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HPV Immune System: Why Immunity Matters More Than You Think After a Diagnosis

HPV Immune System: Why Immunity Matters More Than You Think After a Diagnosis

Lovisa Alatalo
It’s not just about avoiding colds. Your immune system plays a lead role in helping your body clear HPV, and if it’s weighed down by inflammation, it might not be performing at its best. How Does Your Immune System Help Fight HPV? HPV is a common viral infection, and your immune system is your first line of defense. When HPV enters the picture, it’s your immune system - specifically your T-cells - that recognizes and targets infected cells. These vigilant defenders work quietly behind the scenes, mounting a response that can fight the virus. But here’s the catch: chronic inflammation - often hidden in plain sight - can dull this immune response. It lulls your T-cells into low gear and keeps your body in a reactive, defensive state, which leaves less bandwidth to focus on fighting HPV. Most people with HPV don’t notice anything unusual. They may not feel “sick” or run down, but at a cellular level, persistent HPV infections can keep the body in constant defense mode. That means your immune system is working overtime on background fires instead of directing its full strength toward combating HPV. T-Cells, NK Cells, and the HPV Immune Response Your immune system is made up of many moving parts, but two types of cells are particularly important for HPV: T-cells are adaptive immune cells that recognize and destroy HPV-infected cells. Chronic inflammation, often fueled by lifestyle risk factors like poor diet, smoking, unmanaged stress, and environmental toxins, can impair T-cell activation and reduce immune activity. Natural Killer (NK) cells are part of your innate immunity. They act quickly, scanning your body for cells that don’t look right - including virus-infected cells. Research shows that boosting NK cell activity is linked to faster combatting of HPV and better long-term outcomes When inflammation becomes chronic, it “distracts” both T-cells and NK cells. Instead of focusing on viral defense, the immune system is caught in a cycle of constant background repair. The result? A slower, less effective response to HPV. What Can You Do to Support Immunity Naturally? The good news: your immune system is highly adaptable. Even small, consistent changes can help bring inflammation down and restore balance. Eat anti-inflammatory foods: Prioritize colorful fruits and vegetables, leafy greens, cruciferous veggies (like broccoli and kale), and whole plant foods rich in antioxidants. Manage stress: Practices like mindfulness, yoga, or even a daily walk can lower stress hormones that otherwise keep the immune system in overdrive. Prioritize quality sleep: Sleep isn’t just rest - it’s when your immune system resets. Aim for 7-9 hours of restful sleep each night. Move your body: Regular, moderate movement improves circulation, supports immune balance, and helps reduce inflammation. You don’t need intense workouts - consistency matters more. Break Bad Habits – Beyond dietary considerations, not smoking, abstaining from recreational drugs and alcohol, and avoiding egregious amounts of stress will help alleviate excess load on your immune system. Smokers exhibit a 200-300% higher incidence of cervical dysplasia. Drink Green Tea – There is a growing body of evidence that suggests the flavonoid ECGC found in green tea may inhibit the development of HPV warts and cervical lesions. Supporting your immune system doesn’t just help manage HPV - it can also play a role in helping the body prevent HPV from progressing into long-term issues. Can Supplements Like Papillex® and AHCC® Help? For patients with HPV,  reducing smoking and stress can significantly support immune health. Lifestyle changes create the foundation for immune strength. But sometimes your body needs additional, targeted support. That’s where supplements like Papillex® and AHCC® come in. What is Papillex®?Papillex® is a doctor-formulated, plant-based supplement designed specifically to support people managing HPV. It combines a unique blend of nutrients and plant compounds that: Promote cervical cellular health (broccoli sprout extract with indole-3-carbinol, DIM, and sulforaphane) Support immune resilience (reishi mushroom, astragalus, zinc, selenium, folate, vitamins C & E) Provide antioxidant protection (green tea extract, carotenoids, lycopene) Papillex® helps replenish key nutrients that research shows may be low in patients with HPV, creating a supportive environment for your immune system to do its work. What is AHCC® (Active Hexose Correlated Compound)?AHCC® is a clinically studied supplement derived from shiitake mushrooms. It works differently than Papillex® - instead of replenishing nutrients, it modulates immune cell activity: Enhances NK cell activity Improves T-cell cytokine production Supports immune memory and long-term defense Clinical research has shown AHCC® may help support HPV clearance when taken consistently. It’s widely used in immune health, from viral support to recovery and resilience. Why Use Them Together?Papillex® and AHCC® complement each other beautifully: one helps refill the immune system’s toolbox, while the other sharpens the tools themselves. Together, they create a more comprehensive immune-support approach. What’s a Simple Roadmap for Supporting Immunity After HPV? If you’ve recently been diagnosed with HPV, supporting your immunity can feel overwhelming. Breaking it down into steps can help. Weeks 1–4 Focus on anti-inflammatory basics: whole foods, stress management, better sleep. Begin small habits like adding a serving of cruciferous veggies daily. Weeks 3–6 Add Papillex® consistently. Notice subtle changes like energy, digestion, or overall vitality. Weeks 5–8(Optional, consult your healthcare provider) Consider adding AHCC® for enhanced immune support. Weeks 9–12 Reassess: Are you feeling more resilient? Have lifestyle changes become second nature? Continue with Papillex® for maintenance and AHCC® as recommended. Small steps add up. Over three months, you’ll have layered lifestyle changes with targeted support - giving your immune system the best environment to respond to HPV. The Bottom Line? An HPV diagnosis can feel out of your hands - but your immunity doesn’t have to. Your body’s resilience lies in how you support it. The immune system isn’t just for colds and flu - it’s your frontline in combating HPV. By lowering inflammation, nurturing your lifestyle, and choosing evidence-backed support like Papillex® and AHCC® supplements, you’re giving your body the best chance to thrive. References Smith J, et al. Active Hexose Correlated Compound (AHCC) and persistent HPV infections: Clinical outcomes. Frontiers in Oncology. 2019. Read here Ostrander EA, et al. AHCC® supplementation improves immune function in women with HPV. J Gynecologic Oncology. 2022. Read here Clarke JD, Dashwood RH, Ho E. Multi-targeted prevention of cancer by sulforaphane. Cancer Letters. 2008. Read here Rezoagli E, et al. Reishi mushroom (Ganoderma lucidum) and immune regulation: From traditional use to clinical applications. Nutrients. 2020. Read here zur Hausen H. Papillomaviruses and cancer: From basic studies to clinical application. Nature Reviews Cancer. 2002. Read here CDC. Human Papillomavirus (HPV) and Cancer. Centers for Disease Control and Prevention. Read here
Aug 25, 2025
5 min read
Talking to your partner about HPV

