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Does Birth Control Worsen HPV?

Does Birth Control Worsen HPV?

Victoria Gasparini
If you’re reading this, you are likely one of the many people who are taking a closer look at their health and how their daily living impacts their experience with HPV. Well, I’m glad you’re here and I am even more glad that you are taking a proactive approach to your healthcare. This truly is the first step to healing. Okay, so one of the most frequent questions I answer in the direct messages on Papillex’s instagram is “how does birth control impact HPV?” Well, the good news is, I did the research for you. Let’s start with a brief background on how the pill works To really grasp the connection between birth control and HPV, let's first explore the mechanisms behind contraceptive methods. From oral contraceptives to patches, injections and IUD’s, these methods primarily work by altering our natural hormonal levels, affecting the menstrual cycle and ovulation and therefore preventing pregnancy. But in today's day and age, many women take/use methods of birth control to suppress hormonal conditions like acne, hair loss, hair growth and irregular or painful periods. Because of this, A LOT of women are on the pill (or some version of it). With the high prevalence of HPV and the extensive use of contraceptives, it is crucial we understand how one affects the other, namely - how birth control impacts HPV. How birth control impacts HPV Recent studies have explored the potential link between hormonal contraceptives and the persistence of HPV infections. While research is ongoing, there is evidence to suggest that hormonal contraceptives might influence the likelihood of HPV infections lingering in the body. How can this be?  The interplay between hormonal contraceptives and HPV may be rooted in hormonal changes that affect the immune system. Understanding these mechanisms is crucial, as the immune system plays a pivotal role in combating and clearing HPV infections.  Studies have found that the long term use (i’m talking 10+ years) of oral contraceptives has a four-fold increased risk of developing cervical cancer. A study of over 46,000 individuals found that those who used OCP’s had a significant;y higher rate of cervical cancer and abnormal cervical cell growth than non-users. The research also suggests that the risk decreases after stopping the pill. Considerations for Women Using Birth Control Address nutrient deficiencies Nutrient deficiencies are a real concern for those on OCP’s. The pill can deplete essential nutrients like riboflavin, B6, folic acid, vitamin C, and zinc. We know these nutrients are important players in supporting the immune system and some deficiencies in these nutrients have even been linked to persistent HPV.  Address gut health Moreover the OCP is known to alter the gut microbiome. The pill may increase risk for intestinal permeability, dysbiosis and candida overgrowth. A healthy gut is another foundation for our immune and overall health, impairing this system can have a widespread impact on the rest of the body.  Keep up with your regular screenings For women using hormonal contraceptives, it's essential to prioritize regular health check-ups. This includes screenings for HPV, ensuring that any potential infection is detected and addressed promptly. Open communication with healthcare providers is key, allowing for informed decisions regarding both birth control methods and overall reproductive health. Try other methods of birth control that are non-hormonal This may not be suitable for everyone and that is totally okay. If possible, condoms are a favorable form of birth control when it comes to protecting against both pregnancy and STI’s. Condoms form a barrier between mucosal contacts and are found to be 98% effective at protecting against STI’s like chlamydia and gonorrhea. However, because skin to skin contact can occur with condom use, they are less effective at preventing the spread of herpes, genital warts and HPV. Nevertheless, condom use is still warranted and recommended as there is still a reduction in risk of spread compared to no condom-use.  The IUD is another potential option. The hormonal IUD delivers a small amount of progestin to the local uterine tissue. Some individuals notice side effects such as mood changes, bloating, cramping and reduced menses. There is however a non-hormonal IUD option, the copper IUD. This prevents pregnancy by releasing copper in the uterus that is toxic to sperm. The copper IUD does not suppress ovulation and the most common side effect is heavier menstrual bleeds. The benefit is that the copper IUD has no hormonal impact, and therefore does not impact clearance of HPV.  Overall, we are still mostly unclear on how the IUD impacts cervical dysplasia. Please also keep in mind that the iUD does not protect against STI’s. In navigating the complexities of reproductive health, awareness is our strongest ally. By understanding the potential interplay between birth control and HPV, you can make an informed decision about your contraceptive methods and overall health. Regular screenings and open communication with healthcare professionals are vital steps toward maintaining a healthy and informed reproductive life.
Nov 13, 2023
4 min read
How Does Birth Control Impact HPV?

How Does Birth Control Impact HPV?

