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Talking to Your Partner About HPV

Talking to Your Partner About HPV

Victoria Gasparini
The HPV infection: Do I have it?  HPV is a sexually transmitted disease that 1 in 4 of us currently have, and 80% of us will get at some point in our lifetime. It is so ridiculously common, and yet talking about it still fills many of us with a sense of shame, embarrassment and fear.  Most strains of HPV are low-risk and commonly go unnoticed. It is totally possible that you have HPV and don’t even know it. There are a handful of strains that are considered “high risk”, and these are the ones that cause abnormal pap smears, and have greater potential. It should make you feel better that most strains of HPV are not dangerous and have no symptoms (which is why it is spread so easily)!  Here is why we need to talk about HPV The hardest part about talking to your sexual partner about HPV is because of the stigma that surrounds the infection. However, disclosing your HPV status to your sexual partner(s) can be a supportive and affirmative experience. We are all vulnerable beings, and being able to enter that state of vulnerability is empowering and helps us to establish trust with those we spend such intimate moments with. Disclosing your HPV status may help build on that trust and bring you closer to your partner. Being open and honest demonstrates to your partner that you care and value their sexual health as much as your own. It can also help educate people since HPV is the most common sexually transmitted infection and yet there is still so much stigma and misinformation surrounding the topic. The more we talk about HPV, the less power it has over us, because the truth is, there is nothing to be ashamed or embarrassed about. Do I NEED to inform my partner?  Yes. Telling your partner that you have HPV actively breaks the stigma associated with sexually transmitted infections, which is an important part of helping people establish safe sex practices, including those around oral sex. Disclosing your status is also a crucial part of exchanging consent between one another prior to sex. I know that the fear of rejection is a terrifying thing. No matter what your partner's response is, take comfort knowing that you are brave, compassionate and honest and that having HPV does not make you less worthy of intimacy. The right partner will understand (or might even have HPV, as well). Tips for how to discuss HPV with your partner Timing Have the conversation early in your partnership, before sexual contact. Get to know someone and ensure you feel safe and confident when you are having this conversation. Showing your sexual partner how calm and confident you are will also help assure them that you are well informed. Choose the timeline that you are most comfortable with, and make sure your partner is someone you feel comfortable sharing personal details with.  Location Choose a safe and comfortable environment. Check in with yourself, make note of how you feel and act accordingly. Maybe your safety is felt more on a hike or outside of the home, or maybe you feel best disclosing this information in the comfort of your own house. It’s best to talk about HPV status when you are in a quiet, safe place.  Planning Your partner might have questions, and this is normal and to be expected. Anticipate these questions so that you are not blindsided or defensive. There are tons of resources available for education, including the CDC, healthline, and more. Our blogs are also an awesome source of information. Have knowledge of HPV prior to your conversation, not only so you are prepared for questions, but also to stay empowered, yourself. Set the tone By sharing this information in a calm, reassuring and educational manner, you set the tone for the conversation. Listen to your partner and observe their response. Answer questions the best you can, and do not tolerate disrespect. Understand that sometimes your partner may not accept or be okay with this information right away, but disrespect is not tolerated. Honor yourself No matter how the conversation goes, you should take pride knowing that you were brave and honest. Many people do not take initiative in their sexually transmitted infection status or are simply scared to share. By doing so, you are helping others make informed choices about their health. Give yourself a pat on the back for being brave enough to make this decision, and be vulnerable. With each person that is brave enough to speak up, we decrease the risk for HPV transmission while also fighting back against the stigma that simply should not be there.
Apr 10, 2023
3 min read
The 5 Steps to Healing HPV

