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Pap Screening Guidelines for Cervical Cancer
Adrienne Hill-Strathy
The Pap smear is a dreaded appointment for many but, thanks to this handy screening tool, cervical cancer rates and complications from HPV have seen a decline.
Increased screening has led to earlier detection of cervical cell changes and with it, led to earlier treatment. Today, Pap smears are incorporated into regular screening for individuals with a cervix. However, when and how often you get tested can differ depending on your country, age, and past HPV status. Read on to learn more about screening in your location.
First, what is a Pap smear?
The Papanicolaou-stained (Pap) smear was introduced in 1949 by a pathologist named George Papanicolaou. The Pap smear is now the primary screening tool used to assess abnormal cervical changes and screen for the risk of cervical cancers.
The Pap smear involves taking a cell sample of the cervix and assessing for any abnormalities. By monitoring cell changes, earlier treatment and interventions can be implemented which can prevent more severe disease.
While Pap testing and increased screening have resulted in a decline in cervical complications, there remains some debate over how often early screening should take place. Considering 90 percent of HPV infections will regress over time, screening can also lead to harm such as unnecessary stress on the individual, additional follow-up testing and biopsy, and the potential of unnecessary treatment.
The chances of having an abnormal Pap smear are higher in young individuals and decrease with age. Around 10% of individuals with a cervix aged 20-29 years will have an abnormal test result while only 1.6% of those aged 60-69. Of these abnormal results, 1.5% of 20–29-year-olds will have high-grade lesions that lead to further testing and biopsy. However, more than 50% of these will undergo treatment. Many of these infections would clear on their own and lead to no complication of cervical cancer.
For this reason, many countries recommend screening at a later age. Here is what is recommended in Canada, the UK, and the US.
Screening Guidelines Differ Depending on Country
Canada
The Canadian Task Force on Preventive Health Care recommends the following screening for asymptomatic individuals with a cervix without a previously abnormal test and who are sexually active.
Screening is not recommended for individuals under 24. The potential harms in this group out weight the benefit of early screening.
For individuals with a cervix aged 25-29 screening is weakly recommended every 3 years. The concern for cervical cancer increases in this age group, therefore there are benefits to screening.
For those aged 30-69 routine screening every 3 years is strongly recommended. In this age group, the risk of cervical cancer is greater, and screening offers preventative benefits.
At the age of 70 regular screening may be ceased.
In Canada, the recommendations are used as guidance to be used in discussions with patients. Some women may place a higher value on avoiding cervical cancer and would want to undergo more frequent or earlier screening. While others may prefer to follow the screening guidance.
United States
The US Preventive Services Task Force sets the screening guidelines in the United States. The US recommendation incorporates high-risk HPV testing, which can help detect high-grade cervical lesions by identifying strains more likely to cause cervical cancers. They recommend the following:
Screening begins at age 21-29 and should be followed up every 3 years with cervical cytology.
In women aged 30-65, it is recommended to screen every 3 years with cervical cytology and every 5 years with high-risk human papillomavirus testing or every 5 years HPV testing in combination with cytology.
The USPSTF recommends against screening in those under the age of 21 and over the age of 65 and those who have had a hysterectomy.
United Kingdom
The UK has its own set of recommendations through the NHS Cervical Screening Programme. The NHS has also begun including HPV testing in its assessment. Cervical samples will be tested for high-risk Human Papillomavirus to help identify individuals more at risk for developing cervical cancer and implement treatment earlier. Their screening is recommended to begin at age 25 to 65.
For those aged 25-49, screening is offered every three years.
For those aged 50-64 years of age, it is recommended every five years.
What about for those who have had an abnormal Pap previously?
Screening guidelines differ if you have previously had an abnormal Pap and HPV has been detected.
If your Pap test was abnormal, you were likely referred to a gynecologist for a colposcopy. A colposcopy allows for a better view of the cervix and biopsy. Depending on your level of cell changes and health history, your doctor will recommend a treatment course of action or to watch and wait.
In those that have previously tested positive for HPV or had abnormal Paps that turned normal, your doctor will likely recommend follow-up testing a year after a normal result. HPV infections can recur, so it is important to stay on top of testing to see if cell changes recur over time.
The Benefit of Early Detection
Deciding when and how often to screen for cervical cancer and HPV, should be discussed with your medical doctor. Early detection has been beneficial in reducing our overall rates of cervical cancer. However, extra screening has also added anxiety and unnecessary procedures to those whose infections would have regressed within 12-36 months.
Moreover, detecting infection early also allows for earlier intervention with immune supports like Papillex and lifestyle changes like an anti-inflammatory diet, stress reduction, and exercise.
May 02, 2022
4 min read
Adrienne Hill-Strathy
If you have previously had an abnormal Pap or tested positive for the human papillomaviruses (HPV), your doctor might have recommended a procedure to help clear the abnormal cells. Several conventional interventions are available to address HPV and cervical changes. These procedures aim to remove abnormal tissue and cells in order to prevent progression into cancer.
