Being Well Blog

Being informed means being empowered. Welcome to the latest information and actionable insights.

Latest Insights

Tobacco Smoke and HPV

Tobacco Smoke and HPV

Christine Chung
Most tobacco cigarette smokers understand that smoking is damaging to their health. The warning labels on cigarette packets try and make that clear! In addition to being a risk factor for heart disease, stroke and respiratory disease, what people may not know is that tobacco smoking is also linked to persistent HPV infections, worsening of HPV symptoms, and the development of cervical cancer. HPV and Cervical Cancer Cervical cancer is a common and feared outcome of an HPV infection. The climbing rates of cervical cancer can be specifically attributed to the equal rise in HPV infections. HPV 16 and 18 are the two strains mainly responsible for causing cancer. There are many factors that may increase your risk for cervical cancer if you have HPV, including lifestyle factors like diet and exercise.  Tobacco’s Connection to HPV One of the higher risk environmental factors is tobacco smoking. It is suggested that squamous cell carcinoma of the cervix should be added to the list of tobacco-associated cancers. How many cigarettes cause harm? Studies show that current tobacco use was associated with a significant moderate risk of recurring HPV infections, the risk of being HPV positive being specifically associated with increasing number of cigarettes smoked per day. Here are the highlights from a study about cigarette smoking and HPV risk: In a cohort of over 3,000 women, cigarette smoking alone was not a risk factor for CIN 2, but it was a risk for those with a high risk strain of HPV, such as HPV 16 or 18 Women infected with these strains were at high risk to develop CIN 1, 2, or 3. Number of cigarettes was most associated with high risk of CIN development. Your Body and Tobacco The researchers tried to find a connection with the immune response being affected, but the conclusion was that smoking has a special negative effect on high-risk HPV. There is an imbalance of pro- and anti-inflammatory components in your body. There have been analyses done on female smokers showing that their cervical mucus contained constituents related to tobacco, such as nicotine!  We know that these constituents have terrible effects on our health and increased risk of lung cancer; it’s not hard to believe that finding these same constituents in your cervical mucus could have a similar effect. That same study showed increased risk of HPV-related squamous cell carcinoma in smokers.  From a biological perspective, smoking diminishes blood levels of certain antioxidants, such as vitamin C, which impairs your immune system and your body’s ability to fight off infection. And remember that vitamin C is vital in the development of collagen (i.e. in your skin), so if quitting for your health is not motivation enough, quit for vanity – smoking ages your skin and contributes to wrinkles! In a study in the journal Cancer Science, it was found that smokers had twice as high a risk of persistent HPV infection compared to never-smokers, and in young-women, passive smoking since childhood reduced probability of lesion regression. And it was not just smokers who had negative outcomes, it was found that even childhood exposure to second-hand smoke may increase the risk of persistent cervical abnormalities in young women! With all this evidence against smoking when you have HPV, some studies showed that HPV status was not affected by smoking. Another study showed that current BUT NOT PAST smoking history affected the viral load of HPV. They found that it didn’t even vary with intensity and duration of smoking. Quit Smoking Today!  There are many factors, however, that are associated with smoking, such as an unhealthy lifestyle, negatively-rated life events, lack of social support, poor coping mechanisms, distress, and other substance abuse, all of which will increase your risk of developing cervical cancer from your HPV diagnosis. Although this research seems to be up and down, the bottom line is clear – smoking will not do anything to improve your health in HPV or other parts of your life. If you have HPV, quitting smoking should be your top priority. For help with becoming smoke-free, check out the resources below! https://www.canada.ca/en/health-canada/services/health-concerns/tobacco/youth-zone/quit4life.html https://www.cdc.gov/tobacco/campaign/tips/quit-smoking/quitting-resources.html How Can Papillex Help? In conjunction with stopping smoking, Papillex can also help your body to respond to HPV in a natural and healthy way, replenishing vitamin deficiencies that are often found in repeat sufferers of the virus.
Dec 04, 2019
3 min read
Sugar and HPV: The Case Against Sugar