The 5 Steps to Healing HPV

Victoria Gasparini
If you have received an HPV diagnosis from your healthcare provider, you are probably feeling a little lost, frustrated and maybe even overwhelmed with what to do next. Unfortunately, all too often, women are told their next steps are to “watch and wait” for HPV to either progress or stay the same, consistently affecting you as a patient, and leaving you disempowered in this diagnosis. The truth is, the unknown of an HPV diagnosis which can range from completely mild to severe, is really a scary thing to go through on your own.  With that being said, nearly 80% of the population has HPV. Cervical cancer affects about 12,000 women in the United States each year, and other HPV-related cancers such as anal and oropharyngeal are rising too. Though most cases of HPV are mild, benign and even self-resolving, hundreds of thousands of women will be told they have an abnormal pap each year. Doesn’t this feel like something we should be talking about? Doesn’t this seem like a diagnosis that should be taken seriously, with action plans and clinical guidelines to help people with HPV reduce their likelihood for complications? At Papillex®, watching and waiting is simply not good enough for us. So what are some actions you can take to address HPV? Keep reading to find out. There are five key considerations we have when it comes to clearing and healing HPV and cervical dysplasia, and reducing your risk for HPV-related cancers.  Consider Nutrient Deficiencies When many of us think of the health benefits of food, proteins, fats and carbohydrates come to mind. These macronutrients make up the general composition of our foods but within them lie additional health-promoting compounds called micronutrients. Micronutrients include trace minerals and vitamins that support the normal growth and development of living organisms. Without them, body systems like the immune system, nervous system, and digestive system can become impaired. Many individuals are deficient in micronutrients. This can be due to low intake of dietary sources like fruits and vegetables and high intake of processed and nutrient-poor foods. Additionally, it is thought that the micronutrient quality of our fresh food has declined in recent years due to industrial agricultural production. This micronutrient deficiency may be at the root of why some people struggle to eradicate HPV infections compared to others who clear the virus more easily. Several micronutrients have been specifically found to be low in individuals with HPV and cervical dysplasia. The most common micronutrient deficiencies associated with HPV include folate, vitamin A, selenium, vitamin C and vitamin E. For more info on these micronutrients and how to correct deficiencies, click here. Consider Inflammation We know that the immune system is a key factor in regressing HPV infections. Studies have found inflammatory molecules assist the virus to integrate and proliferate into an individual’s tissues. This means that the more inflammation present, the easier it is for viruses to infect our tissues. Inflammation leaves our cells more vulnerable to further damage. HPV itself also drives inflammation. The viral particles produced by the HPV (E6, and E7) are also inflammatory and drive more inflammation which further decreases the level of antioxidants, our main weapons against oxidative damage. Together these processes allow HPV to persist. For more information on how inflammation affects HPV and what to do to control it, click here. Consider the Vaginal Microbiome The vagina is an incredible organ with a protective epithelium and diverse microbial ecosystem. The vaginal tract is rich in all sorts of “commensals”, meaning microbes that are non-harmful and even beneficial for the vagina and our health. The largest species of microbes in the vaginal tract are called lactobacillus, which you may have heard of if you take oral probiotics. Any potentially harmful microbes in the vagina are kept at bay by our unique acidic pH.  Stress is a major disrupter of this microbial balance. Since stress itself is inevitable, cortisol (our fight or flight hormone) has the capacity to disrupt the vaginal microbiome and its ability to fight infections of the genitourinary tract. Researchers from the University of Illinois have even found a potential link between pandemic-related stress and the increase in STI’s amongst young women. The data from this small, but fascinating study found that young women who reported higher levels of pandemic-related stressors also had increased odds of infection. Professor of epidemiology and biostatistics, Mehta, suggests that the uptick in stress-related infections is likely due to changes that occur in the vaginal microbiome during times of chronic stress. This study sheds light on the impact of environment & psychosocial factors on our physical health, as women. Another study in the Frontiers of Endocrinology found that exposure to chronic stress led to a significant decrease in lactobacillus microbes in the vaginal tract. As mentioned above, the lactobacillus species is one of the most significant “commensals” in the vagina, providing us with protection against invaders and therefore amplifying both the severity and frequency of vaginal infection. For more information of supporting a healthy vaginal microbiome, click here. Consider Blood Sugar Balance research finds that glucose spikes and insulin resistance both contribute to malfunctioning immunity and the inability to effectively fight off infections.  One study found that glucose spikes inhibited microbial killing and phagocytosis, as well as increased the production of inflammatory cytokines in otherwise healthy subjects. Trials continue to show that by managing glucose spikes, we can reduce susceptibility to infection and allow us to create healthy immune responses to infections when necessary. Because HPV is a viral infection, supporting the immune system’s ability to fight infections is the most important effort you can make when healing with HPV.  Many lifestyle and dietary habits can be contributing to glucose spikes. As mentioned above, simple carbohydrates on their own, like a bowl of cereal, coffee drinks on an empty stomach, dried or juiced fruits, and other high-sugar foods all contribute to glucose spikes and the susceptibility to insulin resistance seen in diabetics and patients with polycystic ovary syndrome (PCOS). But it is not just diet that leaves us vulnerable to glucose spikes. PMS, lack of sleep, and genetics all play a role in our susceptibility to glucose spikes and insulin resistance as well. Aside from not being able to change or control your genetics, there are many dietary and lifestyle changes (surprisingly some pretty easy ones, too) that can lessen these spikes and thereby reduce your symptoms. For simple tips to help manage your blood sugar, click here. Consider your support system Healing and dealing with a diagnosis like HPV, whether mild or high risk, is a scary and frustrating place to be. You don’t have to do it alone. In fact studies find that a proper support system is crucial in healing all sorts of infections and chronic conditions. Whether you find your support system in your family, friendship groups, care providers or internet besties (us!), this is a consideration that cannot be skipped. At Papillex®, we are here to support you on this incredibly empowering journey to healing HPV. Feel free to share your story with us on instagram, or just send a hello to chat! We are here for you.
Mar 06, 2023
5 min read
Getting Creative: Can We Detect HPV In Sanitary Pads?