An HPV diagnosis can be confusing. Adding a potential surgical procedure into the mix may add to your concern, confusion, and anxiety. We hear you; we would want to know the risks, potential harms, and procedural effectiveness as well. Here, we lay out the pros and cons of LEEP and other common conventional treatments for cervical dysplasia so you can be better informed about your options and what is best for your health.
First, a bit about HPV
HPV is the most common sexually transmitted infection around the world. So common that up to 80 percent of sexually active individuals will contract HPV at some point in their lives. Out of the hundreds of different strains of HPV, around 15 have been identified as high-risk. These high-risk strains are associated with cellular changes on the cervix. If these cell changes persist over time, there is a risk that they may lead to cervical cancer.
If you have contracted HPV, do not worry. Up to 90 percent of individuals that contract an infection will clear it within about two years. In individuals that fail to clear the infection, there is an increased risk of developing persistent cell changes that may progress into cervical cancer.
Cervical cell changes are monitored using Pap testing. Interventions have been developed to address cell changes before they can occur in individuals who have had abnormal Pap tests and persistent high-grade cervical intraepithelial neoplasia (CIN). Depending on your situation, your gynecologist may recommend a LEEP, conization, cryotherapy, or laser.
Here we lay out the pros and cons of each of these procedures.
LEEP- Loop electrosurgical excision procedure
The LEEP is an excision method used to remove abnormal cellular changes from the surface of the cervix. LEEP is typically recommended in cases of CIN2/3 or persistent CIN 1. During the procedure, you will assume a similar position as you would for a regular pelvic exam. A thin wire loop with an electric current will be inserted into the vagina to remove cells from the cervix.
Pros of LEEP
LEEP can be performed in-office. It is quick and generally painless with local anesthesia. The procedure generally takes only 10 minutes.
LEEP removes less tissue than other methods, leaving less scarring and changes to the cervix than other methods.
The tissue removed during the procedure can be used to confirm the degree of cellular changes.
Risks of LEEP
LEEP can cause cramping and light bleeding during and after the procedure.
The procedure increases the risk of infection, cervical scarring, and changes in sexual function.
It is associated with an increased risk of preterm labor and low birth weight. The risk of preterm delivery increases with the depth of LEEP exceeding 10 mm.
Effectiveness of LEEP
The recurrence rate of CIN 2, 3 after treatment varies depending on one’s age, the severity of the disease, the treatment. The five-year recurrence rate of LEEP is estimated at around 8.1%.
Cold Knife Conization
Cold knife conization is another surgical excision method used to remove abnormal tissue from the cervix using a scalpel or laser knife.
This procedure allows your doctor to further examine the cervical tissue to determine cancerous changes. Conization is used to treat cervical dysplasia and very early cervical cancer. The procedure involves the removal of a cone-shaped portion of the cervix to remove a cervical lesion and the transformation zone. Conization may be used when there are conflicting Pap smear and biopsy findings, there is severe dysplasia, or in the early stages of cervical cancer.
Pros of Conization
Conization also allows for histologic review of extracted tissue to assess HPV infection and cervical changes.
The cone biopsy is used to effectively diagnose abnormalities of the cervix and treat the early stages of cervical cancer.
Risks of Conization
Side effects of cone biopsy include risk of infection, cramping, and bleeding during and after the procedure.
Conization has a higher hemorrhage rate compared to LEEP.
The procedure removes more tissue than LEEP and therefore a greater risk of scarring and damage to the cervix.
Conization is also associated with an increased risk of preterm labor and low birth weight.
Effectiveness of Conization
Conization has been found to have the lowest recurrence rate compared to other procedures. The five-year risk of recurrence is estimated at around 4%.
Cryotherapy or Laser
Cryotherapy and laser are ablative methods used to destroy abnormal cervical tissue. Cryotherapy uses a freezing gas or liquid nitrogen to remove precancerous cells on the cervix. With laser surgery, carbon dioxide is used to destroy abnormal cervical cells.
Pros of Cryotherapy or Laser
The procedure is quick and can be done in-office, usually taking between 10 and 15 minutes.
The risk of preterm labor is not increased as it is with excision methods.
Removes less tissue than excision methods.
Risks of Cryotherapy or Laser
Tissue isn’t available for histologic evaluation, so cells cannot be examined for degree of changes.
Can cause mild cramping during the procedure.
The procedure may cause vaginal bleeding and lead to infection.
Cryosurgery can cause scarring of the cervix, cervical stenosis, which may lead to risks to getting pregnant, staying pregnant, and vaginal delivery.
Effectiveness of Cryotherapy or Laser
Cryotherapy was to be least effective at reducing cervical cancer long-term. It was found to have the highest risk of recurrence of CIN 2/3 and invasive cancer after treatment compared to other methods.
