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Fighting HPV and Papillex

Fighting HPV and Papillex

Christine Chung
A Natural Approach to HPV Watching and waiting to see if your HPV progresses into something more serious can be stressful and cause frustration. Papillex contains ingredients that research has shown to help the immune system respond to HPV naturally. It also contains replenishing nutrients that tend to be deficient in cases of persistent HPV infections. Low levels of dietary carotenoids have been shown in women with HPV and are associated with an increased risk of persistent HPV infections. The risk is increased by 50% for high-risk HPV. High levels of vegetable consumption, specifically have been shown to decrease HPV persistence by 54%. Increased levels of lycopene in the blood are also associated with a decreased risk of CIN 1, 3, and cervical cancer. Eat Your Vegetables! One study showed higher dietary intakes of dark green and deep yellow vegetables and fruit were associated with an almost 50% decreased relative risk of CIN 3. This shows the importance of loading up on colorful vegetables such as peppers, tomatoes, carrots, mangos, sweet potatoes, spinach, and kale to support homeostasis and a healthy microbiome. A daily serving of Papillex™ contains the equivalent of 3/4 cup of frozen cooked spinach, 3 cups of raw carrots, or 2.5 cups of raw cantaloupe daily. Indole-3-carbinol, DIM, and sulforaphane are powerful metabolites found in broccoli family vegetables that support the body in the repair of DNA damage and have been shown to lower the risk of cancer. Small human trials suggest indole-3-carbinol (I3C) supplementation may be beneficial in treating conditions related to HPV. One study showed a statistically significant regression of CIN in patients treated with oral I3C, despite a higher prevalence of positive HPV findings in treatment groups. Sulforaphane Specifically was shown to stop the growth of cancer cells by causing cell death. These important ingredients are found in cabbage, broccoli, broccoli sprouts, Brussels sprouts, cauliflower, and kale. To garner the same benefit as a daily serving of Papillex™, you would need to eat one head of broccoli, 2 cups of Brussels sprouts, or 2.8 cups of raw cabbage per day…that’s a lot of crunchy greens! Studies have found that individuals with a folate deficiency have an increased risk of positive HPV status, as well as an increased risk of progression to cervical and oral cancer. There may be a relationship between low levels of folate in the blood and high-risk HPV infection. Folate rich foods include: dark green leafy vegetables (such as: spinach, asparagus and Brussels sprouts), nuts and beans, and liver. A daily serving of Papillex contains the equivalent of 5 ounces of poultry liver, 4 cups of chickpeas, or 40 spears of asparagus. Vitamin C Is Correlated With Lower Prevalence of HPV Vitamin C is a powerful antioxidant. Research studies conclude that individuals with higher Vitamin C levels have a lower HPV viral load, and decreased frequency of the development of oral and cervical cancer. Foods highest in Vitamin C include: yellow bell peppers, guavas, dark green vegetables (especially kale and turnip greens), kiwi and broccoli. A daily serving of Papillex™ contains the equivalent of 1/2 yellow pepper, 1 guavas or 2 cups of kale. Anti-viral Antioxidants Green tea has long been known as a powerful anti-viral and anti-infective plant that stimulates the immune system. Green tea is often used topically for genital warts and cervical dysplasia. Orally, green tea intake has been associated with slowed progression and decreased risk of cancer through its strong antioxidant effects. A daily serving of Papillex™ contains the equivalent of 2.5 cups of green tea with a guaranteed low level of caffeine. For those who are sensitive to caffeine, no need to worry! Vitamin E Vitamin E has been shown through clinical studies to inhibit cancer cell growth and support the immune system through its powerful antioxidant capabilities. Low levels of Vitamin E have been seen in cervical cancer patients and higher rates of HPV-16 and 18 in research. Foods high in Vitamin E include cooked spinach, almonds, roasted sunflower seeds, avocados and fish. A daily serving of Papillex™ contains the equivalent of 32 cups of cooked spinach, 3 cups of whole almonds, or 28 whole avocados. WOW! Selenium Individuals with cervical dysplasia have been reported to have low levels of selenium, an essential trace mineral. In recent animal studies, selenium has also been shown to increase cell death in HPV-infected cells. It can be difficult to supply the body with selenium, as many of our soils are depleted of this essential mineral. Foods that are generally higher in selenium include brazil nuts, oysters, tuna, and sunflower seeds. A daily serving of Papillex™ contains the equivalent of 3 oysters, 4 ounces of tuna, or 3 brazil nuts. Medicinal Magic Astragalus A powerful immune modulator has been used for centuries to promote resilience in the body. Recent studies have shown the herb's impact on the growth of abnormal cervical cells. In an in vitro study, an Astragalus injection into cells slowed down the bad cell growth and regulated immune cells. The study concluded that on a cellular level, Astragalus can reduce the survival of infected cells, the effect increasing with higher doses. Reishi The Reishi mushroom has been celebrated for its antiviral properties over thousands of years. Clinical studies have shown that the use of these medicinal mushrooms has dramatically impacted the clearance rate of HPV, both vaginal and oral. Extracts of Reishi, or Ganoderma lucidum stopped the growth of HPV-infected cells by stopping the cell cycle and causing cell death in transformed cervical cells. Papillex can be an excellent way to support your body during the “watch and wait” period between pap smears. It contains therapeutic dosages of clinically research ingredients that help support the immune system when concerned with HPV. Why watch and wait, when you can be proactive? Order Papillex today!
Aug 21, 2019
4 min read
HPV Infection 101

