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How Managing Blood Sugar Can Help You Heal HPV

Victoria Gasparini
Did you know that nearly 80% of non-diabetics have glucose spikes everyday, without even knowing it. Many of us go about our daily lives dealing with digestive complaints, mood swings, PMS, insomnia, accelerated aging, infertility, hormonal imbalance, weight gain, cravings and increased susceptibility to infections - without asking why. Glucose spikes can actually be the root cause of these symptoms. In fact, glucose spikes are actually more harmful to our health and well-being than a higher, but steadier glucose level. What are glucose spikes? Glucose is a simple sugar that is an essential fuel source for the body and brain, and is a necessary molecule in our diets. However, with an overabundance of high-sugar, carbohydrate-rich foods in our modern day diets, our body’s have to respond to much higher levels of glucose than we are wired for.  When we eat a food rich in simple carbohydrates, like a bowl of cereal for example, our body breaks it down into simple sugars and transports these sugars to the bloodstream. Once there, the pancreas will pump out insulin which acts as a transporter, bringing glucose (sugars) into the cells. When this happens, our glucose spikes and then drops really low, usually causing us to feel an immediate satisfaction, followed by increased cravings, sleepiness, and more. Though this is a normal and healthy response to high amounts of sugar circulating the blood, if there is a chronic, excessive intake of glucose, and therefore a chronic release of insulin into the bloodstream - we often end up with something called Insulin resistance, where our bodies no longer respond as efficiently to insulin, and we end up with lots of free-floating sugars in the bloodstream that should not be there. Insulin resistance is a precursor to diabetes, and is often seen in women with PCOS as well. How do glucose spikes impact your ability to combat HPV? Okay, so what do glucose spikes have to do with your ability to clear HPV? Well, research finds that glucose spikes and insulin resistance both contribute to malfunctioning immunity and the inability to effectively fight off infections. One study found that glucose spikes inhibited microbial killing and phagocytosis, as well as increased the production of inflammatory cytokines in otherwise healthy subjects. Trials continue to show that by managing glucose spikes, we can reduce susceptibility to infection and allow us to create healthy immune responses to infections when necessary.  Because HPV is a viral infection, supporting the immune system's ability to fight infections is the most important effort you can make when healing with HPV.  What causes glucose spikes? Many lifestyle and dietary habits can be contributing to glucose spikes. As mentioned above, simple carbohydrates on their own, like a bowl of cereal, coffee drinks on an empty stomach, dried or juiced fruits, and other high-sugar foods all contribute to glucose spikes and the susceptibility to insulin resistance seen in diabetics and patients with polycystic ovary syndrome (PCOS).  But it is not just diet that leaves us vulnerable to glucose spikes. PMS, lack of sleep, and genetics all play a role in our susceptibility to glucose spikes and insulin resistance as well. Aside from not being able to change or control your genetics, there are many dietary and lifestyle changes (surprisingly some pretty easy ones, too) that can lessen these spikes and thereby reduce your symptoms.  What can we do to lessen glucose spikes? Below are 5 easy-to-try tips for managing glucose and helping your body fight HPV. Pair your carb-heavy foods with a healthy fat or protein source. Research finds that glucose spikes are significantly reduced when we pair our carbs with fat or protein. For example, eating a slice of white bread with jam will create a much more drastic glucose spike than if you ate your bread with a nut butter (fat) and maybe some hemp hearts (protein).  With this amazing tip, you can eat your favorite goods, while being smart about glucose control. Combining these carb and starch heavy foods with fibre, fat and/or protein creates a much smaller glucose spike and prevents us from that post-glucose crash. This helps us achieve a steady mood, less cravings, more satiety and a better immune response. Save the best for last The order in which you eat your food actually has a significant impact on your glucose spike. For example, if your plate has salad, french fries and chicken - it is actually best to start with your salad, then eat your protein, and save those yummy french fries for last.  The science behind this is that veggies contain a ton of fibre, which creates a sort of “fibre mesh” in the small intestine, delaying gastric emptying and lessening the glucose response to whatever else is on your plate. Studies have found that by simply eating your food in this order, you can reduce glucose spikes by up to 73%.  Additionally, if your salad has vinegar on it, even better. Research finds vinegar before meals reduces your glucose spikes by 30%. So, leave your carbohydrate-rich foods for last to reduce your glucose spike.  Go for a walk after meals This is a very simple and effective technique to reduce glucose spikes. After a carb-heavy meal, head outside and walk, or even just get active for 10 minutes. When we are active, our muscles need energy. A fast way for those muscles to get energy and help you power through your movement, is to take up glucose that is floating through the bloodstream. This is an awesome way to reduce glucose spikes while also releasing those happy chemicals we get when we move our bodies.  Get adequate rest Those that do not get much sleep are at an increased risk of glucose spikes throughout the day compared to those who get 7-8 hours of quality rest each night. Prioritize sleep for better glucose management.  Try AHCC Not only is AHCC wonderful for supporting your immune response with HPV (and other viral infections), but there’s actually research that finds AHCC can reduce glucose spikes and help us to better manage our blood sugars.
Jun 27, 2022
5 min read

