within a host.
In about 90 percent of patients, a healthy immune system will typically develop an immune response to regress the virus within a period of 1 to 2 years, with most in fact regressing over the course of a few months.
However, a small number of people who contract an HPV infection may have symptoms or complications that range from low-risk visible papilloma’s on the skin to persistent chronic infections that may develop into precancerous or cancerous lesions.
Here, we outline a few of the most common symptoms of HPV, including potential side effects of HPV vaccination.
HPV Symptoms
Typically, if HPV symptoms do develop, they will either cause visible warts on the surface of the skin or cause chronic infections that persist within the cell tissue and are only detected through clinical examination, like a pap smear.
Warts
The large variety of HPV strains gives rise to several different types of warts on the body surface, face, and genital areas. These warts can be classified into:
Common warts: the common wart is most frequently caused by HPV-2. These warts usually present with an irregular shaped rough nodule that shows up in multiples.
Plane warts: mostly caused by HPV-3, 10, or 28. They cause small and less rough, flesh-colored, or lightly pigmented lesions. Usually on the hands or face. Plane warts have an unusual characteristic in that they can spontaneously regress and cause swelling and a rash at the surface of the skin.
Plantar warts: usually found in 10-14-year-olds. They are contracted through barefoot activity and are found on the bottom of the feet. Plantar warts are typically caused by HPV 1 and 2.
Genital warts: are most frequently caused by HPV 6 and 11. They are renowned for their resilience and ability to continually come back, as well as being both painful and irritating.
Cancerous or Precancerous Changes in the Cells of the Cervix
Only a few of the over 180 different strains of HPV are associated with increased cancer risk.
HPV that causes cervical, anal, or oral cancer is typically caused by a few high-risk strains of HPV that infiltrate the epithelial cells and have developed special mechanisms to evade the immune system.
There are typically no symptoms that HPV is developing into cancer until several years of cell proliferation and development. HPV that has progressed to a stage of cervical cancer may present as symptoms of abnormal vaginal bleeding.
The fact that it takes many years for HPV to develop into cancer is both a positive and a negative for us because it gives us time to detect the virus at an early stage in development before it has progressed into cancer and take action.
It is negative because having no symptoms can prevent some people from being proactive about their health, allowing the situation to progress to a more serious state. Typically, Pap screening should be done every three years from the age of 21 to 65 to screen for these abnormalities.
The HPV Vaccine and Potential Side Effects
Today, we have a vaccine offered as a preventative measure against high and low risk HPV strains, primarily to protect women against cervical cancer.
The Centers for Disease Control and Prevention recommends the HPV vaccine for routine vaccination at age 11 or 12 years. The vaccine may be started as early as age nine.
Females aged 13 to 26 and males aged 13 to 21 are recommended to receive the vaccine. The vaccine is only recommended past the age of 26 for gay, bisexual, transgender, and those who have chronically weakened immune systems.
Gardasil is the most commonly used vaccination, protecting against the two strains of HPV that cause genital warts, and the two strains that are the most high-risk HPV strains, commonly known to cause cancer, such as cervical cancer.
Two doses of the vaccine should be given, the second being 6 to 12 months after the first. If less than 6 months apart, the recipient is of a weakened immune system or is past the age of 15, three doses are required to ensure the vaccination is effective.
It is important to keep in mind that the vaccination does not protect you against all HPV strains, just the most high-risk, so routine screening is still recommended.
Side Effects of Vaccination
Side effects of the HPV vaccine may include:
Injection site irritations such as pain, redness, or swelling
Fever
Systemic reactions such as nausea, muscle pain, malaise, and dizziness
Fainting
The vaccination is quite safe; different types of the vaccine having been studied in almost 75,000 individuals.
These side effects are not commonly experienced, and for most people, it is definitely worth the risk to receive the vaccine than forgo it because of potential mild and temporary side effects.
Feb 01, 2021
4 min read
Could your rash be a symptom of HPV?