Sugar and HPV: The Case Against Sugar

Christine Chung
Sugar: the most enticing, delicious sweetener, tempting you into a life of obesity, diabetes, and other chronic illnesses. We all now know that sugar is the real bad guy in our foods…but why? And what’s the deal with sugar in HPV? What’s the Deal With Sugar? Most people know that “sugar is bad for you” and that reducing its intake is one of the cornerstones to a healthier lifestyle. But what is it exactly about sugar that impacts our health so negatively? For starters, the sheer volume of consumption by the average North American has skyrocketed. The estimated annual per capita consumption in the 1850s was about 25 pounds. This increased to about 120 pounds of sugar per capita by the 1950s. With the introduction of other processed forms of sugar, such as high fructose corn syrup, to virtually all refined foods, modern sugar consumption has grown to about 40 teaspoons of added sugar per person, per day! In addition to the staggering quantity consumed, sugar contains many empty calories, is very energy dense, and has shown to have very harmful, deleterious effects on our immune system. Key Definitions *Empty calories: what do we mean by empty calories? This sweetener contains virtually no minerals, vitamins, or other micronutrients. It is just a very refined carbohydrate, and does very little in the ways of nourishing our bodies. *Energy dense: a little sugar adds up to a lot of extra calories. Only 1 teaspoon (= 5 grams) of sugar has about 16 Calories. This may not seem like much, but it adds up quickly (i.e. multiply that by 40 = an additional 640 Calories a day). *Effects on immune system: excess consumption can have adverse effects on your immune system. In one study, the consumption of 100g (25 teaspoons) in the form of either sucrose, glucose, or fructose by healthy volunteers caused a temporary decrease in the ability of their neutrophils (specialized immune cells) to engulf bacteria. This suggests that reducing your intake of sweeteners (including refined carbohydrates like white bread and pasta) can be helpful in preventing and fighting infections. High fructose corn syrup (HFCS) is a common sweetener found in sodas, candies, fruit-flavoured drinks and pre-packaged foods… in other words, it is found in virtually all processed foods. Take a few minutes to look at the ingredients labels in your cabinets and fridge. HFCS has been known to impact the body’s functions which prevent it from healing and repairing. Stopping the body from healing is the last thing you want to do if diagnosed with HPV. Although fructose is a naturally occurring sugar found in fruits and vegetables, it is the refined forms of fructose used primarily as a food additive that’s being discussed. In fact, the highest source of fructose and HFCS in the North American diet comes from sodas and other sugary drinks. In terms of calories and chemical structure, sugars are very similar to one another, the body appears to metabolize fructose very differently than the rest. In animal models, high fructose diets cause the development of obesity, insulin resistance, diabetes mellitus, and dyslipidemia. How Important Is Blood Sugar Control? If you have cervical cancer, intraepithelial neoplasia, or are at high risk for developing any of the above, studies suggest that controlling blood sugar levels may help improve outcomes. The Diabetes Connection The rates for type 2 diabetes are on the rise. Once considered “late onset” or “adult diabetes” because it historically predominantly affected older populations in the past, this disease is now presenting itself in younger and younger people. Being overweight and obese, the “Standard American Diet” consisting of highly processed, high sugar, and low fruit and vegetable intake, combined with a sedentary lifestyle are major contributing factors to this trend. Blood sugar levels that are higher than normal but not yet high enough to be diagnosed as type 2 diabetes, also called “prediabetes”, is a warning sign that serious changes to diet and lifestyle need to be taken to prevent progression of the disease. It is currently estimated that six million Canadians have prediabetes. Diseases by Diabetes Having type 2 diabetes increases the risk of developing heart disease and stroke. In fact, according to the Canadian Diabetes Foundation, up to 80% of people with diabetes will die as a result of heart attack or stroke.  New research suggests that high blood sugar may also be a contributing factor in poor cervical cancer prognosis, and that obesity and abnormal blood glucose could be risk factors in the development of pre-neoplastic lesions of the cervix. Research published in the journal Gynecological Oncology reported that high glucose levels were associated with a greater risk for recurrence and mortality in non-diabetic women with locally advanced cervical cancer treated with radiation and/or concurrent chemotherapy. Preventing Diabetes The good news is that achieving stable blood glucose control is possible. Depending on the severity of your dysglycemia, this may involve much more dedication to your personal health. Even with the help of medication, the key to glucose control is healthy diet and exercise, which are also key for optimal health. First and foremost, go visit your doctor to have your blood sugar levels tested. Next, under the supervision of your physician, increase your intake of vegetables, fruits, and lean protein, while cutting out processed, refined foods (including white flower, white pasta, white bread, fast food, TV dinners, etc.), sugar, and fried food consumption. Increasing your daily physical activity is critical as well: 20-30 minutes daily of brisk walking is an excellent start, and can have a tremendously positive impact on your health. Try incorporating HIIT workouts 1 or 2 times per week to really optimize your physical health! Whether you have high blood sugar levels or not, these diet and lifestyle modifications can help improve overall health. The bottom line: cut back on sugar and other refined carbohydrate consumption, increase your daily intake of fruits and vegetables, your body will thank you.
Sep 25, 2019
5 min read
Why Folic Acid for HPV?