HPV: 5 Things Every Woman Should Know

Victoria Gasparini
An HPV diagnosis can leave one feeling vulnerable, scared, overwhelmed and even ashamed. So when you take to google to find stories of others dealing with HPV, it can be disappointing to realize that there are not many resources associated with empowering, educating and empathizing with others going through a similar experience.  At Papillex, our goal is to be that voice. We want to ensure that you have access to informative content, quality supplements, and act as a sounding board for those with HPV (and HSV, too!). Below are 5 things we believe every woman should know about their HPV diagnosis.  HPV is common and nothing to be ashamed of Dr. Brene Brown defines shame as an “intensely painful feeling or experience of believing that we are flawed and unworthy of love and belonging”. To break through the barriers built by shame, one must be vulnerable. Vulnerability has the ability to transform fear and shame into belonging and acceptance.  HPV is nothing to be ashamed of. In fact, nearly 80% of people will have HPV at some point in their lives. However, because HPV is a sexually transmitted infection, there tends to be a stigma that prevents many from talking about the condition. Because of the shame many women feel, it can be tough to find support in our peers as it is not widely talked about. HPV is a virus. Viruses spread. This is a normal part of life, and the more we talk about it, the less shame and stigma we attach to it. Discussing and spreading awareness of HPV takes great vulnerability, but it also brings a sense of belonging to you and those around you going through the same thing. Having HPV does not mean you will get cancer. There are nearly 150 strains of HPV, with about 12 of them being linked to cervical cancer. Having HPV does not mean you will have cervical cancer, but it is important to be aware of your condition and keep up with regular screening, as well as lifestyle and dietary management to prevent disease progression. Talk to your doctor about vaccination, and remember to always practice safe sex by using protection like condoms or dental dams. Though these are not fool-proof, they do help to decrease the chances of transmission. A great practice is to strengthen your immune system through science-backed lifestyle changes like adequate sleep, increased consumption of antioxidant rich foods and powerful supplements like Papillex and AHCC. Smoking, excessive alcohol consumption and birth control all contribute to disease progression with HPV.  We have strong evidence to support the link between smoking and alcohol consumption and HPV disease progression. Birth control is another factor that can actually increase a woman's risk of cervical cancer. Studies find that for women with diagnosed HPV, the longer they use oral contraceptives, the higher their risk for cervical cancer. The good news is that once birth control is stopped, the risk does not continue.  Talk to your doctor about what this means for you. If you choose to be on an oral contraceptive, ensure timely screening and monitoring with your trusted health care provider.  You don’t need to “watch and wait”, you can often control HPV with diet and lifestyle  There are many ways to stay ahead of HPV with dietary and lifestyle changes. At Papillex, we strive to find the best available research on diet, supplementation and lifestyle used in the management of HPV.  Some of our favourite science-backed nutrients are folate, vitamin C, selenium, AHCC, carotenoids and more. We also advocate for a healthy lifestyle with lots of movement, stress-reduction, reduced alcohol and smoking consumption, and getting out in nature as much as possible. These practices can help you to better manage your health and stay on top of HPV. The old “watch and wait” approach is out-dated and leaves patients feeling disempowered. It helps to know you have options. There are other cancers caused by HPV Many of us know the risks for cervical cancer, but cancers of the vulva, vagina, penis, anus and oropharynx are also linked to particular strains of HPV. Throat cancer rates are drastically increasing in North America, so it is crucial to be aware of these so that you can get ahead of it. According to the CDC, 90% of both anal and cervical cancers are thought to be a result of HPV. HPV is linked to 70% of vaginal and vulvar cancers and 60% of penile cancers. Up to now, throat cancers were thought to be mostly caused by smoking and alcohol use, but more recent evidence finds that about 60-70% of oropharyngeal cancers may actually be linked to HPV.  Though not all HPV leads to cancer, prevention and early detection are only possible through adequate screening and remaining informed on your risks. Why watch and wait? Head to our instagram and our website for more ideas on how you can take control of your HPV today.
Jun 13, 2022
4 min read
The Best AHCC®