Adrienne Hill-Strathy
You’ve recently noticed a rash developing on your skin, making you wonder, is this HPV?
HPV infections reside within the skin tissue and are transmitted through skin to skin contact. There are over 150 different viral strains of HPV that have evolved to infiltrate different areas within the skin and mucous membranes and are associated with different symptoms and progress to different diseases.
Most HPV Infections are Asymptomatic
Most HPV infections are silent. A person will contract an infection without having any visible symptoms.
In about 90 percent of patients, a healthy immune system will typically develop an immune response to regress the virus within a period of 1 to 2 years.
A small number of people suffer from persistent HPV infections and have an increased risk of developing cancer. However, these infections take many years to develop and through early detection and pap screening, complications rarely develop into malignancies.
HPV Symptoms
Typically, if symptoms do develop, they will either cause visible papilloma’s or warts on the surface of the skin or cause chronic infections that persist within the cell tissue and are only detected through clinical examination like a pap smear.
HPV symptoms may include:
Genital warts
Skin warts
Cancerous or precancerous changes in the cells of the cervix, detected during a pap test.
Genital Warts
Some low-risk strains of HPV can cause visible symptoms on the skin like common warts, genital warts, and plane warts.
Genital warts are also known as condylomata acuminate. They are usually caused by HPV types 6 and 11.
The warts appear as a soft, fleshy, cauliflower-like growths that grow in genital areas including the anus and penis. They can be painful, itchy, annoying, and, worst of all, highly persistent. Genital warts may also cause swelling in the genital area and lead to itching and discomfort.
In women, warts often grow on the vulva, the walls of the vagina, or in between the external genitals and the anus. In men, they usually occur on the tip or shaft of the penis.
Other Warts Caused By HPV
Other warts caused by the HPV infection include plane warts, which tend to show up as small nodules on the hands or face. Plane warts can cause a mild rash on the hands of face during viral regression, but it is uncommon.
Common warts typically show up as irregular shaped rough nodules that occur in multiples. These warts are also most commonly found on the fingers or hands, often featuring small black dots of clotted blood vessels.
How Do I Get Rid of Warts?
Each individual’s immune system responds differently to HPV, so each of us will have a different reaction to the virus as well.
HPV strains that cause warts are classified as low-risk strains because they rarely develop into serious complications like cancer. Most warts will be cleared naturally by a healthy immune system.
Implementing a healthy diet and lifestyle as well as incorporating natural treatments like green-tea extract, found in Papillex, has also been found to improve wart clearance.
Rashes
Although HPV affects the skin tissue, rashes are not typically a symptom of an HPV infection. As mentioned, some plane warts may present with a rash during viral regression but otherwise it is not a common symptom of an HPV infection.
A rash likely indicates another skin infection, irritation, or sexually transmitted disease and requires further examination by your doctor.
Jan 01, 2021
3 min read
Adrienne Hill-Strathy
Contracting a strain of HPV is very common.
You may have had it as a child in the form of a pesky plantar wart on the bottom of your foot or a small nodule that developed on your finger.
In early adulthood, HPV is commonly contracted through sexual contact, with 80% of women contracting a strain within her lifetime.
The common occurrence of HPV and its often-invisible symptoms may make you wonder, what happens after you’ve been infected, and can a virus reactivate?
Here we breakdown a little more about HPV, HPV testing, how the virus enters latency, and whether infection can come back. We also provide some tips to help you maintain optimal immune health.
What is HPV?
The human papillomavirus includes a diverse group of over 150 viruses that infiltrate the body through our skin tissue and use the machinery of our cells to replicate their viral code.
Depending on the strain and the immune system, an HPV infection may present a range of symptoms from visible papilloma, or warts, on the skin surface or genitals to no symptoms at all.
Few high-risk strains may develop into complications like cervical cancer years after infection.
HPV is typically considered a lifelong infection, once you have contracted a viral strain the DNA lives within your cells. However, the HPV virus can get deactivated and stop producing its viral load, referred to as viral latency.