Getting Creative: Can We Detect HPV In Sanitary Pads?

Victoria Gasparini
In the United States, among other countries, we have a growing public health dilemma. People are not showing up to their regular pap screenings. Because of this, an alarming 52% of cervical cancers are detected in advanced stages. Because early detection of cervical cancer cells via pap smear significantly decreases risk of fatality, detecting cervical cancers in advanced stages is putting us at not only a tragic and incomprehensible disadvantage for fighting disease, but also a preventable one.  But, it's not as simple as reminding our friends and families to head to the doctor. In the United States, we have disparities comparable to lower income nations - preventing Americans from attending their regular screenings, such as income, location and other social determinants. In fact, some research suggests your zip code has more impact on your health outcomes, than any other factors.  Because of this, public health experts have to get creative in finding ways to detect HPV that are cheap and effective, and don’t require the same kind of testing that is currently available, albeit inaccessible to some. Are sanitary pads the cheap and effective solution to this public health dilemma? Maybe. A 2003, small study with 17 participants found that 100% of cervical cancer participants had HPV detected in their menstrual pads. After this study, little was done with this information in the United States. However, in India, where access to pap smears is much less available - they’ve begun using sanitary pads as a way of detecting HPV and cervical cancer risk.  In the world's first trial of its kind, women in the community-based study are packaging up used sanitary pads, and shipping them on dry ice to the National Institute of Research in Reproductive and Child Health Laboratory in Mumbai, India to test for HPV. Another group of researchers in China, took used menstrual pads and were able to successfully identify HPV in 94.2% of them. In fact according to the Washington Post, the DNA analysis used on these menstrual pads was more accurate in identifying HPV and multi-strain cervical cancers than other cervical tests available. Does this replace the need for pap smears? Not yet, at least. Despite our best efforts, HPV is still a heavily stigmatized infection. Additionally, some patients find cervical screenings to be invasive and uncomfortable. Public health experts have to adopt out-of-the-box thinking when it comes to preventing advanced cervical cancers, and promoting HPV screening to the public. HPV screening via sanitary pads may be an innovative and less invasive way to encourage others to maintain regular screenings. However, because this approach is not currently practiced throughout the United States, it does not replace the need for regular pap smears. Not yet, at least. What do you think? Send me a DM on instagram to chat!
Aug 08, 2022
2 min read