The Best AHCC®

Adrienne Hill-Strathy
As we’ve increased our understanding of the health benefits of mushrooms, the market for mushroom supplement products has increased as well. One potent mushroom called AHCC, found to be effective in supporting HPV eradication, has seen a boom in interest and availability. Several retailers are now selling AHCC covering a wide range of quality and price points. As a consumer, we understand it can be confusing to know what AHCC you should buy. How do you know which AHCC is best and what is the difference between the products? Here is a simple guide to purchasing AHCC. What is AHCC? AHCC stands for Active Hexose Correlated Compound, a highly-researched mushroom extract derived from the shiitake mushroom species. Over 30 clinical research studies have supported the use, effectiveness, and safety profile of AHCC®. The medicinal mushroom extract has been found to have powerful anti-viral activity against HPV as well as other viruses like influenza. It has been researched as an adjunct in cancer treatment. The compound works by stimulating the production of immune molecules that play a role in responding to infections and tumor growth. Studies show that it can increase the number of readily available natural killer cells, dendritic cells, and cytokines. The gentle and modulating action of mushrooms also makes them general immune supports to promote overall wellbeing. Where does AHCC come from? The compound was created by a Japanese company called Amino Up Chemical Co. Amino Up was founded in the 1970’s, they have since been manufacturing innovative nutritional compounds. In 1989 the company debuted the Lentinula Edodes Extract, also called AHCC. The magic in these mushrooms comes down to their unique manufacturing process. No other mushroom extract is processed in the same way as Amino Up. The company uses an extensive screening process to extract the special strain of mycelia used in AHCC. Mycelia are the part of the mushroom that grows below ground. They look like root-like hairs that grow on wood or soil. Once harvested, the roots are taken to the manufacturing plant to be broken down into tiny molecules. Through cultivation, sterilization, and decomposition, the compound is concentrated and freeze-dried. The final extract is made into a powder or capsule form. Throughout the process, the company ensures the safety and efficacy of every batch. Make sure it is the real thing Look out, some retailers are not selling the real AHCC. Instead of selling the proprietary extract from Amino Up, some retailers have packaged mushroom blends or other forms of shiitake mushroom. You will know the difference if the product is labeled Active Hexose Correlated Compound or AHCC with a registered ® or ™ label. Only AHCC that has been extracted from the Japanese manufacturers can be labeled with the registered trademark. The problem with using the non-AHCC products is that their therapeutic ingredients are not what have been included in the clinical research on AHCC. So, you may save money on a more affordable product, but it likely won’t have the intended impact. How has Papillex made our product more affordable? You might note that other suppliers are selling AHCC for a higher price. If the product contains pure AHCC® and has a trademark symbol, it has come from the same manufacturer and is the same therapeutic product. The difference is only the branding and potentially some added ingredients. Check your labels and look for AHCC® proprietary blend, the dosage, and if they have added other ingredients or fillers.   At Papillex, our goal has always been impact over profit. We wanted to make AHCC as accessible as possible, which is why we lowered our profit margins. We decided to sell AHCC® for $53, instead of over $100. AHCC® by Papillex Our AHCC product contains 60 capsules of 500 mg of pure AHCC per capsule. We add nothing else, no fillers, additives, or preservatives. Ingredient quality is top on our priority list and our products are verified with a certificate of analysis, including microbial testing, heavy metal testing, physical testing, and ingredient identification testing. So, you can be confident in what you’re taking. We added AHCC to our HPV toolbox to optimize your body’s ability to respond to HPV naturally. Our Papillex™ product aims to optimize nutrient levels found to be low in individuals with HPV infections. It also supplies immune-boosting ingredients to support the immune system. Taking AHCC® alongside Papillex™ creates a synergistic effect. Taking the two together offers more support than either of them taken alone. How to Dose AHCC®: The clinically researched dosage of AHCC for HPV is 1-3grams per day. (3 x 500 mg capsules taken twice daily) for 6 months. Papillex™: For acute infections, we recommend 2 capsules twice daily. For maintenance reduce dosage to 2 capsules daily.
Feb 07, 2022
4 min read
Condyloma Acuminatum: Genital Warts