For more information on HPV, check out our article on What Is HPV? for an in-depth guide to HPV.
HPV Testing
HPV testing is done to evaluate the active presence and strain of HPV in a host. The screening tools for cervical cancer typically classify infection on the following levels:
First HPV-positive results: this is a common result and most new infections will likely revert to a negative within 6 to 12 months but require follow-up.
HPV-positive, cytology negative- patients with positive HPV status but negative cytology are at an increased risk of developing cervical cancer. A patient with the result will be recommended to be followed and repeat HPV and cytology in 12 months.
Recurrent HPV-positive- often a positive HPV screen will be followed by an HPV negative. This suggests the immune system has made the HPV infection latent. The HPV infection can still recur upon reactivation due to a weakened immune system.
Persistent HPV positive- a persistent HPV infection, that has been positive for over 12 months, is likely to develop into a CIN 2 infection within five to seven years. The infection should be closely monitored for potential progression.
Persistent HPV-positive, low-risk cytology and negative colposcopy- In the situation, patients may still be at risk of disease progression, and active surveillance is still needed.
Viral Latency
The majority (80-90%) of HPV infections will enter a state of latency. Latency refers to a virus remaining in a resting state without producing its viral code so symptoms or complications don’t develop.
In a healthy immune system, active infections will initiate an immune response through CD4+ T cells. Once these cells are activated more immune molecules accumulate at the site of infiltration and overtake the viral gene expression.
A compromised or weak immune system seems to be the hallmark of HPV infections, where the failure to develop effective cell-mediated immunity to clear or control the infection results in persistent infection and increases the probability that the cells progress to cancer.
Recurrence of Latent Infections
Because the HPV particles continue to exist within the bottom layer of the epithelial cells, the virus can get reactivated following a change in immune status.
Maintaining viral latency requires one to maintain a healthy immune system. When this fails or is compromised the virus can begin replicating again and may lead to symptoms or progress to complications like cervical cancer.
Can I Get Re-infected?
If you have contracted a strain of HPV in the past, you are not immune from catching further infections.
The 150 different strains of HPV all have slightly different DNA and mechanisms of infiltrating an individual.
It is estimated that 75-85% of females and males carry a strain of HPV. Therefore, engaging in sexual activity can expose an individual to further HPV infections and complications. Even women in long-term monogamous relationships can get re-infected.
Research is looking to evaluate whether exposure to HPV viruses, particularly HPV 16 and 18, which cause the most cases of cervical cancer, can lead to natural protection against additional HPV strains. Thus far, there has been a lack of sufficient data on naturally acquired immunity and whether the previous infection can reduce rates of recurrence.
Maintaining a healthy immune system
Regardless of the strain of HPV, you have contracted, the key to silencing the virus and keeping it in its latency state depends on the health of the immune system.
The immune system is multi-faceted, which means supporting it is complex as well.
First, reducing risk factors like smoking, prolonged oral contraceptive use, assessing coinfections, and immune-related diseases is key to ensuring adequate immune functioning.
Second, implementing a healthy diet, rich in diverse plant-based foods and good-quality proteins, reducing stress, getting good quality sleep, and engaging in regular exercise is also important to support our body and immune health.
Lastly, supplementation can help replenish nutritional deficiencies that are essential for proper immune function. Papillex includes a range of nutrients known to be low in patients with persistent HPV infections and a number of herbs that help optimize our immune system.
Dec 01, 2020
4 min read
Adrienne Hill-Strathy
High-Risk HPV, 16 18 45: What You Need to Know
The family of human papillomaviruses contains a variety of over 150 different strains of HPV. These strains have evolved over time to have different ways to infiltrate and evade the immune system of individuals, causing different disease progressions.
Nearly all sexually active individuals will come into contact with a strain of HPV. It is estimated that 80% of women will contract an HPV infection at some point in their lifetime.