Why Folic Acid for HPV?

Christine Chung
What is Folic Acid? Folate is a member of the B vitamin (B9) family, a water-soluble vitamin involved in many chemical processes in the body. Folic acid is the synthetic form of folate. Folate is essential for the production of red and white blood cells and other important cells that help to convert food into energy and make DNA. Folate also plays an important role in the reproductive tract and is needed to maintain a healthy pregnancy. The body cannot create folate on its own so we must obtain it through our diet or supplementation. Research on HPV has begun to highlight a strong association between folate deficiency and cervical dysplasia, emphasizing the importance of incorporating more folate-rich foods into your diet as well as taking a quality supplement. Folate versus Folic Acid Folate differs from folic acid in the way that the vitamin gets converted in the digestive tract. Folate is immediately converted into the active form of vitamin B9, called 5-methyl-THF (5-MTHF). Folic Acid enters the bloodstream and passes through the liver and other tissues in order to be converted. Folic acid is thought to be better absorbed, however, it is metabolized at a slower rate, which means more can accumulate and linger in the system and may lead to excess. Folate, on the other hand, will be excreted if too much is consumed. Folate Deficiency Folate plays a critical role in your body so when it is lacking, it can lead to suboptimal health but it isn’t always easy to know when you are low in vitamin B9. Some symptoms include unexplained fatigue, anemia, muscle weakness, shortness of breath, difficulty focusing, brain fog, headaches, and heart palpitations. Deficiencies in folate can cause megaloblastic anemia, which is when your blood cells form in an improper shape. This hinders their ability to function correctly in your body. Folate is especially important for pregnant women, as deficiencies can cause neural tube defects in a growing fetus. Folate and Methylation Without folate, the body has trouble maintaining methylation. Methylation is a biochemical process that helps support cardiovascular, neurological, and reproductive health.  The cycle of methylation begins with a methyl group (one carbon and three hydrogen molecules) converting amino acid, methionine into S’Adenosylmethionine (SAM-e). Once converted into SAM-e, this molecule travels through the body transferring methyl groups to other bodily systems. SAM-e Is finally converted to the amino acid homocysteine, which creates the antioxidant glutathione. A deficiency in folate or B12 impairs the final stage of methylation, leading to elevated levels of homocysteine. Too much homocysteine increases the risk of heart disease and blood clots. Methylation also regulates our genes, turning them on or off. One of the ways cancer develops is through impaired gene regulation. Not having enough folate can impair the body’s ability to regulate cell growth and increase susceptibility to cervical cancer. MTHFR Gene Mutations Some people have a genetic mutation that prevents them from properly converting dietary folate into its active form (5-MTHF). This mutation may explain why women with healthy diets and lifestyles struggle to clear the infection, while others who smoke and eat poorly can eliminate the infection with no problem. Individuals with the MTHFR mutation have an increased risk of several diseases including heart disease, colon cancer, and breast cancer. Supplementing with the active form of folate (folic acid or methylated folate) can be beneficial for those with the mutation. Methylation is also impacted by diet in general. Studies have found the degree of methylation in the body to correlate with the volume of fruit and vegetables participants consumed. The findings suggest that dietary modifications to include more folate in the diet can reduce the risk of cervical dysplasia. Benefits of Folic Acid The average adult is recommended to take 400mcg of folate daily. Although folate is best known for preventing neural tube defects in fetuses, new research is showing its benefits in cancer prevention including breast, bladder, cervical, ovarian, and pancreatic cancers. Because folate is involved in reducing homocysteine, folate intake can influence heart disease. Recent research is showing benefits in reducing the risk of Autism Spectrum Disorder, Dementia and Alzheimer’s, and depression. Food Sources of Folate We recommend aiming for your daily dose of folate from food, before supplementing. Food sources of folate include:  Dark green leafy vegetables (i.e. kale, spinach), Broccoli, Black-eyed peas, Liver, Asparagus, Brussels sprouts, Avocado, Broccoli, Green peas, Fortified Grains*. *Because of the utmost importance of folate adequacy, the Canadian government, along with other governments have mandated folate fortification to many grains, like breakfast cereals, white flour, and pastas.  