Talking to your partner about HPV

Victoria Gasparini
HPV is a sexually transmitted disease that 1 in 4 of us currently have, and 80% of us will get at some point in our lifetime. It is so ridiculously common, and yet talking about it still fills many of us with a sense of shame, embarrassment and fear.  Most strains of HPV are low-risk and commonly go unnoticed. It is totally possible that you have HPV and don’t even know it. There are a handful of strains that are considered “high risk”, and these are the ones that cause abnormal pap smears, and have greater potential. It should make you feel better that most strains of HPV are not dangerous and have no symptoms (which is why it is spread so easily)!  Here is why we need to talk about HPV The hardest part about talking to your sexual partner about HPV is because of the stigma that surrounds the infection. However, disclosing your HPV status to your sexual partner(s) can be a supportive and affirmative experience.  We are all vulnerable beings, and being able to enter that state of vulnerability is empowering and helps us to establish trust with those we spend such intimate moments with. Disclosing your HPV status may help build on that trust, and bring you closer to your partner. Being open and honest demonstrates to your partner that you care and value their sexual health as much as your own. It can also help educate people since HPV is the most common sexually transmitted infection and yet there is still so much stigma and misinformation surrounding the topic. The more we talk about HPV, the less power it has over us, because the truth is, there is nothing to be ashamed or embarrassed about.  Do I need to inform my partner? Yes, you should. Telling your partner that you have HPV actively breaks the stigma associated with sexually trasmitted infections, which is an important part of helping people establish safe sex practices, including those around oral sex. Disclosing your status is also a crucial part of exchanging consent between one another prior to sex. I know that the fear of rejection is a terrifying thing. No matter what your partner's response is, take comfort knowing that you are brave, compassionate and honest and that having HPV does not make you less worthy of intimacy. The right partner will understand (or will have HPV, as well). Tips for how to discuss HPV with your partner Timing Have the conversation early in your partnership, before sexual contact. Get to know someone and ensure you feel safe and confident when you are having this conversation. Showing your sexual partner how calm and confident you are will also help assure them that you are well informed. Choose the timeline that you are most comfortable with, and make sure your partner is someone you feel comfortable sharing personal details with.  Location Choose a safe and comfortable environment. Check in with yourself, make note of how you feel and act accordingly. Maybe your safety is felt more on a hike or outside of the home, or maybe you feel best disclosing this information in the comfort of your own house. It’s best to talk about HPV status when you are in a quiet, safe place.  Planning Your partner might have questions, and this is normal and to be expected. Anticipate these questions so that you are not blindsided or defensive. There are tons of resources available for education, including the CDC, healthline, and more. Our blogs are also an awesome source of information. Have knowledge of HPV prior to your conversation, not only so you are prepared for questions, but also to stay empowered, yourself.  Set the tone By sharing this information in a calm, reassuring and educational manner, you set the tone for the conversation. Listen to your partner and observe their response. Answer questions the best you can, and do not tolerate disrespect. Understand that sometimes your partner may not accept or be okay with this information right away, but that disrespect is not tolerated.  Honor yourself No matter how the conversation goes, you should take pride knowing that you were brave and honest. Many people do not take initiative in their sexually transmitted infection status or are simply scared to share. By doing so, you are helping others make informed choices about their health. Give yourself a pat on the back for being brave enough to make this decision, and be vulnerable. With each person that is brave enough to speak up, we decrease the risk for HPV transmission while also fighting back against the stigma that simply should not be there. 