While most cases of HPV infections are asymptomatic, some can manifest in lesions from genital warts to cervical cancer. A few HPV strains, in particular, HPV 16, 18, and 45 have been classified as the most high-risk HPV types, accountable for approximately 70% of cervical cancers around the world.
The prevalence of high-risk HPV infections is estimated at around 22.7%. The most common of these high-risk infections to cause changes to the cervix were HPV types 16, 18, and 45.
High-Risk HPV
High-risk strains often do not cause symptoms so many are unaware that they have contracted a strain of HPV. The high-risk strains develop slowly over time, causing minor changes to the cells of the cervix, anus, or oral cavity.
High-risk strains that persist for a number of years can eventually alter the genome of an individual and increase the risk that cancer will evolve.
12 HPVs (16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, and 59) are defined by the World Health Organization (WHO) as being high-risk cancer-causing types. Together these HPV’s cause half a million cases of cervical cancer per year worldwide. These strains can also cause cancers at other sites, including the penis, vagina, and vulva and in the oral cavity.
What Makes High-risk Strains More Cancerous?
The reason high-risk strains are more likely to cause cancer is due to where the virus has evolved to infiltrate the body and specific proteins within the viral machinery.
Particular areas within the cervix lining are more susceptible to fostering cell replication than others. HPV that gains access to the transformational zone in the cervix have been linked to higher rates of cancer progression. This site has a lower density of immune cells called Langerhans cells, that provide our first line of defense in fighting off pathogens.
High-risk HPV strains are the leading cause of cervical cancer
Two viral proteins, E6 and E7, have also been found to be more active on high-risk strains of HPV. These proteins are thought to be responsible for allowing the virus to enter the upper layers of the epithelial tract. The proteins have also been found to downregulate toll-like receptors of the innate immune system, leading to greater threats to the individual's DNA.
These E6 and E7 proteins appear to be inactive or weakly active in low risk HPV types.
High-Risk HPV Strains and Cancer Rates
Despite high-risk strains increasing one’s risk of cancer, contracting a strain does not mean you are going to get cancer. The majority (90%) of individuals will clear the infection within three years and have no complications. Of the 10% of cases that become chronic only 1% will result in cervical cancer.
Women with a high-risk HPV strain have a 210-fold higher risk of developing a CIN 3 complication in 6 years as compared with negative women. This means that instead of every 9 in 10,000 women contracting cervical cancer, 210 in 10,000 with a high-risk strain will develop into cancer.
HPV Testing and mRNA E6 E7
HPV testing can detect which strain of HPV you have contracted and indicate whether you have been infected with a high-risk strain.
To provide a better understanding of the strains risk of developing into cancer, mRNA E6 and E7 testing can also be done. Testing can be done to detect the presence of these proteins within an individual.
E6 and E7 are usually expressed at low levels during a transient HPV infection. When the virus has integrated into the individual gnes, the oncogene transcripts are over-expressed, leading to the development of cervical cancer.
HPV E6 and E7 mRNA expression level are highly correlated with the severity of cervical lesions and can be tested and used as a biomarker for HPV infections that are more likely to progress to cancer.
Having more reliable and better testing for HPV has played a significant role in reducing mortality from cervical cancer in the past several years. Staying on top of your pap testing and monitoring your situation with your doctor is key to fighting off high-risk strains.
What Can You Do If You Have Contracted HPV?
In addition to regular testing, fighting off high-risk strains of HPV requires a healthy immune system. We believe implementing a healthy lifestyle is built around four foundational lifestyle therapies:
1. Nutrition and Supplementation
The gut is home to around 80% of the immune system. Consuming a fruit and vegetable-rich diet, limiting sugar and refined carbohydrate intake has been found to have a positive effect on the overall function of the immune system.
Papillex is a supplement which is designed specifically to help your body respond to HPV and is packed full of ingredients which have been researched with HPV in mind.
