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HPV and the Vaginal Microbiome: What New Research Reveals

HPV and the Vaginal Microbiome: What New Research Reveals

Lovisa Alatalo
When most people think about HPV, they think about the virus itself. But researchers are increasingly asking a bigger question: What role does the surrounding microbial environment play? Over the past decade, scientists studying cervical health have started paying closer attention to the cervicovaginal microbiome - the community of bacteria that lives in the vaginal ecosystem. What they’re finding is fascinating. While HPV infection is common and often clears naturally, the composition of the vaginal microbiome may influence how the immune system interacts with the virus and whether infections persist over time. Let’s walk through what the research is showing so far. The Cervicovaginal Microbiome: A Delicate Ecosystem A healthy vaginal microbiome is typically dominated by Lactobacillus species. These bacteria play several important roles: producing lactic acid that keeps vaginal pH low supporting the mucosal barrier of the cervix helping regulate local immune signaling Lactobacillus-dominant microbiomes - particularly those dominated by Lactobacillus crispatus - are widely considered the most stable and protective microbial states in the vaginal environment [1]. These bacteria produce high amounts of lactic acid and antimicrobial peptides that help maintain the vaginal mucosa and limit colonization by opportunistic organisms [1]. When this balance shifts, however, the microbial environment can look very different. Instead of Lactobacillus dominance, researchers sometimes see higher microbial diversity with increased anaerobic bacteria, including organisms such as: Gardnerella Prevotella Sneathia Atopobium This shift is commonly referred to as vaginal dysbiosis. And this is where HPV research becomes especially interesting. What Happens to the Microbiome in HPV-Positive Women? Multiple sequencing studies have found that women with HPV infections often show different microbiome patterns compared to HPV-negative individuals. Specifically, researchers frequently observe: Reduced Lactobacillus abundance Higher microbial diversity Increased levels of anaerobic bacteria associated with bacterial vaginosis [2][3]. Large sequencing studies using 16S rRNA analysis consistently report that HPV-positive cervicovaginal microbiomes contain fewer Lactobacillus species and more diverse microbial communities [2]. This higher microbial diversity appears repeatedly in the literature and is often linked to a shift toward bacteria such as Gardnerella, Prevotella, and Sneathia [4]. In one analysis examining women with high-risk HPV infections, persistent infections and high-grade lesions were associated with increased Prevotella and Gardnerella alongside reduced Lactobacillus levels [4]. These findings don’t necessarily mean the microbiome causes HPV infection. But they suggest the microbial environment may influence how the infection behaves. Microbial Diversity and HPV Persistence One of the most consistent findings across microbiome studies is that higher microbial diversity tends to correlate with HPV persistence. In a longitudinal study analyzing cervicovaginal microbiomes in women with high-risk HPV, researchers identified Gardnerella as a key microbial marker associated with increased risk of progression to CIN2+ lesions [3]. Interestingly, the study suggested Gardnerella may not directly drive disease progression itself. Instead, it may contribute to a more diverse microbial environment, which then alters the cervicovaginal ecosystem in ways that allow HPV persistence [3]. Researchers suspect several mechanisms could explain this relationship. These include: shifts in vaginal pH changes in immune signaling disruption of epithelial barrier function microbial biofilm formation When these changes occur together, the cervicovaginal environment may become more permissive to persistent viral infections. But the story does not stop there. HPV May Also Influence the Microbiome Another fascinating question researchers are exploring is whether HPV itself can change the microbial environment. Emerging work suggests the relationship may actually go both ways. In laboratory and tissue studies, HPV infection has been shown to alter the expression of innate antimicrobial peptides produced by cervical epithelial cells [2]. These peptides normally help regulate microbial balance. When HPV down-regulates these peptides, the vaginal environment may become less