Mar 26, 2024
3 min read
5 Things No One Tells You When Diagnosed With HPV

5 Things No One Tells You When Diagnosed With HPV

Victoria Gasparini
Being diagnosed with Human Papillomavirus (HPV) can be an emotionally and physically challenging experience. That's why we prioritize educating and empowering our customers on their diagnosis, so that no one is left in the dark. Here are five things to keep in mind if you find yourself facing an HPV diagnosis: 1. You Are Not Alone HPV is NOT your fault. This virus is incredibly common, with millions of new cases occurring worldwide each year. It's estimated that most sexually active individuals will acquire at least one type of HPV at some point in their lives. The prevalence of HPV underscores that anyone can contract the virus, regardless of their background or lifestyle. Remember, having HPV is not a reflection of your character or values. 2. Reducing the Spread of HPV Though HPV is highly contagious, there are effective strategies to reduce the risk of transmission: Vaccination: The HPV vaccine is highly effective in preventing infection from the most harmful strains of the virus. Safe Sex Practices: Using condoms can significantly reduce the risk of spreading HPV, though they do not eliminate the risk entirely due to the virus's ability to infect areas not covered by these barriers. Also, avoiding sexual intercourse during flare ups and communicating with your partner, are both essential to reducing the spread. Regular Screenings: Encourage your partners to get regular HPV screenings and vaccinations, which can help detect and prevent the spread of the virus. 3. Ending the Stigma: There's No Reason to Feel Ashamed Due to the sexual transmission of HPV, a diagnosis can sometimes bring feelings of shame or embarrassment. It's crucial to understand that HPV is a health issue, not a moral judgment. Many people and organizations are working tirelessly to end the stigma associated with HPV (like us!) By talking openly about HPV, we can foster a more supportive and understanding community for those affected (which is most of us!). 4. Exploring Treatment Options: While there's no cure for HPV, there are treatments for the health problems that HPV can cause, such as genital warts and cervical cancer. Beyond conventional medical treatments, holistic approaches can also play a supportive role in managing HPV-related symptoms. This includes: Dietary Adjustments: A diet rich in fruits, vegetables, and antioxidants to support a robust immune system. Stress Reduction: Techniques such as yoga, meditation, and regular exercise can help reduce stress, which may impact the immune system's ability to fight the virus. Supplements: Certain vitamins and supplements, like folic acid, vitamin B12, and AHCC (Active Hexose Correlated Compound), have been studied for their potential to support immune health in those with HPV. Papillex® blends together the most well-studied nutrients to help address persistent HPV without requiring you to purchase each nutrient on its own. 5. You Don't Have to "Watch and Wait" Traditionally, the approach to managing HPV, especially in cases of abnormal Pap smears, has been to "watch and wait" due to the virus's ability to clear on its own. However, for those with recurrent abnormal Pap smears, proactive steps can be taken to manage the condition: Diet and Lifestyle: Adopting a healthy lifestyle can bolster your immune system, potentially helping your body clear the virus more efficiently. Reducing consumption of alcohol and quitting smoking are both important interventions to consider with an HPV diagnosis. Targeted Supplementation: Supplements such as vitamin D, green tea extracts, and probiotics have been suggested to support cervical health and immune function. Regular Monitoring: Keep up with regular Pap smears and HPV tests as recommended by your healthcare provider to monitor any changes in your cervical health. Sometimes this means advocating for yourself and requesting regular check-ups with your trusted health care provider. An HPV diagnosis is not something you have to face alone or in silence. With the right knowledge and support, you can navigate this challenge proactively. Remember, you have control over many aspects of your health and well-being, and there are resources and communities ready to support you every step of the way (like us!).
Feb 19, 2024
3 min read
Papillex™and AHCC®, Which One Should You Take?