HPV: 5 Things Every Woman Should Know

Victoria Gasparini
An HPV diagnosis can leave one feeling vulnerable, scared, overwhelmed and even ashamed. So when you take to google to find stories of others dealing with HPV, it can be disappointing to realize that there are not many resources associated with empowering, educating and empathizing with others going through a similar experience.  At Papillex, our goal is to be that voice. We want to ensure that you have access to informative content, quality supplements, and act as a sounding board for those with HPV (and HSV, too!). Below are 5 things we believe every woman should know about their HPV diagnosis.  HPV is common and nothing to be ashamed of Dr. Brene Brown defines shame as an “intensely painful feeling or experience of believing that we are flawed and unworthy of love and belonging”. To break through the barriers built by shame, one must be vulnerable. Vulnerability has the ability to transform fear and shame into belonging and acceptance.  HPV is nothing to be ashamed of. In fact, nearly 80% of people will have HPV at some point in their lives. However, because HPV is a sexually transmitted infection, there tends to be a stigma that prevents many from talking about the condition. Because of the shame many women feel, it can be tough to find support in our peers as it is not widely talked about. HPV is a virus. Viruses spread. This is a normal part of life, and the more we talk about it, the less shame and stigma we attach to it. Discussing and spreading awareness of HPV takes great vulnerability, but it also brings a sense of belonging to you and those around you going through the same thing. Having HPV does not mean you will get cancer. There are nearly 150 strains of HPV, with about 12 of them being linked to cervical cancer. Having HPV does not mean you will have cervical cancer, but it is important to be aware of your condition and keep up with regular screening, as well as lifestyle and dietary management to prevent disease progression. Talk to your doctor about vaccination, and remember to always practice safe sex by using protection like condoms or dental dams. Though these are not fool-proof, they do help to decrease the chances of transmission. A great practice is to strengthen your immune system through science-backed lifestyle changes like adequate sleep, increased consumption of antioxidant rich foods and powerful supplements like Papillex and AHCC. Smoking, excessive alcohol consumption and birth control all contribute to disease progression with HPV.  We have strong evidence to support the link between smoking and alcohol consumption and HPV disease progression. Birth control is another factor that can actually increase a woman's risk of cervical cancer. Studies find that for women with diagnosed HPV, the longer they use oral contraceptives, the higher their risk for cervical cancer. The good news is that once birth control is stopped, the risk does not continue.  Talk to your doctor about what this means for you. If you choose to be on an oral contraceptive, ensure timely screening and monitoring with your trusted health care provider.  You don’t need to “watch and wait”, you can often control HPV with diet and lifestyle  There are many ways to stay ahead of HPV with dietary and lifestyle changes. At Papillex, we strive to find the best available research on diet, supplementation and lifestyle used in the management of HPV.  Some of our favourite science-backed nutrients are folate, vitamin C, selenium, AHCC, carotenoids and more. We also advocate for a healthy lifestyle with lots of movement, stress-reduction, reduced alcohol and smoking consumption, and getting out in nature as much as possible. These practices can help you to better manage your health and stay on top of HPV. The old “watch and wait” approach is out-dated and leaves patients feeling disempowered. It helps to know you have options. There are other cancers caused by HPV Many of us know the risks for cervical cancer, but cancers of the vulva, vagina, penis, anus and oropharynx are also linked to particular strains of HPV. Throat cancer rates are drastically increasing in North America, so it is crucial to be aware of these so that you can get ahead of it. According to the CDC, 90% of both anal and cervical cancers are thought to be a result of HPV. HPV is linked to 70% of vaginal and vulvar cancers and 60% of penile cancers. Up to now, throat cancers were thought to be mostly caused by smoking and alcohol use, but more recent evidence finds that about 60-70% of oropharyngeal cancers may actually be linked to HPV.  Though not all HPV leads to cancer, prevention and early detection are only possible through adequate screening and remaining informed on your risks. Why watch and wait? Head to our instagram and our website for more ideas on how you can take control of your HPV today.
Jun 13, 2022
4 min read
Oral HPV and Oropharyngeal Cancer

Oral HPV and Oropharyngeal Cancer

Adrienne Hill-Strathy
