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Andrographis for Herpes Infections?
Victoria Gasparini
The virus that is responsible for cold sores and genital herpes is called the Herpes Simples virus, or HSV. There are two subtypes – HSV-1, which most often causes cold sores on the face, and HSV-2, which is usually the genital type. HSV infections are so common, that it is estimated the 90% of the world’s population have at least one of the types. While most people will not suffer any severe consequences from the infection, there are some who will develop serious issues, and since it’s so contagious and ubiquitous, treatment and prevention have become important issues.
Many medications and natural substances have been studied to see if they have any impact on the herpes virus. There are quite a few compounds that have been found to have promise. One of them has been used in Asian medicine for centuries, and has now also been studied in laboratories as a potent antiviral herb – Andrographis panniculata.
Clinical studies have demonstrated that Andrographis is effective at treating upper respiratory viral and bacterial infections. It also appears to have promising effects as an anti-parasitic, and anti-fungal. In other words, Andrographis may well be an invaluable partner for the immune system in fighting off a whole host of invaders. It does that primarily though compounds called andrographolides, which appear to be able to have a variety of interactions with both pathogens (to disable them), and with our immune cells (to support them).
Lab studies have shown some very promising results that support andrographolides for HSV infections. It appears that these compounds can prevent HSV from replicating, and can even have some viricidal activity. Given how well-known Andrographis panniculata is as an antiviral and immune herb, and the excellent safety profile it possess, it makes for a valuable partner in the defence against herpes infections.
May 16, 2023
1 min read
Stress and Herpes: The Virus with the Worst Timing
Victoria Gasparini
So many people can relate to the sheer frustration of having a nasty cold sore erupt on your lip at a time when you want it the least. To be honest, cold sores are not wanted ANYTIME, but why do they seem to show up when you’re the most stressed? Talk about bad timing.
The virus that is responsible for cold sores and genital herpes is called Herpes Simplex Virus (HSV). It is very transmissible, and very common all over the world. The thing that makes this virus especially tenacious is its special ability to evade your immune system and hide out in the body without being eradicated, sometimes for very long periods of time. It’s simply biding its time for the right circumstances to arise that would be favourable for it to re-emerge to replicate and infect someone new.
The circumstances that the herpes virus is waiting for are when you defences are not at their strongest, which very often happens under stress.
How does stress lower immune function?
When the mind and body experience stress, the nervous and endocrine (hormonal) systems start sending out signals that travel throughout the body. These signals come in the form of hormones and neurotransmitters being released. The two prominent such hormones are cortisol and adrenaline (also known as the stress hormones), whose primary function is to ensure your survival by putting your body in a ‘fight of flight’ mode. This is useful if your life is in imminent danger, but since most of our stress tends to be longer-term and chronic in nature, this system doesn’t serve us well in those circumstances. What ends up happening is an increase in inflammation, which in chronic situations tends to hamper the immune system’s ability to defend against infections. The cascade of immune reactions under stress ends up weakening one of the measures that keeps the virus in what is called a ‘latent’ state, ie hiding out in hibernation. In short, stress weakens some of the body’s defences, allowing the virus to reactivate and cause symptoms like herpes and cold sores.
What can you do about it?
Learning healthy ways of managing stress is the best way to avoid the negative reactions that stress causes in the body, like lower immunity. If avoiding all stress entirely is not a viable option for you (and for whom would it be?), the next best thing is to adopt practices that down-regulate that ‘fight or flight’ response. Essentially not letting inevitable stressors initiate that cascade. Here are some ideas to look into if your repertoire of stress coping mechanisms could use a boost:
regular physical exercise
meditation
spending time outdoors, regularly
creative pursuits and hobbies
breathing exercises
counselling and/or therapy
adaptogenic botanicals
working on setting firm boundaries around work and personal life
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Mar 27, 2023
2 min read
Sulfated Polysaccharides for Cold Sores & Herpes
Jenny Henderson
Researchers all over the world have been increasingly studying the many potentially important therapeutic benefits of polysaccharides. These complex molecules have the ability to interact with different factors in our bodies to exert various effects. Most abundantly found in seaweeds and mushroom, these varied molecules have a lot of actions. Studies have shown their ability to be anti-inflammatory, anticancer, antiviral, antioxidant, cholesterol-reducing, and much more. Moreover, these compounds are also considered safe and nontoxic, so they’re worth paying attention to.