Condyloma Acuminatum: Genital Warts

Adrienne Hill-Strathy
Condyloma Acuminatum is a fancy way of saying genital warts - a common symptom of a Human Papillomavirus (HPV) infection. Genital warts can be alarming and irritating. If you are experiencing genital warts, you are probably wondering how you can get rid of them. Is there anything you can do naturally? In this blog, we provide ways to respond to genital warts naturally, both internally and externally. The HPV family While most of the focus on HPV surrounds cervical cancer, the HPV family includes over 100 different viral strains, each having a slightly different impact on the body. HPV is responsible for common and plantar warts found on the hands and feet, as well as genital warts that grow around the vulva, vagina, penis, and scrotum. Only a few of the strains of HPV have the potential to become carcinogenic, causing cervical, oral, and anal cancers.  90% of genital warts are linked to HPV strains 6 and 11: These strains are considered “low risk” because they rarely develop into cancer. 70% of cervical cancers are caused by HPV strains 16 and 18: These strains are known as the highest risk strains and can progress into cancer. What do genital warts look like? Genital warts look like soft, fleshy growths. They may appear as a single or in multiples, some describe them as looking like cauliflower. Genital warts can be irritating but are rarely painful. Genital warts can affect both men and women. The estimated 5-year prevalence of genital warts is 1.3% in men and 1.7% in women. Warts typically emerge around the genitals a few weeks to two to three months after infection. HPV is easily transmitted from one individual to another through skin-to-skin contact, most commonly through sexual activity. Even if the individual has no symptoms or the warts have gone away, they may still be able to transmit HPV. If you suspect that you have genital warts, we recommend seeking advice from a medical professional. Other STIs, like herpes or syphilis, can present with similar symptoms and may warrant further treatment. The lesions may also be something harmless like a mole, ingrown hair, or skin tag - so it’s always better to check! Can I naturally respond to genital warts? Most people’s immune systems will naturally clear HPV infections in anywhere from a few months to a few years. The immune system includes several immune molecules like natural killer cells, cytokines, and macrophages that identify and eradicate viral infections. The immune system also keeps cancer cell growth in check through a process of tumor cell identification and cell death.  A few natural compounds have been found to enhance these immune players, leading to viral clearance. How to respond internally Green tea extract: Green tea extract is a key player when it comes to antiviral support. Green tea is high in compounds called polyphenols that benefit the immune system. Two polyphenols, epigallocatechin gallate (EGCG) and polyphenol E are effective at treating cervical lesions and warts caused by HPV. Drinking green tea as well as supplementation has been found to contribute health benefits and support wart clearance. If drinking tea isn’t your thing or you want to amplify your dose, Papillex supplies the recommended daily serving of green tea to support the immune system. Diet: It is estimated that 80 percent of the immune system is located in the gut. So what we eat and put into the body plays an important role in our immune defense. Eating a diverse array of fruits and vegetables provides ample micro and macronutrients. Amino acids obtained from proteins are essential for immune function as well as probiotics and fiber to support the intestinal microbiome. We also recommend trying to limit sugar, which can act as an immunosuppressant. AHCC: Emerging research on a medicinal mushroom extract called AHCC may support the immune system in eradicating HPV that causes genital warts. AHCC has been found to enhance the production of NK cells and cytokines, known for their role in viral clearance. The extract has not been clinically tested on genital warts but has been found to help eradicate persistent high-risk HPV infections in individuals with cervical dysplasia. How to respond externally Topical treatment for genital warts: Conventional treatment offers several prescription chemical treatments that can be applied topically. Some topical treatments include Podofilox, a gel solution with active podophyllin, has been found to prevent local irritation, and Imiquimod, a topical immune modifier that comes in single-use packets. In addition, there are natural solutions on the market. Green Tea Extract: Green tea extract has also been shown to have benefits when applied topically. The FDA has approved a standardized extract of green tea leaves for topical use on warts. The extract contains 15% catechins, the potent polyphenols found in green tea. Research evaluating the use of green tea extract topically found it to be effective and safe. The study evaluated a 10% green tea catechin ointment on over 100 adults with genital warts. The findings showed that those that used the green tea were 2-fold more effective at clearing existing warts and preventing recurrence 12 weeks after treatment. Tea tree oil: Tea tree is an antimicrobial herb that can be applied topically with a carrier oil such as coconut oil. Tea tree oil should not be taken internally or applied to the vaginal canal. One case report evaluating the use of tea tree oil twice daily with a carrier oil found clearance within 10-20 days for warts to disappear completely. More research is needed to determine the effectiveness on genital warts in larger, randomized clinical trials.  Bottom Line Few people are willing to talk about their experience with genital warts, and this stigma makes it difficult to know what to do. We hope this article gives you an assurance that genital warts are harmless and mostly self-limiting. If you are having trouble clearing genital warts, there are natural ways to respond both internally and externally. When in doubt, we always recommend you consult with a trusted natural health practitioner to find what works best for you.
Aug 23, 2021
5 min read
Amino Up Chemical Co.: The Makers of AHCC®