Papillex™and AHCC®, Which One Should You Take?

Adrienne Hill-Strathy
Supplementation can be confusing. If you have been diagnosed with HPV, you might be wondering, is there a supplement you can take? How much and when should you take it? And how do you know if it is working? The good news, you can supplement to support your immune system to defend against HPV. Recommended supplements and dosages will depend on the supplement and the person’s specific needs. Papillex has formulated two nutritional supplements based on the current evidence-based research on HPV. Our products are formulated with nutrients known to be associated with HPV infections and have been evaluated to support the immune response against viral infections like HPV. In this blog, we spill the beans on our supplements to help you decide which would be best for you. What to know about Papillex™ Papillex™ is a nutritional supplement and immune support that was designed to correct nutrient deficiencies commonly found in individuals with HPV. The supplement contains beta carotene, vitamin E, vitamin C, folate, selenium, and indole-3-carbinol. These nutrients have been consistently found to be low in individuals with persistent HPV infections. Moreover, increased levels have been associated with improvements in HPV through powerful antioxidant capabilities and inhibiting cancer cell growth. Papillex™ also contains immune-modulating compounds like astragalus, reishi, and green tea extract. The research on these compounds shows powerful anti-viral properties that stimulate the immune system to eradicate infections. Together, the supplement offers well-rounded nutrient and immune support. The micronutrients found in Papillex™ can help support general health in most individuals. The supplement might be right for you if your diet is low in fruits in vegetables, you have difficulty absorbing foods into your diet, or you have high levels of stress. Papillex™ is not recommended in pregnancy due to its Vitamin A concentration, which can be toxic in fetal development. Dosage: If you are HPV positive and/or have cervical dysplasia take two capsules twice daily. Once in the morning and once in the afternoon 2-3 hours away from food. As dysplasia improves and HPV is eradicated, you can decrease the dosage to 2 capsules once a day for maintenance and general immune support. What to know about AHCC® AHCC® is new to the Papillex toolbox. The product was launched in 2020 following research studies supporting its use in eradicating high-risk HPV infections. The supplement contains a mushroom extract derived from the shiitake mushroom. The extract is one of a kind and only manufactured by one company out of Japan, Amino Up Chemical Co.   AHCC® acts on the immune system by stimulating molecules like cytokines, NK cells, and dendritic cells. These molecules help support a healthy immune response against viral invaders. We are only starting to research and understand the variety of uses of AHCC®. The compound has been researched for its use in eradicating viral infections, including HPV. In a randomized control trial participants taking AHCC® for 3-6 months had a 66.7% clearance rate of high-risk HPV infection. In contrast, in the general population, the expected clearance rate of HR-HPV is around 0-10%.   AHCC® is well tolerated in most individuals and supports general health. Because AHCC is a strong immune stimulant, it may be too stimulating for individuals with autoimmune conditions. The supplement may be right for you if you are prone to colds and flu and frequent infection. Dosage: If you have an active HPV infection and signs of cervical dysplasia, take 2 capsules twice daily, away from food. Continue this for 3-6 months. Reduced the dosage to 2 capsules daily for another 3-6 months. AHCC® has not been studied for use for over one year. Before purchasing AHCC make sure the product has a registered TM or R sign next to its name. Products sold without this label as not sourced from the real AHCC source and do not include the compounds evaluated in clinical research trials. The power couple You can also supplement AHCC® and Papillex™ together for extra support. The duo provides both micronutrient and added immune support against HPV. How do I know if it’s working? It isn’t always easy to know if your supplements are effective. Herbal and nutritional supplements act slow and gently. It can take time and consistent use to have an impact. Making it difficult to know if they have made any difference. We recommend keeping track of basic indicators like energy levels, the number of days sick, level of dysplasia found on Pap testing, and HPV positivity to see how your supplementation is working for you!
Sep 20, 2021
3 min read
The Nutrient Connection – How Micronutrients Could be at The Root of Your HPV.