favorable for Lactobacillus species and more permissive for other bacteria [2]. This means HPV infection could potentially contribute to microbial imbalance, which then further influences viral persistence. In other words, the virus and the microbiome may interact in a two-way feedback loop. Not All Lactobacillus Species Are the Same Another nuance researchers are beginning to appreciate is that not all Lactobacillus species behave the same way. For example: Lactobacillus crispatus produces high levels of lactic acid strongly associated with stable vaginal ecosystems frequently linked to healthier cervicovaginal environments [1] Meanwhile, another species - Lactobacillus iners - appears much more adaptable. L. iners is commonly found in microbiomes associated with cervical disease and may be more likely to coexist with anaerobic bacteria that characterize dysbiosis [1]. Because of this, microbiomes dominated by L. iners often transition more easily toward dysbiotic states, whereas L. crispatus-dominant ecosystems appear more resilient [1]. This subtle distinction is becoming an important focus of microbiome research. The Bigger Picture: Microbes, Immunity, and Cervical Health Taken together, current research suggests that HPV infection does not occur in isolation. Instead, it exists within a complex microbial and immune environment. Scientists now believe the cervicovaginal microbiome may influence several processes relevant to cervical health: mucosal immune responses inflammation signaling epithelial barrier function viral persistence Changes in microbial composition can influence vaginal pH, inflammatory mediators, and immune activation, all of which may affect how the body responds to viral infections [2]. At the same time, HPV itself may alter epithelial immune defenses in ways that reshape the microbial ecosystem. This growing body of research is helping scientists better understand why HPV infections behave differently between individuals. What This Means for Women’s Health It’s important to remember that HPV infections are extremely common. In many cases, the immune system clears the virus naturally within one to two years. But researchers are increasingly recognizing that the vaginal microbiome may be one of several factors that influence this process. This doesn’t mean the microbiome alone determines outcomes. HPV persistence is influenced by many factors, including: Immune health Smoking Hormonal balance Genetics Sexual health factors However, understanding the microbial environment surrounding the cervix may help researchers better understand why infections persist in some individuals while clearing in others. As microbiome science continues to evolve, it may open new doors for supporting vaginal and cervical health in more targeted ways. The Takeaway The relationship between HPV and the vaginal microbiome is an emerging area of research - but several patterns are becoming clear. Studies to date suggest that: HPV-positive microbiomes often have lower Lactobacillus levels higher microbial diversity may be associated with HPV persistence certain bacteria like Gardnerella and Prevotella appear more frequently in HPV-positive environments HPV infection itself may influence microbial balance through immune signaling The cervicovaginal microbiome is not just a passive environment. It’s an active participant in the complex ecosystem of cervical health. And researchers are only beginning to understand how these microbial communities interact with viral infections like HPV. References Lin D, Kouzy R, Abi Jaoude J, Noticewala SS, Delgado Medrano AY, Klopp AH, et al. (2020), Microbiome factors in HPV-driven carcinogenesis and cancers. PLoS Pathog 16(6): e1008524.https://doi.org/10.1371/journal.ppat.1008524 Lebeau, A., Bruyere, D., Roncarati, P. et al. HPV infection alters vaginal microbiome through down-regulating host mucosal innate peptides used by Lactobacilli as amino acid sources. Nat Commun 13, 1076 (2022). https://doi.org/10.1038/s41467-022-28724-8  Usyk M, Zolnik CP, Castle PE, Porras C, Herrero R, Gradissimo A, et al. (2020) Cervicovaginal microbiome and natural history of HPV in a longitudinal study. PLoS Pathog 16(3): e1008376. https://doi.org/10.1371/journal.ppat.1008376 Huang, Roujie, et al. ‘Cervicovaginal Microbiome, High-Risk HPV Infection and Cervical Cancer: Mechanisms and Therapeutic Potential’. Microbiological Research, vol. 287, Oct. 2024, p. 127857. DOI.org (Crossref), https://doi.org/10.1016/j.micres.2024.127857.
Mar 16, 2026
5 min read
5 Common HPV Questions You Need to Know Answered