Folic Acid’s Role in HPV Management Folate is one of several key nutrients that have been studied in relation to HPV. Folate’s role in HPV is likely related to the methylation cycle mentioned above, which ensures your genes function normally. Current research has highlighted the relationship between low levels of folate in the blood and high-risk HPV infection through the promotion of cervical dysplasia development. Studies have found that individuals with a folate deficiency have an increased risk of positive HPV status, as well as an increased risk of progression to cervical and oral cancer. Whereas women with higher plasma folate and B12 levels with HPV-16 positivity were 60-75% less likely to be diagnosed with moderate cervical dysplasia.  There has been extensive research on the role of folate in HPV. We highlighted some key research below: A 2003 study by Hernandez et al. showed that women with the highest levels of blood folate levels from either food or supplements have lower rates of cervical dysplasia from HPV. A 2016 case-control study by Zhao et al. that included 271 controls and 214 women with both high and low-grade HPV lesions, found that low blood folate levels in women were coupled with a higher risk of cervical cancer from HPV. A large analysis of studies, or a meta-analysis, showed an increased risk of cervical cancer among Asian populations with low blood folate levels. A study by Bai et al. showed that a folate deficiency was associated with an increased risk of squamous cell carcinoma of the cervix and cervical intraepithelial neoplasia (CIN) in subjects who were HPV 16 positive. In an Indian population, improving folate and vitamin B12 status may have a beneficial impact on the prevention of cervical cancer. Scientific evidence shows that folic acid likely plays a protective role in HPV progression to cervical cancer. Folate is one of the many key protective nutrients in Papillex. A daily serving of Papillex contains the equivalent of 5 ounces of poultry liver, 4 cups of chickpeas, or 40 spears of asparagus. Should I Supplement Folic Acid? It is estimated that 5 to 40 percent of the female population has a folate deficiency globally. Ideally, we would obtain our folate from food sources like dark leafy greens, vegetables, fruits, nuts, and seafood. However, it can be difficult to get the recommended amount of folate from food alone. As mentioned, a person’s genetics may also make it difficult to convert dietary folate into its active form. Folic acid supplementation of 400mcg per day is safe. The highest level of daily intake of folate that poses no risk of adverse health effects was set at 1,000 micrograms per day. Folic acid is also a water-soluble vitamin and does not accumulate in fat tissue. Therefore, excess intake will be excreted into the urine and out of the body.  Supplementation with folic acid is often recommended for pregnant women to prevent neural tube defects and prevent megaloblastic anemia. Supporting HPV Naturally Many doctors choose to implore a “watch and wait” tactic, as it is difficult to begin treatment without further progression of abnormal cells. Some people wait years before seeing this progression, and most surgical interventions do not have an immense effect on the early stages of cell changes. Even if you eat the healthiest possible diet, you may still have several nutritional deficiencies which can harm the health of your immune system. This is why in addition to a diet high in richly pigmented fruits and vegetables, it’s important to supplement your diet with clinically supported nutritional supplements. Papillex is a compound that contains high-quality, natural sources of nutrients that have been shown to support beneficial results in eliminating HPV infections. It contains ingredients that nutritionally support the immune system which will help the body to better respond to genital warts, cervical dysplasia, and other HPV-related disorders naturally.
Aug 07, 2019
6 min read
Acrylamide: Are You Sure You Want Fries With That?