Building a strong immune system with good nutrition is an important factor in your body's ability to fight off viral infections
2. Psychological Stress
Prolonged stress has been found to create an imbalance in the ability of the body to fight incoming infection, by over activating areas of the immune system that exacerbate chronic illness. Engaging in daily stress management practices like meditation, exercise, and socializing can have a positive effect in improving the bodies overall resiliency.
3. Sleep
Getting adequate rest, seven to eight hours of quality sleep per night, allows the immune system time to revitalize, balance hormones and it initiates cellular repair. Setting a regular bedtime, limiting caffeine intake in the afternoon, and eating a nutrient-dense diet are all ways we can improve our sleep quality.
4. Exercise and Movement
From improved circulation to naturally increasing the bodies white blood cell and antibody count, staying active has a range of benefits in helping support the immune system and defense against disease. We recommend talking daily walks and engaging in bi-weekly strength training and aerobic activity.
Oct 01, 2020
5 min read
How Many Types of HPV Are There?
Adrienne Hill-Strathy
There are over 150 different HPV strains that have been identified in humans.
Different strains have evolved over time through evolution into five sub-groups, each with unique ways to infiltrate and cause disease in an individual.
Some strains cause minor papilloma’s on the surface of the skin, while others have no symptoms but have the ability to slowly develop into cancers.
The most widely studied HPV sub-group is classified as Alpha types. Alpha types are more researched because they are typically associated with cervical cancer. The alpha types can be divided into high-risk and low-risk strains.
Broadly speaking, we can classify HPV strains into low and high-risk
Low-Risk Strains
Low-risk strains often cause common warts on the surface of the skin. These strains of HPV are considered low-risk because they rarely develop into cancer.
HPV strains 6 and 11 are the most common low-risk HPV strains, causing 90% of genital warts.
Genital warts are soft, fleshy, cauliflower-like growths that can grow in genital areas including the anus and penis. These warts can be painful, itchy, annoying, and, worst of all, highly persistent. Warts generally show up a few weeks or months after sexual contact with an infected partner.
Like most HPV infections, genital warts will usually be cleared by a strong, healthy immune system. Taking supplements like green tea extract, found in papillex, can also help improve wart clearance.
High-Risk Strains
High-risk strains of HPV have a higher likelihood of developing into cancers.
High-risk strains often do not cause symptoms so many are unaware that they have contracted a strain of HPV. The high-risk strains develop slowly overtime, causing minor changes to the cells of the cervix, anus, or oral cavity. High-risk strains that persist for a number of years increase the risk that cancer will evolve.
12 HPVs (16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, and 59) are defined by the World Health Organization (WHO) as being high-risk cancer causing types. Together these HPV’s cause half a million cases of cervical cancer per year worldwide. HPV-16 and 18 are the most common strains associated with cervical cancer, causing about 70% of cervical cancers.
These strains can also cause cancers at other sites, including the penis, vagina, and vulva and in the oral cavity.
The reason high-risk strains are more likely to cause cancer is thought to be due to where the virus has evolved to infiltrate the body and specific proteins within the viral machinery.
Particular areas within the cervix lining are more susceptible to fostering cell replication than others. HPV that gain access to the transformational zone in the cervix have been linked to higher rates of cancer progression.
Viral proteins identified as E6 and E7, have been found to be responsible for stimulating cell cycle entry into the upper epithelial layers and linked to cancerous changes.
Despite high-risk strains increasing one’s risk of cancer, contracting a strain does not mean you are going to get cancer. The majority of individuals will clear the infection within a few years and have no complications.
Transmission and Infection Rates
The variety of HPV strains and the transmissibility of the virus means most individuals will pick up one strain of HPV in their lifetime.
HPV is one of the most easily transmitted sexually transmitted diseases. The virus can be contracted just through skin contact with an infected individual. Because the virus lives within the skin cells, even protected sexual contact can lead to transmission from areas that aren’t covered by a barrier.
Getting Regular Pap Tests
Getting regular pap tests is important to monitor any potential infections and complications. Cell progression is caught easily in pap tests, and awareness is key to taking preventative measures to clear the virus.