Amino Up Chemical Co.: The Makers of AHCC®

Adrienne Hill-Strathy
When it comes to medicinal mushrooms, there isn’t one quite like AHCC®.  AHCC® stands for Active Hexose Correlated Compound, a unique mushroom extract cultured from the shiitake mushroom species. Medicinal mushrooms have been used for centuries in Eastern Medicine to prevent and treat illness. These ancient practices are now being supported by clinical research studies, leading to growth in innovative products that optimize the compounds’ therapeutic benefits. The Amino Up Chemical Co. has spurred innovation in the mushroom world by creating an extract with potent immune-modulating activities. But first, how are mushrooms medicinal?  Before we dive into AHCC® - let’s start with the basics. How can mushrooms be medicinal? We are all familiar with the common white mushrooms, portobello, and oyster mushrooms, but most of us reserve them for our forks, not our medicine cabinets. Out of 14,000 species of fleshy fungi, numerous types have been found to have nutritional and therapeutic effects.  Edible mushrooms contain beneficial nutritional compounds such as B vitamins, zinc, potassium, copper, and magnesium. Mushrooms are also a great source of fiber and can protect against cellular damage due to their concentration of antioxidants.  Medicinal mushrooms contain compounds that support bodily functions that protect against aging and disease. The medicinal mushrooms are not always edible and require advanced techniques to extract the desired medicinal component so that they can be uptaken by the body.   Amino Up Chemical Co. The AHCC® compound is manufactured by a company called Amino Up Chemical Co. in Sapporo, Japan. Amino Up has been manufacturing innovative functional ingredients powered by plants since the 1970s. In 1989 the company debuted the cultured Lentinula Edodes Extract, also known as AHCC®. Today, over 30 clinical trials have investigated the use of Amino Up’s AHCC® in response to viral infections and cancers through its immune-modulating activity. Not only has the compound been found to be supportive in viral infections and influenza, but also a complementary therapy in breast, liver, pancreatic, and colon cancer. The findings provide evidence that AHCC® can improve quality of life and prolong survival.  How was AHCC® created?  AHCC® wouldn’t be the potent immune support that it is without the company's unique manufacturing process.  AHCC® was derived through an extensive screening and manufacturing process. The company screened a vast range of basidiomycetes mushrooms to extract the specialty strain of mycelia used to produce AHCC®. How is AHCC extracted? AHCC® is derived from a mixture of components derived from the cultured mycelia. Mycelia are root-like hairs of the mushroom that grow in wood or soil. AHCC® is derived from mycelia of the Lentinula edodes mushroom, also known as shiitake mushroom. These root-like hairs are broken down into tiny molecules. The final product is taken in capsule or powdered form. Not all supplements are created equal. The source, quality, and effectiveness of a supplement are all important when we are talking about our health. Amino Up uses a standardized extract of the cultured Lentinula edodes mycelia to ensure the highest quality and product consistency. The process regularly undergoes quality and safety control. AHCC® is extracted with the environment in mind by regularly conducting studies into the biodiversity around its property. Amino Up aims to live in harmony with the environment and wildlife.  Why take AHCC®? What makes the extract unique is its concentration of glucans. Normally, medicinal mushrooms contain polysaccharides called beta-glucans. Beta-glucans are known to modulate the immune system and can trigger immune molecules to amplify a response. The cultured extraction process of AHCC® derives another glucan called acylated alpha- 1,4 glucans. These glucans have a very small molecular weight, about 95% smaller than beta-glucan. The lower molecular weight is easier for the digestive system to absorb, helping to directly impact the immune system.  Together this combination acts as immune-modulating agents, helping strengthen the defense against infections and chronic disease.  Look out for products that are not the real AHCC® Clinical research evaluating the use of AHCC® has used this proprietary extract. These studies have researched AHCC® in cancer therapy, antivirals, and immune support.  AHCC® sold without the trademark (TM) or registered trademark (R) symbol next to the “AHCC” is not the clinically researched form of AHCC. Some supplement companies will use the full name – Active Hexose Correlated Compound. This implies that the compound has not been verified by the current clinical research and does not contain the acetylated alpha-glucans found to have an immune-modulating effect.  There is always shroom to grow We are excited by the ever-evolving ways we are learning to use plants and fungi as medicine. As the research unfolds, so too will our application and development of products like AHCC® to help promote longevity and health. As always, we recommend consulting with a natural health practitioner before supplementing AHCC®. The compound is safe and effective in most individuals, but it is always good to check if it is the right choice for you. 
Aug 09, 2021
4 min read
Mushrooms for Inflammation