HPV Infection 101

Christine Chung
Most people know that HPV is spread through skin to skin contact during sexual activity involving the genital area. Although, it is most commonly transmitted through vaginal sex, did you also know that it can also be spread through anal and oral sex too? In the following article, we aim to answer all the questions you have about HPV infections, dispelling some of those myths which could leave you more vulnerable. Common HPV Infection Questions I only have one sexual partner, does this mean I won't get HPV? Even being sexually active with only one person can bring on an HPV infection. Having more sexual partners will put you at higher risk for contracting an HPV infection. I won’t be at risk because my partner didn’t have any symptoms…right? The short answer is: you could still be at risk. Unfortunately, HPV can be passed on even when someone with an HPV infection does not have any symptoms. With a healthy immune system, someone may suppress symptoms of the HPV infection, but the virus can still hop over to another host. With a healthy immune system, chances are it won’t cause any serious complications. Lots of questions arise when talking about HPV. Hopefully we can answer some of them for you :) We use physical protection (i.e. condoms) every time so I’m safe. While condoms provide excellent protection against sexually transmitted infections, they only provide some protection against HPV. Condoms do not cover the entire genital area, so you can still get the HPV virus though skin to skin contact in the genital area even if you’re wearing a condom. It can also be spread through contact with other areas that aren’t covered. In other words, you can get HPV through oral-genital or hand-genital contact – not just sexual intercourse! If I got it once, I’m safe now…right? You can be infected with HPV more than once, even if you’ve already been exposed to HPV before. It is possible that the body may not have developed long-term protection against the virus, or you may come into contact with a completely different strain of the virus, remembering that there are over 100 different types of HPV. What serious conditions can develop from having HPV? The following conditions can all stem from having a particular strain of HPV: Genital warts Cervical dysplasia Precancerous lesions Cervical cancer HPV Detection and Prevention HPV testing is key to detecting and thus preventing further high risk complications of HPV in women. A good way of doing this is to attend routine women’s health screening exams with your medical doctor. Pap Smear Test These are usually done once every 3 years after the age of 21 in sexually active females. The Pap Test detects even the earliest cellular dysplastic changes and this timely detection has led to reduction in the progression to cancers. A Pap test must be repeated every one to two years after the first Pap test. An abnormal Pap smear will be followed up with further testing to detect the stage of abnormality. It could just be abnormal cell growth with no cancerous disposition, or it could be a growth of squamous cells, which are likely to result in cancer. HPV Test It is important to note that the FDA has approved the HPV test to be used for women over 30 years old, as it may be useful in finding HPV before there are cervical changes. There are now very accessible HPV tests kits that you can use from the comfort of your own home. These are quick and easy to use, detecting the highest risk types of HPV, 16 and 18, as well as multiple other strains that may cause health problems. Some popular, high-accuracy kits are listed below: https://evekit.com/ https://www.nurx.com/ https://www.letsgetchecked.com/ca/en/ https://www.everlywell.com/products/hpv-test-female/ In the United Kingdom, they are now sending at-home HPV testing kits in the mail for free to decrease the number of women who have further progressing HPV complications. HPV Treatment HPV treatment is often sought, and although there is no cure for HPV, there are many treatment therapies available for symptoms of genital warts and cervical dysplasia. These include cryotherapy, LEEP, surgical removal, laser surgery, or photodynamic therapy. There are also several clinical trials outlining the success of each therapy. What can I do naturally? Although there is no cure, most HPV infections are easily cleared by a strong, healthy immune system. Your immune system can be supported in a number of natural ways: Eat plenty of fruits and vegetables Quit smoking Reduce alcohol consumption Drink green tea Exercise to sweat Papillex has been designed with HPV sufferers in mind. It is a clinically-researched, nutrient-rich supplement designed to increase your body’s ability to respond to HPV naturally.
Aug 14, 2019
4 min read
Why Folic Acid for HPV?

Why Folic Acid for HPV?