5 Common HPV Questions You Need to Know Answered

Lovisa Alatalo
Human papillomavirus (HPV) is one of the most common viruses in the world, yet it remains one of the most confusing and stigmatized. If you were recently told you have HPV - or you’re trying to understand what it means - you’re not alone. HPV affects people of all genders, at all ages, and often without symptoms. This shame-free guide answers the five most commonly searched questions about HPV with clarity, compassion, and science. If you want to start with the basics, you can read our introductory guide on what HPV actually is. Let’s get into the questions people ask most. 1. Can HPV be cured, or will I have it forever? This is the number-one question people ask - and the source of most fear. Here’s the truth: For 90 percent of people, HPV infections go away on it’s own, often within two years. Your immune system plays the biggest role in whether HPV becomes inactive. When HPV is described as “inactive” or “cleared,” it usually means the virus has dropped to levels that aren’t detectable on standard tests. HPV is not like herpes (HSV), which stays in the body for life.In many cases, HPV can resolve over time. This typically means the immune system suppresses the virus to very low levels so it causes no symptoms and is no longer detectable on standard tests. Want a deeper explanation? Read our article on HPV and the immune system. 2. How did I get HPV? Another extremely common (and emotionally charged) question. You can get HPV from: Skin-to-skin contact Sexual contact (oral, vaginal, anal) A partner who had no idea they were carrying HPV It’s important to know: HPV is the most common STI in the world. Most people carry HPV at some point without knowing it. HPV can be passed between partners even when no symptoms are present. Couples can pass the virus back and forth for months or years without realizing it (called “reciprocal transmission”). This is why HPV says nothing about your behavior, your worth, or your relationship. It is simply common. If you’re wondering how to talk about HPV with a partner, this guide may help:👉 Talking to Your Partner About HPV 3. How do I know which HPV strain I have? This question has surged in search volume over the past few years. For people with a cervix: Your Pap smear may test for: High-risk HPV types (like HPV 16 and 18) Whether high-risk HPV is present at all Whether cervical cells show any changes Not all labs test for every strain, but high-risk HPV detection is usually enough to guide monitoring. For people without a cervix:Unfortunately, routine HPV testing is not widely available. This means many people never know which strain they carry - or whether they carry HPV at all. The good news is:Regardless of your strain, the body’s immune response is what ultimately helps bring HPV under control. The strategies to support immune resilience are similar across strains. 4. Can HPV affect my fertility or pregnancy? This is one of the fastest-growing search queries related to HPV. The science: HPV does not typically affect fertility. Most people with HPV may conceive and carry healthy pregnancies. High-risk strains are about cell changes. If cervical changes occur, your healthcare team will guide monitoring or treatment. In other words:HPV is not a fertility diagnosis.With appropriate follow-up, most people can continue living fully reproductive, healthy lives. You can learn more about HPV and pregnancy here. 5. What can I do to support my body while I have HPV? This is where people feel the most empowered.While there is no medication that directly eliminates HPV, research shows that the immune system plays the leading role in suppressing the virus. Here is what supports that process: A. Foundational lifestyle pillars Getting consistent, restorative sleep Managing stress Reducing smoking and vaping Limited alcohol consumption Eating antioxidant-rich foods Staying physically active B. Nutrients associated with immune and cellular support Research highlights several nutrients associated with oxidative stress support and immune function, including: Zinc & Selenium Mixed carotenoids Vitamin E Green tea catechins You can explore these in-depth in our blog on antioxidants for immune support and our explainer on zinc for immune support. C. Evidence-informed nutritional programs (non-salesy explanation) Many individuals choose to support their wellness with nutritional formulas designed to nourish the immune system and promote healthy cellular function. Wellex’s Papillex® program includes a blend of antioxidants, minerals, and botanicals studied for their role in: Supporting healthy immune responses Providing antioxidant defense Nourishing the body during times of increased physiological stress This is not a cure for HPV - but it is one evidence-informed way people strengthen their immune system. A robust immune system plays a crucial role in managing HPV infections.  Final Thoughts HPV is common, manageable, and in many cases - temporary.You are not alone, you are not “dirty,” and you are not doomed. The more you understand about HPV, the less fearful it becomes. Whether you’re newly diagnosed, supporting a partner, or simply searching for clarity, we hope these answers help you make sense of this incredibly common part of human health. If you’d like additional education, explore our full HPV library on Wellex.co. References  CDC. “Human Papillomavirus (HPV) – Basic Facts.” NIH / PubMed. “HPV Clearance and Immune Response Studies.” World Health Organization. “HPV Epidemiology and Global Prevalence.” National Cancer Institute. “High-Risk HPV and Cervical Cellular Changes.” PubMed. “Antioxidants and Cellular Health Pathways in Viral Infections.”
Jan 19, 2026
4 min read
5 Proven Factors That Shape Women’s Libido — The Science You Need to Know