The human papillomavirus (HPV) is commonly known for its association with cervical cancer and genital warts. But, HPV is also a risk factor for several types of cancers including oropharyngeal cancer. Oropharyngeal cancer includes cancers that affect the back of the tongue, soft palate, tonsils, and side of the throat. In recent years, we have seen a rise in oropharyngeal cancers, highlighting the need for proactive management to address oral HPV. Here, we break down what you need to know about oral HPV and how you can support your immune system to defend against it. What are the Prevalence Rates of Oral HPV? It is estimated that around 7 percent of Americans aged 14 to 69 have detectable HPV in their oral tissue. The prevalence of oral HPV is higher in men than in women, 10.1% compared to 3.6%. The rates of oral cancers have increased between 2003 and 2013 by about 3.4% per year. Rising rates of HPV are thought to be due to rising rates of HPV infection in the population mostly due to changes in sexual behavior. Today, the average person has a greater number of sexual partners and it is more common to engage in oral sex. Oral sex is thought to be the main contributor to the increasing rates of oropharyngeal HPV. A study of oral HPV in men found infection rates increased with prevalence and increased frequency of oral sex. There were also increasing rates in men who smoked, were in non-monogamous relationships, and had a partner with oral or genital HPV. How Is HPV Transmitted? HPV is highly transmittable and is mainly contracted through skin-to-skin or oral contact. Touching the genitals or engaging in oral sex with an infected individual can be enough to transmit HPV. Because HPV is so easily transmitted, most sexually active individuals will contract some strain of HPV in their lifetime. The CDC estimates that 90% of men and 80% of women will be infected with a strain of HPV. Now, we know what you are thinking—“oh no, am going to get cancer?” If I have Oral HPV, Am I Going to Get Cancer? Like genital HPV, most individuals that contract oral HPV will not progress to oropharyngeal cancer. It takes many years for oropharyngeal cancers to develop from an HPV infection. Between the time of infection and cancer development, the immune system often clears the HPV and renders it dormant within the cells. Nevertheless, there is still risk if HPV remains persistent over time. The most common strain of HPV found in oral infections is HPV-16. HPV-16 is a high-risk strain that can cause cancers if it proliferates over time. Approximately 1 percent of men and women are infected by HPV-16. What are the Symptoms of Oral HPV? Like other forms of HPV, in the early stages, oral HPV infections often cause no symptoms at all. Oral HPV that is progressing into oropharyngeal cancers may cause symptoms including: Difficulty swallowing Lump on the neck or in the cheek. Chronic hoarseness Sore throat that doesn’t go away White or red patches on the tonsils Jaw pain or swelling Unintentional weight loss If you notice any of these symptoms or changes, please contact your doctor. How Do you Know if you Have Oral HPV? Oral HPV is not included in regular screening guidelines and practices. There is no test to detect for early signs of HPV cellular changes in the throat like we do with the Pap Smear. However, HPV testing can be done to detect tissue samples for the presence of HPV. For these reasons, many individuals will not know that they have been infected with oral HPV until it has progressed into a cancerous state. Addressing the immune system and limiting risk factors can help reduce overall risk and prevent complications. How to Limit Infection and Complications of HPV Reduce the number of sexual partners: Reducing sexual behavior (vaginal sex, oral sex) is one way to reduce and prevent infection rates. Because HPV is transmitted through sexual contact and touch, limiting sexual partners will lead to less possible exposure to HPV. Using protection can partially help protect against HPV but it is not 100 percent effective. Quit smoking: Smoking puts individuals at greater risk for cancers, especially those in the respiratory pathway, and is associated with an increased risk of oropharyngeal cancers. Not all oropharyngeal cancers are related to HPV. Tobacco, alcohol use, and poor lifestyle habits alone can also cause oropharyngeal cancers. Together the combination of smoking and oral HPV can significantly increase one’s risk. Reduce alcohol intake: Alcohol use is another risk factor for oral cancers. Reducing alcohol consumption and drinking mindfully when needed can help support overall health and the risk of HPV complications. Support the immune system: The immune system is thought to be the hallmark of whether an HPV infection continues to persist over time or is eradicated. You can support your immune system by getting adequate sleep, eating 7-8 servings of vegetables a day, engaging in moderate exercise, managing stressors, getting sunlight, and forming healthy relationships. You can learn more about supporting your immune system here on wellex.co. Four Towering yellow and white pills, daily supplement dose. Can Papillex help with Oral HPV? Papillex was formulated to help correct nutrient deficiencies associated with persistent HPV, and to provide immune-supporting nutrients and herbs. Since the HPV strains that cause cellular changes of the cervix are the same strains that contribute to oropharyngeal cancer, the ingredients in Papillex can help support the immune system response to oral HPV.
Mar 15, 2022
4 min read
The Root Causes of HPV