The Nutrient Connection – How Micronutrients Could be at The Root of Your HPV.

Adrienne Hill-Strathy
When many of us think of the health benefits of food proteins, fats, and carbohydrates come to mind. These macronutrients make up the general composition of our foods but within them lie additional health-promoting compounds called micronutrients. Micronutrients include trace minerals and vitamins that support the normal growth and development of living organisms. Without them, body systems like the immune system, nervous system, and digestive system can become impaired. Many individuals are deficient in micronutrients. This can be due to low intake of dietary sources like fruits and vegetables and high intake of processed and nutrient-poor foods. Additionally, it is thought that the micronutrient quality of our fresh food has declined in recent years due to industrial agricultural production. This micronutrient deficiency may be at the root of why some people struggle to eradicate HPV infections compared to others who clear the virus more easily. Several micronutrients have been specifically found to be low in individuals with HPV and cervical dysplasia - we’ll outline them below. Portrait of female gatherer gathering organic vegetables with a wicker basket at orchard The Key Players Folate – Vitamin B9 Most people know of folate as an important nutrient for fetal development that should be taken during pregnancy. In addition to supporting a healthy pregnancy, Folate also plays a role in DNA production and red and white blood cell formation, and also plays an important role in HPV. When folate levels are low, the body has trouble maintaining a process called methylation. Methylation helps support cardiovascular, neurological, and reproductive health. When the process is impaired, it can increase levels of an inflammatory compound called homocysteine. This compound can increase the risk of heart disease and impact gene regulation that helps regulate cancer cell growth. There is a strong association found between folate deficiency and cervical dysplasia. Several studies have found that high blood levels are associated with a lower risk of cervical dysplasia and HPV and increased risk with low blood folate. Studies have also demonstrated that supplementation with folate may reduce the risk of cervical cancer.  Low dietary intake of folate may not be solely to blame for deficiencies. Some individuals have SNP’s in their genetic pathway that prevents them from converting dietary folate into its active form. These individuals may have higher levels of homocysteine and an increased risk of disease. How to get your dose? Foods that contain folate include leafy greens, brussel sprouts, broccoli, and chickpeas. Folate can also be supplemented. The recommended daily intake of folate is 400 micrograms. Lycopene and Carotenoids- Vitamin A Vitamin A is derived from dietary intakes of those red, orange, and green-colored vegetables rich in lycopene and carotenoids. This vitamin also appears to play a role in cervical health. Studies evaluating dietary intake and blood levels of Vitamin A found higher intake was associated with a reduced risk of cervical cancer. Whereas low dietary intake of carotenoids is associated with an increased risk of persistent HPV infections. How to get your daily dose? To get more lycopene and carotenoids into the diet, aim for 6-8 servings of leafy greens, orange, red and yellow vegetables per day. Foods rich in lycopene and carotenoids include: carrots, squash, tomatoes, broccoli, and red peppers. A dosage of 3000 mcg per day is recommended. Please note that Vitamin A should not be taken if pregnant, as excess stores can build up and cause birth defects. Selenium Selenium is another trace mineral that we must obtain from our diet. Selenium is important for thyroid function, reproductive health, and keeping the immune system running. Many individuals are low in selenium due to the reduced soil quality of our foods. Low levels have been found to increase rates of cervical dysplasia. Selenium deficiency is thought to allow viral strains to mutate and progress. How to get your daily dose? Selenium is found in high doses in brazil nuts. 3 nuts per day are adequate to reach the daily recommended dose of 200 mcg. Oysters have also been found to contain selenium. Vitamin C Who doesn’t love vitamin C? A powerful antioxidant that plays a role in many functions in the body. Vitamin C is important for immune system function, which is why we have all associated oranges and lemons with preventing colds and flu. Vitamin C also supports collagen production, iron absorption, and fuels and protects our cells. Studies have found that higher intake of Vitamin C was associated with lower rates of HPV persistence compared to lower intake. Dietary supplements of Vitamin C were also found to reduce the risk of Cervical dysplasia in high-risk HPV infections. How to get your daily dose? Foods like kiwis, red peppers, broccoli, citrus fruits, apples, and strawberries are high in vitamin C. The recommended daily intake is 75 to 90 milligrams. However, intake of up to 2000 mg a day is considered safe. Vitamin E Finally, Vitamin E deserves a mention - this vitamin is another powerful antioxidant found to protect against DNA damage and oxidative stress. Vitamin E may have anti-cancer effects. A meta-analysis reviewing the relationship between vitamin E intake and blood levels of vitamin E has found the higher levels of vitamin E, the lower level of cervical dysplasia. How to get your dose? Vitamin E is found in foods like sunflower seeds, almonds, peanuts, pumpkin, beet greens, spinach, and red bell pepper. The recommended daily intake is 15 milligrams per day. Receiving our nutrients from foods is always the best method, however, it isn’t always easy to get our daily dose. That is why Papillex formulated its supplement with this research in mind to provide one supplement to meet all of your needs!
Sep 06, 2021
4 min read
Research update:  AHCC® found to clear HPV in a human clinical study conducted by Dr Judith A. Smith