Mushrooms for Inflammation

Adrienne Hill-Strathy
Let’s talk about inflammation. Many have deemed inflammation the driver of all chronic diseases - but, inflammation is crucial to our survival and bodily protection. We need inflammation to heal.  So, what is the balance? And how can we find it?  This blog covers all of that and more - keep reading for all things inflammation. Inflammation- friend or foe? Inflammation is the immune system’s first line of defense when fighting off pathogens like bacteria and viruses and helps us heal from injury. The inflammatory response plays a crucial role in combating infection and repairing tissue damage. Without inflammation, the body couldn’t heal. Several immune molecules play a role in inflammation, including macrophages, fibroblasts, mast cells, and dendritic cells. These molecules circulate in the blood until they pick up on invaders or cell damage to direct their response. With all of that said, chronic activation of the inflammatory response is at the root of many diseases. Our understanding of the connection between inflammation and disease has grown, and so have our tools to balance its response. Medicinal mushrooms are one way we can support the immune system in modulating the inflammatory response. Types of inflammation: Acute inflammation: Acute inflammation is the first player to act in the immune response. A scrape on your knee that turns red and hot, a runny nose, or a fever are all the body’s natural ways of healing. We have all experienced these acute inflammatory stressors and thank our body for its effective response. Chronic inflammation: Chronic inflammation occurs when the immune system is constantly triggered. Instead of healing the body, the immune system creates too many pro-inflammatory molecules, like tumor necrosis factor (TNF), interleukins (ILs), prostaglandins, and free radicals - this excess causes cell damage and creates health issues.  Many factors contribute to chronic inflammation. Inflammation may be triggered by stress, foods, toxic chemicals, heavy metals, and infections. Diet plays a large role because 70-80 percent of the immune system is located in our gut. What we eat directly interacts with the immune system and can initiate an inflammatory response. How do I know if I’m chronically inflamed? Chronic inflammation can be hard to detect and can build up over time. Symptoms such as weight gain, fatigue, moodiness, pain, skin problems like psoriasis and eczema, allergies, and autoimmune conditions may indicate chronic inflammation. You can also measure inflammation through blood tests. C-reactive protein (CRP) is a common inflammatory marker that can be measured in the blood. The optimal range of CRP is < 0.5 mg/L.  Homocysteine is another inflammatory amino acid linked to heart disease and other inflammatory conditions. The optimal range is <7 Umol/L. How can I decrease inflammation? Now that you know a bit more about optimal and chronic inflammation - what can you do?  Here is where the mushrooms step in. Medicinal mushrooms and inflammation Mushrooms have been used for centuries for their therapeutic effects on the body. Mushroom extracts have been used as immune modulators and for their anticancer, antibacterial, and antiviral properties. Medicinal mushrooms contain some of our most potent anti-inflammatory compounds. Medicinal mushrooms contain active compounds that can modulate the inflammatory response. Mushrooms are rich in polysaccharides, phenolic and indolic compounds, mycosteroids, and fatty acids as well as other vitamins and biometals. During chronic inflammation, the immune system is overproducing inflammatory mediators, leading to cell damage. The bioactive compounds found in mushrooms can reduce and suppress the production of inflammatory mediators through downregulating certain genes. This downregulation dampens the immune response, creating homeostasis and preventing chronic disease. The powder of polysaccharides Polysaccharides are one type of bioactive compound found in mushrooms. These polysaccharides inhibit inflammatory molecules including, IL-6, prostaglandins, and leukotrienes. Glucans are one type of polysaccharide found to adjust the immune system by binding to receptors in the digestive tract and activating the immune response. The glucans stimulate the production of immune molecules such as natural killer cells, cytokines, and T helper cells. These immune molecules signal the rest of the immune system to kick into gear.  What mushrooms can help inflammation: Reishi: Also called the mushroom of immortality, Reishi is rich in bioactive compounds including fatty acids, polysaccharides, and peptides found to inhibit inflammation. The polysaccharides found in Reishi may inhibit cancer cell growth and have anti-inflammatory properties with melanoma and breast cancer.  Chaga: Chaga mushrooms have also been found to have a potent anti-inflammatory effect. The mushroom has been found to have anti-inflammatory properties on mast cells and histamine responses. Histamine and mast cells are released in response to tissue damage and other inflammatory conditions and affect the microvasculature.  AHCC: Stands for Active Hexose Correlated Compound, a mushroom extract that contains both alpha and beta-glucans that modulate the immune system. AHCC is a potent immune modulator that stimulates natural killer cells, cytokine, and macrophages. The extract has been evaluated as general immune support as well as an adjunctive in the treatment of cancers and viral infections. Of course, supporting a healthy inflammatory response involves more than just a mushroom supplement. Diet, stress, environmental toxins, etc. also play a vital role. It is important to assess your lifestyle and make adjustments based on your specific risk factors. We recommend including a few mushrooms in your daily routine to offer extra immune support and keep you in balance.  
Jul 12, 2021
4 min read
AHCC® and Genital Warts