Adrienne Hill-Strathy
One question we commonly get asked is how birth control may impact HPV. Birth control is commonly used by women of reproductive age to prevent pregnancy. Today, many also use birth control to support hormonal symptoms like PMS, acne, dysmenorrhea, and heavy menstrual bleeding. Many factors are often considered when choosing a birth control that is right for you. In this article, we will explore three popular birth control methods and things to consider with regard to HPV. Let’s Start With The Oral Contraceptive Pill (OCP) The OCP is a hormone modulating birth control. The OCP contains estrogen and progesterone, two hormones involved in the reproductive cycle. Individuals who menstruate often go on the OCP to prevent pregnancy as well as control hormonal symptoms like premenstrual syndrome (PMS), acne, painful periods, and heavy menstruation. The OCP is speculated to increase HPV persistence and progression. The pill may do this by altering certain genes as well as increasing the cervical maturation process which allows cell proliferation of HPV. By taking a synthetic hormone you may change the susceptibility of the cervical cells to high-risk infections. Moreover, because the OCP contains growth-stimulating hormones estrogen and progesterone, there is some risk that they can increase the risk of cervical cancer. Studies have found that long-term use (10 years or longer) of oral contraceptives has a four-fold increased risk of developing cervical cancer. A study of over 46,000 individuals found that those who are used OCP had a significantly higher rate of cervical cancer and abnormal cervical cell growth than non-users. The research does also suggests that the risk decreases after stopping the pill. HPV rates decline with time since quitting. The OCP may also lead to nutrient deficiencies associated with HPV.  The pill can deplete riboflavin, vitamin B6, folic acid, vitamin C, and zinc. We know these nutrients are important players in supporting the immune system and some have even been specifically linked to HPV. Moreover, the birth control pill is also known to alter the gut microbiome. The pill may increase leaky gut, dysbiosis, and candida overgrowth. A healthy gut is another foundation for our immune and overall health. Impairing this system can have a widespread impact on the rest of the body. Considering these impacts, it is important to support nutrient levels and gut health if taking the OCP. We recommend optimizing dietary intake of diverse fruits and vegetables, fibers, and probiotic foods as well as considering supplementation. Condoms Condoms are a favorable form of birth control when it comes to protecting against Sexually Transmitted Infections (STIs) and pregnancy. Condoms form a barrier between mucosal contacts and are found to be 98 percent effective at protecting against STIs like chlamydia and gonorrhea. However, because skin-to-skin contact can still occur with condom use, they are less effective at preventing the spread of herpes, genital warts, and HPV. That’s right. Unfortunately, HPV can still be transmitted through condom use. Nevertheless, condom use is still warranted and recommended. Some studies have found that the risk for genital warts and the grade of cervical intraepithelial neoplasia (CIN) was reduced in condom users. Condoms also protect against other STIs and infections that can contribute to co-infections and impair the vaginal microbiome. IUD The intrauterine device comes in both a hormonal and non-hormonal form. Both are inserted into the uterus for long-term, effective pregnancy prevention. The hormonal IUD delivers a small amount of progestin to the local uterine tissue. Some individuals notice side effects like changes in mood, bloating, cramping, or reduced menstruation. The IUD can also get displaced and in rare cases perforate the uterus. The hormonal release of the IUD is lower than the OCP. The IUD releases one hormone, progestin, at a dose of fewer than 20 micrograms each day. Whereas the OCP releases 1 milligram of progestin and 0.02 to 0.06 milligrams of estrogen each day. The non-hormonal option is a copper IUD that prevents pregnancy by releasing copper in the uterus that is toxic to sperm. The copper IUD will not suppress ovulation and the most common side effect is heavier menstrual bleeding. While the copper IUD has no hormonal impact, the heavier menstrual bleeding can contribute to iron deficiencies and anemia. What’s The IUD Connection with HPV? Some studies have shown that sexually active individuals with the IUD group had higher clearance rates of HPV. While others, when adjusted for other variables, found no association between IUD use and HPV infection or persistence. Research comparing the difference between the copper IUD and hormonal has found mixed results. One study found the hormonal IUD to have a lower risk of high-risk HPV than the copper IUD. Another study found the copper IUD to have a lower risk of cervical neoplasm. Overall, it is unclear how these devices are influencing cervical dysplasia and HPV infections or the mechanism of action. It is also important to note that the IUD and OCP do also not protect against other STI’s like chlamydia and gonorrhea, while condoms do. So how can you decrease your risk of HPV? You are probably thinking, what then can I use to protect myself against HPV and STI’s? Currently, condoms and engaging with fewer sexual partners are the best ways to reduce your risk of exposure to HPV. However, we understand that other factors are involved. We always recommend talking to your health practitioner to help decide what is best for you. Because most sexually active individuals carry some form of HPV and it can be transmitted through skin contact, no form of birth control can completely protect you. More importantly, you can support your whole-body system so that if you are infected, you are better equipped to defend against pathogens and viruses.
Dec 13, 2021
4 min read
How Do Your Hormones Influence HPV?