5 Proven Factors That Shape Women’s Libido — The Science You Need to Know

Lovisa Alatalo
If your libido feels high some weeks and nearly nonexistent others, you’re not alone - and nothing is wrong with you. Women’s sex drive is responsive, not constant. It shifts with hormones, physical comfort, stress levels, emotional closeness, sleep, and overall wellbeing. These changes aren’t a sign of dysfunction - they’re a reflection of your biology and lived experience. This guide blends science with soft wellness to help you understand why women’s libido changes throughout life, and how certain health conditions may influence desire. Quick Summary Libido naturally rises and falls due to hormones, stress, emotions, sleep, and physical comfort. Arousal is deeply tied to safety, nervous system regulation, and pelvic relaxation. Conditions like PCOS, endometriosis, IC, HPV, and HSV may add layers that influence sex drive. Desire varies across the menstrual cycle and throughout life phases - and that is normal. Supportive lifestyle strategies and pelvic or metabolic care can help align the body with desire. 1. Hormonal Changes Throughout the Menstrual Cycle Hormones are one of the most influential factors in women’s libido. How Estrogen Supports Desire Estrogen peaks around ovulation, which often increases libido, energy, and sexual response. Many women feel more confident, social, and connected during this window. Why Libido Often Drops After Ovulation Once progesterone rises during the luteal phase, you may experience: Fatigue Lower mood Bloating Irritability Less lubrication All of these can make sexual desire feel less accessible, even if nothing is “wrong.” Puberty, postpartum shifts, hormonal birth control, and perimenopause also influence desire - often in ways women are never taught about. 2. Stress, the Nervous System, and “Fight-or-Flight” Mode Your libido is deeply connected to your nervous system. Stress Hormones and Their Impact on Sexual Desire When your brain perceives threat - deadlines, emotional stress, chronic illness flare-ups - cortisol rises, and the body enters fight-or-flight mode. In this state, sexual desire becomes a low priority because your body is trying to preserve energy and stay safe. Stress can also worsen symptoms of chronic conditions (like pain or inflammation), which can further reduce desire. This does not reflect a lack of attraction or interest - it’s simply biology. From a research standpoint, stress is one of the strongest predictors of low libido in women(see NIH review: https://pubmed.ncbi.nlm.nih.gov/33222494/). 3. Pelvic Floor Tension, Pain, and Discomfort Pelvic Pain and Libido - What’s the Connection? A relaxed pelvic floor is essential for comfortable arousal, lubrication, and orgasm.But many women unknowingly hold tension in this area - especially after: Recurrent pain during sex IC flares or urinary discomfort Endometriosis pain Pelvic inflammation Traumatic or negative sexual experiences When the body anticipates pain, it activates protective mechanisms. The result?Desire decreases - not due to lack of interest, but due to learned physical guarding. Pelvic floor physiotherapy, gentle stretching, somatic practices, and pain-aware intimacy can make a meaningful difference. If you’d like to learn more about how pelvic floor therapy can help, see our guide here. 4. Emotional, Relational, and Mental Factors Emotional safety is one of the strongest predictors of women’s libido. The Role of Connection and Emotional Load Desire often decreases when women feel: Disconnected or unseen Overwhelmed by responsibilities Self-conscious or critical of their bodies Anxious, depressed, or burnt out Pressured to “perform” Women also commonly carry the emotional labor in relationships - remembering tasks, managing details, anticipating needs. Mental load has a direct impact on libido, and acknowledging it is key. You’re not “low libido” - you’re human. 5. How Certain Health Conditions Can Influence Libido While libido naturally fluctuates, some women’s health conditions introduce additional factors that may influence desire. PCOS and Libido PCOS is associated with hormonal irregularities, mood shifts, and insulin resistance - all of which can shape libido. Some women notice higher libido; others experience lower desire during symptom flares. Endometriosis and Pelvic Pain Endometriosis is associated with pelvic inflammation and pain, which may make sexual activity uncomfortable or unpredictable. Pain anticipation alone can reduce spontaneous desire. Learn more: newly diagnosed with endometriosis Interstitial Cystitis (IC) Women with IC often experience urinary discomfort, urgency, or flares after intimacy - making libido feel conditioned by fear rather than desire.Learn more: you are not alone navigating IC HPV and Emotional Impact HPV itself doesn’t reduce libido physiologically, but anxiety, stigma, or confusion after diagnosis can impact mood, comfort, and desire.Learn more: navigating HPV with a partner HSV and Sexual Confidence HSV flare-ups can involve pain, inflammation, or fear of transmitting the virus - all of which can influence libido.Learn more: reducing shame around HSV These conditions don’t define your desire - they simply interact with your body’s natural rhythms. Learn more about pain or discomfort during intimacy So… Is There a “Normal” Libido for Women? “Normal” does not exist. Libido varies with: Hormones Stress Life stage Emotional connection Physical comfort Past experiences Health conditions Your desire isn’t a test you pass or fail. It’s a biopsychosocial signal - a reflection of your body’s priorities and your environment. Evidence-Informed Ways to Support a Healthy Libido Supporting libido often means supporting the conditions that allow desire to arise. Support the Nervous System Breathwork Mindfulness Restorative movement Reducing overwhelm Address Hormonal and Metabolic Foundations For women navigating hormonal fluctuations - including PCOS, postpartum shifts, or perimenopause - lifestyle and nutritional support may help balance energy, inflammation, and wellbeing. Care for Pelvic Comfort Pelvic floor therapy Warm compresses Gentle stretching Pain-aware intimacy frameworks Supplement Support Some women explore nutritional support tailored to their unique experience: PCO Well for metabolic and hormonal balance Endo Well for inflammatory support and pelvic comfort IC Well for bladder-focused wellness Papillex® for immune support in response to HPV Simplix® for skin + immune support in response to HSV These aren’t libido supplements - they are context support supplements, helping reduce the barriers that influence desire. Conclusion Women’s libido isn’t a fixed setting - it’s a living, responsive part of overall health. When you understand the hormonal, neurological, emotional, and physical factors behind libido changes, it becomes easier to meet yourself with curiosity instead of criticism. Desire grows where safety, comfort, and connection thrive - and you deserve all three. References Chivers ML. “The complexity of women’s sexual desire.” Annual Review of Sex Research. Basson R. “Women’s sexual response and sexual dysfunction.” Lancet. Brotto LA & Luria M. “Female sexual arousal and desire: A biopsychosocial model.” Journal of Sex Medicine. Vannuccini S, et al. “Pelvic pain, endometriosis, and sexual health.” Human Reproduction Update. NIH Stress & Sexual Function Review: https://pubmed.ncbi.nlm.nih.gov/33222494/
Dec 15, 2025
5 min read
The Foundations That Matter Most For HPV Immune Support (And Often Get Overlooked)

The Foundations That Matter Most For HPV Immune Support (And Often Get Overlooked)