While each procedure carries some risk, there are benefits to each procedure in reducing rates of cervical dysplasia and cancer. We recommend talking to your doctor about your options and what is best suited for your unique situation. Following any procedure, your doctor will schedule a follow-up Pap smear to monitor cell changes over time.
It is important to remember that while the procedures are effective at removing abnormal cellular tissue, they do not remove or suppress HPV activity. Without suppressing the underlying infection, cellular changes can always return, so it is important to continue to monitor the cervix. This continued HPV activity is why supporting the immune system still plays a pivotal role in addressing HPV and preventing long-term complications of the virus.
Mar 04, 2022
5 min read
Adrienne Hill-Strathy
Cervical cancer remains the second most common cancer among women worldwide. Certain high-risk strains of the Human Papilloma Virus (HPV) are responsible for causing cervical cancer.
Around 70-90% of individuals with HPV will clear the virus 12 to 24 months after infection. However, in few individuals, the viral infection can persist and cause cellular changes to the cervix that may lead to cervical cancer.
What allows some people to quickly clear the viral infection and others to develop cancer?
Several identified factors may impact an individual’s ability to clear an infection. These include frequent re-infections, immune health, hormone levels, or infections by more than one HPV type.
Genetic factors also play a role. In this article, we explore the relationship between HPV and genetics.
How Do Genes Influence Cancer?
Genes play a role in directing healthy cellular development by controlling cell growth and cell death.
Genes that control how our cells grow, work, and stay alive are called oncogenes. Other genes, called tumor suppressor genes, keep cell growth under control and initiate cell death at the right time. Cancer occurs when DNA mutations alter the genes that turn on oncogenes or turn off tumor suppressor genes, allowing abnormal cellular growth.
Research has found that high-risk HPV contains special proteins called E6 and E7. These proteins turn off tumor suppressor genes. When these genes are deactivated, cells in the cervix can progress and lead to further gene changes and potentially cancer.
Is Cervical Cancer Heritable?
Research suggests that a familial predisposition to cervical cancer may be present.
If your mother or sister had cervical cancer, your chances of developing cervical dysplasia or cancer are increased. Moreover, the risk increases with the increased degree of genetic relatedness.
A Swedish study found that genetic heritability accounted for 27% of the underlying factors for cervical cancer development. The study also tested the role of the environment but found shared environmental factors accounted for only 0-2% of disease progression. The results showed a greater impact than other cancers like colorectal cancer, lung cancer, and melanoma.
The reason for these genetic correlations is not completely understood. It could be explained by a few factors:
Our genetics may impact our DNA repair pathways associated with CIN3 cervical dysplasia and HPV persistence. Genes have also been associated with supporting viral infection and cell entry.
Genotypes may influence an individual’s likelihood of exposure to HPV. For example, genetics may influence an individual’s sexual or risk behaviors, thereby influencing the risk level of contracting HPV.
Genetics may also influence an individual’s cervical cancer risk through HLA alleles. Seven alleles have been associated with cervical cancer, while another four showed a negative association.
Specific genotypes like BRACA have also been investigated on cervical cancer. It was found that the BRACA1 genotype was associated with a decreased risk of cervical cancer. The same variant is also associated with an increased risk of inherited breast cancer.
Genetics and The Immune System
Cervical cancer may also be driven by genetic factors that influence the immune system, decreasing some women’s ability to fight off infections like HPV.
The immune system is the key factor allowing HPV infections to progress from cervical dysplasia to invasive cancer. The progress from infection to cancer takes several years to decades to develop. The innate and adaptive immune responses are responsible for the regression, persistence, and progression of HPV infections.
For example, women with HPV infections that evolve into high-grade lesions have a reduced immune cellular response. Genetics may also influence the number of immune cells an individual has to defend against infection.
MTHFR Genetic Mutation
Some people have a genetic mutation that prevents them from properly converting dietary folate into its active form (5-MTHF) by a process called “methylation”. This mutation may explain why some women with healthy diets and lifestyles struggle to clear the infection.
The MTHFR mutation increases the risk of several diseases including heart disease, colon cancer, and breast cancer. Studies evaluating the association between genetic variants of MTHFR and cervical cancer show some association between the MTHFR C677T polymorphism and CIN 3. However, further studies are needed to determine the actual cause.
An Emerging Field
The research behind genetic predispositions to cervical cancer and cervical dysplasia is very much still evolving. As more research emerges, we may have more clarity as to what leads some to develop more severe reactions to HPV infection than others.
May 17, 2021
3 min read
Adrienne Hill-Strathy
HPV is very widespread amongst the population. It is estimated that 80 percent of women will contract a strain of HPV in their lifetime. Most of these infections are silent, causing no visible symptoms or side effects within a host.
In about 90 percent of patients, a healthy immune system will typically develop an immune response to regress the virus within a period of 1 to 2 years, with most in fact regressing over the course of a few months.