Research update: AHCC® found to clear HPV in a human clinical study conducted by Dr Judith A. Smith

Adrienne Hill-Strathy
Many of you have expressed interest in the results of Dr. Judith A. Smith’s HPV study on the use of AHCC® in people with HPV. Her previous studies showed positive findings, suggesting that AHCC® may help eradicate HPV in individuals with persistent high-risk infections. We are excited to learn that a further clinical trial confirms positive findings and will soon be published. HPV and Cervical Cancer Cervical cancer represents around 10 percent of all cancers worldwide. The human papillomavirus (HPV) is the virus found to cause 99 percent of cervical cancers and is also associated with cancers of the throat, anus, vagina, vulva, and penis.  High-risk strains of HPV infect the epithelial layer of cells of the cervix. When HPV infections persist overtime (classified by positive HPV testing over two or more years), there is an increased risk of developing cervical cancer. As we understand more about the cause and progression of cervical cancer and HPV, we are also learning more ways to prevent and protect against it. Research has evaluated the use of a natural medicinal compound, AHCC® on HPV infections. What is AHCC® and how can it help eradicate HPV? What Do Your Pap Results Mean? AHCC® stands for Active Hexose Correlated Compound. It is a nutritional supplement derived from shiitake mushroom that acts as an immune modulator. The compound is safe and effective at increasing the number and activity of immune molecules including natural killer cells, dendritic cells, and cytokines, which help the body identify and fight off infections. The standardized extract of AHCC® was developed in Japan in 1992 by the company Amino Up Chemical Co. Ltd. Several studies have reported a variety of therapeutic effects from AHCC®, including antioxidant, anticancer activity, and improved immune responses. The positive findings of AHCC® in enhancing the immune response have led to the question of whether the compound could benefit people with HPV. The human research on AHCC® and HPV has been led by Dr. Judith A. Smith, Pharm D. a Professor and Director of Women’s Health Integrative Medicine Research Program in the Department of Obstetrics, Gynecology and Reproductive Sciences at McGovern Medical School. Here is what we currently know about Dr. Smith’s recent research endeavors: From Bench to Bedside In 2019, Dr. Smith published an article in the Frontiers in Oncology entitled: From Bench to Bedside: Evaluation of AHCC supplementation to Modulate the Host Immunity to Clear High-Risk Human Papillomavirus Infections. The study found clearance of high-risk HPV in vitro, in mouse models, and in two human pilot studies of 10 patients. The human trials found dosing of 1-3 grams of AHCC® daily for 3-8 months led to a 44-66.7% clearance rate of HPV infections. Dosing of 3 grams led to slightly higher clearance rates than 1 gram. This research study spurred further interest in the topic and led to a recently completed phase II trial. The New Research The most recent research study was a human double-blind, placebo-controlled trial. This means that the participants and the researchers were not aware whether the participants had supplemented with AHCC® or with placebo. The study included 50 participants, evaluated for either active treatment with a 3-gram dose of AHCC® for 6 months or a placebo. Participants were followed for 12 to 30 months. Individuals that continued to be HPV positive at the end of the 12 months, were considered treatment failures. Those that were negative after 6 months were followed for another 6 months to confirm if they remained HPV negative. This study also evaluated immune markers like CD8+ T cells or natural killer (NK) cells to monitor the physiological response to AHCC® supplementation. While the results of the study have yet to be published, Dr. Smith has confirmed reports that the results are aligned with the positive findings found in the first two pilot studies. The results of this follow-up study will be published this year. As soon as the new paper is made available, we will be the first to share it with you. What’s next? We are excited about the growing knowledge base around HPV, cervical dysplasia, and cervical cancer prevention and the use of natural medicine to play a role in responding to HPV naturally. Dr. Smith plans to extend the research to evaluate the potential of AHCC® supplementation in combination with chemotherapy for the treatment of HPV related cancers.
Mar 02, 2021
3 min read
The Side Effects Of HPV