Lovisa Alatalo
If you’ve been searching for HPV immune support, you’ve probably seen quick fixes and long supplement lists. Here’s the truth: when it comes to helping your body respond to HPV, the foundations of health often make the biggest difference. This guide breaks down four essentials many women 20–40 overlook: stress and cortisol regulation, gut health, estrogen metabolism and liver support, and micronutrients like zinc, folate, vitamin D, and indole-3-carbinol. You’ll find clear, evidence-informed steps you can start today. Quick takeaway: Start with one foundation this week. Consistency beats intensity. 1) Stress & Cortisol: why calm is powerful for HPV Chronic stress isn’t just a feeling. It’s a hormonal state with real immune consequences. Elevated cortisol over time can blunt T-cell communication and surveillance, the same pathways your body uses to identify and clear abnormal cells . That doesn’t mean stress is “bad.” It means your stress response needs rhythm. Signals your stress response needs support Waking at 3–4 a.m., wired yet tired Afternoon energy crashes Sugar or caffeine dependence Irritability or brain fog Low-lift practices to regulate cortisol Sleep first: 7–9 hours with a consistent wake time 5-minute breathing: 4–6 breaths per minute, twice daily Morning light to anchor circadian rhythm Exercise with intent: mix strength training with zone 2 walks Boundaries: nightly screen break Pro tip: Pick one “anchor habit” you can repeat daily, even on busy days. 2) Gut health: your immune headquarters Roughly 70% of your immune cells live in the gut-associated lymphoid tissue (GALT) . When your microbiome is diverse and balanced, it communicates safety to the immune system. When there’s dysbiosis, inflammation can rise and immune responses weaken . Everyday gut-support wins Fiber diversity goal: 20–30 plant foods per week Fermented foods: kimchi, kefir, sauerkraut Color rule: the deeper the color, the deeper the phytonutrients Limit sugar: cut back on ultra-processed snacks Signs your gut could use attention Bloating or irregularity Recurring yeast or urinary issues Fatigue after meals Consistency matters more than any single probiotic. Food patterns are the microbiome’s daily language. 3) Estrogen metabolism and liver function: support the clearance pathways Inflammation can impair normal liver function, which is central to metabolizing hormones. For many women, supporting estrogen detox is less about “detoxing” and more about supplying nutrients for Phase I and Phase II metabolism. Nutrients and foods to know Cruciferous vegetables: broccoli, kale, cabbage, Brussels sprouts Indole-3-carbinol (I3C): derived from crucifers, supports estrogen metabolism Sulforaphane: from broccoli sprouts, protects cells from oxidative stress Protein: amino acids are required for conjugation pathways Lifestyle supports Stay hydrated and support regular bowel movements Moderate alcohol Daily movement and circulation 4) Micronutrients that quietly move the needle Deficiencies are common and subtle. Four standouts for HPV immune support: Zinc Supports DNA repair and immune signaling Sources: oysters, pumpkin seeds, legumes Folate Supports healthy cervical cell turnover Sources: leafy greens, citrus, legumes Vitamin D Modulates innate and adaptive immune activity Often low in young women in northern regions Indole-3-carbinol (I3C) From cruciferous veg, aids estrogen metabolism+ immune balance Food first. Supplement when diet or labs suggest a gap. FAQs: HPV immune support, foundations, and next steps Q1. How long until these foundations make a difference? Most people feel changes in energy and digestion within 3–6 weeks. Immune changes may take 8–12 weeks. Q2. Do I need supplements if I eat well? Food first. Vitamin D, zinc, and folate are common gaps, especially for women in northern climates . Q3. Can I do all four foundations at once? You can, but you don’t have to. Start with the one that feels most doable. Q4. Are there foods to avoid? Ultra-processed foods and excess alcohol impair gut and liver function. Q5. What if I’m on medication? Always consult your clinician before adding supplements. Bottom line When you think HPV immune support, think foundations first. Regulate cortisol, feed your microbiome, support estrogen metabolism, and cover your micronutrient bases. These small, repeatable choices build the internal environment your immune system needs to do its job. CTA: Want practical, evidence-informed wellness each week? Join The Exhale for expert tips. Explore Papillex®, Simplix®, and Endo Well for targeted support. References Pawelec G. Immunosenescence and immune response to HPV. Vaccine. 2018;36(19): 2711–2717. PMID: 29503293 Glaser R, Kiecolt-Glaser JK. Stress-induced immune dysfunction: implications for health. Nat Rev Immunol. 2005;5(3):243–251. PMID: 15738954 NIH Human Microbiome Project: https://commonfund.nih.gov/hmp Belkaid Y, Hand TW. Role of the microbiota in immunity and inflammation. Cell. 2014;157(1):121–141. PMID: 24679531 Safe S, et al. Indole-3-carbinol and cancer prevention. J Nutr. 2011;141(1):12–16. PMID: 21106930 Zhang Y, et al. A major inducer of anticarcinogenic protective enzymes. Proc Natl Acad Sci USA. 1992;89(6):2399–2403. PMID: 1549603 NIH Zinc Fact Sheet: https://ods.od.nih.gov/factsheets/Zinc-Consumer Flatley JE, et al. Folate and cervical neoplasia. Cancer Epidemiol Biomarkers Prev. 2009;18(4):1102–1109. PMID: 19336558 NIH Vitamin D Fact Sheet: https://ods.od.nih.gov/factsheets/VitaminD-Consumer
Sep 22, 2025
4 min read
#AccelerateAction: The Future of Women’s Health