Herpes Simplex Virus (HSV) is very common and highly transmissible virus. It’s two sub-types, HSV-1 and HSV-2 cause cold sores on the face and genital herpes, respectively (though some mixing can occur). While HSV infections don’t cause very serious problems in a vast majority of people, they can have dangerous complications in some. Additionally, the virus has the ability to go into a ‘latent’ state, which is like hidden hibernation, in the body making it very difficult to clear. Most people never clear it, and it hangs around forever, showing up once in a while as a cold sore or a genital outbreak (or often without any symptoms at all). So given the general grief this virus can cause to millions all over the world, treating it is of high interest in the research community, especially given some concerns about drug resistance. This is why there is a lot of studies are looking at anti-HSV compounds that may be found in nature, such as polysaccharides. We’ve already mentioned that they are antiviral, but there is a specific subset of polysaccharides that is even more so. These are the sulfated polysaccharides. These molecules have sulfate groups attached along the chain, and the more sulfated the chains are, the more antiviral activity they seem to posses.
How do they work against Cold Sore and Herpes?
Sulfated polysaccharides have been shown in laboratory studies to prevent HSV from adhering and entering healthy cells (a process called adsorption), prevent it’s ability to replicate, and in some cases, even disable the virus itself (virucidal). They can do so because they have variable polarities along their length, which makes them able to physically attach to the virus and interfere with its functions.
Another feature that sulfated polysaccharides have that can be handy for HSV infections, is immune-modulation. In order to keep HSV outbreaks brief and infrequent, your immune system has to be always on-point and vigilant. By interacting with various white blood cells, sulfated polysaccharides can boost how well they do their jobs. They can also reduce any excess inflammation that the immune system makes which can interfere with pathogen clearing and give the virus a more hospitable environment to thrive. The more ways in which a compound can help the body fight HSV, the less likely it will become resistant, and the more comprehensive the support will be.
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References
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6680640/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3528127/
Sep 19, 2022
2 min read
Red Algae for Cold Sores and Herpes
Jenny Henderson
Marine algae, or seaweed, families are often distinguished from each other very broadly by their colour. There are green algae, brown algae, and red algae. Quite a bit of research has been devoted to these groups because they seem to poses a variety of compounds that have a lot of promise in medicine. It seems that these marine plants that some cultures have been eating for centuries have real potential therapeutic benefits, some of which could be of real interest for those suffering with cold sores and herpes.
What makes red algae special?
The red and brown algae have been of special interest for many of their potential actions. These include being anti-inflammatory, immune modulating, antiviral, anticancer, anticoagulant, antioxidant, and more. One of the their main features are compounds called sulfated polysaccharides (SPs). These large, complex molecules have the ability to physically interact and influence various immune factors and microbes to have a desired health outcome. There is a huge variety of SPs from many species of algae, and it seems that any one of them seems to carry the potential to be of great medicinal importance. Fucoidan is one such compound from brown algae for example, and the some examples of researched red algae include Gigartina skotssbergii and Chondrus crispus.
How can red algae help cold sores and herpes?
When it comes to the Herpes Simplex Virus (HSV), laboratory studies have shown benefit there too. HSV is highly prolific, common, and easily transmissible human virus that can cause cold sores (HSV-1) as well as genital herpes (HSV-2). Since it effects so many people, and because it is so contagious (even when the infected person has no symptoms), any substance that has the potential to modify its life cycle will be of interest. SP’s are one such group of substances.
SP’s from red algae appear to be have multiple mechanisms against viruses such as HSV:
They can have a direct virucidal action, meaning they may damage the virus itself
Inhibit the virus’s ability to enter healthy cells
Inhibit its ability to replicate
Improve the host immune response
As more and more research is being conducted on these impressive compounds from algae, it will not be surprising to see further benefits being uncovered. The seaweeds themselves are considered safe, as many of them are consumed by humans as part of traditional diets, and the SP’s themselves appear to have an excellent safety profile.
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References
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6680640/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3528127/
Aug 05, 2022
2 min read
Fucoidan for Cold Sores and HSV
Jenny Henderson
Human beings have always had a relationship with the seas, so it’s not surprising that marine ecosystems harbour medicinal and therapeutic factors that can be beneficial to us. Seaweeds are an excellent example of one such source of therapeutics that has been getting some attention from researchers.
As a group, the various seaweeds (aka marine algae) that have been studied, have shown great potential for supporting immune health, reducing inflammation, supporting gut health, being anti-cancer, supporting diabetes and cardiovascular health, and fighting viruses. Even as a food source, many coastal cultures have long consumed seaweeds in their diets for their richness in protein, minerals, and complex carbohydrates.
What makes marine algae so special?
Marine algae and seaweeds contain several different compounds that appear to have therapeutic potential. Of particular interest to us are a group of compounds called polysaccharides. These are complex branched molecular chains that have the ability to physically interact with various immune factors in the body to exert their benefits. They can increase the activity of specialized immune cells, or interfere with the ability of a virus to attach and penetrate cells. One of the most promising polysaccharides is a sulfated polysaccharide called Fucoidan.