Christine Chung
What is Folic Acid? Folate is a member of the B vitamin (B9) family, a water-soluble vitamin involved in many chemical processes in the body. Folic acid is the synthetic form of folate. Folate is essential for the production of red and white blood cells and other important cells that help to convert food into energy and make DNA. Folate also plays an important role in the reproductive tract and is needed to maintain a healthy pregnancy. The body cannot create folate on its own so we must obtain it through our diet or supplementation. Research on HPV has begun to highlight a strong association between folate deficiency and cervical dysplasia, emphasizing the importance of incorporating more folate-rich foods into your diet as well as taking a quality supplement. Folate versus Folic Acid Folate differs from folic acid in the way that the vitamin gets converted in the digestive tract. Folate is immediately converted into the active form of vitamin B9, called 5-methyl-THF (5-MTHF). Folic Acid enters the bloodstream and passes through the liver and other tissues in order to be converted. Folic acid is thought to be better absorbed, however, it is metabolized at a slower rate, which means more can accumulate and linger in the system and may lead to excess. Folate, on the other hand, will be excreted if too much is consumed. Folate Deficiency Folate plays a critical role in your body so when it is lacking, it can lead to suboptimal health but it isn’t always easy to know when you are low in vitamin B9. Some symptoms include unexplained fatigue, anemia, muscle weakness, shortness of breath, difficulty focusing, brain fog, headaches, and heart palpitations. Deficiencies in folate can cause megaloblastic anemia, which is when your blood cells form in an improper shape. This hinders their ability to function correctly in your body. Folate is especially important for pregnant women, as deficiencies can cause neural tube defects in a growing fetus. Folate and Methylation Without folate, the body has trouble maintaining methylation. Methylation is a biochemical process that helps support cardiovascular, neurological, and reproductive health.  The cycle of methylation begins with a methyl group (one carbon and three hydrogen molecules) converting amino acid, methionine into S’Adenosylmethionine (SAM-e). Once converted into SAM-e, this molecule travels through the body transferring methyl groups to other bodily systems. SAM-e Is finally converted to the amino acid homocysteine, which creates the antioxidant glutathione. A deficiency in folate or B12 impairs the final stage of methylation, leading to elevated levels of homocysteine. Too much homocysteine increases the risk of heart disease and blood clots. Methylation also regulates our genes, turning them on or off. One of the ways cancer develops is through impaired gene regulation. Not having enough folate can impair the body’s ability to regulate cell growth and increase susceptibility to cervical cancer. MTHFR Gene Mutations Some people have a genetic mutation that prevents them from properly converting dietary folate into its active form (5-MTHF). This mutation may explain why women with healthy diets and lifestyles struggle to clear the infection, while others who smoke and eat poorly can eliminate the infection with no problem. Individuals with the MTHFR mutation have an increased risk of several diseases including heart disease, colon cancer, and breast cancer. Supplementing with the active form of folate (folic acid or methylated folate) can be beneficial for those with the mutation. Methylation is also impacted by diet in general. Studies have found the degree of methylation in the body to correlate with the volume of fruit and vegetables participants consumed. The findings suggest that dietary modifications to include more folate in the diet can reduce the risk of cervical dysplasia. Benefits of Folic Acid The average adult is recommended to take 400mcg of folate daily. Although folate is best known for preventing neural tube defects in fetuses, new research is showing its benefits in cancer prevention including breast, bladder, cervical, ovarian, and pancreatic cancers. Because folate is involved in reducing homocysteine, folate intake can influence heart disease. Recent research is showing benefits in reducing the risk of Autism Spectrum Disorder, Dementia and Alzheimer’s, and depression. Food Sources of Folate We recommend aiming for your daily dose of folate from food, before supplementing. Food sources of folate include:  Dark green leafy vegetables (i.e. kale, spinach), Broccoli, Black-eyed peas, Liver, Asparagus, Brussels sprouts, Avocado, Broccoli, Green peas, Fortified Grains*. *Because of the utmost importance of folate adequacy, the Canadian government, along with other governments have mandated folate fortification to many grains, like breakfast cereals, white flour, and pastas.  Folic Acid’s Role in HPV Management Folate is one of several key nutrients that have been studied in relation to HPV. Folate’s role in HPV is likely related to the methylation cycle mentioned above, which ensures your genes function normally. Current research has highlighted the relationship between low levels of folate in the blood and high-risk HPV infection through the promotion of cervical dysplasia development. Studies have found that individuals with a folate deficiency have an increased risk of positive HPV status, as well as an increased risk of progression to cervical and oral cancer. Whereas women with higher plasma folate and B12 levels with HPV-16 positivity were 60-75% less likely to be diagnosed with moderate cervical dysplasia.  There has been extensive research on the role of folate in HPV. We highlighted some key research below: A 2003 study by Hernandez et al. showed that women with the highest levels of blood folate levels from either food or supplements have lower rates of cervical dysplasia from HPV. A 2016 case-control study by Zhao et al. that included 271 controls and 214 women with both high and low-grade HPV lesions, found that low blood folate levels in women were coupled with a higher risk of cervical cancer from HPV. A large analysis of studies, or a meta-analysis, showed an increased risk of cervical cancer among Asian populations with low blood folate levels. A study by Bai et al. showed that a folate deficiency was associated with an increased risk of squamous cell carcinoma of the cervix and cervical intraepithelial neoplasia (CIN) in subjects who were HPV 16 positive. In an Indian population, improving folate and vitamin B12 status may have a beneficial impact on the prevention of cervical cancer. Scientific evidence shows that folic acid likely plays a protective role in HPV progression to cervical cancer. Folate is one of the many key protective nutrients in Papillex. A daily serving of Papillex contains the equivalent of 5 ounces of poultry liver, 4 cups of chickpeas, or 40 spears of asparagus. Should I Supplement Folic Acid? It is estimated that 5 to 40 percent of the female population has a folate deficiency globally. Ideally, we would obtain our folate from food sources like dark leafy greens, vegetables, fruits, nuts, and seafood. However, it can be difficult to get the recommended amount of folate from food alone. As mentioned, a person’s genetics may also make it difficult to convert dietary folate into its active form. Folic acid supplementation of 400mcg per day is safe. The highest level of daily intake of folate that poses no risk of adverse health effects was set at 1,000 micrograms per day. Folic acid is also a water-soluble vitamin and does not accumulate in fat tissue. Therefore, excess intake will be excreted into the urine and out of the body.  Supplementation with folic acid is often recommended for pregnant women to prevent neural tube defects and prevent megaloblastic anemia. Supporting HPV Naturally Many doctors choose to implore a “watch and wait” tactic, as it is difficult to begin treatment without further progression of abnormal cells. Some people wait years before seeing this progression, and most surgical interventions do not have an immense effect on the early stages of cell changes. Even if you eat the healthiest possible diet, you may still have several nutritional deficiencies which can harm the health of your immune system. This is why in addition to a diet high in richly pigmented fruits and vegetables, it’s important to supplement your diet with clinically supported nutritional supplements. Papillex is a compound that contains high-quality, natural sources of nutrients that have been shown to support beneficial results in eliminating HPV infections. It contains ingredients that nutritionally support the immune system which will help the body to better respond to genital warts, cervical dysplasia, and other HPV-related disorders naturally.
Aug 07, 2019
6 min read
Vitamin D: The “Sunshine Vitamin”

Vitamin D: The “Sunshine Vitamin”