However, a small number of people who contract an HPV infection may have symptoms or complications that range from low-risk visible papilloma’s on the skin to persistent chronic infections that may develop into precancerous or cancerous lesions.
Here, we outline a few of the most common symptoms of HPV, including potential side effects of HPV vaccination.
HPV Symptoms
Typically, if HPV symptoms do develop, they will either cause visible warts on the surface of the skin or cause chronic infections that persist within the cell tissue and are only detected through clinical examination, like a pap smear.
Warts
The large variety of HPV strains gives rise to several different types of warts on the body surface, face, and genital areas. These warts can be classified into:
Common warts: the common wart is most frequently caused by HPV-2. These warts usually present with an irregular shaped rough nodule that shows up in multiples.
Plane warts: mostly caused by HPV-3, 10, or 28. They cause small and less rough, flesh-colored, or lightly pigmented lesions. Usually on the hands or face. Plane warts have an unusual characteristic in that they can spontaneously regress and cause swelling and a rash at the surface of the skin.
Plantar warts: usually found in 10-14-year-olds. They are contracted through barefoot activity and are found on the bottom of the feet. Plantar warts are typically caused by HPV 1 and 2.
Genital warts: are most frequently caused by HPV 6 and 11. They are renowned for their resilience and ability to continually come back, as well as being both painful and irritating.
Cancerous or Precancerous Changes in the Cells of the Cervix
Only a few of the over 180 different strains of HPV are associated with increased cancer risk.
HPV that causes cervical, anal, or oral cancer is typically caused by a few high-risk strains of HPV that infiltrate the epithelial cells and have developed special mechanisms to evade the immune system.
There are typically no symptoms that HPV is developing into cancer until several years of cell proliferation and development. HPV that has progressed to a stage of cervical cancer may present as symptoms of abnormal vaginal bleeding.
The fact that it takes many years for HPV to develop into cancer is both a positive and a negative for us because it gives us time to detect the virus at an early stage in development before it has progressed into cancer and take action.
It is negative because having no symptoms can prevent some people from being proactive about their health, allowing the situation to progress to a more serious state. Typically, Pap screening should be done every three years from the age of 21 to 65 to screen for these abnormalities.
The HPV Vaccine and Potential Side Effects
Today, we have a vaccine offered as a preventative measure against high and low risk HPV strains, primarily to protect women against cervical cancer.
The Centers for Disease Control and Prevention recommends the HPV vaccine for routine vaccination at age 11 or 12 years. The vaccine may be started as early as age nine.
Females aged 13 to 26 and males aged 13 to 21 are recommended to receive the vaccine. The vaccine is only recommended past the age of 26 for gay, bisexual, transgender, and those who have chronically weakened immune systems.
Gardasil is the most commonly used vaccination, protecting against the two strains of HPV that cause genital warts, and the two strains that are the most high-risk HPV strains, commonly known to cause cancer, such as cervical cancer.
Two doses of the vaccine should be given, the second being 6 to 12 months after the first. If less than 6 months apart, the recipient is of a weakened immune system or is past the age of 15, three doses are required to ensure the vaccination is effective.
It is important to keep in mind that the vaccination does not protect you against all HPV strains, just the most high-risk, so routine screening is still recommended.
Side Effects of Vaccination
Side effects of the HPV vaccine may include:
Injection site irritations such as pain, redness, or swelling
Fever
Systemic reactions such as nausea, muscle pain, malaise, and dizziness
Fainting
The vaccination is quite safe; different types of the vaccine having been studied in almost 75,000 individuals.
These side effects are not commonly experienced, and for most people, it is definitely worth the risk to receive the vaccine than forgo it because of potential mild and temporary side effects.
Feb 01, 2021
4 min read
Green Tea Extract and Cervical Cancer/Warts
Christine Chung
The Greatness of Green Tea
Green Tea Extract is one of the many great ingredients in Papillex™.
Green Tea, also known by its Latin name Camellia sinensis, is high in compounds called polyphenols. Polyphenols are naturally occurring chemicals abundant in plants that have beneficial properties to human health.
The polyphenols found in green tea are specifically beneficial in boosting the immune system in people with HPV. Two polyphenols, in particular, epigallocatechin gallate (EGCG) and polyphenol E are effective in the treatment of cervical lesions and warts caused by HPV.
These master players, EGCG and polyphenol E, are antioxidants that help protect cells from oxidative stress and fight inflammation. EGCG is also associated with relaxation and keeping you alert. It is now recognized for the prevention of several conditions including autoimmune disease, heart disease, neurodegenerative disorders, and Alzheimer’s.
What does the research say?
A handful of studies have begun investigating the use of green tea extract on HPV clearance, preventing cervical cancer, and eliminating genital warts caused by HPV. Green tea has been shown to influence a variety of mechanisms that are favorable towards preventing and treating HPV-related lesions.