#AccelerateAction: The Future of Women’s Health

Victoria Gasparini
For far too long, women’s health has been underfunded, under-researched, and, frankly, overlooked. Despite making up half the population, women still face significant disparities in healthcare funding, research, and treatment options. This International Women’s Day, we’re taking action. At Wellex®, we exist to empower women on their wellness journey by offering real solutions to real health concerns, especially those that have been ignored for far too long. But this isn’t just about our products, it’s about our passion for moving the needle in women’s healthcare. We are committed to being a pillar of support, a trusted resource, and a platform for women to advocate for themselves, take charge of their health, and demand the care they deserve. We are so glad to have you here with us. The Gender Gap in Medical Research These statistics are going to blow your mind. Women’s health conditions make up a significant portion of the global disease burden, yet research funding does not reflect this reality. Consider this: Only 1% of healthcare research funding in the U.S. goes toward female-specific conditions beyond cancer and reproductive health. Women are twice as likely as men to experience chronic pain, yet most pain research has historically been conducted on men. It took nearly 30 years for researchers to realize that heart disease presents differently in women than in men, resulting in thousands of misdiagnosed heart attacks in women annually. Conditions like endometriosis, polycystic ovary syndrome (PCOS), interstitial cystitis, and adenomyosis impact millions of women worldwide, yet they receive a fraction of the research dollars and medical attention they deserve. Where Wellex Comes in Wellex® started by addressing one of the most underfunded and misunderstood areas of women’s health: cervical health and HPV. HPV is the most common sexually transmitted infection globally, yet for decades, research into its long-term effects and potential solutions was minimal. We knew women deserved better, so we set out to change that. Now, we’ve expanded our mission. We’re tackling some of the most prevalent yet neglected health concerns affecting women, conditions related to the ovaries, bladder, and endometrial health. These are conditions that cause pain, disrupt daily life, impact fertility, and, in most cases, significantly impact quality of life. Yet, they continue to be dismissed, misdiagnosed, or brushed off as “normal” parts of being a woman. We refuse to accept that. Beyond Products: Supporting Research and Innovation Our commitment to women’s health goes beyond offering solutions, we actively support clinical research to push the boundaries of what’s possible. We believe that real change happens when we accelerate action not just in conversation but in research, innovation, and systemic change. We collaborate with scientists, practitioners, and industry leaders to fund and advocate for the studies that will shape the future of women’s healthcare, and we are proudly women-owned. It’s Time to Accelerate Action The theme of #AccelerateAction isn’t just a slogan, it’s a call to arms. Women’s health should no longer be an afterthought. It’s time to demand better research, better funding, and better solutions for women everywhere. This International Women’s Day, we invite you to join us in advocating for a future where no woman has to suffer in silence, where every health concern is met with urgency, and where true equality in healthcare becomes a reality. At Wellex®, we’re not just waiting for that future, we’re building it.
Mar 07, 2025
2 min read
Does Birth Control Worsen HPV?

Does Birth Control Worsen HPV?