Acrylamide: Are You Sure You Want Fries With That?

Christine Chung
There are many risky ingredients and chemicals in processed food that can increase your risk of cancer. Did you also know that the way YOU cook or process your food can also have a similar effect? Keep reading below to get the low down on HPV and how acrylamide may affect your cancer risk! What is Acrylamide? Acrylamide is an industrial chemical that can be found in dyes, paper, plastics, and can even be used in treating water sewage. These are commonly seen in products we buy, in the packaging, and adhesives used. Oh, and by the way, this chemical is also present in tobacco smoke. How does this apply? This toxic chemical can form in some foods when using high-temperature cooking methods, such as deep frying, pan frying, roasting, or baking. This comes from a combination of sugars and an amino acid called aspargine that are presently found in food. These two components separately do not have a bad effect on your health, but during high-temperature cooking, they combine and can cause some pretty negative side effects on your health. The exact temperature at which acrylamide forms in food has yet to be determined, but it has so far not been found in food prepared at temperatures below 120 degrees Celsius (248 Fahrenheit). Why Should I Avoid Fried Food? Acrylamide is yet another reason to avoid fried and processed foods since certain food preparation methods lead to the formation of chemicals that pose a potential health concern. It was first detected in certain foods in April 2002 by the Swedish National Food Authority. Acrylamide is a chemical that naturally forms in certain foods, particularly starchy foods that are rich in carbohydrates and low in protein, during processing or high-temperature cooking, such as frying, roasting, and baking but not typically when boiling and steaming even at very high temperatures. Those French fries you can’t help but get as the side of your burger? These are heavily contributing culprits to high levels of acrylamide. In fact, the highest concentrations of acrylamide are found in potato chips and French fries, and are followed by cigarette smoke. Cancer Risk The Joint Food and Agriculture Organization/WHO Expert Committee on Food Additives (JECFA) and the United States Food and Drug Administration has identified dietary exposure to acrylamide as a potential concern. Acrylamide is known to cause cancer in animals at high levels. Elevated doses can also be toxic to the nervous system of both animals and humans. An 11-year study in the journal of Cancer Epidemiology Biomarkers and Prevention found an increased risk of endometrial and ovarian cancer was associated with higher intake of acrylamide from food. Here are other organizations’ takes on acrylamide: The International Agency for Research on Cancer (IARC) classifies acrylamide as a “probable human carcinogen.” The US National Toxicology Program (NTP) has classified acrylamide as “reasonably anticipated to be a human carcinogen.” The US Environmental Protection Agency (EPA) classifies acrylamide as “likely to be carcinogenic to humans.” While adverse effects to your brain and nervous system are unlikely at the estimated average exposure to acrylamide, changes in the actual structure and function of your nerve cannot be excluded for individuals with a high dietary exposure to acrylamide. For a compound that is both genotoxic and carcinogenic, these MOEs indicate a health concern. The take-home message: Avoid fried and processed foods and your body will thank you. In addition to taking Papillex, eat a diet high in fruits and vegetables and minimize the ingestion of saturated fats, and processed foods that impair immunity and contribute to inflammation in the body. 3 Tips to Decrease your Acrylamide Burden 1. Boil or steam your vegetables. By not roasting, baking, or frying your food, this will avoid the combination of sugars and amino acids that creates acrylamide. Boiling and steaming your food, no matter what temperature, is not connected with acrylamide formation. Acrylamide does not form, or forms at lower levels in fish, meat, or dairy products. 2. Don’t overcook your vegetables. Cooking for longer periods of time, especially at higher temperatures can cause acrylamide formation. This will also help to sustain those good fibers to contribute to a happy gut. 3. Avoid fried potato products ...like French fries or potato chips, or any other fried vegetable, especially those with breading. Acrylamide is mainly found in plant-based foods, especially potatoes and grains, and even coffee! So think twice next time you choose French fries or breaded, deep-fried onion rings next time! Bonus Tips for the Fried Food Fiends! *  If you find you just can’t get away from roasted, baked, or fried potato foods, soak your potato slices raw for 15 to 30 minutes before frying – make sure to dry the slices thoroughly to prevent oil fires! *  Avoid storing potatoes in the fridge before cooking. Studies show that this may increase levels of acrylamides formed during the cooking process. *  When frying, baking, or roasting potatoes, bread, or other vegetables, try cooking them to a lighter shade and avoid burning to decrease acrylamide production. Want to know more about healthy eating? Check out our blog on healing HPV through food!
Jul 17, 2019
4 min read
How to Talk to Your Partner About Your HPV Status