Dr Elizabeth Goldspink
Vitamin D comes from the sun. Vitamin D is also a key player in maintaining overall health, supporting immune function, regulating inflammation, bone health, and many other essential body processes. Unfortunately, many people are deficient in this crucial vitamin. Most people in countries in the northern latitudes do not achieve their adequate dose, especially during the winter. Did you know that low Vitamin D levels can also affect your HPV status? This blog covers the basics of HPV and how Vitamin D can be vital to your health and wellbeing. Vitamin D: The Sunshine Vitamin There are two main natural sources of Vitamin D, food and sunshine, with the sun being most people’s primary source of Vitamin D. This is why it can be more difficult to get the appropriate dose of Vitamin D in winter months when daylight shortens in cooler climates. Ultraviolet light is absorbed into the skin, strikes the skin, and triggers Vitamin D synthesis, so sunshine is crucial! Vitamin D is a fat-soluble vitamin as well as a hormone. It is best known for its crucial role in bone health. Without it, the body would not be able to absorb calcium, magnesium, or phosphate from food - which are essential minerals for bone strength. Without adequate calcium absorption, the body “borrows” calcium from the bones, increasing the risk of bone thinning, which may lead to osteoporosis and fracture. Vitamin D helps maintain normal blood levels of phosphorus, magnesium, and calcium for other body functions. Vitamin D is so vital to bone health that governments mandated the fortification of certain food products, such as milk and milk alternatives to prevent severe deficiencies. Diseases caused by severe deficiency, such as rickets in children and osteomalacia in adults, were common before this fortification. Vitamin D-eficient Symptoms It isn’t always obvious when your body is in need of more Vitamin D. While the symptoms are often subtle, low levels of vitamin D can present with: Low immune function – have you noticed you’re getting sick or run down more often than usual? Fatigue – it can be as simple as an increased difficulty of getting out of bed in the morning. Bone loss or pain – new and random aches and pains should be assessed by your primary healthcare provider. Muscle pain and weakness – not able to crush it at the gym like usual? Having difficulty recovering? Low mood or depression – often this is a key symptom of Seasonal Affective Disorder, where those who have dark, cold, long winters are deficient in vitamin D, leading to decreased pleasure or interest in doing things they used to love, low mood, and depression. Impaired skin healing – with low vitamin D, it can be harder to heal something as small as a papercut or a skin blemish scar. Hair loss – hair thinning or hair loss can be caused by low vitamin D levels Can I test if I’m deficient? Vitamin D levels can be checked through a blood test. The most common test is the 25-hydroxyvitamin D or 25(OH)D. It reflects vitamin D produced inside the body from both foods, sun, and supplements. Ranges above 20-30 ng/mL are considered sufficient for bone and overall health in healthy individuals. Levels over 50 ng/mL can be associated with adverse effects. Getting tested can give a general indicator of your status and whether it might be useful to supplement. We always recommend talking to your doctor to get their take on what would be best for you. What’s the connection between Vitamin D and HPV? So now that you know the importance of vitamin D, how does this relate to your HPV status? New research on Vitamin D is constantly emerging, increasing what we know about the many benefits this vitamin has for our health. Low levels have been linked to insulin resistance and diabetes, inflammation, impaired immunity, and certain autoimmune conditions, and cancer. As more research is conducted, the potential benefits of this “sunshine vitamin” are rapidly expanding. The main connection between Vitamin D and HPV is in the immune system. An HPV prognosis can single-handedly be affected by the strength of your immunity, and Vitamin D is an essential part of keeping a robust immune system. A study in the United States links low vitamin D status to increased risk of developing a high-risk HPV infection among sexually active women. Optimal Vitamin D levels have been found to play a positive role in both the adaptive and innate immune systems. Vitamin D has been found to boost the expression of white blood cells, which are the immune molecules known for fighting off infections and managing inflammation. Low levels of Vitamin D have also been associated with autoimmune diseases such as multiple sclerosis, lupus, diabetes, and rheumatoid arthritis.  The hormone has also been found to play a role in managing chronic inflammation, a key factor in nearly every chronic disease. Vitamin D manages inflammation through modulating cytokine production and proliferation. Cytokines are the immune systems chemical messenger systems that tell the rest of the immune system when to respond and react.  Vitamin D’s Anti-Cancer Effects Another study outlined the importance of Vitamin D in the steroid hormone pathway, which regulates calcium. It explained the anti-proliferative, pro-apoptotic, anti-angiogenic effect of Vitamin D in cancer prevention.  In easier terms, Vitamin D was effective in decreasing cancer cell growth and increasing cell death of existing cancer cells. This study found a significant connection between blood levels of Vitamin D and HPV positive status. Vitamin D has proven anti-inflammatory functions, therefore the deficiency of Vitamin D and its metabolites could possibly relate to HPV persistence and other related cervical intraepithelial neoplasia. Getting Your Vitamin D The best way to get Vitamin D is through sun exposure. You need bare skin exposed to sunlight when it’s at its highest so that you can get enough ultraviolet B, or UVB, rays. 10 to 30 minutes per day around 11am to 3pm is optimal. Fair-skinned individuals may spend less time, while those with darker skin tones may need to spend longer. Darker skin tones will have decreased production of Vitamin D in the skin due to increased skin pigments which block UV light absorption. Other factors that may affect Vitamin D synthesis in your skin from the sun include season, time of day, latitude, cloud cover, pollution, skin tone, clothing, sunscreen, and age. Except in summer months, the skin can make little if any Vitamin D from the sun if you live at latitudes above 37 degrees north. This includes all of Canada and most of the United States. Those ages 65 and up have decreased production of vitamin D with increasing age. Although sunscreen is important for protecting the skin against harmful effects of the sun, such as skin cancer, sunscreen blocks your skin’s ability to produce vitamin D. Try sitting in the sun, sunscreen-free for 10 minutes, then generously applying sunscreen or cover-up after filling up your vitamin D stores! To supplement or not to supplement? For those who live in places with long, dark winters, or grey seasons (we’re looking at you, Canada!), supplementation is recommended. You should see your primary healthcare provider to get bloodwork to guide dosing and supplementation -  supplementing too much vitamin D has been known to cause stomach pain and kidney dysfunctions. When picking your supplement, make sure it is in the active form of cholecalciferol. Food sources may help with your Vitamin D levels as well. Food sources highest in Vitamin D include: canned sardines, salmon, tuna, sunflower seeds, liver, eggs, mushrooms, and fortified milk. What else can you do naturally? Most HPV infections are easily cleared by a strong, healthy immune system. You will likely clear the infection with no symptoms with a robust immune system. Your immune system can be supported in a number of natural ways: Eat plenty of fruits and vegetables – fruits and vegetables contain many essential vitamins and nutrients to keep your body functioning at its best! These food groups are specifically high in antioxidants, which may help neutralize bad molecules floating around in your body. Quit smoking – smoking single-handedly increases your risk for HPV-related cancers, even second-hand smoke exposure. While cutting down your cigarette count will still affect, nothing is quite as good as quitting entirely. Reduce alcohol consumption – high consumption of alcohol is related to several negative risks, including a decrease in immune functioning. Drink green tea – green tea has been shown in many studies to have immune-boosting benefits and anti-cancer effects, some specific to HPV. Exercise to sweat – We recommend at least 20-30 minutes of light aerobic walking or cycling each day and 2-3 sessions of resistance training. Get adequate sleep – getting 7 – 8 hours of high-quality sleep is important to regulate your bodily functions, including your circadian rhythm. All of these factors have a distinct effect on your ability to fight infections.
Jul 24, 2019
7 min read
Acrylamide: Are You Sure You Want Fries With That?