What does Fucoidan do?
Quite a bit of research has focused on the various actions of Fucoidan. It can be found in several species of seaweeds, such as Undaria pinnatifida (Wakame), and Laminaria japonica (Kombu).
As an anti-cancer compound, Fucoidan has been found to prevent tumor growth and mediate some of the effects of chemotherapy. It can also stimulate the immune system to attack tumors, as well as viruses. It is a potent antioxidant that is able to prevent damage to cells, and keep excess inflammation from doing the same as an anti-inflammatory. Additionally, it can support the body against metabolic problems by acting as a blood thinner and helping correct high cholesterol.
Can Fucoidan help with herpes and cold sores?
The virus that causes genital herpes and cold sores is called the Herpes Simplex virus (HSV), and it’s a highly transmissible and very common infection globally. Antiviral medications exist to treat HSV, but there is concern about resistance and side effects. Thus far the research data has been very supportive of the antiherpetic potential of Fucoidan for cold sores and HSV. In controlled laboratory and animal studies, brown seaweed Fucoidans have been shown to prevent HSV from infecting cells, directly interfere with the virus (virucidal), and also prevent viral replication.
Is Fucoidan safe to use?
Seaweeds that contain naturally-occuring Fucoidan are safe to eat, and are a common part of many culture’s diets, especially in Asia. According to the data available, there are no safety concerns when it comes to extracted Fucoidan. Some minor side effects are possible, such as nausea, but these are uncommon. As always we recommend that you speak to a qualified health care practitioner before starting any new medicinal supplements.
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References
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6551690/
https://www.mdpi.com/1660-3397/17/3/183
https://www.jstage.jst.go.jp/article/cpb/52/9/52_9_1091/_pdf
https://pubmed.ncbi.nlm.nih.gov/31826428/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7230360/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6836154/
Jul 18, 2022
2 min read
Shiitake Mushrooms for Cold Sores and Herpes Simplex
Jenny Henderson
If you are a fan of Asian cuisine you have very probably eaten, or at least are aware of shiitake mushrooms. These delicious mushrooms, known by their latin name as Lentinula edodes, are also familiar to medical researchers. The research into the therapeutic properties of various mushrooms has been really taking off in recent years, and there are certain ‘favourites’ in the studies that seem to have quite a lot of potential, such as Reshi, Turkey Tail, Agaricus, and of course Shiitake. Some promising research is demonstrating potential benefit for Herpes Simplex virus infections such as cold sores.
What are the benefits of Shiitake mushrooms?
Shiitake mushroom extracts have been shown to have a variety of therapeutic actions, such as being anti-inflammatory, immune-modulating, antioxidant, protective for the liver, cholesterol lowering, anti-tumor, antibacterial, and antiviral.
What about herpes virus?
Shiitake compounds have been studied to observe their effects on many viruses, including the Herpes Simplex virus which causes cold sores and genital herpes. Several laboratory investigations reported that the main way in which the mushroom extracts worked against the virus was by preventing it’s ability to replicate within the cells.
Since the herpes virus has the ability to evade natural immune responses and enter into a latent stage in the body (i.e. hide out in an inactivated state), it is difficult to actually be completely free of it. The best treatment strategy then is to prevent or reduce the likelihood of re-activation of the virus, and subsequent replication. Shiitake mushroom extracts are promising candidates as agent that can support the body in preventing reactivation, replicating, and boosting the natural defence systems.
What are these mushroom extracts?
The principal active compounds in antiviral mushroom extracts such as the ones that can be found in Shiitake are called polysaccharides. These are complex chained molecules that have the ability to physically interact with immune factors as well as viral particles, to enhance or disrupt their functions respectively. According to quite a few studies, some of the most effective polysaccharides are the sulfated polysaccharides. The molecular sulfate groups that give them their name seemed to be directly related to their antiviral activity.
Is Shiitake safe?
Shiitake mushrooms are considered very safe - after all they are a very popular culinary mushroom eaten all over the world. The polysaccharide extracts also have excellent safety profiles, with very few minor side effects reported, such as nausea, and those are fairly rare. As always, we still recommend that you speak with a qualified health care practitioner before starting any new medicinal supplements.
Respond with Confidence | Harness the Power of Shiitake Extract with Simplix
References:
https://pubmed.ncbi.nlm.nih.gov/20491636/
https://repositorio.uam.es/bitstream/handle/10486/660904/antiviral_santoyo_jfnr_2012.pdf;sequence=1
Jun 20, 2022
2 min read
Agaricus Mushroom for Herpes and Cold sores
Jenny Henderson
It is very possible that you may have been hearing more lately about the benefits of medicinal mushrooms. The amount of research that has been devoted to the health effects of various mushrooms in recent years as exploded. There is already a fair body of evidence that demonstrates the power of mushrooms in benefiting the immune system, fighting cancer, reducing inflammation, supplying antioxidants, and fighting viruses, such as herpes and cold sores.