How to Talk to Your Partner About Your HPV Status

Christine Chung
The HPV Infection: Do I Have It? But…I’ve never noticed any symptoms so I couldn’t have gotten an HPV infection? Most strains of HPV are low-risk strains that commonly go by unnoticed. There are a handful a high risk strains of HPV; those are the scary ones that can cause an abnormal pap smear, leading to cancer, most commonly cervical cancer. Some other high risk strains of HPV can also cause oral and genital warts. . Some other high risk strains of HPV can also cause oral and genital warts. With that being said, it is very important to get regular pap smears to catch the presence of an abnormal pap or high risk strain early, before it leads to cancer. Why We Need To Talk About HPV Where do I begin? Knowing where to start and how to tell your sexual partner can be scary, but guess what? Disclosing your HPV status to your sexual partner can be a supportive and affirmative experience. By disclosing your HPV status and making yourself vulnerable, it helps to establish trust between you and a partner. You are actively demonstrating to a partner that you care and value their sexual health as much as your own. It can also help to educate people since HPV is one of the most common sexually transmitted infections and yet there is so much misinformation. For example, it’s probably the first time you’ve heard of how common HPV infections can really be among sexually active people, but that there are only a few high risk strains. Do I NEED to inform my partner? Educating people is one way of actively breaking the stigma associated with sexually transmitted infections, which is crucial to helping people establish safe sex practices, including those around oral sex. The truth is, HPV is so common that it doesn’t have to be a big deal to tell your partner. Read this article from Self on the importance of having that conversation with your partner, and why you shouldn’t worry.  No matter what happens, take comfort in making brave, compassionate and honest choices. Tips For Discussing HPV With Your Partner Here are a few tips from the team at Papillex to help make the conversation more comfortable for you: 1. Timing Have the conversation early in your relationship or before any type of sexual contact. Get to know someone and make sure you feel safe and confident when you have this conversation. Showing your sexual partner how calm and confident you are will also help assure them that you are well informed. Choose the timeline that you are most comfortable with, and make sure your partner is someone you feel comfortable sharing your personal details. 2. Location Choose a place that is private and comfortable. The physical space you are in can make you feel either safe or uneasy. Check in with yourself, make note of how you feel, and act accordingly. This could be while taking a hike or walk together, or while making dinner at your home. It’s best to talk about your HPV infection status when you are in a private, quiet space that makes you feel safe. 3. Planning Your partner might have a lot of questions and this is your opportunity to educate them. types of HPV Pap tests Why most strains won’t lead to cancer Anticipate their questions so you can answer them in an informative way. There are TONS of resources available for education, including the CDC, Healthline, Sex & U, and many more. Our blogs are also a great source of information! Know the information backwards, forwards, and sideways. Preparing this way will also increase your confidence for this conversation.  4. Set the tone By sharing this information in a calm, reassuring, and educational manner, you will set the tone for the conversation. Listen to your partner and observe their response. Answer their questions as best you can, and know that if you exhibit compassion, it’s likely they will too. If you educate yourself about the topic well enough, and display complete honesty with your partner, it sets a tone that you know there doesn’t need to be excessive worrying. Understand when it is beyond your capabilities and accept those boundaries.  5. Honor yourself No matter how the conversation goes, you should know you did something that took bravery and honesty.Many people do not take initiative in their sexually transmitted infection status, or are scared to share it. By doing so, you are helping others make informed choices about their health. Give yourself a tap on the back for being brave enough to make this decision. With each person that educates their partner, the risk for HPV transmission decreases.
May 23, 2019
4 min read

Example subheading

Subscribe & Save

  • Savings of up to 20% off
  • Plus Enjoy Free Shipping to US / CA
  • Switch or Pause anytime
  • Peace of Mind