How Do Your Hormones Influence HPV?

Adrienne Hill-Strathy
Hormones play an important role in the body’s chemical messaging system. Hormones help direct and regulate many bodily processes. Like most systems, hormones operate within a delicate balance that can lead to undesirable symptoms and disease when disturbed. We have talked a lot about the importance of lifestyle and dietary factors as well as genetics and nutrient levels in the progression of HPV. But how do hormones fit into all of this? Here is what we know. Hormones and HPV The role of hormones in the development of HPV first started to be explored following findings that HPV infections were more common in individuals on oral contraceptive pills (OCPs) and women with multiple pregnancies. There is a two to four-fold increase in HPV persistence in individuals on the OCP than non-OCP users. The risk increases the longer the individual is on birth control and declines once they go off it. The mechanism that might explain this is the increase in synthetic estrogen delivered through the OCP, leading to an increase in estrogen in the blood. In individuals with seven or more pregnancies, cervical cancer risk increases 3.8-fold as well. Like the OCP, pregnant women are exposed to elevated estrogen levels, which may explain the correlation. To further understand the estrogen-HPV link, mouse studies have been conducted. In one study mice were injected with estrogen for 6 months or 9 months. All mice in the study developed cervical tumors. However, the mice that were given estrogen for longer (9 months, instead of 6 months) showed a significant increase in the number of tumors and their size. Moreover, the mice treated for less time saw a reduction in tumors compared to those treated for 9 months. This suggests that the longer the exposure to estrogen, the higher incidence of cervical tumor number and size. The study also helped shed light on the part of cancer development impacted by estrogen. Because tumor growth was seen in all mice, estrogen appeared to initiate tumor development. Additionally, the increased growth in the 9-month group also supports estrogen’s role in cancer progression. It is important to note that this study was done in mice models and therefore may not be replicable in humans. Nevertheless, these findings may warrant more caution used with OCPs in HPV-infected individuals and increased screening in women with more pregnancies. A Bit About The Hormone Estrogen Estrogen is a sex hormone. Both males and females carry this hormone, but it plays a larger role in the development of the female reproductive tract. Estrogen is typically released cyclically during the menstrual cycle to stimulate the growth of the egg follicle and the endometrium lining to prepare the uterus for a possible pregnancy. Estrogen also contributes to many other bodily processes like cognitive health and the cardiovascular system. Estrogen levels fluctuate among different individuals and can vary over the month and lifetime. The fluctuations can alter growth processes in the body, influence mood, and create symptoms like hot flashes during menopause. While estrogen generally supports bodily processes, the hormone is carcinogenic in certain doses and can contribute to the formation and growth of tumors. Excess or lost estrogen can also lead to disruptions in the menstrual cycle and increase symptoms of premenstrual syndrome. Other Estrogen Exposures In addition to OCPs and pregnancy, estrogen levels may be increased through other external sources or xenoestrogens. Many foods, environmental contaminants, and personal care products have been found to contain hormone modulating chemicals that mimic estrogen in the body. Accumulated exposure to these compounds may disrupt normal hormone levels and contribute to estrogen-related cancers. Research has found an increased risk of gender-related cancers and xenoestrogen exposure. However, we currently do not have a good understanding of the cumulative impact of these hormone disruptive chemicals on cervical cancer. How to support healthy estrogen levels Avoid the OCP: Given the strong association between OCP and HPV, alternative birth control options may be preferred to reduce the risk of HPV. Buy organic foods: pesticides, chemicals, hormones, and antibiotics added to some foods can alter natural hormone levels in humans. Focus on antibiotic-free and organic produce and meats as much as possible to limit exposure to harmful estrogens. Eat your fruits and vegetables: eating a diversity of plant foods supplies the body with the micronutrients and antioxidants to support healthy detoxification. The liver and gastrointestinal system are primarily responsible for metabolizing and eliminating estrogen to keep them in a healthy balance. Green leafy vegetables and cruciferous vegetables (Brussel sprouts, kale, cauliflower, cabbage) are especially helpful in supporting liver metabolism. Aim for 7-10 servings of plants a day. Consume flaxseeds: flax is a phytoestrogen, a form of estrogen we get from foods. Phytoestrogens have been found to support healthy hormone levels. Aim for 1-2 tbsp of ground flaxseed per day.
Oct 04, 2021
4 min read

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