The Root Causes of HPV

Adrienne Hill-Strathy
We know that the Human Papillomavirus (HPV) causes 98% of all cancers of the cervix. HPV is also linked to anal, vulva, and other cancers of the genital tract. With that said, not everyone who contracts HPV will develop complications. Most cases of HPV will spontaneously regress on their own within 2-3 years. In the small few where HPV doesn’t revert and becomes chronic, it can lead to progressive cellular changes over time which can sometimes lead to cancer. So, what makes one person more susceptible to persistent HPV infections than another? Let’s explore a few root factors that could be at play. Addressing these root causes can help support the body to clear HPV and prevent cervical and other HPV-related cancers. Nutrient Deficiencies Nutrients form the backbone and catalysts for many reactions and processes in the body. Today, many individuals are deficient in important nutrients, and these deficiencies make it difficult for the body ecosystem to function optimally. Studies have found several nutrients to be correlated with HPV infections. Persistent HPV infections are more common in individuals with low levels of folate (B9), vitamin A, vitamin C, vitamin E, and selenium. With these deficiencies, there is also an increased risk of progression to cervical cancer. HPV rates decline in individuals with higher levels of these nutrients. The underlying action of these nutrients is to help support healthy immune function through inhibiting cancer cell growth and their powerful antioxidant activities. Nutrient deficiencies can be corrected by consuming a diet rich in diverse whole foods, especially fruits and vegetables. We like to aim for 8 to 10 servings per day with at least one serving coming from green leafy vegetables.  Nutrient levels can also be corrected through supplementation. Papillex™ was formulated with this research in mind. Our nutritional supplement offers the daily recommended serving of micronutrients known to support HPV.  The Vaginal Microbiome Within our body’s ecosystem exists separate micro-ecosystems including the vaginal microbiome. The vagina is home to trillions of microorganisms – bacteria, fungi, and viruses. These organisms play a role in the health and function of the vagina. When certain species overgrow or get depleted, health complications can occur. The vaginal microbiome is largely populated by the Lactobacillus species. Studies find that HPV is more common in individuals with lower levels of Lactobacillus. In individuals with cervical dysplasia levels of unhealthy microbes like Prevotella, Sneathia, and Clostridiales are increased. Research also seems to indicate that HPV infection can disrupt the vaginal microflora, allowing the virus to persist.  Screening for vaginal infections like bacterial vaginosis, candida, and trichomonas vaginalis can help detect if there is an underlying imbalance and inform how to treat it. If you notice any changes in vaginal symptoms such as irritation, redness, pain, or changes to discharge, contact your doctor. Taking care of your vaginal health is just like taking care of your overall health - eat a nutrient-rich diet, reduce sugar intake and processed food, and fill up on those pre-biotics and probiotics. Maintain proper hygiene practices by avoiding douches and soaps, using organic, scent-free personal care products, and cotton underwear. Safe sex practices are also important to your overall wellbeing - wearing condoms can reduce exposure to other bacteria and sexually transmitted infections as well as maintain vaginal pH. Inflammation Inflammation is a natural immune response to repair tissue damage and defend the body against invaders. However, unchecked and chronic inflammation is at the root of many chronic diseases. It is helpful to think of the body as one interconnected ecosystem when considering the impact of inflammation on cervical health. When inflammation is out of balance, it can contribute to the body’s vulnerability to tissue damage. Research has found inflammation and oxidative stress to play a role in HPV persistence. The HPV virus is better able to infiltrate into the cells when the tissue is inflamed. Chronic inflammation also helps cells proliferate over time, allowing for those cervical cell changes to occur. In addition, the HPV itself is also inflammatory and its cellular process further induces inflammation at the local site. Reducing inflammation is another whole-body approach. Dietary factors play a role in supplying the body with antioxidants, known to balance inflammatory oxidative processes. Antioxidants are best obtained from eating a diverse diet of whole foods. We also recommend reducing exposure to inflammatory triggers like cigarette smoke, alcohol, and processed foods (trans fats and refined carbohydrates) as well as managing blood sugar through consuming adequate protein, fats, and complex carbohydrates to keep inflammation down. In addition to dietary changes, getting 7-8 hours of good quality sleep per night is crucial for the immune system. Genetics Certain genetic factors have also been explored for their role in HPV. Studies suggest there is a familial predisposition to cervical cancer. More specifically, research indicates that individuals whose mother or sister had HPV have an increased chance of developing cervical dysplasia and cervical cancer. This increased risk could be due to several factors. Certain genes were found to be associated with HPV risk as well as HLA alleles. A person’s genotype may also influence risk behaviors that influence HPV. Our genes may also impact our DNA repair and detoxification pathways. Associations between the MTHFR gene and cervical cancer may also exist. MTHFR plays a role in converting dietary folate into folic acid to be used in detoxification and cellular repair pathways. An MTHFR mutation increases the risk of several diseases including heart disease, colon cancer, and breast cancer. Some evidence suggests there is a link between genetic variants of MTHFR and cervical cancer, but more research is needed. Increasing dietary folate through intake of leafy green vegetables, beans, and supplementation, can help support this pathway. Hormones Hormones also play an important role as the chemical messengers that act throughout the body. Hormones were first thought to play a role in HPV infections following findings that HPV infections were more common in individuals on oral contraceptive pills and after having multiple pregnancies. The sex hormone, estrogen, is thought to explain why rates of cervical dysplasia increase in these groups. Reducing exposure to xenoestrogens, estrogens found outside the body can help reduce this risk. Consider non-hormonal methods of birth control as a way to reduce risk. Again, diet and lifestyle factors play a role in supporting healthy hormone production and function. A diet rich in cruciferous vegetables (broccoli, cabbage, and kale) can help support estrogen detoxification and clearance. Intake of phytoestrogens like flaxseed and soy can help support a healthy hormone balance. Why lifestyle is key The good thing is most of these factors are modifiable through lifestyle practices. The daily choices you make can influence your likelihood of developing cervical cancer or other HPV complications. As we have said, supporting the body against invaders like HPV is a whole systems approach. Focusing on a nutrient-rich diet, reducing stress and exposure to harmful chemicals, and targeted supplementation can help address many of the underlying root causes that lead one to develop complications of HPV.
Jan 03, 2022
5 min read
Inflammation and HPV