The recommendation for disease control and prevention is to get one pap test every three years to keep an eye on your cervical cells, and more frequently if you have ever had an abnormal pap test.
It is essential to go for regular pap smear tests if you are a young woman, even if you display no symptoms
How Can I Protect Myself Against HPV?
The most important thing you can do to protect yourself from HPV complications is maintaining your overall health. A healthy immune system is the hallmark of HPV infections, where the failure to develop effective cell-mediated immunity to clear or control the infection results in persistent infection and increases the probability that the cells progress to cancer.
We can support and build our immune system by making healthy choices every day. Some important factors in supporting your overall health include:
Optimizing Nutrition and Supplementation
Consuming a fruit and vegetable-rich diet, limiting sugar and refined carbohydrate intake has been found to have a positive effect on the overall function of the immune system.
Managing Psychological Stress
Prolonged stress has been found to create an imbalance in the ability of the body to fight incoming infection, by over activating areas of the immune system that exacerbate chronic illness. Engaging in daily stress management practices like meditation, exercise, and socializing can have a positive effect in improving the bodies overall resiliency.
Getting Good Quality Sleep
Getting adequate rest, seven to eight hours of quality sleep per night, allows the immune system time to revitalize, balance hormones and it initiates cellular repair. Setting a regular bedtime, limiting caffeine intake in the afternoon, and eating a nutrient-dense diet are all ways we can improve our sleep quality.
Engaging in Regular Exercise and Movement
From improved circulation to naturally increasing the bodies white blood cell and antibody count, staying active has a range of benefits in helping support the immune system and defense against disease. We recommend talking daily walks and engaging in bi-weekly strength training and aerobic activity.
Sep 01, 2020
4 min read
Dr Elizabeth Goldspink
With the rising rates of HPV, people are seeking out more natural options to manage their symptoms and prevent recurrences. That's why we've put together our top 10 list of herbs for HPV!
Lifestyle changes can really help support your immune system against viral infections of any kind, not just HPV!
Read below to know more about HPV, if you should be worried, and how to manage it using natural methods!
Herbal Remedies
Human papillomavirus is highly contagious and is responsible for warty growths in human beings with some strains having also been linked to cancers of cervix and penis.
If you are looking for natural treatments, herbs are one way to help treat HPV. These herbs are not only effective against HPV but almost all types of viruses can benefit from herbal remedies as most of them carry strong antiviral properties.
There are many antiviral herbal remedies for HPV that can also boost the immune system; we’ve included some of the best studied ones below:
Thuja Oil and Tea Tree Oil
Tea tree and thuja oils are natural antibacterial, antifungals and antivirals. The oils broad-spectrum properties can be used to treat a number of skin ailments, including HPV warts.
A drop of pure tea tree oil applied to affected areas daily has been found to be an effective topical treatment to clear warts.
Tea Tree Oil
Goldenseal
Goldenseal is one of the best anti-microbials, commonly known as a natural antibiotic. The herb is one of the top selling botanical medicine in North America, often taken to prevent cold and flus.
An alkaloid component of goldenseal, called berberine has been found to inhibit certain tumor promoters and inhibit angiogenesis.
More research is needed on the direct impact of berberine on HPV infections but its actions in stimulating the immune system are thought to improve viral clearance.
Goldenseal
Astragalus
This herb appears to increase antibodies and interferon levels in the body. It enhances the immune-system activity by stimulating the activity of helper-T cells and is therefore helpful in the treatment of immune deficiency-related problems.
It works so well that it’s not recommended long term as it can overstimulate your immune system. It’s available in the form of daily supplements for whole body benefits and can also be applied topically.
Astragalus has also been specifically studied for its inhibitory effect on cervical epithelial cell growth (cervical cancer cell growth).
Astragalus
Reishi Mushroom Extract
Medicinal mushroom enhances the activity of T-helper cells or CD4 cells, both of which are immensely important for immune function.