Most notably, green tea extract has been found to play a role in regulating immune molecules called T cells. T cells are important immune system modulators. EGCG from green tea extract has been found to increase the production of T regulatory cells, helping regulate and balance the immune response.
How do these compounds impact HPV?
A review investigating the potential mechanism of action of green tea extract on HPV cells found that EGCG and polyphenol E specifically stopped the spread of HPV-related cancer cells by halting cervical epithelial and cancer cell growth. The study also found the compounds had a greater effect on squamous cells and less in adenocarcinoma cells. EGCG was also found to have a stronger growth inhibition than polyphenol E.
One study conducted in South Korea of 51 patients evaluated the use of green tea extracts, polyphenol E and EGCG, in a form of ointment or capsule in patients with mild to severe cervical dysplasia. The local ointment was applied to half the participants twice a week. The patients that received the oral treatment took 200 mg capsules every day for 8-12 weeks.
The findings showed an overall reduction of 69% of cervical dysplasia lesions in patients who received green tea extracts, compared to only 10% improvement in the group with no green tea treatment. The participants in the ointment application had a slightly better response.
How is green tea extract used to clear HPV warts?
Warts are another pesky symptom of HPV. Green tea extract has been studied as a treatment option for both plantar warts and genital warts caused by HPV.
A study in the British Journal of Dermatology has found the topical treatment of green tea to be both effective and safe. The study used an ointment containing 10% green tea catechins and evaluated over 1000 adults with external genital and perianal warts. The participants that used the ointment containing green tea extract were found to be 2-folds more effective than the participants without green tea in their ointment. The green tea cleared existing warts and prevented recurrence 12 weeks after treatment.
All of this promising research shows that green tea extract can serve as a worthwhile natural therapy for men and women with HPV associated cervical lesions (CIN) or warts.
Is it safe for me to take?
Green tea has an excellent safety profile in moderate doses, both orally and topically, and is associated with many health benefits ranging from heart health to anti-cancer properties.
The efficacy and safety of this topical green tea extract were confirmed by one of the few clinical trials available, including 397 adults with HPV genital warts. People who applied the treatment 3 times a day had complete clearance of warts in 16 weeks.
So, do I just drink a lot of tea?
Now you may be wondering, how many cups of green tea do I need to be drinking to benefit from these positive effects?
Unfortunately, to get enough of the green tea catechins to have an actual effect on prevention and healing, you would need to drink a ridiculous amount of green tea every day. Something in the 20 to 30 cup-per-day range! Nevertheless, the data does suggest that regular and high consumption of green tea may contribute to the prevention of cervical cancer.
To obtain the optimal dose, we recommend consuming green tea extract as a supplement. Luckily, there are many high-quality products, including Papillex™, that can provide you with a therapeutic dose to help your body naturally rid of HPV.
What about topical application?
The FDA approved a topical cream called Veregen®, a standardized extract of green tea leaves, containing 85% catechins, most abundant being EGCG. The compound is also being evaluated for its use in skin cancers like basal cell carcinoma. The topical cream can be applied in a thin layer twice daily to affected areas.
How Can Papillex Help?
Attaining the therapeutic daily dosage of green tea can be a challenge without supplementation. Papillex has made it easy for you, combining high-quality therapeutic level extracts of EGCG from green tea containing in combination with several ingredients that work together to boost the immune system to respond to HPV naturally.
Papillex is a simple and effective way to support your body and immune health.
Jan 15, 2021
4 min read
Superfoods and Juice Recipes to Fight Cervical Cancer
Christine Chung
Human beings are naturally programmed to eat foods that are healing and beneficial for our bodies.
However, we all know that it isn’t always easy to follow this inner wisdom.
When we really tap in and listen, healthy eating can become second nature – it’s truly conscious eating.
Knowing the value of the foods you eat, as well as where they’ve come from and how to best infuse your body with the nutrients it needs, helps you help your body and allows you to thrive.
Excellent HPV Protection Properties
So, which foods should we be packing our kitchens with to protect against HPV & cervical cancer?
In general, stocking up on green leafy vegetables like spinach and romaine lettuce (packed with lutein and carotenoids), broccoli and cabbage (which have indole-3-carbinol) plus foods rich in antioxidants, vitamins C, E, and A (oranges, grapefruit, raspberries, carrots, and kale) offer protection from cancer by preventing the growth of free radicals in your body.
Free radicals
One way a healthy diet can positively impact health is by stabilizing free radicals in the body. Free radicals are molecules that contain an unpaired electron in their atomic structure. This electron is highly reactive in the body, damaging cell membranes, DNA, proteins, carbohydrates, and lipids.
The body naturally produces free radicals during normal metabolic processes. However, we can also obtain free radicals from external sources like exposure to cigarette smoke, air pollutants, and chemicals.
Cancers often stem from free radical diseases, as defects and oncogene activation get initiated by free radical reactions.