Inflammation and HPV

Adrienne Hill-Strathy
Inflammation is the body’s natural response to injury and infection. Without the natural inflammatory response, we would not fair very well! When inflammation occurs, immune molecules are recruited to the site of injury or invasion to release other immune cells (cytokines, hormones, and white blood cells). These immune cells help repair and restore the body to optimal, healthy function. However, inflammation can also cause harm. If the inflammatory response is stimulated too much and for too long, chronic inflammation occurs. During prolonged inflammation, the balance between oxidants and antioxidants is thrown off causing oxidative stress. Oxidative stress promotes the release of more inflammatory molecules. These reactive oxygen molecules damage proteins, cells, and DNA, which increases the risk of diseases and cancers. This inflammatory response is thought to contribute to the progression of HPV infections to cervical cancers. Inflammation and cervical health We know that the immune system is a key factor in regressing HPV infections. Studies have found inflammatory molecules assist the virus to integrate and proliferate into an individual’s tissues. This means that the more inflammation present, the easier it is for viruses to infect our tissues. Inflammation leaves our cells more vulnerable to further damage. HPV itself also drives inflammation. The viral particles produced by the HPV (E6, and E7) are also inflammatory and drive more inflammation which further decreases the level of antioxidants, our main weapons against oxidative damage. Together these processes allow HPV to persist. What increases inflammation? Chronic inflammation is caused by multiple factors. Some factors we have little control over like infections and injury. Other factors are lifestyle-based like diet, nutrient levels, environmental toxins, stress, and lack of sleep. Fortunately, we do have some control over these factors. How to tame the flame Eliminate inflammatory triggers Reducing exposure to known inflammatory triggers like smoking and alcohol is number one in lowering our overall load. Processed foods, refined sugar, and hydrogenated oils can also be pro-inflammatory. We also know smoking increases the risk of HPV and cervical cancer. Fuel up on antioxidants Antioxidants are some of our best sources of inflammation-fighting molecules. Obtaining antioxidants is best done through the diet. With 80 percent of the immune system located in the gut, so what we put into our bodies in the form of food directly interacts with the immune system. Plant-based whole foods offer our greatest source of antioxidants. Aim for 8-10 servings of colorful fruits and vegetables each day. Rotate your veggies often to optimize the unique nutrients and antioxidants in different plant foods. Supplementation can also play a role in supplying antioxidants. By consuming a greater ratio of antioxidants, we can reduce chronic inflammation. Studies find intake of antioxidants like vitamin A, vitamin E, and vitamin C can neutralize free radicals and are associated with a preventative effect on cervical cancer. The star players Some antioxidants have potent disease-fighting properties than others. Our favorites include Glutathione Glutathione is best known for its powerful antioxidant activities. The compound is composed of three naturally occurring amino acids, cysteine, glutamic acid, and glycine. Glutathione can help repair cellular damage caused by oxidative stress and supports the liver in detoxifying hormones and toxins. Studies have found glutathione levels to be low in individuals with cervical cell changes. We can support the body’s natural production of glutathione through supplementing NAC, a natural form of cysteine. Vitamin C, methyl folate, selenium, and curcumin also support glutathione production. Green tea extract Green tea contains powerful polyphenols, called EGCG, that have been found to play a role in regressing HPV infections. The antioxidants in EGCG inhibit the cell changes that occur in cervical cancer. Several studies have found supplementing green tea extract has anti-viral and anti-infective effect that stimulates the immune system. The compound can also be used topically to clear genital warts. To obtain the therapeutic amount of green tea extract, drinking a cup of green tea isn’t enough. Supplementing offers a much stronger dose. We recommend taking 300-600 mg a day. Indole-3-Carbinol (I3C) and diindolylmethane (DIM) I3C and DIM are superfood antioxidants found in the broccoli family. 3C and DIM are produced in the stomach after consuming cruciferous vegetables. The compounds have been found to help naturally support and repair DNA damage and reduce the risk of cancer. One study evaluated oral DIM treatment in individuals with CIN 2 or 3 cervical lesions scheduled for LEEP procedure. Those in the treatment group took 2 mg/kg/day of DIM for 12 weeks. The placebo took a rice bran pill for 12 weeks. At the 6 months follow-up of the study, 84% of the treatment group had improved findings on colposcopy and 85% didn’t require a LEEP. However, no statistical significance was found between the treatment and placebo. While it is unclear if DIM treatment alone can clear HPV, its powerful antioxidant capabilities in combination with other nutrients and support can contribute to our overall HPV defense.  Medicinal mushrooms Medicinal mushrooms are another natural compound that has been used for centuries to support the immune system and inflammatory processes. Mushrooms contain active compounds called polysaccharides. These compounds can inhibit chronically elevated inflammatory molecules like IL-6, prostaglandins, and leukotrienes. Glucans are a type of polysaccharide that stimulates the production of immune molecules like natural killer cells and cytokines. These cells help the immune system clear away unwanted invaders. Reishi mushroom is commonly used for immune support. It has been found to have anti-inflammatory properties in melanoma and breast cancers. Active Hexose Correlated Compound or AHCC is another mushroom extract that contains a high level of alpha and beta-glucans that modulate the immune system. AHCC has been found to support immune support in cancers and viral infections.
Nov 29, 2021
4 min read
How the Vaginal Microbiome may be Contributing to your HPV