It also stimulates the production of interferons, IL-1 and IL-2, involved in quickly initiating the immune system to react. This helps fight serious conditions by not only supporting but also regulating the immune system.
Clinical studies have also shown that the use of Reishi can dramatically impact the clearance of HPV.
Reishi Mushroom
Green Tea Extract
This herb contains polyphenols, catechins, and flavanoids. These are potent anti-cancer compounds. Results of a controlled study confirmed that a botanical supplement containing green tea extract is an effective and well-tolerated treatment for external genital and anal warts.
In viral infections, the active compound called epigallocatechinagallate (EGCG), has been found to inhibit the early stage of infections, through attachment, entry and membrane fusion by interfering with viral membrane proteins.
Read our latest post about green tea extract and cervical cancer to find out more!
Green Tea
Echinacea
A popular botanical used to fight colds and flu has anti-inflammatory and immunostimulatory properties. Numerous studies have also shown the extract to possess significant antiviral activity, with virucidal effect against influenza, herpes, and coronaviruses.
The herb works by inhibiting initial contact with the virus at the beginning of infection and preventing further transmission to infected cells.
Echinacea has been found to reduce the relapse risk and induce a protective immune response to viral clearance in patients with HPV lesions over a period of 12 months.
Echinacea can be taken as a supplement, tonic, and can also be used for topical application.
Echinacea
Curcumin
This is the active ingredient in Indian spice turmeric. It contains a class of compounds called curcuminoids that act by suppressing regulatory molecules and signaling pathways involved in upregulating cancers and other diseases.
The compound has been found to suppress cell growth and tumor formation and induce phase II metabolizing enzymes and antiangiogenic effects.
Curcumin has an effect on enhancing the clearance of high risk HPV 16, and downregulating the HPV oncogene expression against cancers.
Cucumin derived from Turmeric
Garlic
Garlic has long been supported for its role in preventing disease and supporting health. The herb is said to have pharmacologic effects based on its ability to be hypoglycemic, hypolipemic, anticoagulant, antimicrobial, and an immune system modulator.
Garlics immune boosting and anti-viral properties provide benefits to HPV clearance, through enhancing natural killer cells that destroy viral pathogens and other immune molecules that target infected cells.
The herb can be taken orally through food, applied topically to warts, and also ingested in high doses for immune functioning.
Garlic
Birch
Willow bark, or birch bark can be used as an astringent in wound and wart healing. The extract contains salicin, as acid that helps dissolve warts.
Birch can be applied topically to break down the hard coverings of the warts.
Birtch Bark
Ginkgo Biloba
This herb is a potent antioxidant and also helps improve circulation, particularly the circulation of blood to your brain. It has been used for years in traditional medicine.
Ginkgo contains ginkgolic acids with alkylphenol constituents that have been shown to have antitumor effects through disrupting cellular function and viral entry into a variety of viruses.
There is limited research on ginkgo on HPV but the underlying mechanisms found in exisiting research suggest it would be useful in clearing HPV infections as well.
Ginkgo Biloba
Olive Leaf
Olive leaf contains a high quantity and variety polyphenols that are anti-inflammatory and protect against DNA damage.
The leaf has been shown to be useful against many viral illnesses, the olive leaf induces cell death of cervical cancer cells, a common outcome of high risk HPV strains.
Olive Leaf
Herbs for HPV: Special Mentions
Bayberry, Horehound, Red clover, Fenugreek and Hawthorn can also be useful herbal remedies for HPV as these enhance the immune system’s response to viruses.
These herbal remedies for HPV are available as supplements (to act internally), tonics, and can also be applied topically. Herbal remedies for HPV have little to no side effects.
Conclusion
So there you have it! Our top 10 herbs for HPV!
If you are interested in finding out our recommendations for herbal antiviral remedies in general, please take a look at our antiviral herbs article!
For a supplement that packs essential ingredients to help you better respond to HPV, why not check out Papillex and make a positive change today!
Aug 15, 2020
5 min read
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