The Side Effects Of HPV

Adrienne Hill-Strathy
HPV is very widespread amongst the population. It is estimated that 80 percent of women will contract a strain of HPV in their lifetime. Most of these infections are silent, causing no visible symptoms or side effects within a host. In about 90 percent of patients, a healthy immune system will typically develop an immune response to regress the virus within a period of 1 to 2 years, with most in fact regressing over the course of a few months. However, a small number of people who contract an HPV infection may have symptoms or complications that range from low-risk visible papilloma’s on the skin to persistent chronic infections that may develop into precancerous or cancerous lesions. Here, we outline a few of the most common symptoms of HPV, including potential side effects of HPV vaccination. HPV Symptoms Typically, if HPV symptoms do develop, they will either cause visible warts on the surface of the skin or cause chronic infections that persist within the cell tissue and are only detected through clinical examination, like a pap smear. Warts The large variety of HPV strains gives rise to several different types of warts on the body surface, face, and genital areas. These warts can be classified into: Common warts: the common wart is most frequently caused by HPV-2. These warts usually present with an irregular shaped rough nodule that shows up in multiples. Plane warts: mostly caused by HPV-3, 10, or 28. They cause small and less rough, flesh-colored, or lightly pigmented lesions. Usually on the hands or face. Plane warts have an unusual characteristic in that they can spontaneously regress and cause swelling and a rash at the surface of the skin. Plantar warts: usually found in 10-14-year-olds. They are contracted through barefoot activity and are found on the bottom of the feet. Plantar warts are typically caused by HPV 1 and 2. Genital warts: are most frequently caused by HPV 6 and 11. They are renowned for their resilience and ability to continually come back, as well as being both painful and irritating. Cancerous or Precancerous Changes in the Cells of the Cervix Only a few of the over 180 different strains of HPV are associated with increased cancer risk. HPV that causes cervical, anal, or oral cancer is typically caused by a few high-risk strains of HPV that infiltrate the epithelial cells and have developed special mechanisms to evade the immune system. There are typically no symptoms that HPV is developing into cancer until several years of cell proliferation and development. HPV that has progressed to a stage of cervical cancer may present as symptoms of abnormal vaginal bleeding. The fact that it takes many years for HPV to develop into cancer is both a positive and a negative for us because it gives us time to detect the virus at an early stage in development before it has progressed into cancer and take action. It is negative because having no symptoms can prevent some people from being proactive about their health, allowing the situation to progress to a more serious state. Typically, Pap screening should be done every three years from the age of 21 to 65 to screen for these abnormalities. The HPV Vaccine and Potential Side Effects Today, we have a vaccine offered as a preventative measure against high and low risk HPV strains, primarily to protect women against cervical cancer. The Centers for Disease Control and Prevention recommends the HPV vaccine for routine vaccination at age 11 or 12 years. The vaccine may be started as early as age nine. Females aged 13 to 26 and males aged 13 to 21 are recommended to receive the vaccine. The vaccine is only recommended past the age of 26 for gay, bisexual, transgender, and those who have chronically weakened immune systems. Gardasil is the most commonly used vaccination, protecting against the two strains of HPV that cause genital warts, and the two strains that are the most high-risk HPV strains, commonly known to cause cancer, such as cervical cancer. Two doses of the vaccine should be given, the second being 6 to 12 months after the first. If less than 6 months apart, the recipient is of a weakened immune system or is past the age of 15, three doses are required to ensure the vaccination is effective. It is important to keep in mind that the vaccination does not protect you against all HPV strains, just the most high-risk, so routine screening is still recommended. Side Effects of Vaccination Side effects of the HPV vaccine may include: Injection site irritations such as pain, redness, or swelling Fever Systemic reactions such as nausea, muscle pain, malaise, and dizziness Fainting The vaccination is quite safe; different types of the vaccine having been studied in almost 75,000 individuals. These side effects are not commonly experienced, and for most people, it is definitely worth the risk to receive the vaccine than forgo it because of potential mild and temporary side effects.
Feb 01, 2021
4 min read
Could your rash be a symptom of HPV?