AHCC® and Genital Warts

Adrienne Hill-Strathy
Genital Warts are one symptom of the Human Papillomavirus (HPV). Warts are caused by specific strains of the HPV family. These strains cause soft, fleshy, and often irritating growths around the genital areas. If you have developed genital warts, you are probably wondering, “how do I get rid of them?” and “what does this mean for my health?” In this blog, we break down all things genital warts, as well as provide information about a new medicinal mushroom compound called AHCC®. AHCC® has been found to support the immune system and eradicate viral infections like HPV.  What are Genital Warts? Genital warts usually appear on the vulva, vagina, scrotum, or penis a few weeks to two to three months after exposure to an HPV infection. The warts tend to be soft, fleshy, skin-colored, or appear as white bumps. They may grow in singles or multiples, sometimes appearing as a cauliflower-like growth. While genital warts can be itchy, annoying, and persistent, they are harmless. How Did I Contract Genital Warts? The HPV family includes over 100 different viruses that commonly infect humans. The virus is so common because it is easily transmitted through skin-to-skin contact.  Genital warts can be transmitted through sexual interaction with the vagina, anus, oral sex, or hand contact. Transmission can even occur through individuals without visible warts or symptoms. Given the ease of transmission, it is estimated that 80 percent of people will be exposed to an HPV infection at some point in their lifetime. The risk of developing complications depends on the viral strain of HPV that you have contracted.  What are the complications of contracting genital warts? Fortunately, the strains of HPV that cause genital warts do not cause cancer. The strains of HPV associated with warts are considered low-risk. HPV tends to arise two to three months after infection and can last anywhere from a few weeks to a few years. High-risk strains that are often asymptomatic can eventually progress into cancer. It is important to note that contracting one strain of HPV does not make you immune to contracting other strains of HPV. Even if you have low-risk HPV, you can still be exposed to high-risk strains and should follow your physicians’ recommendations and receive regular testing. You can also pass the infection on to another person even once the warts have gone away. Can genital warts be treated? If you have recently noticed an outbreak of genital warts - what can you do to get rid of them? HPV and genital warts can be treated. Viruses and other pathogens that affect humans are suppressed by the immune system. Immune molecules such as natural killer cells, cytokines, and macrophages play a role in identifying and eliminating these foreign invaders. One way to naturally enhance the function and production of the immune system is through medicinal mushrooms. AHCC® and genital warts Active hexose correlated compound, or AHCC®, is a medicinal mushroom extract with immune-modulating and antioxidant activities. AHCC® has been researched for its use in supporting immune function in cancer treatment, viral infections, and enhancing immune function. Studies have found AHCC® to increase the natural killer cell and cytokine production, allowing for greater activation of the immune system. AHCC® also enhances T-cell and macrophage production, helping eradicate and eliminate invaders. AHCC® has been clinically researched as immune support for people suffering from persistent high-risk HPV infections. Dr. Judith A. Smith, of the University of Texas, has led two clinical trials of the use of AHCC® in people with HPV. The studies have evaluated a dose of 1 and 3 grams of AHCC® daily in high-risk HPV-infected individuals. The results of both studies have found AHCC® to have statistical significance in eradicating HPV infections compared to placebo.   No research studies have specifically evaluated AHCC® on genital warts. However, the underlying immune system support is important for clearing viral infections because it is the first to respond to and identify threats to the body for elimination.  What else can I do? There are certain lifestyle changes you can make to reduce your risk of infection: Quit Smoking and reduce alcohol: Smoking cigarettes impacts nearly every tissue in the body. No safe limit is recommended for use.  Reduce alcohol intake: Drinking alcohol can suppress the immune system. If you choose to drink, aim for less than 2-3 glasses per week.  Long-term use of oral contraceptives: Oral contraceptives have been linked to an increased risk of cervical cancer. Amp up your diet: Eating a nutrient-dense diet full of fruits and vegetables. Individuals who consumed more vegetables are less likely to have HPV.  Green tea extract: Green tea extract has also been shown to inhibit the development of HPV warts and cervical lesions.
Jun 28, 2021
4 min read
How To Supplement AHCC® for HPV