How the Vaginal Microbiome may be Contributing to your HPV

Adrienne Hill-Strathy
Our bodies are inhabited by millions of tiny living microbes. You may already be familiar with the living organisms in the gut. Our genitals each have an ecosystem of microbes as well. The bacterial composition of our vaginal microbiome plays a role in our overall health, including simmering infections like HPV. Vaginal microbial diversity and richness is a key player in the immune system. Healthy microbes help prevent many urogenital diseases, yeast infections, and other Sexually Transmitted Infections. Breaking down the microbes The key player in the vaginal microbiome is a bacteria called Lactobacillus. This lactic-acid-producing organism is thought to be the main defense against incoming invaders in the vagina. Lactobacillus helps maintain a low vaginal pH and protects the vaginal mucosal lining. The abundance of Lactobacillus species is lower in individuals infected with HPV. Moreover, individuals with cervical dysplasia show higher proportions of unhealthy microorganisms like Prevotella, Sneathia, and Clostridiales. The chicken or the egg? It seems HPV infections may impact normal microflora. Likewise, an unhealthy flora can also allow for HPV to persist. As the virus initiates healthy cervical cell immune defenses, it can disrupt the vaginal microbiome and promote HPV persistence and progression. As we continue to learn more about the microbial connection to STIs, it is important to consider how the vaginal microbiome may be contributing to your HPV infection and what you can do to fix it. Types of vaginal infections: There are three main types of vaginal infections.  Bacterial vaginosis (BV) is the most common type of vaginal infection in adult women. Around 30 percent of women between the ages of 20 and 50 have BV. BV is characterized by an overgrowth of certain bacteria and an elevated vaginal pH. It often presents with symptoms of a fishy odor, greyish discharge, itching, and irritation. Studies have found a positive correlation between BV infections and HPV. The connection is thought to be due to reductions in Lactobacillus (the beneficial microbes) and an increase in sialidases (the pathogenic ones). The loss of beneficial bacteria reduces the protective microorganisms and changes in the vaginal microflora, which may promote the survival and development of HPV. The increase in the presence of sialidases can cause microdamage to the epithelial cells and increase the susceptibility to cervical HPV infections. Trichomonas vaginalis (TV) is another common STI. It can also cause a foul odor, genital redness or burning, and pain with urination and intercourse. A positive association was also found between TV infections and positive HPV infections. Vulvovaginal candidiasis, also known as a yeast infection, is another common vaginal infection. Candida results from an overgrowth of fungal species in the vaginal canal. Research has found that candida infections were not associated with an increased risk of HPV infections. This is likely because candida does not impair the lactobacillus-predominated vaginal microbiota. How do I know if I have a vaginal infection? Vaginal infections often present with signs and symptoms. You may notice: Vaginal irritation Changes in color, odor (often fishy), and/or consistency of discharge Redness Pain or tenderness Itching Burning or pain on urination If you notice changes in vaginal symptoms, contact your doctor. A vaginal exam and swab can be done to determine the cause. Tips to take care of your vaginal health Lifestyle choices can play an important role in supporting the vaginal microbiome. Optimal vaginal health depends on the health of the whole body. Treatment is focused on supporting both the local environment, as well as the wider body system. organic basil herbs on display at the farmer's market. Diet: Because the body is one interconnected system, what you eat can influence the vaginal microbiome. A diet low in sugar and refined carbohydrates can support a healthy microflora. Sugars are found in cakes, cookies, pastries, and alcohol should be limited to special occasions. Sugars from fruits and other natural sources like honey and maple syrup should be enjoyed but not overdone. By reducing sugar intake, blood sugar is better managed allowing for healthy hormone regulation. Consuming a diet rich in a diversity of fruits and vegetables can also help support a healthy microbiome and supply micronutrients to enhance overall health. Probiotics: oral and vaginal probiotics can help support the vaginal microflora. It is important to opt for a high-quality probiotic. Probiotics that contain Lactobacillus reuteri, Lactobacillus rhamnosus, and Lactobacillus crispatus are known to support vaginal microflora. For vaginal suppositories, probiotics are often recommended for 10 days through insertion into the vaginal canal each night before bed.   Hygiene: The vagina is self-cleaning. Maintaining proper vaginal hygiene by simply washing with warm water and avoiding douches and soaps is also helpful. Because the tissue in the vagina is some of the most absorptive tissue in the body, toxins, and chemicals in tampons can be easily absorbed and disrupt the microbiome and cause inflammation. We recommend opting for organic, scent-free products to reduce disruption. Sexual activity: Sexual intercourse and semen can also change the vaginal microflora and alter the vaginal pH. New partners can initiate the vaginal immune defenses and cause inflammation. Wearing condoms has been found to reduce occurrences of BV and other Sexually Transmitted Infections.
Nov 01, 2021
4 min read

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