Acrylamide: Are You Sure You Want Fries With That?

Christine Chung
There are many risky ingredients and chemicals in processed food that can increase your risk of cancer. Did you also know that the way YOU cook or process your food can also have a similar effect? Keep reading below to get the low down on HPV and how acrylamide may affect your cancer risk! What is Acrylamide? Acrylamide is an industrial chemical that can be found in dyes, paper, plastics, and can even be used in treating water sewage. These are commonly seen in products we buy, in the packaging, and adhesives used. Oh, and by the way, this chemical is also present in tobacco smoke. How does this apply? This toxic chemical can form in some foods when using high-temperature cooking methods, such as deep frying, pan frying, roasting, or baking. This comes from a combination of sugars and an amino acid called aspargine that are presently found in food. These two components separately do not have a bad effect on your health, but during high-temperature cooking, they combine and can cause some pretty negative side effects on your health. The exact temperature at which acrylamide forms in food has yet to be determined, but it has so far not been found in food prepared at temperatures below 120 degrees Celsius (248 Fahrenheit). Why Should I Avoid Fried Food? Acrylamide is yet another reason to avoid fried and processed foods since certain food preparation methods lead to the formation of chemicals that pose a potential health concern. It was first detected in certain foods in April 2002 by the Swedish National Food Authority. Acrylamide is a chemical that naturally forms in certain foods, particularly starchy foods that are rich in carbohydrates and low in protein, during processing or high-temperature cooking, such as frying, roasting, and baking but not typically when boiling and steaming even at very high temperatures. Those French fries you can’t help but get as the side of your burger? These are heavily contributing culprits to high levels of acrylamide. In fact, the highest concentrations of acrylamide are found in potato chips and French fries, and are followed by cigarette smoke. Cancer Risk The Joint Food and Agriculture Organization/WHO Expert Committee on Food Additives (JECFA) and the United States Food and Drug Administration has identified dietary exposure to acrylamide as a potential concern. Acrylamide is known to cause cancer in animals at high levels. Elevated doses can also be toxic to the nervous system of both animals and humans. An 11-year study in the journal of Cancer Epidemiology Biomarkers and Prevention found an increased risk of endometrial and ovarian cancer was associated with higher intake of acrylamide from food. Here are other organizations’ takes on acrylamide: The International Agency for Research on Cancer (IARC) classifies acrylamide as a “probable human carcinogen.” The US National Toxicology Program (NTP) has classified acrylamide as “reasonably anticipated to be a human carcinogen.” The US Environmental Protection Agency (EPA) classifies acrylamide as “likely to be carcinogenic to humans.” While adverse effects to your brain and nervous system are unlikely at the estimated average exposure to acrylamide, changes in the actual structure and function of your nerve cannot be excluded for individuals with a high dietary exposure to acrylamide. For a compound that is both genotoxic and carcinogenic, these MOEs indicate a health concern. The take-home message: Avoid fried and processed foods and your body will thank you. In addition to taking Papillex, eat a diet high in fruits and vegetables and minimize the ingestion of saturated fats, and processed foods that impair immunity and contribute to inflammation in the body. 3 Tips to Decrease your Acrylamide Burden 1. Boil or steam your vegetables. By not roasting, baking, or frying your food, this will avoid the combination of sugars and amino acids that creates acrylamide. Boiling and steaming your food, no matter what temperature, is not connected with acrylamide formation. Acrylamide does not form, or forms at lower levels in fish, meat, or dairy products. 2. Don’t overcook your vegetables. Cooking for longer periods of time, especially at higher temperatures can cause acrylamide formation. This will also help to sustain those good fibers to contribute to a happy gut. 3. Avoid fried potato products ...like French fries or potato chips, or any other fried vegetable, especially those with breading. Acrylamide is mainly found in plant-based foods, especially potatoes and grains, and even coffee! So think twice next time you choose French fries or breaded, deep-fried onion rings next time! Bonus Tips for the Fried Food Fiends! *  If you find you just can’t get away from roasted, baked, or fried potato foods, soak your potato slices raw for 15 to 30 minutes before frying – make sure to dry the slices thoroughly to prevent oil fires! *  Avoid storing potatoes in the fridge before cooking. Studies show that this may increase levels of acrylamides formed during the cooking process. *  When frying, baking, or roasting potatoes, bread, or other vegetables, try cooking them to a lighter shade and avoid burning to decrease acrylamide production. Want to know more about healthy eating? Check out our blog on healing HPV through food!
Jul 17, 2019
4 min read
HPV and Pregnancy: The Ins and Outs of Having HPV While Pregnant