Victoria Gasparini
If you’re reading this, you are likely one of the many people who are taking a closer look at their health and how their daily living impacts their experience with HPV. Well, I’m glad you’re here and I am even more glad that you are taking a proactive approach to your healthcare. This truly is the first step to healing. Okay, so one of the most frequent questions I answer in the direct messages on Papillex’s instagram is “how does birth control impact HPV?” Well, the good news is, I did the research for you. Let’s start with a brief background on how the pill works To really grasp the connection between birth control and HPV, let's first explore the mechanisms behind contraceptive methods. From oral contraceptives to patches, injections and IUD’s, these methods primarily work by altering our natural hormonal levels, affecting the menstrual cycle and ovulation and therefore preventing pregnancy. But in today's day and age, many women take/use methods of birth control to suppress hormonal conditions like acne, hair loss, hair growth and irregular or painful periods. Because of this, A LOT of women are on the pill (or some version of it). With the high prevalence of HPV and the extensive use of contraceptives, it is crucial we understand how one affects the other, namely - how birth control impacts HPV. How birth control impacts HPV Recent studies have explored the potential link between hormonal contraceptives and the persistence of HPV infections. While research is ongoing, there is evidence to suggest that hormonal contraceptives might influence the likelihood of HPV infections lingering in the body. How can this be?  The interplay between hormonal contraceptives and HPV may be rooted in hormonal changes that affect the immune system. Understanding these mechanisms is crucial, as the immune system plays a pivotal role in combating and clearing HPV infections.  Studies have found that the long term use (i’m talking 10+ years) of oral contraceptives has a four-fold increased risk of developing cervical cancer. A study of over 46,000 individuals found that those who used OCP’s had a significant;y higher rate of cervical cancer and abnormal cervical cell growth than non-users. The research also suggests that the risk decreases after stopping the pill. Considerations for Women Using Birth Control Address nutrient deficiencies Nutrient deficiencies are a real concern for those on OCP’s. The pill can deplete essential nutrients like riboflavin, B6, folic acid, vitamin C, and zinc. We know these nutrients are important players in supporting the immune system and some deficiencies in these nutrients have even been linked to persistent HPV.  Address gut health Moreover the OCP is known to alter the gut microbiome. The pill may increase risk for intestinal permeability, dysbiosis and candida overgrowth. A healthy gut is another foundation for our immune and overall health, impairing this system can have a widespread impact on the rest of the body.  Keep up with your regular screenings For women using hormonal contraceptives, it's essential to prioritize regular health check-ups. This includes screenings for HPV, ensuring that any potential infection is detected and addressed promptly. Open communication with healthcare providers is key, allowing for informed decisions regarding both birth control methods and overall reproductive health. Try other methods of birth control that are non-hormonal This may not be suitable for everyone and that is totally okay. If possible, condoms are a favorable form of birth control when it comes to protecting against both pregnancy and STI’s. Condoms form a barrier between mucosal contacts and are found to be 98% effective at protecting against STI’s like chlamydia and gonorrhea. However, because skin to skin contact can occur with condom use, they are less effective at preventing the spread of herpes, genital warts and HPV. Nevertheless, condom use is still warranted and recommended as there is still a reduction in risk of spread compared to no condom-use.  The IUD is another potential option. The hormonal IUD delivers a small amount of progestin to the local uterine tissue. Some individuals notice side effects such as mood changes, bloating, cramping and reduced menses. There is however a non-hormonal IUD option, the copper IUD. This prevents pregnancy by releasing copper in the uterus that is toxic to sperm. The copper IUD does not suppress ovulation and the most common side effect is heavier menstrual bleeds. The benefit is that the copper IUD has no hormonal impact, and therefore does not impact clearance of HPV.  Overall, we are still mostly unclear on how the IUD impacts cervical dysplasia. Please also keep in mind that the iUD does not protect against STI’s. In navigating the complexities of reproductive health, awareness is our strongest ally. By understanding the potential interplay between birth control and HPV, you can make an informed decision about your contraceptive methods and overall health. Regular screenings and open communication with healthcare professionals are vital steps toward maintaining a healthy and informed reproductive life.
Nov 13, 2023
4 min read
HPV: Debunking Myths and Misconceptions

HPV: Debunking Myths and Misconceptions

Victoria Gasparini
Human Papillomavirus (HPV) is a widespread infection, affecting more than 80% of sexually active individuals, both male and female. Despite its widespread prevalence, a stigma surrounds this topic, giving rise to numerous myths and misconceptions.These myths not only contribute to misunderstandings but can also hinder our efforts to manage HPV-related health issues. Many people with HPV struggle to access accurate information, and hesitate to consult medical professionals due to this stigma. Let’s debunk these myths and misconceptions once and for all, shall we?  Myth 1: Only Women Can Get HPV Fact: HPV does not discriminate based on gender. Both men and women can contract HPV through intimate skin-to-skin contact. While HPV is a leading cause of cervical cancer in women, it can also lead to various cancers and health issues in men, making it crucial for everyone to be aware of the risks. Myth 2: HPV Always Leads to Cancer Fact: HPV is a group of viruses, and not all of them lead to cancer. In fact, most HPV infections clear on their own without causing any health problems. While certain strains can cause cancer, regular screenings and vaccinations can significantly reduce the risk of developing HPV-related cancers. Myth 3: Condoms Provide Complete Protection Against HPV Fact: While using condoms can reduce the risk of HPV transmission, they do not provide complete protection. HPV can infect areas not covered by a condom. The most effective way to prevent HPV-related health issues is through vaccination. The HPV vaccine protects against the most common cancer-causing strains of the virus. Myth 4: Only Promiscuous People Get HPV Fact: HPV is incredibly common, and anyone who is sexually active can contract the virus, even if they have had only one sexual partner. The number of sexual partners does increase the risk, but HPV can be transmitted through even limited sexual contact. Myth 5: HPV Is Untreatable Fact: While there is no cure for HPV, most infections clear on their own without causing any health problems. HPV-related health issues such as genital warts or abnormal Pap smears can be managed with medical intervention. Regular screenings and early detection are crucial for timely and effective treatment. Myth 6: If You Have HPV, You Will Always Have It Fact: Many HPV infections clear from the body within a couple of years. The immune system often fights off the virus naturally. However, in some cases, the virus may persist. Regular screenings and follow-ups with healthcare providers are essential for managing persistent infections and preventing related health problems. Knowledge is Power Dispelling these myths is essential for promoting accurate information about HPV. Understanding the facts can empower individuals to take proactive steps, such as practicing safe sex and undergoing regular screenings. By debunking these myths, we can collectively work towards a world where HPV-related health issues are minimized and well-managed. Remember, open communication with healthcare providers and sexual partners, along with staying informed, are the keys to protecting yourself and others from HPV-related health problems.
Nov 01, 2023
2 min read
Abnormal Pap? Here's What To Do Next