Antioxidants, on the other hand, are molecules that can donate an electron to a rampaging free radical and neutralize it, reducing its capacity to cause damage. Consuming a plant and animal-rich diet, supplies the body with these antioxidants.
Vitamin C, for example, is one antioxidant found in both animals and plants. It cannot be made by the body so we need to obtain it from our diet. The compounds from vitamin C reduce oxidative reactions in the body, helping maintain balance and reduce disease.
Top 3 Superfoods
The super foods we’ve included on this list are known for their exceptional HPV & cervical cancer fighting nutrients.
Green Tea
Green tea has also been shown to suppress urokinase, a type of enzyme that is thought to play a key role in the spread of cancer cells.
Epigallocatechin gallate, or EGCG, and polyphenols E showed the inhibition of cervical dysplasia and cancer cell growth in cell studies. These studies actually show EGCG stopping the cancer cells right in their path and inducing cell death.
Green tea extracts in ointment topically AND capsule forms were also shown to treat cervical lesions!
Papaya
Papaya is one of the best sources of vitamin C, and carotenoids. Papaya’s nutrient combo has been associated with lower HPV infection rates and lower risk of cervical lesions.
Low levels of carotenoids, found in many fruits and vegetables, was associated with increased risk of persistent HPV infections.
Vitamin C levels were also seen to be significantly lower in cervical cancer patients with high positive rates of HPV 16 and 18, the cancer-causing strains of HPV.
Turmeric
In recent years western medicine has started to pay attention to this extraordinary root. The compound found in turmeric that induce self-destruction of harmful cells is called Curcumin.
Curcumin contains a class of compounds called curcuminoids that act by suppress regulatory molecules and signaling pathways involved in upregulating cancers and other diseases.
Curcumin has been shown in research to not only eliminate HPV infections, but also help treat cervical cancer. It has been previously seen to have protective effects against cancer in HPV and non-HPV related cancers.
Recipes
Incorporating HPV fighting superfoods into your diet can be easy and delicious, which is why we’ve included three of our favourite easy recipes that will allow you to incorporate more of these ingredients into your day to day menu.
If you don’t have all of the ingredients, creativity is key when it comes to keeping things fresh in the kitchen – so sub in what you do have and challenge yourself to add at least one of these foods into your life daily.
So, here's a few of our favourites :)
Papaya Coconut Green Smoothie
This smoothie requires only a few ingredients.
The papaya provides a boost of those HPV fighting carotenoids and vitamin C, while the kale is rich in antioxidants called quercetin and kaempferol. Add in some coconut milk and flakes for some extra creaminess and help keep you full.
Frozen papaya
Coconut milk
Coconut flakes
Fresh Kale
Image via Loving it Vegan
Matcha Green Tea Smoothie
Drink this smoothie in the morning for a perfect hint of caffeine or it works as an afternoon pick.
The subtle green tea flavor gives you cancer-fighting benefits of EGCG and a dose of vitamin C and carotenoids from the mango.
Spinach provides an extra hit of folic acid another important vitamin in protecting against HPV infections.
Mango (fresh or frozen)
Frozen Bananas
Handfuls Baby Spinach
Matcha Green Tea Powder
Coconut Milk
Carrot & Turmeric Tonic
Juicing can also be a great and delicious option to get in your daily nutrients.
This juice provides a delicious mixture of carotenoids from carrots and cancer-fighting curcuminoids from turmeric.
Lemons are full of vitamin C, folate and antioxidants.
The ginger adds a flavourful bite and naturally reduces inflammation in the body and stimulates the immune system.
Golden Delicious Apple
Turmeric
Ginger
Lemon
Carrots
Cucumber
Oct 15, 2020
4 min read
A Cure For HPV? Or Too Good To Be True?
Christine Chung
Recently there has been buzz online surrounding a cure for HPV.
Is there a cure? Will it reverse the damage that’s already occurred? Do I have to go to Mexico?
Learn about HPV and whether or not there is a cure here.
What is Human Papillomavirus?
Human Papillomavirus is one of the most common viruses that affect humans and the most common sexually transmitted infection in the United States.
It affects countless men and women every year. That’s right - HPV affects men, too.
The Center for Disease Control and Prevention estimates that almost every sexually active adult will get HPV at some point in their lifetime. It can be spread by skin-to-skin contact, most commonly through sexual activity.
How does it become Cervical Cancer?
HPV causes 91% of cervical cancer. However, not all HPV infections can or will cause cancer. Only a few out of the 100+ known strains of HPV have the potential to become carcinogenic.
Most infections will present with no symptoms at all and be cleared naturally over time with a robust immune system!
However, when your immune system is weakened, or when your body is invaded by a strong strain of HPV, cell proliferation can occur. This is the growth of abnormal cervical cells, which can lead to cervical intraepithelial neoplasia (CIN), and eventually, cancer.
Is there a cure?