HPV and Pregnancy: The Ins and Outs of Having HPV While Pregnant

Christine Chung
The number of people with positive HPV diagnoses is climbing every year. Millions of Americans are newly diagnosed with HPV and are unaware of the potential consequences. HPV is now the most common sexually transmitted infection. The Center of Disease Control now estimates that nearly everyone who is sexually active will have contracted a strain of HPV at some point in their lives. The good news is, most strains will be cleared by your immune system and will not cause any health concerns. There are a few strains that may cause genital warts and some high-risk strains of HPV that have the potential to cause cervical cancer. This growing concern is a high concern for pregnant women, or those considering pregnancy in the near future. What can you do if you plan on getting pregnant? Get regular pap tests. High-risk types of HPV have been known to cause cervical cancer. This is a serious complication in fertility and pregnancy. Most women do not ever reach the stage of cervical cancer, as cell progression is caught easily in pap tests, and preventative measures can be taken. The recommendation for disease control and prevention is to get one pap test every three years to keep an eye on your cervical cells, and more frequently if you have ever had an abnormal pap test. Papillex is not recommended for pregnancy due to the mixed carotenoids in the ingredient formula. While beta-carotene, great against HPV, has not been associated with any complications in pregnancy, high doses of vitamin A have been. It is always important to consult your healthcare practitioner when taking any new supplements, especially if you are pregnant. However, Papillex may be a great supplement for you prior to pregnancy. It will help keep your immune system robust, fighting the HPV infection. This will bar any complications of HPV starting off in your pregnancy. What can you do if you’re already pregnant? Pregnant women are screened according to the current guidelines. Being pregnant does not change the amount of pap tests you get; meaning you’re still allocated to one pap test every three years. If you have not had any abnormal cell findings in your past pap tests, you are likely to be in the clear until your pregnancy is complete. Most pregnancies continue to full-term with no complications and babies are born with no signs of being carried by someone with an HPV infection. What are the risks? With high-risk strains of HPV infection, HPV-16 and HPV-18, abnormal cervical cells can progress to cervical intraepithelial neoplasia. If you have ever gotten this diagnosis, you probably know if it is a CIN 1, 2, or 3. CIN 1 is the least concerning, and CIN 3 is the most concerning and most likely to progress into cervical cancer. When an HPV infection causes CIN damage to the cervical cells, these lesions have been associated with premature labour and low birth weight in some cases. There is a very low risk of transmission of the pregnant woman’s HPV infection to the child. One study followed 153 pregnant women through their pregnancies, some of which had previous HPV infections, and some with newly diagnosed HPV diagnoses through their pregnancies. HPV DNA was detected at birth in 5.2% of the babies born to healthy women and was associated with the detection of HPV DNA in the mothers during any given trimester. To add: just because the child has HPV DNA, does not mean that they will get cervical cancer, or even show any symptoms throughout their life. In the worst case scenario, the HPV strains causing genital warts may cause respiratory papillomatosis in the baby, which is the development of warts in the baby’s throat, which must be removed surgically. If you have a high-risk strain and must pursue treatment throughout your pregnancy, check out our blog post on HPV and Photodynamic Therapy to get the low-down on this potential option to treat warts and abnormal cervical tissue. What else can you do as a pregnant woman with HPV? Most doctors will recommend a “watch-and-wait” protocol and may have some other suggestions with therapies for pregnant women. The bottom line is, the earlier you catch any abnormal cell changes, the better. Starting treatment right away is a preventative measure to stop further progression. This is as easy as making lifestyle changes, eating better, exercising, sleeping well, keeping your stress levels low, cutting out smoking, alcohol consumption, and other toxic components of your life. This will all help to support your body through your pregnancy, and keep your HPV infection at bay while growing another human! Why watch and wait, when you can be proactive? Order Papillex today!
Jul 01, 2019
4 min read
HPV Treatment