How To Supplement AHCC® for HPV

Adrienne Hill-Strathy
Natural health products are growing in popularity, likely due to their generally strong safety profiles and wide-ranging impact on the body.  Before starting any supplement, it is important to know if it’s right for you. AHCC® is a powerful immune support derived from medicinal mushrooms. Papillex has recently added AHCC® to our HPV arsenal and wanted to lay out everything you should know before jumping on this supplement train! What is AHCC®? AHCC® stands for active hexose correlated compound, a nutritional supplement derived from the medicinal mushroom, shiitake. After being used for many years in Traditional Chinese Medicine and medical practices in countries like Japan, AHCC® is recently being adopted globally for its immune-modulating activities. Several clinical research studies have found the compound to be effective as both a therapeutic and preventative immune support. Interested in learning more? We have laid out everything you need to know about supplementing AHCC® so you can decide if it’s right for you.  Is AHCC® safe? One of the magical things about medicinal mushrooms is that they are generally safe and well-tolerated in most individuals when taken in the appropriate dose. AHCC® has been tested in individuals in dosages up to 9 grams. Overall, findings have shown AHCC® to be safe with only some reports of mild nausea, headaches, and diarrhea. AHCC® has also been found to be well-tolerated alongside other medications, including being used as an adjunctive in chemotherapy. It is important to note that the compound may interfere with drugs metabolized using the CYP450 2D6 pathways and should not be combined with drugs such as doxorubicin or ondansetron.   Despite the compound’s strong safety record, there is still a lot to learn about the fungi. Research has mostly evaluated the use of AHCC® in patients with cancer, influenza, and viral infections. The compounds’ immune-boosting properties could potentially be too stimulating in individuals with immune-related disorders such as MS, Lupus, rheumatoid arthritis that present with immune activation. AHCC® Dosage for HPV  Typically, a dose of 1-3 grams of AHCC® is recommended for general immune support in patients with HPV. Higher doses of 3-6 grams daily are typically used in cancer patients. Two clinical trials, conducted by Dr. Judith A. Smith, have specifically evaluated the use of AHCC® in individuals with persistent high-risk HPV infections. The first study included ten female participants, using a dose of 3 grams daily for 5 weeks up until 6 months. The second study included another ten females but used a dose of 1 gram daily. Both groups found AHCC® to be more effective than controls at eliminating the infection, however, the 3-gram dose was slightly more effective.  How to take AHCC®? AHCC® by Papillex comes in pills of 500mg. For general use, we recommend taking 2 capsules in the morning at least 30 minutes before eating. Why take AHCC® on an empty stomach? We recommend taking AHCC® without food because most clinical studies have evaluated AHCC® on an empty stomach. We also know that taking some supplements away from food can help increase the absorption of the compound into the bloodstream, ensuring optimal therapeutic effect. However, some patients may experience nausea or have difficulty taking supplements without food. In which case, taking AHCC® with a light meal or a small amount of food will still allow for absorption. Consistency is important for the compound to have its intended effect. It can be helpful to set a designated time to take your supplements. It can also help to pair it with another daily activity, like when you brush your teeth in the morning. Setting an alarm or having your supplements in a visible, easily accessible space can also be helpful for maintaining consistency. Can I take AHCC® together with Papillex™? AHCC® and Papillex™ can be taken together for added immune support. Papillex™ helps restore nutrient deficiencies that may be low in individuals with HPV. Papillex™ also contains immune-supportive herbs like astragalus and reishi. AHCC® is a powerful immune support, providing additional support in helping identify and clear viral infections.  Duration - How long do I need to be on this supplement? AHCC® can be taken as a daily supplement in lower dosages of 1 gram per day to help support general immune function. For higher dosing of 3-6 grams, it is recommended to only supplement for 3-6 months. After 3-6 months, you can reduce the dose to 1-3 grams daily. Research studies have not evaluated the long-term use of AHCC®, therefore we cannot say whether it is safe to take for years on years.   How do you find out more and if it’s right for you? Despite the compound’s strong safety profile, we are all unique individuals.  We recommend consulting a healthcare professional before supplementing AHCC®. Naturopathic doctors, Traditional Chinese Medicine practitioners, and Functional Medicine doctors are often more informed about nutritional and herbal supplements and may be more suited to answer your questions about AHCC® and whether it is right for you.
May 31, 2021
4 min read

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