The short answer is no. There is no magic treatment that will completely eradicate HPV or reverse all damage. But, outcomes for HPV and cervical cancer are very good with routine screening and well-informed treatments.
How can we naturally respond to HPV?
There are many ways to naturally respond to symptoms and complications of HPV including genital warts and cervical dysplasia. The two most popular treatment options are Cryotherapy and LEEP.
Cryotherapy
Cryotherapy uses liquid nitrogen, a very cold substance, to freeze off abnormal cells from your cervix. Cryotherapy is also a commonly used procedure for wart removal. This treatment kills off the cancerous cells allowing for new growth of healthy cells in its place.
How it works: Similar to a Pap test, you will be laying down and your doctor will insert a speculum into your vagina. Instead of the brush used for Pap testing, your doctor will use a cryoprobe, holding it at certain places on your cervix to freeze the cells. The whole process should only take 5 minutes or so. You may feel some cold sensation or mild cramping.
The result: Cryotherapy is quite effective for eliminating abnormal cells with a low recurrence rate.
Loop Electrosurgical Excision Procedure (LEEP)
LEEP is another cervical cancer prevention treatment, where abnormal cervical cells are removed from your cervix using a small electrical wire loop.
How it works: Similar to a Pap, you will be lying down while your doctor inserts a speculum into your vagina. Numbing cream will be applied, and your doctor will use the wire loop to remove the cells. The electricity of the loop cauterizes the blood vessels in the area to prevent bleeding. The whole process should take about 10 minutes.
The result: Highly effective. LEEP will usually remove all the abnormal cells. One study even showed LEEP was more effective than cryotherapy.
Other treatments
Conization, or a cone biopsy, removes a cone-shaped section of the abnormal tissue for lab examination of CIN.
Surgical removal, including electrocautery, laser surgery, and excision.
Photodynamic therapy, combined with Aminolevulinic acid, has been a novel treatment generating a lot of hype in the media as the “cure to HPV”. Photodynamic therapy uses wavelengths to damage the surface layer cells affected by HPV. The treatment poses a lower risk to women looking to get pregnant in the future. However, the treatment is still in its infancy. Further quality research is needed to determine its long-term effectiveness.
You may read conflicting information about these treatments online. You and your doctor will know what’s best for you; every treatment should be specific to each case.
Vaccination
An HPV vaccine exists that protects against two strains of HPV, HPV 16 and 18, that cause genital warts and two strains that most commonly cause cervical cancer.
For the vaccine to be effective, it must be given before the virus has been contracted. Typically, it is recommended for females aged 13 to 26 and males aged 13 to 21.
While the vaccine protects against a few of the high-risk and common strains, it is important to keep in mind that the vaccination does not protect against all HPV strains. Several other high-risk strains exist and are being detected in patients that have been vaccinated, so routine screenings are still recommended.
HPV Vaccines typically take place between the ages of 13 and 26
Are new vaccines on the way?
A new immune-based vaccine was recently developed that may be effective in treating women with existing HPV and precancerous changes on the cervix.
The therapeutic vaccine injects a specific protein that triggers the immune system to attack high-risk HPV which is known to cause cervical cancer.
A randomized controlled trial that followed women for over two years post-vaccination found that those who received the vaccine were more than twice as likely to see their CIN eliminated compared to those who received placebo.
The vaccine shows promising evidence that it may not only eliminate the lesions but also the HPV infection. However, research is still in its infancy and more long-term trials are needed to determine the safety and effectiveness of treatment.
Consult your doctor to work out the best plan of action for you to stay healthy
Natural Methods to Fight HPV
Most HPV infections can be easily cleared by a strong, healthy immune system. Immunity can be heavily supported and improved through our daily lifestyle choices, including:
Eat plenty of fruits and vegetables – fruits and vegetables contain many essential vitamins and nutrients to keep your body functioning at its best! These food groups are specifically high in antioxidants, which may help neutralize bad molecules floating around in your body. The food we eat also plays a crucial role in supporting our gut health, where nearly 70% of our immune system is housed.
Quit smoking – smoking significantly increases your risk for HPV-related cancers, and even second-hand smoke exposure increases your risk. While cutting down your cigarette count will still have an effect, nothing is quite as good as quitting entirely.
Reduce alcohol consumption – high consumption of alcohol is related to several negative outcomes, including a reduction of immune function.
Drink green tea – green tea has been shown in many studies to have immune benefits and anti-cancer effects, some specific to HPV.
Exercise to sweat – movement is important to improve your circulation for immune benefits and general well-being, while sweating will help release toxins from within your body.
Get adequate sleep – getting 7 to 8 hours of high-quality sleep is important to regulate your bodily functions, including your circadian rhythm. All of these factors have a distinct effect on your ability to fight infections.
Keep a positive mindset – positivity has several health benefits, including stress reduction which will keep your immune system strong.