HPV Treatment

Christine Chung
About 80 % of women around the world get HPV. What is the treatment? The Low Down On HPV The number of people with HPV are rising every year. Wondering if you could be at risk? Read below to learn about the climbing risks of HPV. What Is HPV? Human Papillomavirus is one of the most common viruses that affects humans, being the most sexually transmitted infection in the United States. HPV infection affects millions of men and women every year. The Center for Disease Control and Prevention estimates that almost every sexually active adult will get HPV at some point in their lifetime. It can be spread by skin to skin contact, most commonly through sexual activity. Vaginal, oral, and anal sex can lead to the transmission of HPV. Should You Be Worried? There are low risk and high risk types of HPV. Most HPV infections are self-limiting and usually resolve within a period of 1-2 years. The person may not even be aware that they had contracted an infection with a robust immune system. Like any other virus, your immune system will be able to clear HPV pretty easily. There are, however, a few high risk strains that can be responsible for some health concerns in women, such as the following clinical conditions: Genital warts Cervical dysplasia Precancerous lesions Cervical cancer Genital Warts Genital warts appear as papules near vagina, cervix, vulva, or anus. These warts are visible to the naked eye and can be easily detected by a visual examination. They are itchy, painless, pink papules and may appear as cauliflower-like growths, termed condyloma acuminatum. The growths could be flat or raised and can appear as single growths or even in groups. Cervical Dysplasia Cervical dysplasia is an abnormal cell growth that is commonly precancerous, on the surface lining of the cervix or the opening between the uterus and the vagina. You may see this in your pap smear results as Cervical Intraepithelial Neoplasia (CIN). Precancerous Lesions Precancerous lesions may also occur in the female genital tract. These may become cancerous as the cell abnormalities continue to increase. Cervical Cancer Cervical Cancer and HPV are synonymous together, given that it is the most common cancer due to HPV. It is caused by 2 high-risk types of HPV, HPV 16 and 18 that cause 70% of cervical cancers and precancerous lesions. Don't panic! By following your doctor’s medical advice, attending regular checkups, and keeping your immune system strong, the chance of your HPV leading to cancer is unlikely. Testing is an important element of any successful prevention strategy when it comes to HPV and its complications. Prevention In terms of prevention through sexual activity, condoms are the best physical method of prevention, but they do not prevent HPV completely because there are still some exposed genital areas that may come into contact. Being sexually monogamous with a monogamous partner is also a good way to increase prevention. Vaccinations There are multiple HPV vaccinations available that are FDA approved to prevent diseases caused by HPV. It is recommended to get before the age of 25. There are now school-based HPV vaccination programs offered to boys and girls around grades 7 and 8, prior to the onset of sexual activity to optimize prevention strategies. It is also most optimal at this stage as vaccines are more effective with a young teen immune system. There are 2 or 3 vaccinations over a 6 to 12-month period to receive full immunization. Is There a Cure? There is currently no cure for the virus available. There are many treatment therapies available for symptoms of genital warts and cervical dysplasia, such as cryotherapy, LEEP, surgical removal, laser surgery, or photodynamic therapy. There are many clinical trials outlining the success of each therapy – they are discussed in further detail in our other blogs, so go check them out for more learning! What Can I Do Without Treatment? Although there is no cure, most HPV infections are easily cleared by a strong healthy immune system. Your immune system can be supported in a number of natural ways: Eat plenty of fruits and vegetables Quit smoking Reduce alcohol consumption Drink green tea Exercise to sweat A healthy diet is key to helping your body fight off infection Papillex, is a compound that contains high quality, phytoceutical nutrients that have been shown to support beneficial results with respect to HPV. It is packed full of ingredients that nutritionally support the immune system, helping the body to better respond to genital warts, cervical dysplasia, and other HPV-related disorders naturally.
Jul 01, 2019
3 min read
HPV In Men