Abnormal Pap? Here's What To Do Next

Victoria Gasparini
In 2022, an estimated 14,100 women in the United States have been/will be diagnosed with cervical cancer, caused by HPV. In 2020, over 600,000 women were diagnosed across the globe. While the HPV vaccine has drastically reduced cervical cancer rates as a direct result of preventing high-risk HPV, there are still approximately 4300 deaths per year in the United States alone, from cervical cancer. Take comfort knowing that most HPV cases do not cause cancer, and that many strains of HPV can be controlled and suppressed naturally by supporting the body’s immune system and encouraging adequate viral clearance. The high risk strains of HPV are 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 66 and 68. HPV 16 and 18 are typically the higher risk types and are responsible for most types of HPV-related cancers.  What to do after receiving an abnormal pap smear The Pap smear involves taking a cell sample of the cervix and assessing for any abnormalities. By monitoring cell changes, earlier treatment and interventions can be implemented which can prevent more severe disease. If you receive an abnormal pap smear result, it is best to talk to your doctor about what your next steps are. This may include more frequent tests, among other possible solutions. Unfortunately, from a conventional standpoint, the advice is typically to “watch and wait” at this point in the diagnosis.  Fortunately, more and more research is finding that there are ways to control and manage HPV naturally, with dietary and lifestyle changes. Let’s dive into your post-diagnosis plan, below.  First things first, know that you aren’t alone.  HPV is one of the most common sexually transmitted infections, affecting 80% of sexually active women. In fact, most sexually active men and women will contract some strain of HPV at some point in their lives. It is not uncommon to have an abnormal pap smear during routine testing. It is, however, important to do what you can to get HPV under control.  Talk to your doctor about follow-ups, strains and risk. While Pap testing and increased screening have resulted in a decline in cervical complications, there remains some debate over how often early screening should take place. Considering 90 percent of HPV infections will regress over time, screening can also lead to harm such as unnecessary stress on the individual, additional follow-up testing and biopsy, and the potential of unnecessary treatment.  The chances of having an abnormal Pap smear are higher in young individuals and decrease with age. Around 10% of individuals with a cervix aged 20-29 years will have an abnormal test result while only 1.6% of those aged 60-69. Of these abnormal results, 1.5% of 20–29-year-olds will have high-grade lesions that lead to further testing and biopsy. However, more than 50% of these will undergo treatment. Many of these infections would clear on their own and lead to no complication of cervical cancer. Depending on where you live and your unique, individual case - your screening guidelines may differ. It is best to work with your physician to develop a plan that is right for you. Find out the screening guidelines in your country here.  Adopt a healthy immunity plan.  We dive into the research on building your immune system to help prevent and clear infections like HPV. Here are some of our favorite, evidence-based tips for building and adopting a healthy immunity plan to help you take control of HPV. Find movement that you enjoy  Consistency is key when it comes to exercise and movement - so if it does not come naturally, know that you probably won’t stick with it. Try finding a daily movement you enjoy such as walking outdoors, weight lifting, kayaking, swimming, hiking, rock climbing - anything that gets you up and going.  Eat a wide array of colorful vegetables and fruits. The more variety you consume with regards to veggies and fruits, the better. Nutrients like carotenoids, sulforaphane, folate, vitamin C, selenium and more, have all been shown to boost immunity and increase clearance of HPV.  While all foods are welcome in a healthy, balanced diet, it is best to focus on anti-inflammatory, antioxidant and phytonutrient-rich foods, with limited intake of starches and sugars. You can find out more about diet and HPV here.  Practice mindfulness  Addressing stressors in our lives is often the biggest barrier to healing, and also often the most important barrier to knock down. The connection between stress and persistent infections is clear which is what makes mindfulness such an integral part of your healing. Studies continuously find a connection between stress and its impact on immunity, which is supported in pathogenesis and persistence of HPV infections. You cannot always control stressful events from occurring, but you can manage perceived stress through methods of talk therapy, finding good friends to chat with, getting adequate sleep and nutrients, and getting outside in nature. Reducing perceived stressors can help with HPV disease management and progression and is an important part of any HPV treatment plan. Other things you can do to manage stress include, positive self-talk and reinforcement, surrounding yourself with positive people, trying acupuncture and/or massage, and more. Click here for more stress-management tips.  Most of all... It's crucial to remember that abnormal pap smears are extremely common, and in many cases, they resolve on their own. Be gentle with yourself during this process. While a "watch and wait" approach is typical, being proactive about your health is essential. There are options available, empowering you to take charge of your healthcare journey. By staying informed and proactive, you can navigate this experience with confidence and assurance, ultimately ensuring your health and peace of mind.
Oct 02, 2023
4 min read

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