Could your rash be a symptom of HPV?

Adrienne Hill-Strathy
You’ve recently noticed a rash developing on your skin, making you wonder, is this HPV? HPV infections reside within the skin tissue and are transmitted through skin to skin contact. There are over 150 different viral strains of HPV that have evolved to infiltrate different areas within the skin and mucous membranes and are associated with different symptoms and progress to different diseases. Most HPV Infections are Asymptomatic Most HPV infections are silent. A person will contract an infection without having any visible symptoms. In about 90 percent of patients, a healthy immune system will typically develop an immune response to regress the virus within a period of 1 to 2 years. A small number of people suffer from persistent HPV infections and have an increased risk of developing cancer. However, these infections take many years to develop and through early detection and pap screening, complications rarely develop into malignancies. HPV Symptoms Typically, if symptoms do develop, they will either cause visible papilloma’s or warts on the surface of the skin or cause chronic infections that persist within the cell tissue and are only detected through clinical examination like a pap smear. HPV symptoms may include: Genital warts Skin warts Cancerous or precancerous changes in the cells of the cervix, detected during a pap test. Genital Warts Some low-risk strains of HPV can cause visible symptoms on the skin like common warts, genital warts, and plane warts. Genital warts are also known as condylomata acuminate. They are usually caused by HPV types 6 and 11. The warts appear as a soft, fleshy, cauliflower-like growths that grow in genital areas including the anus and penis. They can be painful, itchy, annoying, and, worst of all, highly persistent. Genital warts may also cause swelling in the genital area and lead to itching and discomfort. In women, warts often grow on the vulva, the walls of the vagina, or in between the external genitals and the anus. In men, they usually occur on the tip or shaft of the penis. Other Warts Caused By HPV Other warts caused by the HPV infection include plane warts, which tend to show up as small nodules on the hands or face. Plane warts can cause a mild rash on the hands of face during viral regression, but it is uncommon. Common warts typically show up as irregular shaped rough nodules that occur in multiples. These warts are also most commonly found on the fingers or hands, often featuring small black dots of clotted blood vessels. How Do I Get Rid of Warts? Each individual’s immune system responds differently to HPV, so each of us will have a different reaction to the virus as well. HPV strains that cause warts are classified as low-risk strains because they rarely develop into serious complications like cancer. Most warts will be cleared naturally by a healthy immune system. Implementing a healthy diet and lifestyle as well as incorporating natural treatments like green-tea extract, found in Papillex, has also been found to improve wart clearance. Rashes Although HPV affects the skin tissue, rashes are not typically a symptom of an HPV infection. As mentioned, some plane warts may present with a rash during viral regression but otherwise it is not a common symptom of an HPV infection. A rash likely indicates another skin infection, irritation, or sexually transmitted disease and requires further examination by your doctor.
Jan 01, 2021
3 min read

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