HPV In Men

Christine Chung
Often the conversation around HPV focuses on females, but HPV can also impact males. We know the information available can be confusing. You may be wondering if HPV affects sexes differently? Why is the HPV vaccine now being recommended to all grade school children? Is there anything that can be done to help? We have compiled some of the most common questions around HPV in males to clarify all that you need to know to tackle this common infection. How does HPV affect people differently? Human papillomavirus (HPV) is the most prevalent sexually transmitted infection worldwide. HPV includes a family of several viruses that reside in the skin and mucosal tissues in the human body. Some strains of HPV are harmless, causing warts on the hands and feet or genitals, while others are associated with more serious risks and may progress into cancer. The strains of HPV that cause cancer often make home in tissue found in areas like the cervix, oral canal, anus, and vagina. Because HPV likes to attach to these tissues, there is a higher risk to individuals with female anatomy. The higher risk of cervical cancer and other related symptoms put the spotlight of HPV prevention and treatment on those with female anatomy. The risk and symptoms of HPV in females explain why there is more information about best practices for HPV in females, but less information about how HPV impacts those with male anatomy. With that said, there are more than 40 types of HPV, and males are susceptible to all of the same HPV strains that females are. That’s right - males are just as likely to get HPV as females, but with less severe potential complications. A Strong Immune System Helps Fight off HPV Transmission All individuals, regardless of their sex, can contract, carry, and transmit HPV. More than half of sexually active males will contract a strain of HPV in their lifetime compared to 80 percent of sexually active females.  HPV is spread through skin-to-skin contact during sexual activity involving the genital area. HPV is most commonly spread through vaginal and anal sex, but can also be spread through oral sex and hand contact. HPV is so common that any level of sexual activity, with one or just a few partners, can bring on an HPV infection. Your risk for contracting an HPV infection increases with an increased number of sexual partners. Susceptible Groups Some groups of males are more likely to develop symptoms or complications of HPV than others. Gay and bisexual males are 17 times more likely to develop anal cancer than heterosexual individuals. Males who have weakened immune systems, including those with HIV, autoimmune conditions, or medications, are also more likely to develop cancer or severe genital warts that are hard to treat. HPV Symptoms Most HPV-positive males will never develop symptoms of HPV. However, a small subset of this population may have HPV develop into cancer. Most males with HPV, and especially those with a strong immune system, may never show symptoms of HPV, or develop health problems from it. Certain types of HPV can cause genital warts, while other high-risk strains can develop into penile, anal, or oropharynx cancer (back of the throat, tongue, and tonsils). The following are more specific details of potential HPV complications in males: Genital warts: single or multiple warty growths in the genital area, including thighs, penis, testicles, and anus. These may appear days, weeks, or months after sexual contact with an HPV-positive sexual partner. Anal cancer: can present with no symptoms, or you may see anal pain, itching, discharge, or bleeding, swollen lymph nodes, or changes in stool. Penile cancer: early changes will include thickening of skin, changes in color, or tissue buildup. Later symptoms may show growths that can be painless, or painful, possibly with blood. Throat cancer: sore throat or ear pain that is not cleared with conventional medicine, coughing, pain with swallowing, unintentional weight loss, voice changes, or lumps. Protecting Your Sexual Partner Because males can be carriers of HPV, they can spread the virus through sexual contact. Limiting sexual partners, disclosing your sexual health history to your partner, and engaging in protected sex can all help prevent the spread of HPV. High-risk strains transmitted through males to females can put women at risk of cervical dysplasia and progression of HPV into cancer. Cervical dysplasia and cervical cancers are a high-risk complication of HPV for women. So, even if you don’t show symptoms, you should be sure to take necessary precautions with your female sexual partners. Maintaining a healthy and strong immune system through healthy diet and lifestyle factors can suppress the virus, reduce risks, and prevent transmission to more sexual partners. It is important to remain HPV-free so as to prevent transmission to your sexual partners HPV Frequently Asked Questions: If my partner doesn’t have any symptoms, I am not at risk… right? The short answer is: you could still be at risk.Unfortunately, HPV can be passed on even when someone with an HPV infection does not have any symptoms. A healthy immune system may suppress symptoms of the HPV infection, but the virus can still be transmitted to another individual. With that said, if their partner has an equally healthy immune system, the HPV will likely not cause any serious complications. We use physical protection (i.e. condoms) every time, am I safe? While condoms provide excellent protection against sexually transmitted infections, they only provide some protection against HPV. Condoms do not cover the entire genital area, so you can still get the HPV virus through skin to skin contact in the genital area even if you’re wearing a condom. It can also be spread through skin-to-skin contact with other areas that aren’t covered. You can get HPV through oral-genital or hand-genital contact – not just sexual intercourse! Having oral sex without physical protection can lead to throat cancer! If I’ve been infected once, am I safe now? You can be infected with HPV more than once, even if you’ve already been exposed to HPV before. Your body may not have developed long-term protection against the virus, or you may come into contact with a completely different strain of the virus as there are over 100 different types of HPV. How do I know if I have HPV? HPV detection is key to preventing further high-risk complications of HPV in women. Women should get routine pap smears and can get HPV tests to screen for cervical changes related to HPV. HPV testing is the only way to know if you are HPV positive. The CDC does not recommend any testing to screen men for HPV given the high prevalence of HPV in the general population. There is no current test recommended for men with HPV, specific HPV testing would require out of pocket payment. The best option is to continue to attend routine appointments with your medical doctor and make sure they are aware of any changes to your health, including your sexual health. Some health care providers will screen men at risk for anal cancer by performing an anal pap test. Do males also need to get the HPV vaccine? There are multiple FDA approved HPV vaccinations available to prevent diseases caused by HPV. Vaccinating young males against HPV may also prevent transmission and spread of the virus. It is recommended to get the vaccine before the age of 25. There are 2 or 3 vaccinations over a 6 to 12-month period to receive full immunization. There are now school-based HPV vaccination programs offered to students of all sexes around grades 7 and 8, prior to the onset of sexual activity to optimize prevention strategies. It is also most optimal at this stage, as these  vaccines are more effective with a young teen immune system.  How can I prevent transmission of HPV? Aside from abstaining from sex, practicing safe sex measures is a way to prevent the transmission of HPV. During sexual activity, condoms are the best physical method of prevention, but they do not offer complete protection against HPV because there are still some exposed genital areas that may come into contact. Being sexually monogamous with a monogamous partner is also a good way to prevent HPV infection. You can also be proactive by staying aware of any abnormalities on your penis, scrotum, or around the anus. See your doctor for a checkup if you find warts, blisters, sores, ulcers, white patches, or other abnormal lesions. What are common treatment options for HPV Complications? There is no complete treatment for HPV in either sex. The complications associated with the human papillomavirus, however, may be managed and eradicated. Genital warts can be treated with creams, medication, or removed completely through surgery or by freezing them off. The latter will require a visit to your doctor, but other options can include home treatments. Cancers, such as penile, anal, or oropharyngeal cancer, can be managed and potentially treated with surgery, radiation, chemotherapy, and other adherence to recommended treatments by your doctor. How can I avoid HPV? HPV is very easily transmitted through sexual contact. Even being sexually active with only one person can transmit an HPV infection. Having more sexual partners will put you at higher risk for contracting an HPV infection. How can I naturally support my immune system to protect against HPV? Although there is no cure for HPV, there are ways to strengthen your immune system to prevent outbreaks and the progression of the virus. The team at Papillex suggests a few ways for men to help strengthen their immune system when concerned with HPV: Eat a healthy diet with plenty of fruits and vegetables, particularly broccoli and other cruciferous vegetables, sweet potatoes, and carrots, all of which help to build a healthy immune system. There are natural supplements for HPV that have been used successfully by Naturopathic Doctors for decades. Be sure to either consume in therapeutic doses in your diet, or supplement with folic acid, selenium, green tea extract, and broccoli sprouts – all of which are key ingredients in Papillex. Get adequate sleep, anywhere from 7-8 hours a night, and exercise regularly. Try to incorporate wellness activities to help reduce stress; some methods include breath work, meditation and yoga. The focus of HPV largely surrounds the female population, but males are also at risk of infection, transmission, and potential complications. However, cancers from HPV are much less prevalent in the male anatomy, which is why a heavier focus has been placed on people with female reproductive parts. Because transmission can occur in both males and females, vaccination in adolescents is now recommended in all sexes.  Given the high prevalence and transmissibility of the virus, maintaining health and a robust immune system through lifestyle factors and diet plays an important role in reducing complications of HPV in both sexes.  Sources: Government of Canada, Public Health Agency of Canada. “Institutional links.” Human Papillomavirus (HPV) and Men: Questions and Answers – Sexual Health & STI – Public Health Agency of Canada. N.p., 07 June 2012. Accessed: 22 July 2017.
May 24, 2019
8 min read

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