Supplement your diet appropriately – for some people, it can be difficult to get the nutrition they need to keep their immune system working at 100%. Papillex is a supplement specifically designed to help both women and men respond to HPV naturally and give their immune systems the support it needs.
Could Medicinal Mushrooms be the Cure?
Promising new research on the benefits of a shiitake mushroom compound called Active Hexose Correlated Compound (AHCC) could help eradicate persistent HPV infections. Two small human clinical research trials have been conducted by Dr. Judith A. Smith, Pharm D., an associate professor in the Department of Gynecologic Oncology and Reproductive Medicine at the University of Texas.
The studies have found daily intake of 1-3 grams of AHCC eradicated the virus in 44-66.7% of patients with high-risk HPV status after 3-7 months.
Medicinal mushrooms have been used for centuries in traditional medicine to support the immune system and fight viral infections and cancers. You can learn more about AHCC for HPV here.
While the trials have been successful so far, more research is needed to determine if it is effective. Patients should talk with their doctors before starting any supplementation.
The Ultimate Cure-All?
It seems we are always looking for the ultimate cure-all - that one thing that will do the trick and solve our problems. Unfortunately, a magic pill rarely exists, and instead, a more nuanced and multi-faceted approach is needed. This nuanced approach applies when we talk about curing HPV.
Sep 15, 2020
6 min read
Apple Cider Vinegar For Cervical Dysplasia
Adrienne Hill-Strathy
Is Apple Cider Vinegar Actually Good for You?
In the web of natural health remedies, it is hard to find an ailment that apple cider vinegar can’t help treat.
Apple cider vinegar is claimed by many as a miracle remedy for everything from soothing digestion to clearing acne.
Despite the popularity, and longstanding legend of the vinegars' use, we wanted to investigate if the science has been able to back up the main claims. Including whether it can be beneficial in the treatment of cervical dysplasia.
What Is Apple Cider Vinegar?
Apple cider vinegar is a fermented apple juice.
It is made by combing a mixture of chopped raw apples, sugar, and water in a sterilized glass jar for several weeks. As the mixture ferments the sugar gets converted into alcohol and acetic acid.
The vinegar can be added to salads and sauces for an added flavor punch. Wellness shops and juice bars have also turned apple cider vinegar into immune shots, but you need to be a bit braver to go for them!
Perceived Health Benefits
The health benefits of the vinegar are thought to come from acetic acid, which has been shown to possess antifungal and antiviral properties.
The acid has been studied in vitro for its role in inducing tumor necrosis factor (TNF), a pro-inflammatory immune molecule that facilitates cell survival, proliferation, and death.
Acetic acid has been linked to increased cognitive functioning. The acetic acid and bacteria found in traditional foods like apple cider vinegar have a unique and highly pure membrane lipid component called sphingolipids that are also components of brain tissue. Ingestion of sphingolipid-derivatives find improvements in cognitive function.
Acetic acid in ACV is though to increase cognitive function
Apple cider vinegar also contains probiotics that form during fermentation. When consumed, these bacteria supply the body with beneficial microbes important for gut function and our overall health.
The strongest evidence around the health impacts of apple cider vinegar comes from its impact on cardiovascular health and diabetes. The vinegar may protect against heart disease due to its chlorogenic acid content. It may also have a positive effect on blood lipid levels, making it an attractive addition for managing hyperlipidemia and regulating blood sugar.
However, the research supporting apple cider vinegar in other areas like improving constipation, weight loss, acid reflux, teeth whitening, and acne remains anecdotal. More research is needed to verify whether actual health benefits exist.
Apple Cider Vinegar and HPV
Likewise, there are no studies to date investigating the role of apple cider vinegar on cervical dysplasia.
Anecdotal evidence has claimed apple cider vinegar can be used topically as a treatment for warts. The remedy is thought to be due to the acid, which burns the wart and causes it to peel off from the skin.
But again, no studies have specifically looked at whether application of the vinegar improves clearance rate of warts and elimination of HPV.
Should You Consume Apple Cider Vinegar?
Apple cider vinegar can be a tasty addition to salad dressings, sauces, and meals. It adds a pungent flavor and delicious taste.
Health wise, incorporating the vinegar into your regime can add some extra nutrients, probiotics, and beneficial compounds from the acids to potentially boost brain power and keep your blood glucose in check.
But the vinegar is not a saving grace to your health problems. Incorporating more nutrient dense and whole foods in your diet, getting enough exercise, reducing stress, getting quality sleep, etc. is likely to have a greater impact on your health than an extra tablespoon of vinegar.
I also wouldn’t overdo it on the vinegar. Apple cider vinegar is very acidic and difficult to consume in large quantities. The acid can damage the enamel on your teeth and upset the stomach.
Topical application of the vinegar can also be rough on the skin. When applied to the face and neck, vinegar should always be diluted to avoid irritation.
Aug 01, 2020
3 min read
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