One of these mushrooms is a bit newer to the research scene than some of the veteran mushrooms like Reishi. We’re talking about Agaricus subrufescence (aka Agaricus blazei). Found in Brazil, this mushroom has long been used in globally for a variety of ailments, and is quite popular in Japan.
What kind of research does Agaricus have?
A lot of the research into this mushroom has focused on tumours and cancers, both in vitro as well as a some clinical trials. It appears that the extracts of Agaricus blazei have the ability to modulate the immune system to attack cancer cells, and to have direct anti-tumor effects (like inhibiting tumor growth).
Clinical trials have also looked into the anti-inflammatory effects of Agaricus, in both healthy people, and those with inflammatory conditions like IBD.
Traditional uses of Agaricus have often focused around reducing cholesterol, atherosclerosis, and liver ailments. Liver protection had been shown in studies, as well as benefits against diabetes, and viral infections.
What about the herpes and cold sores virus?
It appears that Agaricus possesses anti-herpetic activity, meaning that it can act against the Herpes Simplex virus that causes cold sores and genital herpes. Laboratory studies have looked into how exactly it acts on the virus and found that generally the mushroom extracts bind with the virus and interfere with its ability to attach and enter healthy cells.
What gives it these properties?
There is a type compound found within Agaricus (as well as other medicinal mushrooms and marine algae) called polysaccharides. These varied and complex molecular chains all seem to have very beneficial functions, including anti-viral activity. They do not kill viruses, but they stimulate the immune system to target the invaders, as well as interfere with the virus itself, making it hard for them to enter cells and replicate. The most effective group of polysaccharides are called sulfated polysaccharides, because they have some sulfate groups attached to the chains. It is this sulfation that makes these compounds especially anti-viral, and potentially beneficial against herpes and cold sores.
Is Agaricus safe?
Agaricus subrufescence as an edible mushroom has an excellent safety profile and is generally considered safe to consume. Extracts of this mushrooms also are generally considered safe, with very few reports of adverse events. Of course, as always, we recommend that you speak to a qualified health care practitioner before starting a new medicinal supplement.
The right combination is already here - Respond with Confidence
References
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3730566/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7285126/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3716167/
Jun 06, 2022
2 min read
Lysine for Cold Sores: Theory & Evidence
Jenny Henderson
If you’ve been looking into natural cold sores and herpes remedies, you may have come across Lysine as a common recommendation for preventing new outbreaks. It has been around for quite some time, so let us have a look at why it’s been such a widespread recommendation, and whether it’s as promising as it seems.
What is Lysine?
Lysine (or sometimes written as L-lysine), is an amino acid that is found in proteins, both in our bodies and in the foods we eat. It is one of the ‘essential’ amino acids, meaning that our body cannot make it on its own, and we must consume it in our diets.
How is Lysine implicated in herpes and cold sores?
The virus that is responsible for causing herpes and facial cold sores, called HSV, is known to have proteins that are especially rich in the amino acid Arginine, and very few proteins with Lysine. Since so many of it’s proteins require Arginine, it becomes a critical amino acid for its ability to replicate. Both Arginine and Lysine are taken up by the virus using the same transporter in its walls. In theory then, if the virus’s environment was particularly rich in Lysine and low in Arginine, the transporter will be overloaded with all the Lysine, and miss out on the more critical Arginine. This would hamper its ability to multiply and therefore lessen outbreaks.
What does the evidence say?
The theory of Lysine out-competing Arginine was good enough to inspire some research into the matter. The quality of the research overall has been rather mixed, and the results are equally so. Some evidence was convincing enough that Lysine supplementation has been approved and recommended for herpes prophylaxis for many years, but more recent evidence that looked into the collective data has shown that it is not as effective as hoped. Nonetheless, many users of lysine report anecdotally that it is effective at reducing outbreaks.
What’s the takeaway?
Since Lysine is a relatively safe and low-risk substance, it may be worthwhile to speak with a healthcare practitioner about it and give it a try to see if it could reduce your frequency and severity of outbreaks. It can be taken as a supplement, or increased in the diet by consuming high lysine foods such as legumes, poultry, fish, parmesan cheese, eggs, spirulina, and soy. Other immune supporting foods can also help. However, given the body of evidence, it probably shouldn’t be the sole therapy you undertake to manage HSV, but rather a supportive one.
Take a well-rounded approach - Respond with Confidence
References
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419779/
May 23, 2022
2 min read
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